Gene Page: ZSCAN2
Summary ?
| GeneID | 54993 |
| Symbol | ZSCAN2 |
| Synonyms | ZFP29|ZNF854 |
| Description | zinc finger and SCAN domain containing 2 |
| Reference | HGNC:HGNC:20994|Ensembl:ENSG00000176371|HPRD:15898|Vega:OTTHUMG00000074027 |
| Gene type | protein-coding |
| Map location | 15q25.2 |
| Pascal p-value | 2.506E-10 |
| Fetal beta | 2.533 |
| DMG | 2 (# studies) |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 3 |
| DMG:Nishioka_2013 | Genome-wide DNA methylation analysis | The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. | 3 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg01173291 | 15 | 85144040 | ZSCAN2 | -0.022 | 0.33 | DMG:Nishioka_2013 | |
| cg25130800 | 15 | 85143846 | ZSCAN2 | 2.53E-10 | -0.022 | 6.3E-7 | DMG:Jaffe_2016 |
| cg12448664 | 15 | 85143675 | ZSCAN2 | 1.71E-9 | -0.033 | 1.5E-6 | DMG:Jaffe_2016 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| LPCAT4 | 0.90 | 0.89 |
| C6orf136 | 0.89 | 0.89 |
| GABRD | 0.89 | 0.83 |
| GLS2 | 0.88 | 0.89 |
| AC068580.3 | 0.88 | 0.86 |
| ABTB1 | 0.88 | 0.81 |
| THY1 | 0.87 | 0.89 |
| ZFYVE28 | 0.87 | 0.86 |
| C16orf5 | 0.87 | 0.89 |
| TUBG2 | 0.87 | 0.87 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| RBMX2 | -0.52 | -0.56 |
| KIAA1949 | -0.49 | -0.39 |
| TUBB2B | -0.49 | -0.50 |
| ZNF300 | -0.48 | -0.30 |
| YBX1 | -0.47 | -0.42 |
| C9orf46 | -0.47 | -0.51 |
| AIM2 | -0.47 | -0.42 |
| FNBP1L | -0.47 | -0.27 |
| IDH1 | -0.47 | -0.36 |
| TIGD1 | -0.47 | -0.33 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| DARWICHE PAPILLOMA PROGRESSION RISK | 74 | 44 | All SZGR 2.0 genes in this pathway |
| DARWICHE PAPILLOMA RISK HIGH VS LOW DN | 32 | 21 | All SZGR 2.0 genes in this pathway |
| BENPORATH SOX2 TARGETS | 734 | 436 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MCV6 LCP WITH H3K4ME3 | 162 | 80 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF LCP WITH H3K4ME3 | 128 | 68 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN IPS LCP WITH H3K4ME3 | 174 | 100 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN NPC LCP WITH H3K4ME3 | 58 | 34 | All SZGR 2.0 genes in this pathway |
| DUTERTRE ESTRADIOL RESPONSE 24HR DN | 505 | 328 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |