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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: TTN

Summary

GeneID

7273

Symbol

TTN

Synonyms

CMD1G|CMH9|CMPD4|CONNECTIN|DKFZp451N061|EOMFC|FLJ26020|FLJ26409|FLJ32040|FLJ34413|FLJ39564|FLJ43066|HMERF|LGMD2J|TMD

Description

titin

Locus tag

Gene type

protein-coding

Map location

2q31

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0863

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

TRAP1

0.88

0.87

CFL1

0.87

0.88

PPP2R1A

0.87

DCTN2

0.86

0.88

ARPC1A

0.86

KAT5

0.86

0.85

PSMD3

0.85

0.84

CCT5

0.84

0.86

AKR1B1

0.84

0.85

NOC2L

0.84

Top 10 negatively co-expressed genes

AF347015.27

-0.76

AF347015.31

-0.75

-0.74

AF347015.8

-0.74

-0.73

AF347015.33

-0.73

-0.74

MT-CO2

-0.73

-0.71

AF347015.21

-0.73

-0.76

MT-CYB

-0.73

AF347015.2

-0.71

AF347015.15

-0.71

MT-ATP8

-0.68

-0.75

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000166

nucleotide binding

IEA

GO:0005089

Rho guanyl-nucleotide exchange factor activity

IEA

GO:0004601

peroxidase activity

IEA

GO:0005516

calmodulin binding

TAS

10481174

GO:0005524

ATP binding

IEA

GO:0005524

ATP binding

TAS

9804419

GO:0004674

protein serine/threonine kinase activity

IDA

9804419

GO:0004674

protein serine/threonine kinase activity

IEA

GO:0004713

protein tyrosine kinase activity

IEA

GO:0004197

cysteine-type endopeptidase activity

IEA

GO:0016740

transferase activity

IEA

GO:0020037

heme binding

IEA

GO:0008307

structural constituent of muscle

TAS

7569978

GO:0017022

myosin binding

TAS

11717165

GO:0042802

identical protein binding

IPI

9804419

GO:0051393

alpha-actinin binding

TAS

10481174

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006468

protein amino acid phosphorylation

IEA

GO:0006508

proteolysis

IEA

GO:0005975

carbohydrate metabolic process

IEA

GO:0007067

mitosis

TAS

10481174

GO:0006979

response to oxidative stress

IEA

GO:0006941

striated muscle contraction

TAS

7569978

GO:0035023

regulation of Rho protein signal transduction

IEA

GO:0030239

myofibril assembly

IMP

9804419

GO:0046777

protein amino acid autophosphorylation

IMP

9804419

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000794

condensed nuclear chromosome

TAS

10481174

GO:0005622

intracellular

IEA

GO:0005634

nucleus

IEA

GO:0005737

cytoplasm

IEA

GO:0030017

sarcomere

TAS

7569978

GO:0030018

Z disc

IDA

9501083

GO:0030018

Z disc

TAS

8937992

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTN1	FLJ40884	actinin, alpha 1	-	HPRD,BioGRID	11305911 \|11846417
ANK1	ANK \| SPH1 \| SPH2	ankyrin 1, erythrocytic	-	HPRD,BioGRID	12444090
ANKRD1	ALRP \| C-193 \| CARP \| CVARP \| MCARP \| bA320F15.2	ankyrin repeat domain 1 (cardiac muscle)	-	HPRD,BioGRID	14583192
ANKRD2	ARPP \| MGC104314	ankyrin repeat domain 2 (stretch responsive muscle)	-	HPRD,BioGRID	14583192
ANKRD23	DARP \| FLJ32449 \| MARP3 \| MGC129593	ankyrin repeat domain 23	-	HPRD,BioGRID	14583192
ASF1B	CIA-II \| FLJ10604	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	Affinity Capture-MS	BioGRID	17353931
CALM1	CALML2 \| CAMI \| DD132 \| PHKD	calmodulin 1 (phosphorylase kinase, delta)	-	HPRD	11178895
CAPN3	CANP3 \| CANPL3 \| LGMD2 \| LGMD2A \| MGC10767 \| MGC11121 \| MGC14344 \| MGC4403 \| nCL-1 \| p94	calpain 3, (p94)	-	HPRD	8537379 \|9642272\|9185618 \|9763216 \|10987085
CAPN3		calpain 3, (p94)	-	HPRD,BioGRID	8537379 \|9642272
FHL2	AAG11 \| DRAL \| SLIM3	four and a half LIM domains 2	An unspecified isoform of FHL2 (DRAL) interacts with TTN (titin).	BIND	12432079
FHL2	AAG11 \| DRAL \| SLIM3	four and a half LIM domains 2	-	HPRD,BioGRID	12432079
KY	FLJ33207	kyphoscoliosis peptidase	KY interacts with an unspecified isoform of TTN. This interaction was modeled on a demonstrated interaction between mouse KY and human TTN.	BIND	15385448
MYBPC3	CMH4 \| DKFZp779E1762 \| FHC \| MYBP-C	myosin binding protein C, cardiac	-	HPRD,BioGRID	8631348 \|12202917
MYOM1	MGC134946 \| MGC134947 \| SKELEMIN	myomesin 1, 185kDa	-	HPRD	7588733
