Gene Page: TEK

Summary ?
GeneID7010
SymbolTEK
SynonymsCD202B|TIE-2|TIE2|VMCM|VMCM1
DescriptionTEK receptor tyrosine kinase
ReferenceMIM:600221|HGNC:HGNC:11724|Ensembl:ENSG00000120156|HPRD:02571|Vega:OTTHUMG00000019712
Gene typeprotein-coding
Map location9p21
Pascal p-value1.501E-4
Sherlock p-value0.103
TADA p-value0.003
Fetal beta-1.312
eGeneCerebellar Hemisphere
Cerebellum
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DNM:McCarthy_2014Whole Exome Sequencing analysisWhole exome sequencing of 57 trios with sporadic or familial schizophrenia.
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@DNM table

GeneChromosomePositionRefAltTranscriptAA changeMutation typeSiftCG46TraitStudy
TEKchr927197558GTNM_000459p.E624Xnonsense SNVCNASchizophreniaDNM:McCarthy_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
HLA-E0.830.84
LRRC320.830.90
MMRN20.830.85
PTRF0.810.87
EPAS10.810.87
ABCB10.810.85
PRELP0.800.85
CLEC14A0.780.83
APOL30.770.73
TNS10.770.84
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FRG1-0.60-0.67
POLB-0.59-0.67
C18orf21-0.58-0.63
MED19-0.58-0.61
TCTEX1D2-0.58-0.67
COMMD3-0.57-0.66
SCNM1-0.56-0.64
OXSM-0.56-0.66
ZNF32-0.56-0.68
CWC15-0.56-0.63

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004714transmembrane receptor protein tyrosine kinase activityTASneurite (GO term level: 8)8382358 
GO:0000166nucleotide bindingIEA-
GO:0004872receptor activityIEA-
GO:0004872receptor activityTAS10766762 
GO:0005524ATP bindingIEA-
GO:0004713protein tyrosine kinase activityIEA-
GO:0016740transferase activityIEA-
GO:0016301kinase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayTAS8980225 
GO:0007160cell-matrix adhesionIEA-
GO:0006468protein amino acid phosphorylationIEA-
GO:0007267cell-cell signalingTAS8980225 
GO:0007165signal transductionTAS8382358 
GO:0016337cell-cell adhesionIEA-
GO:0030334regulation of cell migrationIEA-
GO:0045765regulation of angiogenesisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneEXP14665640 |14749497 
GO:0005887integral to plasma membraneTAS8382358 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ANGPT1AGP1 | AGPT | ANG1angiopoietin 1-HPRD8980223 |8980224 
|9723709 |12427764 
ANGPT1AGP1 | AGPT | ANG1angiopoietin 1Tie2 interacts with Ang1.BIND15542434 
ANGPT1AGP1 | AGPT | ANG1angiopoietin 1Affinity Capture-Western
Reconstituted Complex		BioGRID8980223 |9723709 
|12427764 
ANGPT2AGPT2 | ANG2angiopoietin 2The receptor binding domain (RBD) of Ang2 interacts with the Tie2 ligand binding domain (LBD). This interaction was modelled on a demonstrated interaction between human Ang2 and Tie2 from an unspecified species.BIND15893672 
ANGPT2AGPT2 | ANG2angiopoietin 2Tie2 interacts with Ang2.BIND15542434 
ANGPT2AGPT2 | ANG2angiopoietin 2-HPRD,BioGRID9723709 
ANGPT4AGP4 | ANG-3 | ANG4 | MGC138181 | MGC138183angiopoietin 4Tie2 interacts with Ang4.BIND15542434 
ANGPT4AGP4 | ANG-3 | ANG4 | MGC138181 | MGC138183angiopoietin 4-HPRD,BioGRID10051567 
ANGPTL1ANG3 | ANGPT3 | ARP1 | AngY | KIAA0351 | UNQ162 | dJ595C2.2angiopoietin-like 1Tie2 interacts with Ang3. This interaction was modeled on a demonstrated interaction between human Tie2 and mouse Ang3.BIND15542434 
ANGPTL1ANG3 | ANGPT3 | ARP1 | AngY | KIAA0351 | UNQ162 | dJ595C2.2angiopoietin-like 1-HPRD10051567 
DOK2p56DOK | p56dok-2docking protein 2, 56kDa-HPRD,BioGRID9764820 
GRB14-growth factor receptor-bound protein 14-HPRD10521483 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD7478529 |10521483 
GRB7-growth factor receptor-bound protein 7-HPRD10521483 
LCKYT16 | p56lck | pp58lcklymphocyte-specific protein tyrosine kinase-HPRD7545683 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)-HPRD10521483 
PTPN11BPTP3 | CFC | MGC14433 | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2protein tyrosine phosphatase, non-receptor type 11-HPRD10521483 
SOCS1CIS1 | CISH1 | JAB | SOCS-1 | SSI-1 | SSI1 | TIP3suppressor of cytokine signaling 1Socs1 interacts with TEK. This interaction was modeled on a demonstrated interaction between mouse Socs1 and Tek from an unspecified species.BIND10022833 
SOCS1CIS1 | CISH1 | JAB | SOCS-1 | SSI-1 | SSI1 | TIP3suppressor of cytokine signaling 1-HPRD10022833 
TIE1JTK14 | TIEtyrosine kinase with immunoglobulin-like and EGF-like domains 1-HPRD,BioGRID10995770 
TNIP2ABIN-2 | ABIN2 | FLIP1 | KLIP | MGC4289TNFAIP3 interacting protein 2-HPRD12609966 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID ANGIOPOIETIN RECEPTOR PATHWAY 5041All SZGR 2.0 genes in this pathway
PID SHP2 PATHWAY 5846All SZGR 2.0 genes in this pathway
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 9165All SZGR 2.0 genes in this pathway
REACTOME TIE2 SIGNALING 1713All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER DN 232154All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS F UP 185119All SZGR 2.0 genes in this pathway
TAKADA GASTRIC CANCER COPY NUMBER DN 2915All SZGR 2.0 genes in this pathway
INGRAM SHH TARGETS UP 12779All SZGR 2.0 genes in this pathway
BERTUCCI INVASIVE CARCINOMA DUCTAL VS LOBULAR DN 4634All SZGR 2.0 genes in this pathway
ROSS AML OF FAB M7 TYPE 6844All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546351All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555346All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 UP 182119All SZGR 2.0 genes in this pathway
HARRIS HYPOXIA 8164All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830547All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY UP 8648All SZGR 2.0 genes in this pathway
ZHANG PROLIFERATING VS QUIESCENT 5141All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681420All SZGR 2.0 genes in this pathway
KRASNOSELSKAYA ILF3 TARGETS DN 4638All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN DN 353226All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL DN 216143All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546362All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE 242168All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP 165118All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435289All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER LATE RECURRENCE DN 6948All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION 368247All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721492All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 718401All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 1 UP 12561All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 3 UP 17097All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 6 UP 14081All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS UP 387225All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898516All SZGR 2.0 genes in this pathway
WIEDERSCHAIN TARGETS OF BMI1 AND PCGF2 5739All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745475All SZGR 2.0 genes in this pathway
MADAN DPPA4 TARGETS 4626All SZGR 2.0 genes in this pathway