Gene Page: SI
Summary ?
| GeneID | 6476 |
| Symbol | SI |
| Synonyms | - |
| Description | sucrase-isomaltase (alpha-glucosidase) |
| Reference | MIM:609845|HGNC:HGNC:10856|Ensembl:ENSG00000090402|HPRD:01962|Vega:OTTHUMG00000158065 |
| Gene type | protein-coding |
| Map location | 3q25.2-q26.2 |
| Pascal p-value | 0.222 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizotypy,schizophrenias,schizotypal | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| HLA-B | 0.54 | 0.60 |
| GBP2 | 0.50 | 0.54 |
| HLA-F | 0.48 | 0.59 |
| AF347015.31 | 0.47 | 0.56 |
| AF347015.9 | 0.47 | 0.56 |
| GBP1 | 0.47 | 0.54 |
| MT-CO2 | 0.46 | 0.58 |
| ABCG2 | 0.46 | 0.53 |
| CD8BP | 0.46 | 0.54 |
| C1QTNF1 | 0.46 | 0.57 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| PGBD1 | -0.48 | -0.59 |
| ZNF821 | -0.47 | -0.57 |
| MARK3 | -0.47 | -0.55 |
| SHF | -0.47 | -0.56 |
| UTP6 | -0.47 | -0.57 |
| WDR70 | -0.47 | -0.57 |
| C11orf61 | -0.47 | -0.56 |
| ZNF7 | -0.47 | -0.54 |
| SETDB1 | -0.47 | -0.55 |
| SUPV3L1 | -0.47 | -0.56 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG STARCH AND SUCROSE METABOLISM | 52 | 33 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF CARBOHYDRATES | 247 | 154 | All SZGR 2.0 genes in this pathway |
| SABATES COLORECTAL ADENOMA DN | 291 | 176 | All SZGR 2.0 genes in this pathway |
| LIU CDX2 TARGETS UP | 36 | 22 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| YOSHIOKA LIVER CANCER EARLY RECURRENCE DN | 65 | 31 | All SZGR 2.0 genes in this pathway |