Gene Page: SATB1

Summary
GeneID  6304
Symbol  SATB1
Synonyms  -
Description  SATB homeobox 1
See related  HGNC:10541|MIM:602075|Ensembl:ENSG00000182568|HPRD:03647|
Locus tag  -
Gene type  protein-coding
Map location  3p23
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.006 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PILRB0.880.90
MAN2C10.850.84
CPT1B0.840.88
AP1G20.840.90
LIME10.830.83
IDUA0.820.80
ACCN30.820.84
RHOT20.810.77
LRCH40.810.80
HSF40.810.80
Top 10 negatively co-expressed genes
GIMAP4-0.38-0.36
CAPZA2-0.37-0.41
DNAJB9-0.36-0.40
GMFB-0.36-0.37
ELTD1-0.36-0.31
ITM2A-0.36-0.36
PNPLA8-0.36-0.40
RAP1A-0.35-0.39
TM4SF18-0.34-0.29
MOBKL3-0.33-0.34
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003690double-stranded DNA bindingTAS1505028 
GO:0003700transcription factor activityIEA-
GO:0043565sequence-specific DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000122negative regulation of transcription from RNA polymerase II promoterIMP15851481 
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006325establishment or maintenance of chromatin architectureIEA-
GO:0006325establishment or maintenance of chromatin architectureTAS1505028 
GO:0016571histone methylationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005634nucleusTAS1505028 
GO:0005720nuclear heterochromatinIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BAZ1AACF1 | DKFZp586E0518 | FLJ14383 | WALp1 | WCRF180 | hACF1bromodomain adjacent to zinc finger domain, 1ACo-fractionation
Reconstituted Complex		BioGRID12374985 
CHD3Mi-2a | Mi2-ALPHA | ZFHchromodomain helicase DNA binding protein 3-HPRD12374985 
CHD4DKFZp686E06161 | Mi-2b | Mi2-BETAchromodomain helicase DNA binding protein 4Affinity Capture-Western
Co-fractionation		BioGRID12374985 
CUX1CASP | CDP | CDP/Cut | CDP1 | COY1 | CUTL1 | CUX | Clox | Cux/CDP | GOLIM6 | Nbla10317 | p100 | p110 | p200 | p75cut-like homeobox 1-HPRD,BioGRID10373541 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1-HPRD,BioGRID12374985 
HDAC2RPD3 | YAF1histone deacetylase 2Co-fractionationBioGRID12374985 
MTA2DKFZp686F2281 | MTA1L1 | PIDmetastasis associated 1 family, member 2-HPRD,BioGRID12374985 
POLR2JMGC71910 | POLR2J1 | RPB11 | RPB11A | RPB11m | hRPB14polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDaReconstituted Complex
Two-hybrid		BioGRID12036295 
SATB1-SATB homeobox 1-HPRD12374985 
SIN3ADKFZp434K2235 | FLJ90319 | KIAA0700SIN3 homolog A, transcription regulator (yeast)Co-fractionationBioGRID12374985 
SMARCA5ISWI | SNF2H | WCRF135 | hISWI | hSNF2HSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5-HPRD,BioGRID12374985 
UBE2IC358B7.1 | P18 | UBC9ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)Two-hybridBioGRID16189514 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_CASPASE_PATHWAY 5239All SZGR genes in this pathway
REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS 4026All SZGR genes in this pathway
REACTOME_APOPTOSIS 14894All SZGR genes in this pathway
REACTOME_APOPTOTIC_EXECUTION_PHASE 5437All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN 634384All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_DN 267178All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_UP 255177All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_DN 11679All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_DN 406230All SZGR genes in this pathway
HOEBEKE_LYMPHOID_STEM_CELL_UP 9564All SZGR genes in this pathway
ODONNELL_TFRC_TARGETS_UP 456228All SZGR genes in this pathway
ODONNELL_TARGETS_OF_MYC_AND_TFRC_UP 8350All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN 329219All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_SKIN_UP 177113All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
LUI_THYROID_CANCER_PAX8_PPARG_UP 4429All SZGR genes in this pathway
STREICHER_LSM1_TARGETS_UP 4434All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN 800473All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION_12HR 4335All SZGR genes in this pathway
LUI_THYROID_CANCER_CLUSTER_1 5133All SZGR genes in this pathway
AIYAR_COBRA1_TARGETS_UP 3925All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_NEUROEPITHELIUM_DN 164111All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN 514319All SZGR genes in this pathway
