Gene Page: RAD51B
Summary ?
| GeneID | 5890 |
| Symbol | RAD51B |
| Synonyms | R51H2|RAD51L1|REC2 |
| Description | RAD51 paralog B |
| Reference | MIM:602948|HGNC:HGNC:9822|Ensembl:ENSG00000182185|HPRD:04255|Vega:OTTHUMG00000157530 |
| Gene type | protein-coding |
| Map location | 14q23-q24.2 |
| Pascal p-value | 0.182 |
| Sherlock p-value | 0.349 |
| Fetal beta | 0.348 |
| DMG | 1 (# studies) |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Montano_2016 | Genome-wide DNA methylation analysis | This dataset includes 172 replicated associations between CpGs with schizophrenia. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg10975863 | 14 | 68830704 | RAD51B | 6.9E-7 | 0.011 | 0.014 | DMG:Montano_2016 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| DOPEY1 | 0.91 | 0.93 |
| KIAA0528 | 0.91 | 0.93 |
| BRWD1 | 0.90 | 0.93 |
| BTAF1 | 0.90 | 0.92 |
| C12orf30 | 0.89 | 0.94 |
| ZFC3H1 | 0.89 | 0.90 |
| YTHDC2 | 0.89 | 0.93 |
| ZNF655 | 0.89 | 0.92 |
| HLTF | 0.89 | 0.93 |
| ZNF248 | 0.88 | 0.93 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.70 | -0.78 |
| MT-CO2 | -0.70 | -0.78 |
| FXYD1 | -0.69 | -0.77 |
| HIGD1B | -0.69 | -0.81 |
| IFI27 | -0.67 | -0.77 |
| HSD17B14 | -0.67 | -0.73 |
| CST3 | -0.66 | -0.77 |
| MT-CYB | -0.66 | -0.74 |
| METRN | -0.66 | -0.78 |
| ENHO | -0.66 | -0.81 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG HOMOLOGOUS RECOMBINATION | 28 | 17 | All SZGR 2.0 genes in this pathway |
| REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | 132 | 101 | All SZGR 2.0 genes in this pathway |
| REACTOME HEMOSTASIS | 466 | 331 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
| KAUFFMANN DNA REPAIR GENES | 230 | 137 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER MYC TGFA UP | 61 | 40 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER ACOX1 UP | 64 | 40 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER MYC E2F1 UP | 56 | 34 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER CIPROFIBRATE UP | 60 | 42 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER DENA UP | 60 | 40 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER E2F1 UP | 62 | 35 | All SZGR 2.0 genes in this pathway |
| WENG POR TARGETS GLOBAL DN | 23 | 14 | All SZGR 2.0 genes in this pathway |
| WENG POR TARGETS LIVER DN | 20 | 11 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY E2F4 UNSTIMULATED | 728 | 415 | All SZGR 2.0 genes in this pathway |
| SARRIO EPITHELIAL MESENCHYMAL TRANSITION UP | 180 | 114 | All SZGR 2.0 genes in this pathway |
| GRESHOCK CANCER COPY NUMBER UP | 323 | 240 | All SZGR 2.0 genes in this pathway |
| BOYLAN MULTIPLE MYELOMA C D UP | 139 | 95 | All SZGR 2.0 genes in this pathway |
| FONTAINE FOLLICULAR THYROID ADENOMA UP | 75 | 43 | All SZGR 2.0 genes in this pathway |
| FONTAINE PAPILLARY THYROID CARCINOMA DN | 80 | 53 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN ES ICP WITH H3K4ME3 | 718 | 401 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN NPC ICP WITH H3K4ME3 | 445 | 257 | All SZGR 2.0 genes in this pathway |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 0 | 76 | 54 | All SZGR 2.0 genes in this pathway |
| OHGUCHI LIVER HNF4A TARGETS UP | 44 | 30 | All SZGR 2.0 genes in this pathway |
| LEE BMP2 TARGETS UP | 745 | 475 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D | 658 | 397 | All SZGR 2.0 genes in this pathway |
| YU BAP1 TARGETS | 29 | 21 | All SZGR 2.0 genes in this pathway |