Gene Page: STAP2

Summary ?
GeneID55620
SymbolSTAP2
SynonymsBKS
Descriptionsignal transducing adaptor family member 2
ReferenceMIM:607881|HGNC:HGNC:30430|Ensembl:ENSG00000178078|HPRD:07430|Vega:OTTHUMG00000181884
Gene typeprotein-coding
Map location19p13.3
Pascal p-value0.799
Sherlock p-value0.96
Fetal beta-0.898
eGeneCaudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Frontal Cortex BA9
Hypothalamus
Nucleus accumbens basal ganglia
Putamen basal ganglia
Myers' cis & trans
Meta
SupportCompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DNM:Xu_2012Whole Exome Sequencing analysisDe novo mutations of 4 genes were identified by exome sequencing of 795 samples in this study

Section I. Genetics and epigenetics annotation

@DNM table

GeneChromosomePositionRefAltTranscriptAA changeMutation typeSiftCG46TraitStudy
STAP2chr194338685ATNM_001013841
NM_017720		p.22Y>*
p.22Y>*		nonsense
nonsense		SchizophreniaDNM:Xu_2012

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs7258060chr194332104STAP2556201.158E-4cis
rs7258060chr194332104STAP2556200.01trans
rs374392257194331940STAP2ENSG00000178078.71.29977E-60.0110843gtex_brain_putamen_basal
rs7258060194332105STAP2ENSG00000178078.75.24181E-70.0110678gtex_brain_putamen_basal
rs11673317194332650STAP2ENSG00000178078.72.64591E-70.0110133gtex_brain_putamen_basal
rs10413905194333666STAP2ENSG00000178078.75.06307E-70.019117gtex_brain_putamen_basal
rs60010631194334310STAP2ENSG00000178078.75.00993E-70.018473gtex_brain_putamen_basal
rs55913120194334402STAP2ENSG00000178078.71.56962E-60.018381gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
GAB10.840.84
TRIM590.800.79
JAM30.800.84
BBX0.790.84
MYBL10.780.84
TMTC20.770.81
CCNE20.760.79
SEPT100.760.71
SLAIN10.750.66
CREB50.740.84
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ST20-0.34-0.45
TBC1D10A-0.32-0.38
PRR5-0.31-0.32
SYCP3-0.31-0.37
IL32-0.30-0.38
RP9P-0.30-0.46
AC016757.1-0.30-0.35
AC087071.1-0.30-0.43
DUSP23-0.29-0.33
EMID1-0.29-0.38

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
JAEGER METASTASIS DN 258141All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781465All SZGR 2.0 genes in this pathway
COLDREN GEFITINIB RESISTANCE DN 230115All SZGR 2.0 genes in this pathway
SCHEIDEREIT IKK INTERACTING PROTEINS 5845All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734436All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464276All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540340All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS DN 14593All SZGR 2.0 genes in this pathway
GRADE METASTASIS DN 4531All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL DN 428246All SZGR 2.0 genes in this pathway