SZGR2

Summary ?

GeneID	5747
Symbol	PTK2
Synonyms	FADK\|FAK\|FAK1\|FRNK\|PPP1R71\|p125FAK\|pp125FAK
Description	protein tyrosine kinase 2
Reference	MIM:600758\|HGNC:HGNC:9611\|Ensembl:ENSG00000169398\|HPRD:02859\|Vega:OTTHUMG00000067438
Gene type	protein-coding
Map location	8q24.3
Pascal p-value	0.04
Sherlock p-value	0.065
Fetal beta	-0.566
DMG	1 (# studies)
eGene	Caudate basal ganglia Cerebellar Hemisphere Cerebellum
Support	G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL CompositeSet Darnell FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 4
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 1.1049

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg03277652	8	142011117	PTK2	1.89E-5	-0.263	0.016	DMG:Wockner_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0004871	signal transducer activity	IEA		-
GO:0005515	protein binding	IPI		8649368 \|10822899 \|14688263
GO:0005524	ATP binding	IEA		-
GO:0004713	protein tyrosine kinase activity	IEA		-
GO:0004715	non-membrane spanning protein tyrosine kinase activity	IEA		-
GO:0016740	transferase activity	IEA		-
GO:0042169	SH2 domain binding	IPI		15077193
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0001764	neuron migration	IEA	neuron (GO term level: 8)	-
GO:0051964	negative regulation of synaptogenesis	IEA	Synap (GO term level: 10)	-
GO:0021955	central nervous system neuron axonogenesis	IEA	neuron, axon (GO term level: 13)	-
GO:0050771	negative regulation of axonogenesis	IEA	axon, neurogenesis (GO term level: 14)	-
GO:0000226	microtubule cytoskeleton organization	IEA		-
GO:0001570	vasculogenesis	IEA		-
GO:0001568	blood vessel development	IEA		-
GO:0001525	angiogenesis	IEA		-
GO:0007172	signal complex assembly	IEA		-
GO:0006468	protein amino acid phosphorylation	IEA		-
GO:0007229	integrin-mediated signaling pathway	TAS		9636140
GO:0040023	establishment of nucleus localization	IEA		-
GO:0030198	extracellular matrix organization	IEA		-
GO:0043542	endothelial cell migration	IEA		-
GO:0046621	negative regulation of organ growth	IEA		-
GO:0046777	protein amino acid autophosphorylation	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	EXP		9325343
GO:0005856	cytoskeleton	IEA		-
GO:0005856	cytoskeleton	TAS		10801330
GO:0005737	cytoplasm	IDA		18029348
GO:0030027	lamellipodium	IEA		-
GO:0005925	focal adhesion	IEA		-
GO:0005886	plasma membrane	IEA		-
GO:0016324	apical plasma membrane	IEA		-
GO:0030054	cell junction	IDA		18029348
GO:0030054	cell junction	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AMPH	AMPH1	amphiphysin	Affinity Capture-Western	BioGRID	12558988
APC	BTPS2 \| DP2 \| DP2.5 \| DP3 \| GS	adenomatous polyposis coli	-	HPRD	7744883
ARHGAP26	FLJ42530 \| GRAF \| KIAA0621 \| OPHN1L \| OPHN1L1	Rho GTPase activating protein 26	-	HPRD,BioGRID	8649427
ASAP1	AMAP1 \| CENTB4 \| DDEF1 \| KIAA1249 \| PAG2 \| PAP \| ZG14P	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	-	HPRD	12058076
ATG12	APG12 \| APG12L \| FBR93 \| HAPG12	ATG12 autophagy related 12 homolog (S. cerevisiae)	Two-hybrid	BioGRID	16189514
BCAR1	CAS \| CAS1 \| CASS1 \| CRKAS \| P130Cas	breast cancer anti-estrogen resistance 1	-	HPRD	11514617
