Gene Page: SPR

Summary ?
GeneID6697
SymbolSPR
SynonymsSDR38C1
Descriptionsepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
ReferenceMIM:182125|HGNC:HGNC:11257|Ensembl:ENSG00000116096|HPRD:01632|Vega:OTTHUMG00000129777
Gene typeprotein-coding
Map location2p14-p12
Pascal p-value0.011
Fetal beta-1.433
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17022908chr238783057SPR66970.13trans
rs7607798chr2102043108SPR66970.13trans
rs10178499chr2127937434SPR66970.17trans
rs2461463chr2128708062SPR66970.07trans
rs1397611chr4120225347SPR66970.16trans
rs11722940chr4120233215SPR66970.13trans
rs17595790chr4120276219SPR66970.12trans
rs7706288chr5141864248SPR66970trans
rs1898661chr5153338309SPR66970.12trans
rs11996557chr8102901392SPR66970.15trans
rs16868715chr8102922408SPR66970.08trans
rs10739219chr9108938328SPR66970.18trans
rs10980452chr9113332327SPR66970.14trans
rs6478513chr9124238226SPR66970.11trans
rs17152865chr1013171768SPR66970.04trans
snp_a-20553210SPR66970.17trans
rs11030327chr113956554SPR66970.07trans
rs17007452chr1281243404SPR66970.01trans
rs3899870chr1397205717SPR66970.02trans
rs9300361chr1397210272SPR66970.14trans
rs3784005chr1476077230SPR66970.05trans
rs17757723chr1479323591SPR66970.06trans
rs2829739chr2126791883SPR66970.06trans
rs216780chr2127324318SPR66970.16trans
rs2829996chr2127326755SPR66970.06trans
rs1001022chr2226403487SPR66970.04trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TAP10.720.47
IRF90.710.43
MX10.700.40
IFIT30.700.38
IFITM30.700.35
SP1100.690.54
IFIT10.690.31
PLSCR10.690.45
IFI44L0.690.46
PARP90.680.52
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
OR2W3-0.35-0.38
PRRT2-0.35-0.37
PKNOX2-0.35-0.36
LRRC4C-0.35-0.38
SLITRK5-0.35-0.36
CSMD1-0.34-0.36
KIAA1239-0.34-0.40
MYLIP-0.34-0.38
ARPP-21-0.34-0.38
CHD5-0.34-0.36

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG FOLATE BIOSYNTHESIS 1110All SZGR 2.0 genes in this pathway
REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION 139All SZGR 2.0 genes in this pathway
REACTOME ENOS ACTIVATION AND REGULATION 2014All SZGR 2.0 genes in this pathway
WATANABE RECTAL CANCER RADIOTHERAPY RESPONSIVE DN 9251All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 3 4831All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 UP 309199All SZGR 2.0 genes in this pathway
FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE DN 9859All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN 514330All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS EARLY PROGENITOR 532309All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR UP 14896All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566371All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911527All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011592All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL OPTIMAL DEBULKING 246152All SZGR 2.0 genes in this pathway
TOOKER GEMCITABINE RESISTANCE DN 12284All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway