Gene Page: BID

Summary ?
GeneID637
SymbolBID
SynonymsFP497
DescriptionBH3 interacting domain death agonist
ReferenceMIM:601997|HGNC:HGNC:1050|Ensembl:ENSG00000015475|HPRD:03590|Vega:OTTHUMG00000150087
Gene typeprotein-coding
Map location22q11.1
Pascal p-value0.507
Sherlock p-value0.189
Fetal beta0.602
eGeneCaudate basal ganglia
Cerebellum
Cortex
Frontal Cortex BA9

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IGenome scan meta-analysisPsr: 0.031 
ExpressionMeta-analysis of gene expressionP value: 1.541 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005123death receptor bindingTAS8918887 
GO:0005515protein bindingISS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0051402neuron apoptosisTASneuron, axon, dendrite (GO term level: 7)16167175 
GO:0001836release of cytochrome c from mitochondriaIDA17052454 
GO:0008625induction of apoptosis via death domain receptorsTAS9727491 
GO:0008633activation of pro-apoptotic gene productsEXP15231831 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP10629050 |11099414 |11114298 
|12804595 
GO:0005829cytosolTAS8918887 
GO:0005624membrane fractionTAS8918887 
GO:0005737cytoplasmIEA-
GO:0005739mitochondrionTAS9727491 
GO:0005741mitochondrial outer membraneEXP9727492 |10950869 |12624108 
GO:0016020membraneIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARHGDIAGDIA1 | MGC117248 | RHOGDI | RHOGDI-1Rho GDP dissociation inhibitor (GDI) alphaCo-purificationBioGRID15659383 
BAK1BAK | BAK-LIKE | BCL2L7 | CDN1 | MGC117255 | MGC3887BCL2-antagonist/killer 1-HPRD10950869 
BAXBCL2L4BCL2-associated X proteinBax interacts with Bid.BIND15574335 
BCL2Bcl-2B-cell CLL/lymphoma 2Bid interacts with Bcl-2.BIND15694340 
BCL2Bcl-2B-cell CLL/lymphoma 2Protein-peptideBioGRID15520201 |15694340 
BCL2Bcl-2B-cell CLL/lymphoma 2Bid interacts with Bcl-2.BIND15574335 
BCL2Bcl-2B-cell CLL/lymphoma 2-HPRD9727491 
BCL2A1ACC-1 | ACC-2 | BCL2L5 | BFL1 | GRS | HBPA1BCL2-related protein A1Bid interacts with A1. This interaction was modelled on a demonstrated interaction between human Bid and mouse A1.BIND15694340 
BCL2A1ACC-1 | ACC-2 | BCL2L5 | BFL1 | GRS | HBPA1BCL2-related protein A1-HPRD,BioGRID11929871 
BCL2L1BCL-XL/S | BCL2L | BCLX | Bcl-X | DKFZp781P2092 | bcl-xL | bcl-xSBCL2-like 1Bid interacts with Bcl-XL.BIND15694340 
BCL2L1BCL-XL/S | BCL2L | BCLX | Bcl-X | DKFZp781P2092 | bcl-xL | bcl-xSBCL2-like 1Protein-peptideBioGRID15694340 
BCL2L1BCL-XL/S | BCL2L | BCLX | Bcl-X | DKFZp781P2092 | bcl-xL | bcl-xSBCL2-like 1BCL-XL interacts with the alpha-helical region of the BID-EL BH3 death domain.BIND15353804 
BCL2L1BCL-XL/S | BCL2L | BCLX | Bcl-X | DKFZp781P2092 | bcl-xL | bcl-xSBCL2-like 1BCL-XL interacts with the alpha-helical region of the BID BH3 death domain.BIND15353804 
BCL2L1BCL-XL/S | BCL2L | BCLX | Bcl-X | DKFZp781P2092 | bcl-xL | bcl-xSBCL2-like 1Bcl-XL interacts with Bid. This interaction was modelled on a demonstrated interaction between Bcl-XL from an unspecified species and human Bid.BIND15721256 
BCL2L1BCL-XL/S | BCL2L | BCLX | Bcl-X | DKFZp781P2092 | bcl-xL | bcl-xSBCL2-like 1Bid interacts with Bcl-xL.BIND15574335 
BCL2L2BCL-W | BCLW | KIAA0271BCL2-like 2Protein-peptideBioGRID15694340 
BCL2L2BCL-W | BCLW | KIAA0271BCL2-like 2Bid interacts with Bcl-w.BIND15694340 
BIDFP497 | MGC15319 | MGC42355BH3 interacting domain death agonist-HPRD,BioGRID11805084 
BNC1BNC | BSN1 | HsT19447basonuclin 1Bid interacts with Mcl-1. This interaction was modelled on a demonstrated interaction between human Bid and mouse Mcl-1.BIND15694340 
CAPN1CANP | CANP1 | CANPL1 | muCANP | muCLcalpain 1, (mu/I) large subunit-HPRD12000759 