JAZAG_TGFB1_SIGNALING_VIA_SMAD4_UP 10866All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_B_LYMPHOCYTE_DN 3825All SZGR genes in this pathway
FLECHNER_PBL_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 151100All SZGR genes in this pathway
POMEROY_MEDULLOBLASTOMA_PROGNOSIS_UP 4730All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_DN 6340All SZGR genes in this pathway
GUO_HEX_TARGETS_UP 8154All SZGR genes in this pathway
WANG_IMMORTALIZED_BY_HOXA9_AND_MEIS1_DN 2415All SZGR genes in this pathway
KUMAR_TARGETS_OF_MLL_AF9_FUSION 405264All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_DN 318220All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_UP 268157All SZGR genes in this pathway
CARDOSO_RESPONSE_TO_GAMMA_RADIATION_AND_3AB 1811All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3 491310All SZGR genes in this pathway
ZHENG_FOXP3_TARGETS_IN_T_LYMPHOCYTE_DN 3729All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_DN 353226All SZGR genes in this pathway
MOLENAAR_TARGETS_OF_CCND1_AND_CDK4_UP 6748All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_UP 295149All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
RAY_TARGETS_OF_P210_BCR_ABL_FUSION_DN 1611All SZGR genes in this pathway
CHANG_CORE_SERUM_RESPONSE_DN 209137All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
LEE_DIFFERENTIATING_T_LYMPHOCYTE 200115All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
MCMURRAY_TP53_HRAS_COOPERATION_RESPONSE_DN 6746All SZGR genes in this pathway
ELLWOOD_MYC_TARGETS_DN 4027All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3 142103All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_UP 442263All SZGR genes in this pathway
JISON_SICKLE_CELL_DISEASE_DN 18197All SZGR genes in this pathway
YAGI_AML_WITH_T_9_11_TRANSLOCATION 13087All SZGR genes in this pathway
CAIRO_LIVER_DEVELOPMENT_UP 166105All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_PR_DN 4434All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3 210148All SZGR genes in this pathway
LI_INDUCED_T_TO_NATURAL_KILLER_DN 11683All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_PRONEURAL 177132All SZGR genes in this pathway
HOELZEL_NF1_TARGETS_DN 11573All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_DN 321200All SZGR genes in this pathway
IKEDA_MIR30_TARGETS_UP 11687All SZGR genes in this pathway
HUANG_GATA2_TARGETS_UP 14996All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_DN 308187All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-137873879m8hsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-1539099151Ahsa-miR-153UUGCAUAGUCACAAAAGUGA
hsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-155334340m8hsa-miR-155UUAAUGCUAAUCGUGAUAGGGG
miR-189629681Ahsa-miR-18aUAAGGUGCAUCUAGUGCAGAUA
hsa-miR-18bUAAGGUGCAUCUAGUGCAGUUA
miR-186115511611Ahsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-191231291Ahsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-194111811241Ahsa-miR-194UGUAACAGCAACUCCAUGUGGA
miR-2088048101Ahsa-miR-208AUAAGACGAGCAAAAAGCUUGU
miR-21933939m8hsa-miR-21brainUAGCUUAUCAGACUGAUGUUGA
hsa-miR-590GAGCUUAUUCAUAAAAGUGCAG
miR-219102810341Ahsa-miR-219brainUGAUUGUCCAAACGCAAUUCU
miR-236406471A,m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-30-5p102410301Ahsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-3236406461Ahsa-miR-323brainGCACAUUACACGGUCGACCUCU
hsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-34/449539545m8hsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC
miR-376110011061Ahsa-miR-376aAUCAUAGAGGAAAAUCCACGU
hsa-miR-376bAUCAUAGAGGAAAAUCCAUGUU
miR-376c861867m8hsa-miR-376cAACAUAGAGGAAAUUCCACG
miR-381525531m8hsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-4489759811Ahsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
hsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-485-5p3233291Ahsa-miR-485-5pAGAGGCUGGCCGUGAUGAAUUC
miR-495111611221Ahsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
hsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-4998048101Ahsa-miR-499UUAAGACUUGCAGUGAUGUUUAA
miR-544116211691A,m8hsa-miR-544AUUCUGCAUUUUUAGCAAGU
miR-710131019m8hsa-miR-7SZUGGAAGACUAGUGAUUUUGUUG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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