BCAR1	CAS \| CAS1 \| CASS1 \| CRKAS \| P130Cas	breast cancer anti-estrogen resistance 1	Affinity Capture-Western Reconstituted Complex	BioGRID	8649427 \|8810278 \|11577104 \|12135674 \|12615911
BCAR1	CAS \| CAS1 \| CASS1 \| CRKAS \| P130Cas	breast cancer anti-estrogen resistance 1	-	HPRD	7479864 \|11514617
BCAR1	CAS \| CAS1 \| CASS1 \| CRKAS \| P130Cas	breast cancer anti-estrogen resistance 1	CAS interacts with FAK. This interaction was modeled on a demonstrated interaction between human CAS and mouse FAK.	BIND	9148935
BIN1	AMPH2 \| AMPHL \| DKFZp547F068 \| MGC10367 \| SH3P9	bridging integrator 1	-	HPRD,BioGRID	12558988
BMX	ETK \| PSCTK2 \| PSCTK3	BMX non-receptor tyrosine kinase	-	HPRD,BioGRID	11331870
CCR5	CC-CKR-5 \| CCCKR5 \| CD195 \| CKR-5 \| CKR5 \| CMKBR5	chemokine (C-C motif) receptor 5	-	HPRD,BioGRID	10384144
CD4	CD4mut	CD4 molecule	-	HPRD	10384144
CD47	IAP \| MER6 \| OA3	CD47 molecule	-	HPRD	9169439
CIB1	CIB \| KIP \| KIP1 \| SIP2-28	calcium and integrin binding 1 (calmyrin)	-	HPRD,BioGRID	12881299
CRK	CRKII	v-crk sarcoma virus CT10 oncogene homolog (avian)	Affinity Capture-Western Reconstituted Complex	BioGRID	10085298 \|12615911
CRKL	-	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	Two-hybrid	BioGRID	15494733
CSK	MGC117393	c-src tyrosine kinase	-	HPRD,BioGRID	7529872
CSPG4	HMW-MAA \| MCSP \| MCSPG \| MEL-CSPG \| MSK16 \| NG2	chondroitin sulfate proteoglycan 4	-	HPRD	10587647
CXCR4	CD184 \| D2S201E \| FB22 \| HM89 \| HSY3RR \| LAP3 \| LCR1 \| LESTR \| NPY3R \| NPYR \| NPYRL \| NPYY3R \| WHIM	chemokine (C-X-C motif) receptor 4	Affinity Capture-Western	BioGRID	11668182
DCC	CRC18 \| CRCR1	deleted in colorectal carcinoma	Affinity Capture-Western Two-hybrid	BioGRID	15494733
DCC	CRC18 \| CRCR1	deleted in colorectal carcinoma	DCC interacts with FAK.	BIND	15494732
DCC	CRC18 \| CRCR1	deleted in colorectal carcinoma	FAK interacts with DCC.	BIND	15494733
DNM2	CMTDI1 \| CMTDIB \| DI-CMTB \| DYN2 \| DYNII	dynamin 2	PTK2 (FAK) interacts with DNM2 (DYN2).	BIND	15895076
DOCK1	DOCK180 \| ced5	dedicator of cytokinesis 1	Affinity Capture-Western	BioGRID	12615911
EFS	CAS3 \| CASS3 \| EFS1 \| EFS2 \| HEFS \| SIN	embryonal Fyn-associated substrate	-	HPRD	9750131
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	-	HPRD,BioGRID	10806474
EPHA2	ECK	EPH receptor A2	-	HPRD,BioGRID	10655584
ERBB2	CD340 \| HER-2 \| HER-2/neu \| HER2 \| NEU \| NGL \| TKR1	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	-	HPRD	11807823
ERBB3	ErbB-3 \| HER3 \| LCCS2 \| MDA-BF-1 \| MGC88033 \| c-erbB-3 \| c-erbB3 \| erbB3-S \| p180-ErbB3 \| p45-sErbB3 \| p85-sErbB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	-	HPRD	11807823
EZR	CVIL \| CVL \| DKFZp762H157 \| FLJ26216 \| MGC1584 \| VIL2	ezrin	-	HPRD,BioGRID	11468295
FGR	FLJ43153 \| MGC75096 \| SRC2 \| c-fgr \| c-src2 \| p55c-fgr \| p58c-fgr	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	-	HPRD,BioGRID	12387730
FYN	MGC45350 \| SLK \| SYN	FYN oncogene related to SRC, FGR, YES	-	HPRD,BioGRID	11278857
GIT1	-	G protein-coupled receptor kinase interacting ArfGAP 1	-	HPRD,BioGRID	10938112
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	Tyrosine-phosphorylated FAK interacts with Grb2.	BIND	7597091