MYOM2	TTNAP	myomesin (M-protein) 2, 165kDa	-	HPRD	7505783
MYPN	MYOP	myopalladin	Two-hybrid	BioGRID	14583192
NEB	DKFZp686C1456 \| FLJ11505 \| FLJ36536 \| FLJ39568 \| FLJ39584 \| NEB177D \| NEM2	nebulin	-	HPRD	11851340 \|12482578
OBSCN	DKFZp666E245 \| FLJ14124 \| KIAA1556 \| KIAA1639 \| MGC120409 \| MGC120410 \| MGC120411 \| MGC120412 \| MGC138590 \| UNC89	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	-	HPRD,BioGRID	11448995
PUF60	FIR \| FLJ31379 \| RoBPI \| SIAHBP1	poly-U binding splicing factor 60KDa	Affinity Capture-MS	BioGRID	17353931
SQSTM1	A170 \| OSIL \| PDB3 \| ZIP3 \| p60 \| p62 \| p62B	sequestosome 1	Titin interacts with p62. This interaction was modelled on a demonstrated interaction between human Titin and rat p62.	BIND	15802564
TCAP	CMD1N \| LGMD2G \| T-cap \| TELE \| telethonin	titin-cap (telethonin)	-	HPRD,BioGRID	9645487 \|9804419 \|9817758 \|12446666
TCAP	CMD1N \| LGMD2G \| T-cap \| TELE \| telethonin	titin-cap (telethonin)	Titin interacts with telethonin. This interaction was modelled on a demonstrated interaction between human Titin and telethonin from unspecified species.	BIND	15802564
TRIM63	FLJ32380 \| IRF \| MURF1 \| MURF2 \| RNF28 \| SMRZ	tripartite motif-containing 63	Reconstituted Complex Two-hybrid	BioGRID	11243782
TRIM63	FLJ32380 \| IRF \| MURF1 \| MURF2 \| RNF28 \| SMRZ	tripartite motif-containing 63	-	HPRD	11927605

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM	85	65	All SZGR genes in this pathway
KEGG_DILATED_CARDIOMYOPATHY	92	68	All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_DN	68	49	All SZGR genes in this pathway
HOOI_ST7_TARGETS_DN	123	78	All SZGR genes in this pathway
AKL_HTLV1_INFECTION_DN	68	41	All SZGR genes in this pathway
DARWICHE_PAPILLOMA_PROGRESSION_RISK	74	44	All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2B	392	251	All SZGR genes in this pathway
KORKOLA_YOLK_SAC_TUMOR	62	33	All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_HIGH_VS_LOW_DN	32	21	All SZGR genes in this pathway
DAIRKEE_TERT_TARGETS_DN	124	79	All SZGR genes in this pathway
RICKMAN_HEAD_AND_NECK_CANCER_F	54	32	All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_DN	200	112	All SZGR genes in this pathway
SHEPARD_BMYB_TARGETS	74	41	All SZGR genes in this pathway
SHEPARD_CRUSH_AND_BURN_MUTANT_DN	185	111	All SZGR genes in this pathway
CHIARETTI_ACUTE_LYMPHOBLASTIC_LEUKEMIA_ZAP70	67	33	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP	390	242	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP	1691	1088	All SZGR genes in this pathway
KUNINGER_IGF1_VS_PDGFB_TARGETS_UP	82	51	All SZGR genes in this pathway
WANG_CISPLATIN_RESPONSE_AND_XPC_UP	202	115	All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_UP	170	107	All SZGR genes in this pathway
DAIRKEE_CANCER_PRONE_RESPONSE_BPA_E2	118	65	All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_UP	295	149	All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_DN	264	159	All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP	338	225	All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_DN	235	144	All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_DN	245	150	All SZGR genes in this pathway
GUTIERREZ_CHRONIC_LYMPHOCYTIC_LEUKEMIA_DN	56	39	All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A	898	516	All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE	1137	655	All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_EARLY_LATE	317	190	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	205	211	1A	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-144	204	211	1A,m8	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-17-5p/20/93.mr/106/519.d	530	536	1A	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-208	538	544	m8	hsa-miR-208	AUAAGACGAGCAAAAAGCUUGU
miR-24	830	836	1A	hsa-miR-24^SZ	UGGCUCAGUUCAGCAGGAACAG
miR-433-3p	574	580	m8	hsa-miR-433^brain	AUCAUGAUGGGCUCCUCGGUGU
miR-451	224	231	1A,m8	hsa-miR-451^brain	AAACCGUUACCAUUACUGAGUUU
miR-493-5p	198	204	m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-542-3p	560	566	1A	hsa-miR-542-3p	UGUGACAGAUUGAUAACUGAAA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.