Gene Page: THBS2

Summary
GeneID  7058
Symbol  THBS2
Synonyms  TSP2
Description  thrombospondin 2
See related  HGNC:11786|MIM:188061|Ensembl:ENSG00000186340|HPRD:01766|
Locus tag  -
Gene type  protein-coding
Map location  6q27
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 1.735 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SOX90.870.78
PALLD0.850.76
SALL10.840.73
NOTCH20.840.83
YAP10.840.83
FBXL70.830.79
SALL30.830.78
CRB10.820.76
GPR980.820.74
NOTCH10.820.65
Top 10 negatively co-expressed genes
FBXW7-0.26-0.21
SLC26A4-0.26-0.25
RALYL-0.26-0.24
DYNC1I1-0.25-0.23
ARHGAP20-0.25-0.17
FGF12-0.25-0.18
FAM134B-0.25-0.19
FABP3-0.24-0.15
ELMOD1-0.24-0.18
LNX1-0.24-0.18
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005509calcium ion bindingIEA-
GO:0005515protein bindingIEA-
GO:0005198structural molecule activityIEA-
GO:0008201heparin bindingTAS1459996 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007155cell adhesionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionEXP6338048 
GO:0005576extracellular regionIEA-
GO:0031093platelet alpha granule lumenEXP6338048 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
MMP2CLG4 | CLG4A | MMP-II | MONA | TBE-1matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)-HPRD,BioGRID10900205 
MMP9CLG4B | GELB | MMP-9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)-HPRD,BioGRID10900205 
THBS2TSP2thrombospondin 2-HPRD1459996 
THBS3MGC119564 | MGC119565 | TSP3thrombospondin 3-HPRD1459996 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_TGF_BETA_SIGNALING_PATHWAY 8664All SZGR genes in this pathway
KEGG_FOCAL_ADHESION 201138All SZGR genes in this pathway
KEGG_ECM_RECEPTOR_INTERACTION 8453All SZGR genes in this pathway
PID_INTEGRIN1_PATHWAY 6644All SZGR genes in this pathway
PID_INTEGRIN_A4B1_PATHWAY 3324All SZGR genes in this pathway
REACTOME_SIGNALING_BY_PDGF 12293All SZGR genes in this pathway
WATANABE_RECTAL_CANCER_RADIOTHERAPY_RESPONSIVE_DN 9251All SZGR genes in this pathway
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP 351230All SZGR genes in this pathway
TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_DUCTAL_NORMAL_UP 6938All SZGR genes in this pathway
TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_DN 7442All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_UP 305185All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_ADVANCED_VS_EARLY_UP 175120All SZGR genes in this pathway
MOROSETTI_FACIOSCAPULOHUMERAL_MUSCULAR_DISTROPHY_UP 2011All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_UP 293179All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_UP 12672All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_CDC25_UP 12073All SZGR genes in this pathway
CHEBOTAEV_GR_TARGETS_DN 12073All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_A_UP 191128All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_DN 394258All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_4_5WK_UP 271175All SZGR genes in this pathway
BEGUM_TARGETS_OF_PAX3_FOXO1_FUSION_DN 4534All SZGR genes in this pathway
HUMMERICH_SKIN_CANCER_PROGRESSION_UP 8858All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_5 14789All SZGR genes in this pathway
LI_AMPLIFIED_IN_LUNG_CANCER 178108All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2B 392251All SZGR genes in this pathway
HERNANDEZ_ABERRANT_MITOSIS_BY_DOCETACEL_2NM_UP 8157All SZGR genes in this pathway
HERNANDEZ_MITOTIC_ARREST_BY_DOCETAXEL_2_UP 6445All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
HOWLIN_PUBERTAL_MAMMARY_GLAND 6940All SZGR genes in this pathway
LIEN_BREAST_CARCINOMA_METAPLASTIC 3525All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_OCT4_TARGETS 290172All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
BENPORATH_NOS_TARGETS 179105All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
SUNG_METASTASIS_STROMA_UP 11070All SZGR genes in this pathway
AFFAR_YY1_TARGETS_DN 234137All SZGR genes in this pathway
KANG_IMMORTALIZED_BY_TERT_DN 10267All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C8 7256All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN 408274All SZGR genes in this pathway
NIELSEN_MALIGNAT_FIBROUS_HISTIOCYTOMA_UP 1811All SZGR genes in this pathway
KUNINGER_IGF1_VS_PDGFB_TARGETS_DN 4628All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
GERHOLD_ADIPOGENESIS_DN 6444All SZGR genes in this pathway
ZHU_CMV_24_HR_DN 9164All SZGR genes in this pathway
VERRECCHIA_DELAYED_RESPONSE_TO_TGFB1 3926All SZGR genes in this pathway
LEE_AGING_CEREBELLUM_UP 8458All SZGR genes in this pathway
JACKSON_DNMT1_TARGETS_UP 7757All SZGR genes in this pathway
ZHU_CMV_ALL_DN 12893All SZGR genes in this pathway
LY_AGING_MIDDLE_UP 1411All SZGR genes in this pathway
BURTON_ADIPOGENESIS_PEAK_AT_0HR 6348All SZGR genes in this pathway
VERRECCHIA_RESPONSE_TO_TGFB1_C4 1310All SZGR genes in this pathway
WANG_CISPLATIN_RESPONSE_AND_XPC_UP 202115All SZGR genes in this pathway
BURTON_ADIPOGENESIS_9 9259All SZGR genes in this pathway
URS_ADIPOCYTE_DIFFERENTIATION_DN 3020All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_12HR_DN 10164All SZGR genes in this pathway
JI_CARCINOGENESIS_BY_KRAS_AND_STK11_DN 1712All SZGR genes in this pathway
BOQUEST_STEM_CELL_UP 260174All SZGR genes in this pathway
WINTER_HYPOXIA_METAGENE 242168All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
SEKI_INFLAMMATORY_RESPONSE_LPS_DN 2316All SZGR genes in this pathway
SCHRAETS_MLL_TARGETS_DN 3324All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
CROONQUIST_STROMAL_STIMULATION_UP 6042All SZGR genes in this pathway
CROONQUIST_NRAS_VS_STROMAL_STIMULATION_DN 9965All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G56_DN 179All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_DN 170105All SZGR genes in this pathway
MIKKELSEN_IPS_ICP_WITH_H3K27ME3 5432All SZGR genes in this pathway
NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_UP 7646All SZGR genes in this pathway
CHANDRAN_METASTASIS_UP 221135All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_2 8650All SZGR genes in this pathway
NAKAMURA_ADIPOGENESIS_EARLY_DN 3827All SZGR genes in this pathway
NAKAMURA_ADIPOGENESIS_LATE_DN 3825All SZGR genes in this pathway
CHICAS_RB1_TARGETS_SENESCENT 572352All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
STEGER_ADIPOGENESIS_DN 2515All SZGR genes in this pathway
BILANGES_SERUM_SENSITIVE_VIA_TSC2 3925All SZGR genes in this pathway
SERVITJA_ISLET_HNF1A_TARGETS_UP 163111All SZGR genes in this pathway
WANG_MLL_TARGETS 289188All SZGR genes in this pathway
ANASTASSIOU_CANCER_MESENCHYMAL_TRANSITION_SIGNATURE 6440All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
NABA_ECM_GLYCOPROTEINS 19699All SZGR genes in this pathway
NABA_CORE_MATRISOME 275148All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
FARMER_BREAST_CANCER_CLUSTER_4 1912All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-182190619131A,m8hsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-30-5p3113171Ahsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-495291297m8hsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-9190919151Ahsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
miR-96190719131Ahsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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