Gene Page: TEK

Summary
GeneID  7010
Symbol  TEK
Synonyms  CD202B|TIE-2|TIE2|VMCM|VMCM1
Description  TEK tyrosine kinase, endothelial
See related  HGNC:11724|MIM:600221|Ensembl:ENSG00000120156|HPRD:02571|
Locus tag  -
Gene type  protein-coding
Map location  9p21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
HLA-E0.830.84
LRRC320.830.90
MMRN20.830.85
PTRF0.810.87
EPAS10.810.87
ABCB10.810.85
PRELP0.800.85
CLEC14A0.780.83
APOL30.770.73
TNS10.770.84
Top 10 negatively co-expressed genes
FRG1-0.60-0.67
POLB-0.59-0.67
C18orf21-0.58-0.63
MED19-0.58-0.61
TCTEX1D2-0.58-0.67
COMMD3-0.57-0.66
SCNM1-0.56-0.64
OXSM-0.56-0.66
ZNF32-0.56-0.68
CWC15-0.56-0.63
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004714transmembrane receptor protein tyrosine kinase activityTASneurite (GO term level: 8)8382358 
GO:0000166nucleotide bindingIEA-
GO:0004872receptor activityIEA-
GO:0004872receptor activityTAS10766762 
GO:0005524ATP bindingIEA-
GO:0004713protein tyrosine kinase activityIEA-
GO:0016740transferase activityIEA-
GO:0016301kinase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayTAS8980225 
GO:0007160cell-matrix adhesionIEA-
GO:0006468protein amino acid phosphorylationIEA-
GO:0007267cell-cell signalingTAS8980225 
GO:0007165signal transductionTAS8382358 
GO:0016337cell-cell adhesionIEA-
GO:0030334regulation of cell migrationIEA-
GO:0045765regulation of angiogenesisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneEXP14665640 |14749497 
GO:0005887integral to plasma membraneTAS8382358 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ANGPT1AGP1 | AGPT | ANG1angiopoietin 1-HPRD8980223 |8980224 
|9723709 |12427764 
Tie2 interacts with Ang1.BIND15542434 
Affinity Capture-Western
Reconstituted Complex		BioGRID8980223 |9723709 
|12427764 
ANGPT2AGPT2 | ANG2angiopoietin 2The receptor binding domain (RBD) of Ang2 interacts with the Tie2 ligand binding domain (LBD). This interaction was modelled on a demonstrated interaction between human Ang2 and Tie2 from an unspecified species.BIND15893672 
Tie2 interacts with Ang2.BIND15542434 
-HPRD,BioGRID9723709 
ANGPT4AGP4 | ANG-3 | ANG4 | MGC138181 | MGC138183angiopoietin 4Tie2 interacts with Ang4.BIND15542434 
-HPRD,BioGRID10051567 
ANGPTL1ANG3 | ANGPT3 | ARP1 | AngY | KIAA0351 | UNQ162 | dJ595C2.2angiopoietin-like 1Tie2 interacts with Ang3. This interaction was modeled on a demonstrated interaction between human Tie2 and mouse Ang3.BIND15542434 
-HPRD10051567 
DOK2p56DOK | p56dok-2docking protein 2, 56kDa-HPRD,BioGRID9764820 
GRB14-growth factor receptor-bound protein 14-HPRD10521483 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD7478529 |10521483 
GRB7-growth factor receptor-bound protein 7-HPRD10521483 
LCKYT16 | p56lck | pp58lcklymphocyte-specific protein tyrosine kinase-HPRD7545683 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)-HPRD10521483 
PTPN11BPTP3 | CFC | MGC14433 | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2protein tyrosine phosphatase, non-receptor type 11-HPRD10521483 
SOCS1CIS1 | CISH1 | JAB | SOCS-1 | SSI-1 | SSI1 | TIP3suppressor of cytokine signaling 1Socs1 interacts with TEK. This interaction was modeled on a demonstrated interaction between mouse Socs1 and Tek from an unspecified species.BIND10022833 
-HPRD10022833 
TIE1JTK14 | TIEtyrosine kinase with immunoglobulin-like and EGF-like domains 1-HPRD,BioGRID10995770 
TNIP2ABIN-2 | ABIN2 | FLIP1 | KLIP | MGC4289TNFAIP3 interacting protein 2-HPRD12609966 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_ANGIOPOIETIN_RECEPTOR_PATHWAY 5041All SZGR genes in this pathway
PID_SHP2_PATHWAY 5846All SZGR genes in this pathway
REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL 9165All SZGR genes in this pathway
REACTOME_TIE2_SIGNALING 1713All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
DELYS_THYROID_CANCER_DN 232154All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_F_UP 185119All SZGR genes in this pathway
TAKADA_GASTRIC_CANCER_COPY_NUMBER_DN 2915All SZGR genes in this pathway
INGRAM_SHH_TARGETS_UP 12779All SZGR genes in this pathway
BERTUCCI_INVASIVE_CARCINOMA_DUCTAL_VS_LOBULAR_DN 4634All SZGR genes in this pathway
ROSS_AML_OF_FAB_M7_TYPE 6844All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_UP 182119All SZGR genes in this pathway
HARRIS_HYPOXIA 8164All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_UP 8648All SZGR genes in this pathway
ZHANG_PROLIFERATING_VS_QUIESCENT 5141All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
KRASNOSELSKAYA_ILF3_TARGETS_DN 4638All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_DN 353226All SZGR genes in this pathway
BOQUEST_STEM_CELL_DN 216143All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
WINTER_HYPOXIA_METAGENE 242168All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_LATE_RECURRENCE_DN 6948All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION 368247All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3 718401All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_1_UP 12561All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_3_UP 17097All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_6_UP 14081All SZGR genes in this pathway
CHYLA_CBFA2T3_TARGETS_UP 387225All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
WIEDERSCHAIN_TARGETS_OF_BMI1_AND_PCGF2 5739All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
MADAN_DPPA4_TARGETS 4626All SZGR genes in this pathway


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