Gene Page: PPARD

Summary
GeneID  5467
Symbol  PPARD
Synonyms  FAAR|MGC3931|NR1C2|NUC1|NUCI|NUCII|PPAR-beta|PPARB
Description  peroxisome proliferator-activated receptor delta
See related  HGNC:9235|MIM:600409|Ensembl:ENSG00000112033|HPRD:02679|
Locus tag  -
Gene type  protein-coding
Map location  6p21.2-p21.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.033 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.04433 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
MRPL380.880.84
ERI30.880.85
MRPL40.880.83
MRPL170.880.84
MRPS120.860.83
MRPS70.860.83
ARF50.850.82
SLC25A110.850.83
MRPS110.850.80
MRP630.850.80
Top 10 negatively co-expressed genes
AF347015.18-0.54-0.45
AC010300.1-0.50-0.55
AF347015.26-0.48-0.38
MT-ATP8-0.46-0.38
AF347015.2-0.46-0.35
AF347015.8-0.46-0.36
AC100783.1-0.45-0.40
AF347015.15-0.44-0.34
AC016705.1-0.43-0.43
NSBP1-0.41-0.41
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityNAS11551955 
GO:0003707steroid hormone receptor activityTAS1333051 
GO:0005504fatty acid bindingNAS-
GO:0008270zinc ion bindingIEA-
GO:0008144drug bindingIDA9113987 
GO:0016564transcription repressor activityISS-
GO:0046872metal ion bindingIEA-
GO:0043565sequence-specific DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008366axon ensheathmentISSneuron, axon (GO term level: 12)-
GO:0000122negative regulation of transcription from RNA polymerase II promoterISS-
GO:0006350transcriptionIEA-
GO:0006091generation of precursor metabolites and energyTAS1333051 
GO:0006006glucose metabolic processNAS15793256 
GO:0008203cholesterol metabolic processTAS15192438 
GO:0008283cell proliferationISS-
GO:0008283cell proliferationTAS11847022 
GO:0008544epidermis developmentISS-
GO:0007566embryo implantationTAS11551955 
GO:0015758glucose transportNAS15793256 
GO:0006635fatty acid beta-oxidationISS-
GO:0006635fatty acid beta-oxidationTAS15192438 |15803109 
GO:0006629lipid metabolic processISS-
GO:0006915apoptosisIMP11551955 
GO:0014068positive regulation of phosphoinositide 3-kinase cascadeIEA-
GO:0015908fatty acid transportISS-
GO:0030154cell differentiationIEA-
GO:0042640anagenIEA-
GO:0045600positive regulation of fat cell differentiationNAS10991946 
GO:0046697decidualizationTAS11551955 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusNAS11551955 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BCL6BCL5 | BCL6A | LAZ3 | ZBTB27 | ZNF51B-cell CLL/lymphoma 6PPAR-delta interacts with BCL-6. This interaction was modelled on a demonstrated interaction between mouse PPAR-delta and human BCL-6.BIND12970571 
CEP350CAP350 | FLJ38282 | FLJ44058 | GM133 | KIAA0480centrosomal protein 350kDaCAP350 interacts with PPAR-delta.BIND15615782 
DUTFLJ20622 | dUTPasedeoxyuridine triphosphatase-HPRD8910358 
EP300KAT3B | p300E1A binding protein p300-HPRD10567538 
GADD45BDKFZp566B133 | GADD45BETA | MYD118growth arrest and DNA-damage-inducible, beta-HPRD10872826 
GADD45GCR6 | DDIT2 | GADD45gamma | GRP17growth arrest and DNA-damage-inducible, gamma-HPRD,BioGRID10872826 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1-HPRD,BioGRID11867749 
HDAC2RPD3 | YAF1histone deacetylase 2-HPRD,BioGRID11867749 
HDAC3HD3 | RPD3 | RPD3-2histone deacetylase 3Affinity Capture-Western
Reconstituted Complex		BioGRID11867749 |12943985 
HDAC4HA6116 | HD4 | HDAC-A | HDACA | KIAA0288histone deacetylase 4Reconstituted ComplexBioGRID12943985 
HDAC7DKFZp586J0917 | FLJ99588 | HD7A | HDAC7Ahistone deacetylase 7PPAR-delta interacts with HDAC7. This interaction was modelled on a demonstrated interaction between PPAR-delta and HDAC7 from unspecified sources.BIND12970571 
NCOR1KIAA1047 | MGC104216 | N-CoR | TRAC1 | hCIT529I10 | hN-CoRnuclear receptor co-repressor 1Two-hybridBioGRID11867749 
NCOR2CTG26 | SMRT | SMRTE | SMRTE-tau | TNRC14 | TRAC-1 | TRAC1nuclear receptor co-repressor 2-HPRD,BioGRID11867749 
PPAR-delta interacts with SMRT. This interaction was modelled on a demonstrated interaction between PPAR-delta and SMRT from unspecified sources.BIND12970571 
SPENKIAA0929 | MINT | RP1-134O19.1 | SHARPspen homolog, transcriptional regulator (Drosophila)-HPRD,BioGRID11867749 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_PPAR_SIGNALING_PATHWAY 6947All SZGR genes in this pathway
KEGG_WNT_SIGNALING_PATHWAY 151112All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_ACUTE_MYELOID_LEUKEMIA 6047All SZGR genes in this pathway
BIOCARTA_NUCLEARRS_PATHWAY 1512All SZGR genes in this pathway
BIOCARTA_WNT_PATHWAY 2624All SZGR genes in this pathway
PID_PS1_PATHWAY 4639All SZGR genes in this pathway
PID_RXR_VDR_PATHWAY 2624All SZGR genes in this pathway
REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 352181All SZGR genes in this pathway
REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY 4936All SZGR genes in this pathway
WINTER_HYPOXIA_UP 9257All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_DN 241146All SZGR genes in this pathway
SMIRNOV_CIRCULATING_ENDOTHELIOCYTES_IN_CANCER_UP 158103All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN 335193All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_20Q13_AMPLIFICATION_DN 180101All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_UP 380236All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_ERYTHROCYTE_UP 157104All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_DN 536332All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_UP 293179All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_UP 769437All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN 637377All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_DN 382224All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_MODERATELY_DN 11064All SZGR genes in this pathway
ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP 223140All SZGR genes in this pathway
MANALO_HYPOXIA_DN 289166All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_MUSCLE_UP 4333All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN 287208All SZGR genes in this pathway
URS_ADIPOCYTE_DIFFERENTIATION_DN 3020All SZGR genes in this pathway
HELLER_HDAC_TARGETS_UP 317208All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP 461298All SZGR genes in this pathway
LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_DN 4531All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN 940425All SZGR genes in this pathway
LABBE_WNT3A_TARGETS_DN 9753All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP 338225All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_UP 418282All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP 408276All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6 456285All SZGR genes in this pathway
FONTAINE_FOLLICULAR_THYROID_ADENOMA_UP 7543All SZGR genes in this pathway
SENGUPTA_EBNA1_ANTICORRELATED 17385All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_1HR_DN 222147All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_1_DN 4830All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_3_DN 4224All SZGR genes in this pathway
SERVITJA_LIVER_HNF1A_TARGETS_DN 157105All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1383683751A,m8hsa-miR-138brainAGCUGGUGUUGUGAAUC
miR-2919491955m8hsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-95185241Ahsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.