CAPN2CANP2 | CANPL2 | CANPml | FLJ39928 | mCANPcalpain 2, (m/II) large subunitBiochemical ActivityBioGRID12000759 
CASP10ALPS2 | FLICE2 | MCH4caspase 10, apoptosis-related cysteine peptidaseCo-purificationBioGRID15659383 
CASP2CASP-2 | ICH-1L | ICH-1L/1S | ICH1 | NEDD2caspase 2, apoptosis-related cysteine peptidase-HPRD,BioGRID11832478 
CASP3CPP32 | CPP32B | SCA-1caspase 3, apoptosis-related cysteine peptidaseBiochemical ActivityBioGRID11399776 
CASP8ALPS2B | CAP4 | FLICE | FLJ17672 | MACH | MCH5 | MGC78473caspase 8, apoptosis-related cysteine peptidaseBiochemical Activity
Co-purification		BioGRID11832478 |15659383 
EZRCVIL | CVL | DKFZp762H157 | FLJ26216 | MGC1584 | VIL2ezrinCo-purificationBioGRID15659383 
FADDGIG3 | MGC8528 | MORT1Fas (TNFRSF6)-associated via death domainCo-purificationBioGRID15659383 
FASALPS1A | APO-1 | APT1 | CD95 | FAS1 | FASTM | TNFRSF6Fas (TNF receptor superfamily, member 6)Co-purificationBioGRID15659383 
FASLGAPT1LG1 | CD178 | CD95L | FASL | TNFSF6Fas ligand (TNF superfamily, member 6)Co-purificationBioGRID15659383 
MAPK8JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1mitogen-activated protein kinase 8Co-purificationBioGRID15659383 
MCL1BCL2L3 | EAT | MCL1L | MCL1S | MGC104264 | MGC1839 | TMmyeloid cell leukemia sequence 1 (BCL2-related)Affinity Capture-Western
Protein-peptide
Reconstituted Complex		BioGRID15637055 |15694340 
MSN-moesinCo-purificationBioGRID15659383 
PACS2FLJ25488 | KIAA0602 | PACS1Lphosphofurin acidic cluster sorting protein 2PACS2 interacts with BID.BIND15692567 
RHOAARH12 | ARHA | RHO12 | RHOH12ras homolog gene family, member ACo-purificationBioGRID15659383 
TNFRSF10BCD262 | DR5 | KILLER | KILLER/DR5 | TRAIL-R2 | TRAILR2 | TRICK2 | TRICK2A | TRICK2B | TRICKB | ZTNFR9tumor necrosis factor receptor superfamily, member 10bCo-purificationBioGRID15659383 
TNFRSF1ACD120a | FPF | MGC19588 | TBP1 | TNF-R | TNF-R-I | TNF-R55 | TNFAR | TNFR1 | TNFR55 | TNFR60 | p55 | p55-R | p60tumor necrosis factor receptor superfamily, member 1ACo-purificationBioGRID15659383 
YWHABGW128 | HS1 | KCIP-1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide-HPRD12871587 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG P53 SIGNALING PATHWAY 6945All SZGR 2.0 genes in this pathway
KEGG APOPTOSIS 8862All SZGR 2.0 genes in this pathway
KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY 13792All SZGR 2.0 genes in this pathway
KEGG ALZHEIMERS DISEASE 169110All SZGR 2.0 genes in this pathway
KEGG AMYOTROPHIC LATERAL SCLEROSIS ALS 5343All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328259All SZGR 2.0 genes in this pathway
KEGG VIRAL MYOCARDITIS 7358All SZGR 2.0 genes in this pathway
BIOCARTA CHEMICAL PATHWAY 2215All SZGR 2.0 genes in this pathway
BIOCARTA HIVNEF PATHWAY 5843All SZGR 2.0 genes in this pathway
BIOCARTA DEATH PATHWAY 3324All SZGR 2.0 genes in this pathway
BIOCARTA MITOCHONDRIA PATHWAY 2115All SZGR 2.0 genes in this pathway
SA PROGRAMMED CELL DEATH 129All SZGR 2.0 genes in this pathway
PID ATM PATHWAY 3425All SZGR 2.0 genes in this pathway
PID FAS PATHWAY 3829All SZGR 2.0 genes in this pathway
PID CERAMIDE PATHWAY 4837All SZGR 2.0 genes in this pathway
PID P53 DOWNSTREAM PATHWAY 13794All SZGR 2.0 genes in this pathway
PID HIV NEF PATHWAY 3526All SZGR 2.0 genes in this pathway
PID CASPASE PATHWAY 5239All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS 14894All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF BH3 ONLY PROTEINS 1712All SZGR 2.0 genes in this pathway
