Gene Page: SMPD3
Summary ?
| GeneID | 55512 |
| Symbol | SMPD3 |
| Synonyms | NSMASE2 |
| Description | sphingomyelin phosphodiesterase 3 |
| Reference | MIM:605777|HGNC:HGNC:14240|Ensembl:ENSG00000103056|HPRD:16154|Vega:OTTHUMG00000137559 |
| Gene type | protein-coding |
| Map location | 16q22.1 |
| Pascal p-value | 0.002 |
| eGene | Cerebellar Hemisphere Cerebellum |
| Support | INTRACELLULAR SIGNAL TRANSDUCTION CompositeSet Darnell FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SARM1 | 0.95 | 0.96 |
| EDC4 | 0.95 | 0.96 |
| FZR1 | 0.95 | 0.95 |
| MEN1 | 0.94 | 0.96 |
| GPR173 | 0.93 | 0.96 |
| SMPD4 | 0.93 | 0.95 |
| CARM1 | 0.93 | 0.94 |
| LSM14B | 0.93 | 0.95 |
| GTPBP3 | 0.93 | 0.94 |
| TSC2 | 0.93 | 0.94 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.79 | -0.89 |
| AF347015.27 | -0.78 | -0.88 |
| MT-CO2 | -0.77 | -0.88 |
| AF347015.33 | -0.76 | -0.85 |
| MT-CYB | -0.75 | -0.85 |
| AF347015.8 | -0.74 | -0.88 |
| C5orf53 | -0.74 | -0.77 |
| S100B | -0.73 | -0.81 |
| FXYD1 | -0.72 | -0.81 |
| COPZ2 | -0.72 | -0.79 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG SPHINGOLIPID METABOLISM | 40 | 26 | All SZGR 2.0 genes in this pathway |
| PID CERAMIDE PATHWAY | 48 | 37 | All SZGR 2.0 genes in this pathway |
| REACTOME GLYCOSPHINGOLIPID METABOLISM | 38 | 22 | All SZGR 2.0 genes in this pathway |
| REACTOME PHOSPHOLIPID METABOLISM | 198 | 112 | All SZGR 2.0 genes in this pathway |
| REACTOME SPHINGOLIPID METABOLISM | 69 | 40 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS | 478 | 302 | All SZGR 2.0 genes in this pathway |
| KIM RESPONSE TO TSA AND DECITABINE UP | 129 | 73 | All SZGR 2.0 genes in this pathway |
| ZHONG RESPONSE TO AZACITIDINE AND TSA UP | 183 | 119 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| MANTOVANI VIRAL GPCR SIGNALING DN | 49 | 37 | All SZGR 2.0 genes in this pathway |
| BENPORATH ES WITH H3K27ME3 | 1118 | 744 | All SZGR 2.0 genes in this pathway |
| HELLER HDAC TARGETS SILENCED BY METHYLATION UP | 461 | 298 | All SZGR 2.0 genes in this pathway |
| DE YY1 TARGETS UP | 20 | 14 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER BASAL DN | 701 | 446 | All SZGR 2.0 genes in this pathway |
| MILI PSEUDOPODIA HAPTOTAXIS DN | 668 | 419 | All SZGR 2.0 genes in this pathway |
| SENGUPTA EBNA1 ANTICORRELATED | 173 | 85 | All SZGR 2.0 genes in this pathway |
| PURBEY TARGETS OF CTBP1 NOT SATB1 UP | 344 | 215 | All SZGR 2.0 genes in this pathway |