Gene Page: RPTOR

Summary ?
GeneID57521
SymbolRPTOR
SynonymsKOG1|Mip1
Descriptionregulatory associated protein of MTOR, complex 1
ReferenceMIM:607130|HGNC:HGNC:30287|Ensembl:ENSG00000141564|HPRD:06184|Vega:OTTHUMG00000177622
Gene typeprotein-coding
Map location17q25.3
Pascal p-value3.715E-6
Sherlock p-value0.071
Fetal beta-0.376
DMG2 (# studies)
eGeneMyers' cis & trans
Meta
SupportCompositeSet
Darnell FMRP targets
Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 5
DMG:Montano_2016Genome-wide DNA methylation analysisThis dataset includes 172 replicated associations between CpGs with schizophrenia. 5
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg135496381778860076RPTOR6.7E-70.0130.014DMG:Montano_2016
cg274572011778854232RPTOR7.92E-60.0080.038DMG:Montano_2016
cg166609711778860029RPTOR5.97E-50.0110.103DMG:Montano_2016
cg220912361778853966RPTOR1.52E-40.0070.141DMG:Montano_2016
cg228824601778654648RPTOR1.43E-80.0225.52E-6DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17281577chr3119051988RPTOR575210.17trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
EIF3BEIF3-ETA | EIF3-P110 | EIF3-P116 | EIF3S9 | MGC104664 | MGC131875 | PRT1eukaryotic translation initiation factor 3, subunit BAffinity Capture-WesternBioGRID16286006 
EIF3CEIF3S8 | FLJ78287 | MGC189744 | eIF3-p110eukaryotic translation initiation factor 3, subunit CAffinity Capture-WesternBioGRID16286006 
EIF4EBP14E-BP1 | 4EBP1 | BP-1 | MGC4316 | PHAS-Ieukaryotic translation initiation factor 4E binding protein 1Affinity Capture-Western
Reconstituted Complex		BioGRID12150926 |12604610 
|12747827 |12912989 
|15767663 |16798736 
|16824195 |16837165 
FKBP1AFKBP-12 | FKBP1 | FKBP12 | FKBP12C | PKC12 | PKCI2 | PPIASEFK506 binding protein 1A, 12kDaAffinity Capture-WesternBioGRID15268862 |15467718 
FRAP1FLJ44809 | FRAP | FRAP2 | MTOR | RAFT1 | RAPT1FK506 binding protein 12-rapamycin associated protein 1-HPRD,BioGRID12150925 
FRAP1FLJ44809 | FRAP | FRAP2 | MTOR | RAFT1 | RAPT1FK506 binding protein 12-rapamycin associated protein 1mTOR interacts with raptor.BIND15718470 
GDI2P-GDP dissociation inhibitor 2 pseudogeneAffinity Capture-WesternBioGRID16354680 
MAPKAP1JC310 | MGC2745 | MIP1 | SIN1 | SIN1b | SIN1gmitogen-activated protein kinase associated protein 1Affinity Capture-MSBioGRID16962653 
PDK1-pyruvate dehydrogenase kinase, isozyme 1Affinity Capture-WesternBioGRID12150926 
PLD2-phospholipase D2Affinity Capture-WesternBioGRID16837165 
RHEBMGC111559 | RHEB2Ras homolog enriched in brainRaptor interacts with Rheb.BIND15854902 
RHEBMGC111559 | RHEB2Ras homolog enriched in brainAffinity Capture-Western
Reconstituted Complex		BioGRID15854902 
RICTORDKFZp686B11164 | KIAA1999 | MGC39830 | mAVO3rapamycin-insensitive companion of mTORAffinity Capture-MSBioGRID16962653 
RPS6KB1PS6K | S6K | S6K1 | STK14A | p70(S6K)-alpha | p70-S6K | p70-alpharibosomal protein S6 kinase, 70kDa, polypeptide 1Affinity Capture-Western
Reconstituted Complex		BioGRID12150926 |12604610 
|15809305 |16837165 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG MTOR SIGNALING PATHWAY 5240All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY 137103All SZGR 2.0 genes in this pathway
PID MET PATHWAY 8060All SZGR 2.0 genes in this pathway
PID LKB1 PATHWAY 4737All SZGR 2.0 genes in this pathway
PID MTOR 4PATHWAY 6955All SZGR 2.0 genes in this pathway
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE 8764All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 1513All SZGR 2.0 genes in this pathway
REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 1815All SZGR 2.0 genes in this pathway
REACTOME PKB MEDIATED EVENTS 2923All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY INSULIN RECEPTOR 10872All SZGR 2.0 genes in this pathway
REACTOME MTORC1 MEDIATED SIGNALLING 118All SZGR 2.0 genes in this pathway
REACTOME PI3K CASCADE 7151All SZGR 2.0 genes in this pathway
CORRADETTI MTOR PATHWAY REGULATORS DN 65All SZGR 2.0 genes in this pathway
SILIGAN BOUND BY EWS FLT1 FUSION 4734All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747453All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335181All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940425All SZGR 2.0 genes in this pathway
GYORFFY DOXORUBICIN RESISTANCE 5634All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 227149All SZGR 2.0 genes in this pathway