Gene Page: CC2D1A
Summary ?
| GeneID | 54862 |
| Symbol | CC2D1A |
| Synonyms | FREUD-1|Freud-1/Aki1|MRT3 |
| Description | coiled-coil and C2 domain containing 1A |
| Reference | MIM:610055|HGNC:HGNC:30237|Ensembl:ENSG00000132024|HPRD:08616|Vega:OTTHUMG00000181852 |
| Gene type | protein-coding |
| Map location | 19p13.12 |
| Pascal p-value | 0.72 |
| Sherlock p-value | 0.002 |
| Fetal beta | -0.25 |
| eGene | Myers' cis & trans |
| Support | CompositeSet Ascano FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg14269716 | 19 | 14016603 | C19orf57;CC2D1A | 2.44E-4 | 0.301 | 0.037 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs17220846 | chr10 | 64187530 | CC2D1A | 54862 | 0.09 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ADSL | 0.86 | 0.90 |
| RPL26L1 | 0.85 | 0.87 |
| NSMCE1 | 0.84 | 0.78 |
| SNRPC | 0.83 | 0.88 |
| PSMA7 | 0.83 | 0.86 |
| COQ5 | 0.83 | 0.83 |
| TSTA3 | 0.83 | 0.85 |
| RFC2 | 0.83 | 0.86 |
| PPIL1 | 0.82 | 0.88 |
| VPS25 | 0.82 | 0.82 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.26 | -0.64 | -0.78 |
| AF347015.8 | -0.64 | -0.75 |
| MT-CYB | -0.64 | -0.75 |
| MT-CO2 | -0.64 | -0.72 |
| AF347015.15 | -0.64 | -0.76 |
| AF347015.2 | -0.63 | -0.75 |
| AF347015.27 | -0.63 | -0.74 |
| AF347015.33 | -0.63 | -0.73 |
| AF347015.31 | -0.62 | -0.71 |
| AF347015.9 | -0.57 | -0.70 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN | 663 | 425 | All SZGR 2.0 genes in this pathway |
| WAMUNYOKOLI OVARIAN CANCER LMP UP | 265 | 158 | All SZGR 2.0 genes in this pathway |
| SWEET KRAS TARGETS DN | 66 | 39 | All SZGR 2.0 genes in this pathway |
| JIANG HYPOXIA NORMAL | 311 | 205 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY E2F4 UNSTIMULATED | 728 | 415 | All SZGR 2.0 genes in this pathway |
| AMBROSINI FLAVOPIRIDOL TREATMENT TP53 | 109 | 63 | All SZGR 2.0 genes in this pathway |
| BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING | 510 | 309 | All SZGR 2.0 genes in this pathway |
| TOYOTA TARGETS OF MIR34B AND MIR34C | 463 | 262 | All SZGR 2.0 genes in this pathway |
| VERHAAK GLIOBLASTOMA CLASSICAL | 162 | 122 | All SZGR 2.0 genes in this pathway |