Gene Page: BID

Summary
GeneID  637
Symbol  BID
Synonyms  FP497|MGC15319|MGC42355
Description  BH3 interacting domain death agonist
See related  HGNC:1050|MIM:601997|Ensembl:ENSG00000015475|HPRD:03590|
Locus tag  -
Gene type  protein-coding
Map location  22q11.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.031 
ExpressionExpressionP value: 1.541 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005123death receptor bindingTAS8918887 
GO:0005515protein bindingISS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0051402neuron apoptosisTASneuron, axon, dendrite (GO term level: 7)16167175 
GO:0001836release of cytochrome c from mitochondriaIDA17052454 
GO:0008625induction of apoptosis via death domain receptorsTAS9727491 
GO:0008633activation of pro-apoptotic gene productsEXP15231831 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP10629050 |11099414 |11114298 
|12804595 
GO:0005829cytosolTAS8918887 
GO:0005624membrane fractionTAS8918887 
GO:0005737cytoplasmIEA-
GO:0005739mitochondrionTAS9727491 
GO:0005741mitochondrial outer membraneEXP9727492 |10950869 |12624108 
GO:0016020membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARHGDIAGDIA1 | MGC117248 | RHOGDI | RHOGDI-1Rho GDP dissociation inhibitor (GDI) alphaCo-purificationBioGRID15659383 
BAK1BAK | BAK-LIKE | BCL2L7 | CDN1 | MGC117255 | MGC3887BCL2-antagonist/killer 1-HPRD10950869 
BAXBCL2L4BCL2-associated X proteinBax interacts with Bid.BIND15574335 
BCL2Bcl-2B-cell CLL/lymphoma 2Bid interacts with Bcl-2.BIND15694340 
Protein-peptideBioGRID15520201 |15694340 
Bid interacts with Bcl-2.BIND15574335 
-HPRD9727491 
BCL2A1ACC-1 | ACC-2 | BCL2L5 | BFL1 | GRS | HBPA1BCL2-related protein A1Bid interacts with A1. This interaction was modelled on a demonstrated interaction between human Bid and mouse A1.BIND15694340 
-HPRD,BioGRID11929871 
BCL2L1BCL-XL/S | BCL2L | BCLX | Bcl-X | DKFZp781P2092 | bcl-xL | bcl-xSBCL2-like 1Bid interacts with Bcl-XL.BIND15694340 
Protein-peptideBioGRID15694340 
BCL-XL interacts with the alpha-helical region of the BID-EL BH3 death domain.BIND15353804 
BCL-XL interacts with the alpha-helical region of the BID BH3 death domain.BIND15353804 
Bcl-XL interacts with Bid. This interaction was modelled on a demonstrated interaction between Bcl-XL from an unspecified species and human Bid.BIND15721256 
Bid interacts with Bcl-xL.BIND15574335 
BCL2L2BCL-W | BCLW | KIAA0271BCL2-like 2Protein-peptideBioGRID15694340 
Bid interacts with Bcl-w.BIND15694340 
BIDFP497 | MGC15319 | MGC42355BH3 interacting domain death agonist-HPRD,BioGRID11805084 
BNC1BNC | BSN1 | HsT19447basonuclin 1Bid interacts with Mcl-1. This interaction was modelled on a demonstrated interaction between human Bid and mouse Mcl-1.BIND15694340 
CAPN1CANP | CANP1 | CANPL1 | muCANP | muCLcalpain 1, (mu/I) large subunit-HPRD12000759 
CAPN2CANP2 | CANPL2 | CANPml | FLJ39928 | mCANPcalpain 2, (m/II) large subunitBiochemical ActivityBioGRID12000759 
CASP10ALPS2 | FLICE2 | MCH4caspase 10, apoptosis-related cysteine peptidaseCo-purificationBioGRID15659383 
CASP2CASP-2 | ICH-1L | ICH-1L/1S | ICH1 | NEDD2caspase 2, apoptosis-related cysteine peptidase-HPRD,BioGRID11832478 
CASP3CPP32 | CPP32B | SCA-1caspase 3, apoptosis-related cysteine peptidaseBiochemical ActivityBioGRID11399776 
CASP8ALPS2B | CAP4 | FLICE | FLJ17672 | MACH | MCH5 | MGC78473caspase 8, apoptosis-related cysteine peptidaseBiochemical Activity
Co-purification		BioGRID11832478 |15659383 
EZRCVIL | CVL | DKFZp762H157 | FLJ26216 | MGC1584 | VIL2ezrinCo-purificationBioGRID15659383 
FADDGIG3 | MGC8528 | MORT1Fas (TNFRSF6)-associated via death domainCo-purificationBioGRID15659383 
FASALPS1A | APO-1 | APT1 | CD95 | FAS1 | FASTM | TNFRSF6Fas (TNF receptor superfamily, member 6)Co-purificationBioGRID15659383 
FASLGAPT1LG1 | CD178 | CD95L | FASL | TNFSF6Fas ligand (TNF superfamily, member 6)Co-purificationBioGRID15659383 
MAPK8JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1mitogen-activated protein kinase 8Co-purificationBioGRID15659383 
MCL1BCL2L3 | EAT | MCL1L | MCL1S | MGC104264 | MGC1839 | TMmyeloid cell leukemia sequence 1 (BCL2-related)Affinity Capture-Western
Protein-peptide
Reconstituted Complex		BioGRID15637055 |15694340 
MSN-moesinCo-purificationBioGRID15659383 
PACS2FLJ25488 | KIAA0602 | PACS1Lphosphofurin acidic cluster sorting protein 2PACS2 interacts with BID.BIND15692567 
RHOAARH12 | ARHA | RHO12 | RHOH12ras homolog gene family, member ACo-purificationBioGRID15659383 
TNFRSF10BCD262 | DR5 | KILLER | KILLER/DR5 | TRAIL-R2 | TRAILR2 | TRICK2 | TRICK2A | TRICK2B | TRICKB | ZTNFR9tumor necrosis factor receptor superfamily, member 10bCo-purificationBioGRID15659383 
