Gene Page: PCDHB2
Summary ?
GeneID | 56133 |
Symbol | PCDHB2 |
Synonyms | PCDH-BETA2 |
Description | protocadherin beta 2 |
Reference | MIM:606328|HGNC:HGNC:8687|HPRD:07558| |
Gene type | protein-coding |
Map location | 5q31 |
Pascal p-value | 0.009 |
eGene | Cerebellar Hemisphere |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
GSMA_I | Genome scan meta-analysis | Psr: 0.0032 | |
GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 2 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
ATHL1 | 0.78 | 0.82 |
C1orf175 | 0.74 | 0.75 |
COL16A1 | 0.73 | 0.76 |
MICALL2 | 0.72 | 0.72 |
ITIH4 | 0.72 | 0.77 |
COL5A3 | 0.72 | 0.77 |
LCN12 | 0.70 | 0.68 |
ADCY4 | 0.70 | 0.75 |
RGL3 | 0.67 | 0.68 |
ITGA7 | 0.67 | 0.71 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
TXNL1 | -0.49 | -0.56 |
MOBKL3 | -0.47 | -0.54 |
MRPL44 | -0.46 | -0.56 |
MMADHC | -0.46 | -0.53 |
TAF9 | -0.45 | -0.51 |
CCT4 | -0.45 | -0.53 |
MED19 | -0.45 | -0.51 |
EIF3M | -0.45 | -0.53 |
ASNSD1 | -0.45 | -0.51 |
METTL9 | -0.45 | -0.52 |
Section III. Gene Ontology annotation
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0005509 | calcium ion binding | IEA | - | |
GO:0005515 | protein binding | NAS | 11322959 | |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0007416 | synaptogenesis | TAS | Synap (GO term level: 6) | 12231349 |
GO:0007268 | synaptic transmission | TAS | neuron, Synap, Neurotransmitter (GO term level: 6) | 12231349 |
GO:0007155 | cell adhesion | TAS | 10380929 | |
GO:0007156 | homophilic cell adhesion | IEA | - | |
GO:0016339 | calcium-dependent cell-cell adhesion | NAS | 11322959 | |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0005886 | plasma membrane | IEA | - | |
GO:0005887 | integral to plasma membrane | TAS | 10380929 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
HAMAI APOPTOSIS VIA TRAIL DN | 186 | 107 | All SZGR 2.0 genes in this pathway |
LOPEZ MBD TARGETS | 957 | 597 | All SZGR 2.0 genes in this pathway |
RICKMAN HEAD AND NECK CANCER A | 100 | 63 | All SZGR 2.0 genes in this pathway |
MIKKELSEN IPS ICP WITH H3K27ME3 | 54 | 32 | All SZGR 2.0 genes in this pathway |
MIKKELSEN NPC ICP WITH H3K4ME3 | 445 | 257 | All SZGR 2.0 genes in this pathway |