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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: SDCBP

Summary

GeneID

6386

Symbol

SDCBP

Synonyms

MDA-9|ST1|SYCL|TACIP18

Description

syndecan binding protein (syntenin)

Locus tag

Gene type

protein-coding

Map location

8q12

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 1.0012

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

C6orf167

0.92

0.80

DTL

0.91

0.67

TIMELESS

0.90

0.80

MCM2

0.90

0.79

CDK2

0.89

0.52

MCM10

0.89

0.61

BRCA2

0.89

0.59

MCM5

0.89

0.76

RRM2

0.89

0.61

FAM83D

0.89

0.75

Top 10 negatively co-expressed genes

C5orf53

-0.41

-0.62

PTH1R

-0.40

-0.63

SLC9A3R2

-0.40

-0.35

SLC16A11

-0.39

-0.49

LGI4

-0.38

-0.36

AIFM3

-0.38

-0.56

HLA-F

-0.38

-0.54

TNFSF12

-0.38

-0.52

FXYD7

-0.38

-0.33

TMEM54

-0.38

-0.48

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005137

interleukin-5 receptor binding

ISS

11498591

GO:0005515

protein binding

IEA

GO:0008093

cytoskeletal adaptor activity

NAS

9391086

GO:0016491

oxidoreductase activity

IEA

GO:0045545

syndecan binding

NAS

9391086

GO:0047485

protein N-terminus binding

IPI

15371445

GO:0046982

protein heterodimerization activity

IPI

11152476

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007268

synaptic transmission

NAS

neuron, Synap, Neurotransmitter (GO term level: 6)

9883737

GO:0007265

Ras protein signal transduction

IEA

GO:0007242

intracellular signaling cascade

NAS

9391086

GO:0008152

metabolic process

IEA

GO:0006930

substrate-bound cell migration, cell extension

NAS

12037664

GO:0006612

protein targeting to membrane

NAS

10230395

GO:0030036

actin cytoskeleton organization

NAS

12037664

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005856

cytoskeleton

NAS

9391086

GO:0005789

endoplasmic reticulum membrane

IEA

GO:0005634

nucleus

NAS

11179419

GO:0005737

cytoplasm

IEA

GO:0005783

endoplasmic reticulum

IEA

GO:0005912

adherens junction

NAS

11179419

GO:0005895

interleukin-5 receptor complex

ISS

11498591

GO:0005886

plasma membrane

IEA

GO:0042470

melanosome

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CADM1	BL2 \| DKFZp686F1789 \| IGSF4 \| IGSF4A \| MGC149785 \| MGC51880 \| NECL2 \| Necl-2 \| RA175 \| ST17 \| SYNCAM \| TSLC1 \| sTSLC-1 \| sgIGSF \| synCAM1	cell adhesion molecule 1	-	HPRD,BioGRID	12202822
EFNB1	CFND \| CFNS \| EFL3 \| EPLG2 \| Elk-L \| LERK2 \| MGC8782	ephrin-B1	-	HPRD,BioGRID	9920925
EFNB2	EPLG5 \| HTKL \| Htk-L \| LERK5 \| MGC126226 \| MGC126227 \| MGC126228	ephrin-B2	Ephrin-B2 interacts with ST-1. This interaction was modelled on a demonstrated interaction between human Ephrin-B2 and rat ST-1.	BIND	11152476
EFNB2		ephrin-B2	-	HPRD	10473577
EPHA7	EHK3 \| HEK11	EPH receptor A7	EphA7 interacts with ST-1. This interaction was modelled on a demonstrated interaction between human EphA7 and rat ST-1.	BIND	11152476
GRIA1	GLUH1 \| GLUR1 \| GLURA \| HBGR1 \| MGC133252	glutamate receptor, ionotropic, AMPA 1	-	HPRD,BioGRID	11891216
GRIA2	GLUR2 \| GLURB \| GluR-K2 \| HBGR2	glutamate receptor, ionotropic, AMPA 2	Reconstituted Complex	BioGRID	11891216
GRIA3	GLUR-C \| GLUR-K3 \| GLUR3 \| GLURC \| MRX94	glutamate receptor, ionotrophic, AMPA 3	Reconstituted Complex	BioGRID	11891216
GRIA4	GLUR4 \| GLUR4C \| GLURD	glutamate receptor, ionotrophic, AMPA 4	-	HPRD,BioGRID	11891216
GRIK1	EAA3 \| EEA3 \| GLR5 \| GLUR5	glutamate receptor, ionotropic, kainate 1	-	HPRD,BioGRID	12597860
GRIK2	EAA4 \| GLR6 \| GLUK6 \| GLUR6 \| MGC74427 \| MRT6	glutamate receptor, ionotropic, kainate 2	-	HPRD,BioGRID	12597860
GRIK3	EAA5 \| GLR7 \| GLUR7 \| GluR7a	glutamate receptor, ionotropic, kainate 3	Reconstituted Complex	BioGRID	11891216
GRM3	GLUR3 \| GPRC1C \| MGLUR3 \| mGlu3	glutamate receptor, metabotropic 3	-	HPRD,BioGRID	11891216
GRM7	FLJ40498 \| GLUR7 \| GPRC1G \| MGLUR7 \| mGlu7	glutamate receptor, metabotropic 7	Syntenin interacts with mGluR7b. This interaction was modeled on a demonstrated interaction between GRIP from an unspecified species and human mGluR7b.	BIND	11891216
IL5RA	CD125 \| CDw125 \| HSIL5R3 \| IL5R \| MGC26560	interleukin 5 receptor, alpha	-	HPRD,BioGRID	11498591
NF2	ACN \| BANF \| SCH	neurofibromin 2 (merlin)	Schwannomin interacts with syntenin.	BIND	11432873
NF2	ACN \| BANF \| SCH	neurofibromin 2 (merlin)	-	HPRD,BioGRID	11432873
NFASC	DKFZp686P2250 \| FLJ46866 \| KIAA0756 \| NF \| NRCAML	neurofascin homolog (chicken)	-	HPRD	11152476
NRXN1	DKFZp313P2036 \| FLJ35941 \| Hs.22998 \| KIAA0578	neurexin 1	Neurexin I-alpha interacts with ST-1. This interaction was modelled on a demonstrated interaction between human neurexin I-alpha and rat ST-1.	BIND	11152476
PTPRJ	CD148 \| DEP1 \| HPTPeta \| R-PTP-ETA \| SCC1	protein tyrosine phosphatase, receptor type, J	-	HPRD,BioGRID	12403354
RAB5A	RAB5	RAB5A, member RAS oncogene family	Affinity Capture-Western Two-hybrid	BioGRID	15014045
SDC1	CD138 \| SDC \| SYND1 \| syndecan	syndecan 1	-	HPRD,BioGRID	11179419
SDC2	HSPG \| HSPG1 \| SYND2	syndecan 2	-	HPRD,BioGRID	9391086
SDC3	N-syndecan \| SDCN \| SYND3	syndecan 3	Syndecan-3 interacts with ST-1. This interaction was modelled on a demonstrated interaction between human syndecan-3 and rat ST-1.	BIND	11152476
SDC4	MGC22217 \| SYND4	syndecan 4	-	HPRD	12241528
SDCBP2	FLJ12256 \| SITAC18 \| ST-2	syndecan binding protein (syntenin) 2	-	HPRD	11152476
SOX4	EVI16	SRY (sex determining region Y)-box 4	-	HPRD,BioGRID	11498591
TGFA	TFGA	transforming growth factor, alpha	Pro-TGF-alpha interacts with ST-1. This interaction was modelled on a demonstrated interaction between human Pro-TGF-alpha and rat ST-1.	BIND	11152476
ULK1	ATG1 \| FLJ38455 \| UNC51 \| Unc51.1	unc-51-like kinase 1 (C. elegans)	-	HPRD,BioGRID	15014045