TNFRSF1ACD120a | FPF | MGC19588 | TBP1 | TNF-R | TNF-R-I | TNF-R55 | TNFAR | TNFR1 | TNFR55 | TNFR60 | p55 | p55-R | p60tumor necrosis factor receptor superfamily, member 1ACo-purificationBioGRID15659383 
YWHABGW128 | HS1 | KCIP-1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide-HPRD12871587 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_P53_SIGNALING_PATHWAY 6945All SZGR genes in this pathway
KEGG_APOPTOSIS 8862All SZGR genes in this pathway
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 13792All SZGR genes in this pathway
KEGG_ALZHEIMERS_DISEASE 169110All SZGR genes in this pathway
KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 5343All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_VIRAL_MYOCARDITIS 7358All SZGR genes in this pathway
BIOCARTA_CHEMICAL_PATHWAY 2215All SZGR genes in this pathway
BIOCARTA_HIVNEF_PATHWAY 5843All SZGR genes in this pathway
BIOCARTA_DEATH_PATHWAY 3324All SZGR genes in this pathway
BIOCARTA_MITOCHONDRIA_PATHWAY 2115All SZGR genes in this pathway
SA_PROGRAMMED_CELL_DEATH 129All SZGR genes in this pathway
PID_ATM_PATHWAY 3425All SZGR genes in this pathway
PID_FAS_PATHWAY 3829All SZGR genes in this pathway
PID_CERAMIDE_PATHWAY 4837All SZGR genes in this pathway
PID_P53_DOWNSTREAM_PATHWAY 13794All SZGR genes in this pathway
PID_HIV_NEF_PATHWAY 3526All SZGR genes in this pathway
PID_CASPASE_PATHWAY 5239All SZGR genes in this pathway
REACTOME_APOPTOSIS 14894All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS 1712All SZGR genes in this pathway
REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS 3021All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_UP 430232All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_UP 380236All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP 418263All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_UP 12895All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP 11784All SZGR genes in this pathway
LAU_APOPTOSIS_CDKN2A_UP 5540All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_1_DN 378231All SZGR genes in this pathway
MARKEY_RB1_ACUTE_LOF_UP 215137All SZGR genes in this pathway
DARWICHE_SKIN_TUMOR_PROMOTER_DN 185115All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_LOW_DN 165107All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_HIGH_UP 147101All SZGR genes in this pathway
DARWICHE_SQUAMOUS_CELL_CARCINOMA_UP 146104All SZGR genes in this pathway
RAMJAUN_APOPTOSIS_BY_TGFB1_VIA_MAPK1_DN 86All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
GALLUZZI_PERMEABILIZE_MITOCHONDRIA 4331All SZGR genes in this pathway
ROSTY_CERVICAL_CANCER_PROLIFERATION_CLUSTER 14073All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP 223140All SZGR genes in this pathway
STANELLE_E2F1_TARGETS 2920All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
HESS_TARGETS_OF_HOXA9_AND_MEIS1_UP 6544All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR 532309All SZGR genes in this pathway
TRAYNOR_RETT_SYNDROM_UP 4533All SZGR genes in this pathway
GERHOLD_ADIPOGENESIS_DN 6444All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_INTERMEDIATE_PROGENITOR 14984All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_24HR_UP 14896All SZGR genes in this pathway
BILD_MYC_ONCOGENIC_SIGNATURE 206117All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3 720440All SZGR genes in this pathway
HOWLIN_CITED1_TARGETS_2_DN 1711All SZGR genes in this pathway
SANSOM_APC_TARGETS_REQUIRE_MYC 210123All SZGR genes in this pathway
LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP 7451All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
MOOTHA_HUMAN_MITODB_6_2002 429260All SZGR genes in this pathway
MOOTHA_PGC 420269All SZGR genes in this pathway
MOOTHA_MITOCHONDRIA 447277All SZGR genes in this pathway
VANASSE_BCL2_TARGETS_DN 7450All SZGR genes in this pathway
COLINA_TARGETS_OF_4EBP1_AND_4EBP2 356214All SZGR genes in this pathway
MOOTHA_GLUCONEOGENESIS 3223All SZGR genes in this pathway
MOOTHA_GLYCOLYSIS 2113All SZGR genes in this pathway
LI_DCP2_BOUND_MRNA 8957All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_D 280158All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_DN 448282All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_UP 279155All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_PARTIAL 160106All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38 337236All SZGR genes in this pathway
RATTENBACHER_BOUND_BY_CELF1 467251All SZGR genes in this pathway


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