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD	7997267
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	Affinity Capture-Western Reconstituted Complex	BioGRID	8649427 \|10085298 \|10806474 \|12005431 \|12558988
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	Grb2 interacts with FAK. This interaction was modeled on a demonstrated interaction between human Grb2 and mouse FAK.	BIND	9148935
GRB7	-	growth factor receptor-bound protein 7	-	HPRD,BioGRID	10446223
GSK3B	-	glycogen synthase kinase 3 beta	-	HPRD,BioGRID	11809746
GSN	DKFZp313L0718	gelsolin (amyloidosis, Finnish type)	Affinity Capture-Western	BioGRID	11577104
IGF1R	CD221 \| IGFIR \| JTK13 \| MGC142170 \| MGC142172 \| MGC18216	insulin-like growth factor 1 receptor	Affinity Capture-Western	BioGRID	10082579
IRS1	HIRS-1	insulin receptor substrate 1	-	HPRD,BioGRID	9822703
ITGA4	CD49D \| IA4 \| MGC90518	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	Affinity Capture-Western	BioGRID	11919182
ITGAV	CD51 \| DKFZp686A08142 \| MSK8 \| VNRA	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	-	HPRD	11927607
ITGB1	CD29 \| FNRB \| GPIIA \| MDF2 \| MSK12 \| VLA-BETA \| VLAB	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	-	HPRD	8649427
ITGB2	CD18 \| LAD \| LCAMB \| LFA-1 \| MAC-1 \| MF17 \| MFI7	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	-	HPRD	8649427
ITGB3	CD61 \| GP3A \| GPIIIa	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	FAK interacts with integrin beta 3.	BIND	11927607
ITGB3	CD61 \| GP3A \| GPIIIa	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	Affinity Capture-Western Reconstituted Complex	BioGRID	9169439 \|11927607
ITGB3	CD61 \| GP3A \| GPIIIa	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	-	HPRD	8649427
ITGB5	FLJ26658	integrin, beta 5	Affinity Capture-Western Reconstituted Complex	BioGRID	11927607
JAK2	JTK10	Janus kinase 2 (a protein tyrosine kinase)	-	HPRD,BioGRID	9553131 \|10925297
KCNMA1	BKTM \| DKFZp686K1437 \| KCa1.1 \| MGC71881 \| MaxiK \| SAKCA \| SLO \| SLO-ALPHA \| SLO1 \| mSLO1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	-	HPRD	14584897
LYN	FLJ26625 \| JTK8	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	Affinity Capture-Western	BioGRID	9169439
LYN	FLJ26625 \| JTK8	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	-	HPRD	11389892
MAPK8IP3	DKFZp762N1113 \| FLJ00027 \| JIP3 \| JSAP1 \| KIAA1066 \| SYD2	mitogen-activated protein kinase 8 interacting protein 3	Affinity Capture-Western	BioGRID	12226752
MICAL1	DKFZp434B1517 \| FLJ11937 \| FLJ21739 \| MICAL \| MICAL-1 \| NICAL	microtubule associated monoxygenase, calponin and LIM domain containing 1	-	HPRD	10808124
NCK1	MGC12668 \| NCK \| NCKalpha	NCK adaptor protein 1	Affinity Capture-Western Reconstituted Complex	BioGRID	8879209 \|11950595
NCK2	GRB4 \| NCKbeta	NCK adaptor protein 2	-	HPRD,BioGRID	11950595
NEDD9	CAS-L \| CAS2 \| CASL \| CASS2 \| HEF1 \| dJ49G10.2 \| dJ761I2.1	neural precursor cell expressed, developmentally down-regulated 9	-	HPRD,BioGRID	8668148 \|8879209 \|10455189
NEO1	DKFZp547A066 \| DKFZp547B146 \| HsT17534 \| NGN	neogenin homolog 1 (chicken)	FAK interacts with Neogenin.	BIND	15494733
