Gene Page: SSTR3

Summary ?
GeneID6753
SymbolSSTR3
SynonymsSS-3-R|SS3-R|SS3R|SSR-28
Descriptionsomatostatin receptor 3
ReferenceMIM:182453|HGNC:HGNC:11332|Ensembl:ENSG00000278195|HPRD:01675|Vega:OTTHUMG00000150537
Gene typeprotein-coding
Map location22q13.1
Pascal p-value0.052
Fetal beta0.293
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0471 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg147571732237602542SSTR34.61E-5-0.2620.021DMG:Wockner_2014
cg033891332237608611SSTR32.527E-4-0.2290.037DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PHF120.820.83
ST3GAL10.820.78
BAZ2A0.820.79
EP3000.820.81
MICALL10.820.84
SMG60.820.82
SEPN10.820.88
KIAA03550.810.84
GATAD2A0.810.81
PIK3C2B0.810.82
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C5orf53-0.63-0.69
ACOT13-0.61-0.67
ACYP2-0.57-0.62
MYL3-0.56-0.66
AF347015.31-0.56-0.69
CA4-0.55-0.60
AF347015.27-0.55-0.66
MT3-0.55-0.66
B2M-0.55-0.62
S100B-0.54-0.63

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0004994somatostatin receptor activityTAS8405411 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007187G-protein signaling, coupled to cyclic nucleotide second messengerTAS8405411 
GO:0007267cell-cell signalingTAS1337145 
GO:0007165signal transductionIEA-
GO:0008285negative regulation of cell proliferationTAS8961277 
GO:0008628induction of apoptosis by hormonesTAS8961277 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS1337145 
GO:0031513nonmotile primary ciliumISS-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272195All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 188108All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305177All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME G ALPHA I SIGNALLING EVENTS 195114All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408246All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR DN 3720All SZGR 2.0 genes in this pathway