REACTOME INTRINSIC PATHWAY FOR APOPTOSIS 3021All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579346All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP 430232All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP 380236All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP 418263All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722443All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR UP 12895All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP 11784All SZGR 2.0 genes in this pathway
LAU APOPTOSIS CDKN2A UP 5540All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443294All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN 378231All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF UP 215137All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER DN 185115All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW DN 165107All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH UP 147101All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA UP 146104All SZGR 2.0 genes in this pathway
RAMJAUN APOPTOSIS BY TGFB1 VIA MAPK1 DN 86All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174695All SZGR 2.0 genes in this pathway
GALLUZZI PERMEABILIZE MITOCHONDRIA 4331All SZGR 2.0 genes in this pathway
ROSTY CERVICAL CANCER PROLIFERATION CLUSTER 14073All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795478All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP 223140All SZGR 2.0 genes in this pathway
STANELLE E2F1 TARGETS 2920All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
HESS TARGETS OF HOXA9 AND MEIS1 UP 6544All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS EARLY PROGENITOR 532309All SZGR 2.0 genes in this pathway
TRAYNOR RETT SYNDROM UP 4533All SZGR 2.0 genes in this pathway
GERHOLD ADIPOGENESIS DN 6444All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS INTERMEDIATE PROGENITOR 14984All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR UP 14896All SZGR 2.0 genes in this pathway
BILD MYC ONCOGENIC SIGNATURE 206117All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953554All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911527All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011592All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720440All SZGR 2.0 genes in this pathway
HOWLIN CITED1 TARGETS 2 DN 1711All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS REQUIRE MYC 210123All SZGR 2.0 genes in this pathway
LEE METASTASIS AND ALTERNATIVE SPLICING UP 7451All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673430All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602364All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601369All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002 429260All SZGR 2.0 genes in this pathway
MOOTHA PGC 420269All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA 447277All SZGR 2.0 genes in this pathway
VANASSE BCL2 TARGETS DN 7450All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2 356214All SZGR 2.0 genes in this pathway
MOOTHA GLUCONEOGENESIS 3223All SZGR 2.0 genes in this pathway
MOOTHA GLYCOLYSIS 2113All SZGR 2.0 genes in this pathway
LI DCP2 BOUND MRNA 8957All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP D 280158All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN 448282All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658397All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770480All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP 279155All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 PARTIAL 160106All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38 337236All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467251All SZGR 2.0 genes in this pathway