PCSK1	BMIQ12 \| NEC1 \| PC1 \| PC3 \| SPC3	proprotein convertase subtilisin/kexin type 1	Affinity Capture-Western	BioGRID	11113628
PDGFRB	CD140B \| JTK12 \| PDGF-R-beta \| PDGFR \| PDGFR1	platelet-derived growth factor receptor, beta polypeptide	-	HPRD	10806474
PIAS1	DDXBP1 \| GBP \| GU/RH-II \| MGC141878 \| MGC141879 \| ZMIZ3	protein inhibitor of activated STAT, 1	-	HPRD	14500712
PIK3R1	GRB1 \| p85 \| p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	-	HPRD,BioGRID	7537275 \|8649427 \|10806474
PKD1	PBP	polycystic kidney disease 1 (autosomal dominant)	-	HPRD	11113628
PKD1	PBP	polycystic kidney disease 1 (autosomal dominant)	polycystin-1 interacts with FAK.	BIND	11113628
PLCG1	PLC-II \| PLC1 \| PLC148 \| PLCgamma1	phospholipase C, gamma 1	-	HPRD,BioGRID	8660853\|10430888
PPP1CB	MGC3672 \| PP-1B \| PPP1CD	protein phosphatase 1, catalytic subunit, beta isoform	-	HPRD,BioGRID	11513739
PTEN	10q23del \| BZS \| MGC11227 \| MHAM \| MMAC1 \| PTEN1 \| TEP1	phosphatase and tensin homolog	-	HPRD,BioGRID	10400703
PTK2	FADK \| FAK \| FAK1 \| pp125FAK	PTK2 protein tyrosine kinase 2	FAK autophosphorylates.	BIND	11359909
PTK2	FADK \| FAK \| FAK1 \| pp125FAK	PTK2 protein tyrosine kinase 2	-	HPRD,BioGRID	12005431
PTPN11	BPTP3 \| CFC \| MGC14433 \| NS1 \| PTP-1D \| PTP2C \| SH-PTP2 \| SH-PTP3 \| SHP2	protein tyrosine phosphatase, non-receptor type 11	-	HPRD,BioGRID	7589239 \|8986614 \|10082579 \|10655584
PTPN12	PTP-PEST \| PTPG1	protein tyrosine phosphatase, non-receptor type 12	-	HPRD	9497381
PTPRH	FLJ39938 \| MGC133058 \| MGC133059 \| SAP-1	protein tyrosine phosphatase, receptor type, H	-	HPRD	11278335
PXN	FLJ16691	paxillin	FAK interacts with paxillin.	BIND	11113628
PXN	FLJ16691	paxillin	-	HPRD,BioGRID	8922390
RB1CC1	CC1 \| DRAGOU14 \| FIP200	RB1-inducible coiled-coil 1	-	HPRD,BioGRID	10769033
RIPK1	FLJ39204 \| RIP \| RIP1	receptor (TNFRSF)-interacting serine-threonine kinase 1	FAK interacts with RIP.	BIND	15121855
SELE	CD62E \| ELAM \| ELAM1 \| ESEL \| LECAM2	selectin E	-	HPRD,BioGRID	8609175
SHC1	FLJ26504 \| SHC \| SHCA	SHC (Src homology 2 domain containing) transforming protein 1	-	HPRD,BioGRID	11980671
SHC1	FLJ26504 \| SHC \| SHCA	SHC (Src homology 2 domain containing) transforming protein 1	Shc interacts with FAK. This interaction was modeled on a demonstrated interaction between human Shc and mouse FAK.	BIND	9148935
SOCS2	CIS2 \| Cish2 \| SOCS-2 \| SSI-2 \| SSI2 \| STATI2	suppressor of cytokine signaling 2	Two-hybrid	BioGRID	16189514
SORBS1	CAP \| DKFZp451C066 \| DKFZp586P1422 \| FLAF2 \| FLJ12406 \| KIAA1296 \| R85FL \| SH3D5 \| SH3P12 \| SORB1	sorbin and SH3 domain containing 1	-	HPRD	9461600
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	c-Src interacts with FAK. This interaction was modeled on a demonstrated interaction between human c-Src and mouse FAK.	BIND	9148935
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	Affinity Capture-Western Reconstituted Complex	BioGRID	10085298 \|11980671 \|12387730 \|12558988 \|12615911
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	-	HPRD	7529876 \|8054685 \|10931187
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	-	HPRD	7529876 \|8054685
