Summary ?
GeneID54993
SymbolZSCAN2
SynonymsZFP29|ZNF854
Descriptionzinc finger and SCAN domain containing 2
ReferenceHGNC:HGNC:20994|Ensembl:ENSG00000176371|HPRD:15898|Vega:OTTHUMG00000074027
Gene typeprotein-coding
Map location15q25.2
Pascal p-value2.506E-10
Fetal beta2.533
DMG2 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 3
DMG:Nishioka_2013Genome-wide DNA methylation analysisThe authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 3

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg011732911585144040ZSCAN2-0.0220.33DMG:Nishioka_2013
cg251308001585143846ZSCAN22.53E-10-0.0226.3E-7DMG:Jaffe_2016
cg124486641585143675ZSCAN21.71E-9-0.0331.5E-6DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
LPCAT40.900.89
C6orf1360.890.89
GABRD0.890.83
GLS20.880.89
AC068580.30.880.86
ABTB10.880.81
THY10.870.89
ZFYVE280.870.86
C16orf50.870.89
TUBG20.870.87
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
RBMX2-0.52-0.56
KIAA1949-0.49-0.39
TUBB2B-0.49-0.50
ZNF300-0.48-0.30
YBX1-0.47-0.42
C9orf46-0.47-0.51
AIM2-0.47-0.42
FNBP1L-0.47-0.27
IDH1-0.47-0.36
TIGD1-0.47-0.33

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
DARWICHE PAPILLOMA PROGRESSION RISK 7444All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH VS LOW DN 3221All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734436All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 LCP WITH H3K4ME3 16280All SZGR 2.0 genes in this pathway
MIKKELSEN MEF LCP WITH H3K4ME3 12868All SZGR 2.0 genes in this pathway
MIKKELSEN IPS LCP WITH H3K4ME3 174100All SZGR 2.0 genes in this pathway
MIKKELSEN NPC LCP WITH H3K4ME3 5834All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN 505328All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839928All SZGR 2.0 genes in this pathway