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
PID_IL5_PATHWAY	14	11	All SZGR genes in this pathway
PID_SYNDECAN_4_PATHWAY	32	25	All SZGR genes in this pathway
PID_SYNDECAN_1_PATHWAY	46	29	All SZGR genes in this pathway
PID_SYNDECAN_2_PATHWAY	33	27	All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY	396	292	All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE	251	188	All SZGR genes in this pathway
REACTOME_L1CAM_INTERACTIONS	86	62	All SZGR genes in this pathway
GARY_CD5_TARGETS_UP	473	314	All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP	1382	904	All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN	460	312	All SZGR genes in this pathway
LAIHO_COLORECTAL_CANCER_SERRATED_UP	112	71	All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2A_DN	141	84	All SZGR genes in this pathway
OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_UP	117	85	All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN	712	443	All SZGR genes in this pathway
FERREIRA_EWINGS_SARCOMA_UNSTABLE_VS_STABLE_UP	167	92	All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_UP	176	115	All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_8Q12_Q22_AMPLICON	132	82	All SZGR genes in this pathway
DER_IFN_ALPHA_RESPONSE_UP	74	48	All SZGR genes in this pathway
DORSAM_HOXA9_TARGETS_DN	32	22	All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP	555	346	All SZGR genes in this pathway
DER_IFN_GAMMA_RESPONSE_UP	71	45	All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_MATURE_CELL	293	160	All SZGR genes in this pathway
WANG_CISPLATIN_RESPONSE_AND_XPC_DN	228	146	All SZGR genes in this pathway
JIANG_HYPOXIA_NORMAL	311	205	All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED	1022	619	All SZGR genes in this pathway
ZHENG_FOXP3_TARGETS_IN_THYMUS_UP	196	137	All SZGR genes in this pathway
SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_DN	154	101	All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP	973	570	All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP	863	514	All SZGR genes in this pathway
ALONSO_METASTASIS_EMT_UP	36	24	All SZGR genes in this pathway
ALONSO_METASTASIS_NEURAL_UP	18	13	All SZGR genes in this pathway
ALONSO_METASTASIS_UP	198	128	All SZGR genes in this pathway
CROONQUIST_NRAS_SIGNALING_UP	41	24	All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_UP	442	263	All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN	253	192	All SZGR genes in this pathway
DORN_ADENOVIRUS_INFECTION_12HR_DN	33	25	All SZGR genes in this pathway
DORN_ADENOVIRUS_INFECTION_24HR_DN	43	32	All SZGR genes in this pathway
DORN_ADENOVIRUS_INFECTION_32HR_DN	39	28	All SZGR genes in this pathway
DORN_ADENOVIRUS_INFECTION_48HR_DN	40	29	All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_9	76	45	All SZGR genes in this pathway
LU_EZH2_TARGETS_DN	414	237	All SZGR genes in this pathway
ALFANO_MYC_TARGETS	239	156	All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN	784	464	All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_COMPLETE	227	151	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-1/206	497	503	1A	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
miR-124.1	592	598	1A	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-135	279	285	m8	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	279	285	m8	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-142-5p	1036	1042	m8	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-155	508	515	1A,m8	hsa-miR-155	UUAAUGCUAAUCGUGAUAGGGG
miR-17-5p/20/93.mr/106/519.d	1035	1041	1A	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-196	562	568	m8	hsa-miR-196a	UAGGUAGUUUCAUGUUGUUGG
miR-196	562	568	m8	hsa-miR-196b	UAGGUAGUUUCCUGUUGUUGG
miR-496	837	843	1A	hsa-miR-496	AUUACAUGGCCAAUCUC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.