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	Src interacts with tyrosine autophosphorylated FAK. This interaction was modeled on a demonstrated interaction between human Src and avian FAK.	BIND	7515480
STAT1	DKFZp686B04100 \| ISGF-3 \| STAT91	signal transducer and activator of transcription 1, 91kDa	-	HPRD,BioGRID	11278462
STAT3	APRF \| FLJ20882 \| HIES \| MGC16063	signal transducer and activator of transcription 3 (acute-phase response factor)	Affinity Capture-Western	BioGRID	10925297
SYK	DKFZp313N1010 \| FLJ25043 \| FLJ37489	spleen tyrosine kinase	-	HPRD,BioGRID	9169439 \|9342235
TGFB1I1	ARA55 \| HIC-5 \| HIC5 \| TSC-5	transforming growth factor beta 1 induced transcript 1	-	HPRD	9422762 \|9756887
TGFB1I1	ARA55 \| HIC-5 \| HIC5 \| TSC-5	transforming growth factor beta 1 induced transcript 1	Affinity Capture-Western Reconstituted Complex	BioGRID	9422762 \|9858471 \|11463817
TLN1	ILWEQ \| KIAA1027 \| TLN	talin 1	-	HPRD,BioGRID	7622520
TRIP6	MGC10556 \| MGC10558 \| MGC29959 \| MGC3837 \| MGC4423 \| OIP1 \| ZRP-1	thyroid hormone receptor interactor 6	-	HPRD,BioGRID	14688263
TSC1	KIAA0243 \| LAM \| MGC86987 \| TSC	tuberous sclerosis 1	Affinity Capture-Western	BioGRID	17043358
TSC2	FLJ43106 \| LAM \| TSC4	tuberous sclerosis 2	Affinity Capture-Western Reconstituted Complex	BioGRID	17043358
YES1	HsT441 \| P61-YES \| Yes \| c-yes	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	Affinity Capture-Western	BioGRID	12558988

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG ERBB SIGNALING PATHWAY	87	71	All SZGR 2.0 genes in this pathway
KEGG CHEMOKINE SIGNALING PATHWAY	190	128	All SZGR 2.0 genes in this pathway
KEGG AXON GUIDANCE	129	103	All SZGR 2.0 genes in this pathway
KEGG VEGF SIGNALING PATHWAY	76	53	All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION	201	138	All SZGR 2.0 genes in this pathway
KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION	118	78	All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON	216	144	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG SMALL CELL LUNG CANCER	84	67	All SZGR 2.0 genes in this pathway
BIOCARTA AGR PATHWAY	36	31	All SZGR 2.0 genes in this pathway
BIOCARTA AT1R PATHWAY	36	28	All SZGR 2.0 genes in this pathway
BIOCARTA CHEMICAL PATHWAY	22	15	All SZGR 2.0 genes in this pathway
BIOCARTA SPPA PATHWAY	22	18	All SZGR 2.0 genes in this pathway
BIOCARTA CCR3 PATHWAY	23	21	All SZGR 2.0 genes in this pathway
BIOCARTA CELL2CELL PATHWAY	14	11	All SZGR 2.0 genes in this pathway
BIOCARTA CXCR4 PATHWAY	24	22	All SZGR 2.0 genes in this pathway
BIOCARTA ECM PATHWAY	24	17	All SZGR 2.0 genes in this pathway
BIOCARTA HIVNEF PATHWAY	58	43	All SZGR 2.0 genes in this pathway
BIOCARTA INTEGRIN PATHWAY	38	29	All SZGR 2.0 genes in this pathway
BIOCARTA MCALPAIN PATHWAY	25	16	All SZGR 2.0 genes in this pathway
BIOCARTA EDG1 PATHWAY	27	24	All SZGR 2.0 genes in this pathway
BIOCARTA PTEN PATHWAY	18	14	All SZGR 2.0 genes in this pathway
BIOCARTA ACH PATHWAY	16	13	All SZGR 2.0 genes in this pathway
BIOCARTA MET PATHWAY	37	30	All SZGR 2.0 genes in this pathway
BIOCARTA TFF PATHWAY	21	15	All SZGR 2.0 genes in this pathway
BIOCARTA UCALPAIN PATHWAY	18	11	All SZGR 2.0 genes in this pathway
