Gene Page: ATP7B

Summary
GeneID  540
Symbol  ATP7B
Synonyms  PWD|WC1|WD|WND
Description  ATPase, Cu++ transporting, beta polypeptide
See related  HGNC:870|MIM:606882|Ensembl:ENSG00000123191|HPRD:06050|
Locus tag  RP11-327P2.3
Gene type  protein-coding
Map location  13q14.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIEA-
GO:0004008copper-exporting ATPase activityIEA-
GO:0004008copper-exporting ATPase activityNAS12763797 
GO:0004008copper-exporting ATPase activityTAS16472602 
GO:0005375copper ion transmembrane transporter activityIEA-
GO:0005507copper ion bindingIDA12029094 
GO:0005507copper ion bindingIEA-
GO:0005515protein bindingIPI16554302 |16884690 
GO:0005524ATP bindingIDA16567646 
GO:0005524ATP bindingIEA-
GO:0016787hydrolase activityIEA-
GO:0016820hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substancesIEA-
GO:0015662ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanismIEA-
GO:0046872metal ion bindingIEA-
GO:0046873metal ion transmembrane transporter activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0030001metal ion transportIEA-
GO:0008152metabolic processIEA-
GO:0007595lactationIEA-
GO:0006825copper ion transportIEA-
GO:0006811ion transportIEA-
GO:0006810transportIEA-
GO:0006878cellular copper ion homeostasisTAS16554302 
GO:0006882cellular zinc ion homeostasisIEA-
GO:0015680intracellular copper ion transportIEA-
GO:0015677copper ion importIDA16472602 
GO:0051208sequestering of calcium ionIDA16472602 
GO:0046688response to copper ionIDA15269005 |16472602 |16939419 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005794Golgi apparatusIEA-
GO:0005802trans-Golgi networkIDA15269005 |16472602 
GO:0005624membrane fractionIEA-
GO:0005737cytoplasmIEA-
GO:0005739mitochondrionIEA-
GO:0005770late endosomeIDA15681833 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0016023cytoplasmic membrane-bounded vesicleIDA16472602 
GO:0005887integral to plasma membraneTAS8298641 
GO:0048471perinuclear region of cytoplasmIDA16939419 
GO:0016323basolateral plasma membraneIDA15269005 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATOX1ATX1 | HAH1 | MGC138453 | MGC138455ATX1 antioxidant protein 1 homolog (yeast)-HPRD,BioGRID10497213 |10557326 
|12763797 
GLRXGRX | GRX1 | MGC117407glutaredoxin (thioltransferase)Affinity Capture-Western
Two-hybrid		BioGRID16884690 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 413270All SZGR genes in this pathway
REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES 3421All SZGR genes in this pathway
REACTOME_ION_CHANNEL_TRANSPORT 5542All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
LAIHO_COLORECTAL_CANCER_SERRATED_DN 8647All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_UP 15791All SZGR genes in this pathway
LUCAS_HNF4A_TARGETS_UP 5836All SZGR genes in this pathway
FARMER_BREAST_CANCER_BASAL_VS_LULMINAL 330215All SZGR genes in this pathway
GARCIA_TARGETS_OF_FLI1_AND_DAX1_UP 5734All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_16HR_UP 225139All SZGR genes in this pathway
JOSEPH_RESPONSE_TO_SODIUM_BUTYRATE_DN 6445All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN 287208All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3 720440All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
MOOTHA_HUMAN_MITODB_6_2002 429260All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3 142103All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_SCP2_QTL_TRANS 2513All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3 210148All SZGR genes in this pathway
CHYLA_CBFA2T3_TARGETS_DN 242146All SZGR genes in this pathway


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