Gene Page: NPDC1
Summary ?
| GeneID | 56654 |
| Symbol | NPDC1 |
| Synonyms | CAB|CAB-|CAB-1|CAB1|NPDC-1 |
| Description | neural proliferation, differentiation and control, 1 |
| Reference | MIM:605798|HGNC:HGNC:7899|Ensembl:ENSG00000107281|HPRD:12048|Vega:OTTHUMG00000020956 |
| Gene type | protein-coding |
| Map location | 9q34.3 |
| Pascal p-value | 0.957 |
| Sherlock p-value | 0.541 |
| Fetal beta | -0.463 |
| DMG | 1 (# studies) |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| DMG:Montano_2016 | Genome-wide DNA methylation analysis | This dataset includes 172 replicated associations between CpGs with schizophrenia. | 1 |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg26581729 | 9 | 139939792 | NPDC1 | 1.95E-5 | -0.01 | 0.063 | DMG:Montano_2016 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| CCND1 | BCL1 | D11S287E | PRAD1 | U21B31 | cyclin D1 | - | HPRD,BioGRID | 11042687 |
| CCND2 | KIAK0002 | MGC102758 | cyclin D2 | - | HPRD,BioGRID | 11042687 |
| CCND3 | - | cyclin D3 | - | HPRD,BioGRID | 11042687 |
| CDK2 | p33(CDK2) | cyclin-dependent kinase 2 | - | HPRD,BioGRID | 11042687 |
| E2F1 | E2F-1 | RBAP1 | RBBP3 | RBP3 | E2F transcription factor 1 | - | HPRD,BioGRID | 11042687 |
| HNRNPK | CSBP | FLJ41122 | HNRPK | TUNP | heterogeneous nuclear ribonucleoprotein K | Two-hybrid | BioGRID | 16189514 |
| KRTAP4-12 | KAP4.12 | KRTAP4.12 | keratin associated protein 4-12 | Two-hybrid | BioGRID | 16189514 |
| MADD | DENN | FLJ35600 | FLJ36300 | IG20 | KIAA0358 | RAB3GEP | MAP-kinase activating death domain | - | HPRD | 10970871 |
| MDFI | I-MF | I-mfa | MyoD family inhibitor | Two-hybrid | BioGRID | 16189514 |
| PLSCR1 | MMTRA1B | phospholipid scramblase 1 | Two-hybrid | BioGRID | 16189514 |
| TFDP1 | DP1 | DRTF1 | Dp-1 | transcription factor Dp-1 | - | HPRD,BioGRID | 11042687 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| CHARAFE BREAST CANCER LUMINAL VS BASAL UP | 380 | 215 | All SZGR 2.0 genes in this pathway |
| CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP | 450 | 256 | All SZGR 2.0 genes in this pathway |
| HAMAI APOPTOSIS VIA TRAIL UP | 584 | 356 | All SZGR 2.0 genes in this pathway |
| YORDY RECIPROCAL REGULATION BY ETS1 AND SP100 UP | 25 | 11 | All SZGR 2.0 genes in this pathway |
| LIEN BREAST CARCINOMA METAPLASTIC VS DUCTAL DN | 114 | 58 | All SZGR 2.0 genes in this pathway |
| SHETH LIVER CANCER VS TXNIP LOSS PAM2 | 153 | 102 | All SZGR 2.0 genes in this pathway |
| LOPEZ MBD TARGETS | 957 | 597 | All SZGR 2.0 genes in this pathway |
| RICKMAN TUMOR DIFFERENTIATED MODERATELY VS POORLY UP | 121 | 71 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS | 882 | 572 | All SZGR 2.0 genes in this pathway |
| SANSOM APC TARGETS DN | 366 | 238 | All SZGR 2.0 genes in this pathway |
| REN ALVEOLAR RHABDOMYOSARCOMA DN | 408 | 274 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER RELAPSE IN BRAIN DN | 85 | 58 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER BASAL DN | 701 | 446 | All SZGR 2.0 genes in this pathway |
| VANTVEER BREAST CANCER ESR1 UP | 167 | 99 | All SZGR 2.0 genes in this pathway |
| SWEET LUNG CANCER KRAS UP | 491 | 316 | All SZGR 2.0 genes in this pathway |
| CHEN METABOLIC SYNDROM NETWORK | 1210 | 725 | All SZGR 2.0 genes in this pathway |
| VALK AML CLUSTER 10 | 33 | 22 | All SZGR 2.0 genes in this pathway |
| VALK AML WITH EVI1 | 25 | 15 | All SZGR 2.0 genes in this pathway |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 16 | 79 | 47 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP B | 549 | 316 | All SZGR 2.0 genes in this pathway |
| LEE BMP2 TARGETS UP | 745 | 475 | All SZGR 2.0 genes in this pathway |
| FEVR CTNNB1 TARGETS UP | 682 | 433 | All SZGR 2.0 genes in this pathway |