BIOCARTA VEGF PATHWAY	29	18	All SZGR 2.0 genes in this pathway
SIG PIP3 SIGNALING IN CARDIAC MYOCTES	67	54	All SZGR 2.0 genes in this pathway
ST GA12 PATHWAY	23	16	All SZGR 2.0 genes in this pathway
ST INTEGRIN SIGNALING PATHWAY	82	62	All SZGR 2.0 genes in this pathway
ST GA13 PATHWAY	37	32	All SZGR 2.0 genes in this pathway
PID FCER1 PATHWAY	62	43	All SZGR 2.0 genes in this pathway
PID LYSOPHOSPHOLIPID PATHWAY	66	53	All SZGR 2.0 genes in this pathway
PID MET PATHWAY	80	60	All SZGR 2.0 genes in this pathway
PID EPHB FWD PATHWAY	40	38	All SZGR 2.0 genes in this pathway
PID NECTIN PATHWAY	30	20	All SZGR 2.0 genes in this pathway
PID RET PATHWAY	39	29	All SZGR 2.0 genes in this pathway
PID ANGIOPOIETIN RECEPTOR PATHWAY	50	41	All SZGR 2.0 genes in this pathway
PID NETRIN PATHWAY	32	27	All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY	102	78	All SZGR 2.0 genes in this pathway
PID IGF1 PATHWAY	30	23	All SZGR 2.0 genes in this pathway
PID ERBB1 RECEPTOR PROXIMAL PATHWAY	35	29	All SZGR 2.0 genes in this pathway
PID AVB3 INTEGRIN PATHWAY	75	53	All SZGR 2.0 genes in this pathway
PID SYNDECAN 4 PATHWAY	32	25	All SZGR 2.0 genes in this pathway
PID AR NONGENOMIC PATHWAY	31	27	All SZGR 2.0 genes in this pathway
PID ERBB1 INTERNALIZATION PATHWAY	41	35	All SZGR 2.0 genes in this pathway
PID CASPASE PATHWAY	52	39	All SZGR 2.0 genes in this pathway
PID VEGFR1 2 PATHWAY	69	57	All SZGR 2.0 genes in this pathway
PID EPHA2 FWD PATHWAY	19	16	All SZGR 2.0 genes in this pathway
PID INTEGRIN A4B1 PATHWAY	33	24	All SZGR 2.0 genes in this pathway
PID FAK PATHWAY	59	45	All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	40	26	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME CELL CELL COMMUNICATION	120	77	All SZGR 2.0 genes in this pathway
REACTOME INTEGRIN CELL SURFACE INTERACTIONS	79	48	All SZGR 2.0 genes in this pathway
REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	15	11	All SZGR 2.0 genes in this pathway
REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	15	10	All SZGR 2.0 genes in this pathway
REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING	27	17	All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE	251	188	All SZGR 2.0 genes in this pathway
REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH	64	49	All SZGR 2.0 genes in this pathway
REACTOME NETRIN1 SIGNALING	41	30	All SZGR 2.0 genes in this pathway
REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	13	11	All SZGR 2.0 genes in this pathway
REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	12	10	All SZGR 2.0 genes in this pathway
REACTOME PLATELET AGGREGATION PLUG FORMATION	36	23	All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS	148	94	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION	208	138	All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC EXECUTION PHASE	54	37	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP	783	507	All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP	423	283	All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN	663	425	All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL DN	60	39	All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP	368	234	All SZGR 2.0 genes in this pathway
