SZGR2

Summary ?

GeneID	7322
Symbol	UBE2D2
Synonyms	E2(17)KB2\|PUBC1\|UBC4\|UBC4/5\|UBCH4\|UBCH5B
Description	ubiquitin conjugating enzyme E2 D2
Reference	MIM:602962\|HGNC:HGNC:12475\|Ensembl:ENSG00000131508\|HPRD:04268\|Vega:OTTHUMG00000163282
Gene type	protein-coding
Map location	5q31.2
Pascal p-value	0.005
Sherlock p-value	0.456
eGene	Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
GSMA_I	Genome scan meta-analysis	Psr: 0.0032

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs6516671	chr21	26806125	UBE2D2	7322		0.12		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005515	protein binding	IPI		12878161 \|14667819
GO:0004842	ubiquitin-protein ligase activity	TAS		8090726
GO:0016874	ligase activity	IEA		-
GO:0019787	small conjugating protein ligase activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006511	ubiquitin-dependent protein catabolic process	IEA		-
GO:0006511	ubiquitin-dependent protein catabolic process	TAS		7724550
GO:0051246	regulation of protein metabolic process	IEA		-
GO:0043687	post-translational protein modification	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AMFR	GP78 \| RNF45	autocrine motility factor receptor	-	HPRD,BioGRID	11724934
BARD1	-	BRCA1 associated RING domain 1	Reconstituted Complex	BioGRID	12431996
BTRC	BETA-TRCP \| FBW1A \| FBXW1 \| FBXW1A \| FWD1 \| MGC4643 \| bTrCP \| bTrCP1 \| betaTrCP	beta-transducin repeat containing	Biochemical Activity	BioGRID	10531035
BTRC	BETA-TRCP \| FBW1A \| FBXW1 \| FBXW1A \| FWD1 \| MGC4643 \| bTrCP \| bTrCP1 \| betaTrCP	beta-transducin repeat containing	-	HPRD	10918611
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	-	HPRD,BioGRID	10514377
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	c-Cbl interacts with Ubc4.	BIND	10514377
DTX3L	BBAP	deltex 3-like (Drosophila)	-	HPRD,BioGRID	12670957
FBXL3	FBL3 \| FBL3A \| FBXL3A	F-box and leucine-rich repeat protein 3	Biochemical Activity	BioGRID	10531035
FBXO4	DKFZp547N213 \| FBX4 \| FLJ10141	F-box protein 4	Biochemical Activity	BioGRID	10531035
FBXO7	DKFZp686B08113 \| FBX \| FBX07 \| FBX7 \| PARK15 \| PKPS	F-box protein 7	Biochemical Activity	BioGRID	10531035
FBXW2	FBW2 \| Fwd2 \| MGC117371 \| Md6	F-box and WD repeat domain containing 2	Biochemical Activity	BioGRID	10531035
NEDD4	KIAA0093 \| MGC176705 \| NEDD4-1 \| RPF1	neural precursor cell expressed, developmentally down-regulated 4	-	HPRD,BioGRID	9182527
PJA1	RNF70	praja 1	in vitro in vivo	BioGRID	12036302
PJA2	KIAA0438 \| Neurodap1 \| RNF131	praja 2, RING-H2 motif containing	-	HPRD,BioGRID	12036302
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	Biochemical Activity	BioGRID	11676916
RNF11	CGI-123 \| MGC51169 \| SID1669	ring finger protein 11	RNF11 interacts with UbcH5b.	BIND	14562029
RNF2	BAP-1 \| BAP1 \| DING \| HIPI3 \| RING1B \| RING2	ring finger protein 2	Biochemical Activity	BioGRID	11513855
STUB1	CHIP \| HSPABP2 \| NY-CO-7 \| SDCCAG7 \| UBOX1	STIP1 homology and U-box containing protein 1	Reconstituted Complex	BioGRID	11676916
TRIM5	RNF88 \| TRIM5alpha	tripartite motif-containing 5	Biochemical Activity	BioGRID	12878161
UBE3A	ANCR \| AS \| E6-AP \| EPVE6AP \| FLJ26981 \| HPVE6A	ubiquitin protein ligase E3A	Biochemical Activity Reconstituted Complex Two-hybrid	BioGRID	9182527 \|9990509

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG UBIQUITIN MEDIATED PROTEOLYSIS	138	98	All SZGR 2.0 genes in this pathway
PID ERBB1 INTERNALIZATION PATHWAY	41	35	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN	25	17	All SZGR 2.0 genes in this pathway
REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	18	12	All SZGR 2.0 genes in this pathway
REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	31	19	All SZGR 2.0 genes in this pathway
REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS	73	57	All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM	279	178	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	All SZGR 2.0 genes in this pathway
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	251	156	All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	212	129	All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING DN	46	29	All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL UP	285	181	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS LOBULAR NORMAL UP	73	50	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP	305	185	All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS UP	126	72	All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION CDC25 UP	120	73	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN	483	336	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN	584	395	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS	957	597	All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215	893	528	All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPAIR GENES	230	137	All SZGR 2.0 genes in this pathway
WILLERT WNT SIGNALING	24	13	All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH REARRANGEMENTS DN	48	26	All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD1 VS CD2 DN	52	35	All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS UP	206	118	All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE DN	123	76	All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C1	72	45	All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN	434	302	All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN	271	175	All SZGR 2.0 genes in this pathway
WONG PROTEASOME GENE MODULE	49	35	All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP	425	253	All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP	259	185	All SZGR 2.0 genes in this pathway
ALONSO METASTASIS UP	198	128	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP	518	299	All SZGR 2.0 genes in this pathway
SAKAI CHRONIC HEPATITIS VS LIVER CANCER UP	83	63	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
IKEDA MIR30 TARGETS UP	116	87	All SZGR 2.0 genes in this pathway
BOUDOUKHA BOUND BY IGF2BP2	111	59	All SZGR 2.0 genes in this pathway
KUMAR PATHOGEN LOAD BY MACROPHAGES	275	155	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	179	185	1A	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-101	179	185	1A	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-130/301	1336	1343	1A,m8	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-144	1377	1383	1A	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-144	1377	1383	1A	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-19	1588	1594	1A	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
				hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
				hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
				hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-224	282	288	1A	hsa-miR-224	CAAGUCACUAGUGGUUCCGUUUA
miR-30-5p	121	127	m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-342	257	264	1A,m8	hsa-miR-342^brain	UCUCACACAGAAAUCGCACCCGUC
miR-376	86	92	m8	hsa-miR-376a	AUCAUAGAGGAAAAUCCACGU
miR-376	86	92	m8	hsa-miR-376b	AUCAUAGAGGAAAAUCCAUGUU
miR-377	223	229	m8	hsa-miR-377	AUCACACAAAGGCAACUUUUGU
miR-377	223	229	m8	hsa-miR-377	AUCACACAAAGGCAACUUUUGU
miR-433-3p	999	1006	1A,m8	hsa-miR-433^brain	AUCAUGAUGGGCUCCUCGGUGU
miR-539	693	699	1A	hsa-miR-539	GGAGAAAUUAUCCUUGGUGUGU
miR-7	1398	1404	m8	hsa-miR-7^SZ	UGGAAGACUAGUGAUUUUGUUG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: UBE2D2