DITTMER PTHLH TARGETS DN	73	51	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 2HR UP	27	19	All SZGR 2.0 genes in this pathway
CHIN BREAST CANCER COPY NUMBER UP	27	18	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B	392	251	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN	483	336	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN	1024	594	All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 8Q23 Q24 AMPLICON	157	87	All SZGR 2.0 genes in this pathway
HADDAD T LYMPHOCYTE AND NK PROGENITOR UP	78	56	All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D6	37	25	All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN	312	203	All SZGR 2.0 genes in this pathway
CHIBA RESPONSE TO TSA DN	23	14	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN	318	220	All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G6	153	112	All SZGR 2.0 genes in this pathway
YIH RESPONSE TO ARSENITE C1	24	14	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP	461	298	All SZGR 2.0 genes in this pathway
LEE METASTASIS AND ALTERNATIVE SPLICING DN	45	31	All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D UP	210	124	All SZGR 2.0 genes in this pathway
FUJII YBX1 TARGETS DN	202	132	All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS	425	261	All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP	871	505	All SZGR 2.0 genes in this pathway
LU TUMOR ANGIOGENESIS UP	25	22	All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D UP	139	95	All SZGR 2.0 genes in this pathway
GU PDEF TARGETS UP	71	49	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER UP	298	174	All SZGR 2.0 genes in this pathway
WENDT COHESIN TARGETS UP	33	19	All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE UP	181	106	All SZGR 2.0 genes in this pathway
FONTAINE FOLLICULAR THYROID ADENOMA UP	75	43	All SZGR 2.0 genes in this pathway
FONTAINE THYROID TUMOR UNCERTAIN MALIGNANCY UP	36	23	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP	605	377	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 7	76	46	All SZGR 2.0 genes in this pathway
KARLSSON TGFB1 TARGETS UP	127	78	All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS DN	242	146	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 DN	336	211	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN	918	550	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP D	280	158	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE MIDDLE	98	56	All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3	824	528	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-135	820	826	m8	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	820	826	m8	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-138	56	63	1A,m8	hsa-miR-138^brain	AGCUGGUGUUGUGAAUC
miR-199	844	850	1A	hsa-miR-199a	CCCAGUGUUCAGACUACCUGUUC
miR-199	844	850	1A	hsa-miR-199b	CCCAGUGUUUAGACUAUCUGUUC
miR-25/32/92/363/367	495	501	1A	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-378	1003	1009	1A	hsa-miR-378	CUCCUGACUCCAGGUCCUGUGU
miR-410	795	801	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-7	875	881	m8	hsa-miR-7^SZ	UGGAAGACUAGUGAUUUUGUUG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: PTK2