Gene Page: UBE2D2

Summary
GeneID  7322
Symbol  UBE2D2
Synonyms  E2(17)KB2|PUBC1|UBC4|UBC4/5|UBCH5B
Description  ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)
See related  HGNC:12475|MIM:602962|Ensembl:ENSG00000131508|HPRD:04268|
Locus tag  -
Gene type  protein-coding
Map location  5q31.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0032 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI12878161 |14667819 
GO:0004842ubiquitin-protein ligase activityTAS8090726 
GO:0016874ligase activityIEA-
GO:0019787small conjugating protein ligase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006511ubiquitin-dependent protein catabolic processIEA-
GO:0006511ubiquitin-dependent protein catabolic processTAS7724550 
GO:0051246regulation of protein metabolic processIEA-
GO:0043687post-translational protein modificationIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AMFRGP78 | RNF45autocrine motility factor receptor-HPRD,BioGRID11724934 
BARD1-BRCA1 associated RING domain 1Reconstituted ComplexBioGRID12431996 
BTRCBETA-TRCP | FBW1A | FBXW1 | FBXW1A | FWD1 | MGC4643 | bTrCP | bTrCP1 | betaTrCPbeta-transducin repeat containingBiochemical ActivityBioGRID10531035 
-HPRD10918611 
CBLC-CBL | CBL2 | RNF55Cas-Br-M (murine) ecotropic retroviral transforming sequence-HPRD,BioGRID10514377 
c-Cbl interacts with Ubc4.BIND10514377 
DTX3LBBAPdeltex 3-like (Drosophila)-HPRD,BioGRID12670957 
FBXL3FBL3 | FBL3A | FBXL3AF-box and leucine-rich repeat protein 3Biochemical ActivityBioGRID10531035 
FBXO4DKFZp547N213 | FBX4 | FLJ10141F-box protein 4Biochemical ActivityBioGRID10531035 
FBXO7DKFZp686B08113 | FBX | FBX07 | FBX7 | PARK15 | PKPSF-box protein 7Biochemical ActivityBioGRID10531035 
FBXW2FBW2 | Fwd2 | MGC117371 | Md6F-box and WD repeat domain containing 2Biochemical ActivityBioGRID10531035 
NEDD4KIAA0093 | MGC176705 | NEDD4-1 | RPF1neural precursor cell expressed, developmentally down-regulated 4-HPRD,BioGRID9182527 
PJA1RNF70praja 1in vitro
in vivo		BioGRID12036302 
PJA2KIAA0438 | Neurodap1 | RNF131praja 2, RING-H2 motif containing-HPRD,BioGRID12036302 
RAF1CRAF | NS5 | Raf-1 | c-Rafv-raf-1 murine leukemia viral oncogene homolog 1Biochemical ActivityBioGRID11676916 
RNF11CGI-123 | MGC51169 | SID1669ring finger protein 11RNF11 interacts with UbcH5b.BIND14562029 
RNF2BAP-1 | BAP1 | DING | HIPI3 | RING1B | RING2ring finger protein 2Biochemical ActivityBioGRID11513855 
STUB1CHIP | HSPABP2 | NY-CO-7 | SDCCAG7 | UBOX1STIP1 homology and U-box containing protein 1Reconstituted ComplexBioGRID11676916 
TRIM5RNF88 | TRIM5alphatripartite motif-containing 5Biochemical ActivityBioGRID12878161 
UBE3AANCR | AS | E6-AP | EPVE6AP | FLJ26981 | HPVE6Aubiquitin protein ligase E3ABiochemical Activity
Reconstituted Complex
Two-hybrid		BioGRID9182527 |9990509 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 13898All SZGR genes in this pathway
PID_ERBB1_INTERNALIZATION_PATHWAY 4135All SZGR genes in this pathway
REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN 2517All SZGR genes in this pathway
REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA 1812All SZGR genes in this pathway
REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING 3119All SZGR genes in this pathway
REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS 7357All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM 279178All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 251156All SZGR genes in this pathway
REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 212129All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_DN 4629All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_UP 285181All SZGR genes in this pathway
TURASHVILI_BREAST_DUCTAL_CARCINOMA_VS_LOBULAR_NORMAL_UP 7350All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_UP 305185All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_UP 12672All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_CDC25_UP 12073All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
KAUFFMANN_DNA_REPAIR_GENES 230137All SZGR genes in this pathway
WILLERT_WNT_SIGNALING 2413All SZGR genes in this pathway
FAELT_B_CLL_WITH_VH_REARRANGEMENTS_DN 4826All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_CD1_VS_CD2_DN 5235All SZGR genes in this pathway
RAMALHO_STEMNESS_UP 206118All SZGR genes in this pathway
KAYO_AGING_MUSCLE_DN 12376All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C1 7245All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
MARTINEZ_RESPONSE_TO_TRABECTEDIN_DN 271175All SZGR genes in this pathway
WONG_PROTEASOME_GENE_MODULE 4935All SZGR genes in this pathway
ZHANG_BREAST_CANCER_PROGENITORS_UP 425253All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
ALONSO_METASTASIS_UP 198128All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP 518299All SZGR genes in this pathway
SAKAI_CHRONIC_HEPATITIS_VS_LIVER_CANCER_UP 8363All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
IKEDA_MIR30_TARGETS_UP 11687All SZGR genes in this pathway
BOUDOUKHA_BOUND_BY_IGF2BP2 11159All SZGR genes in this pathway
KUMAR_PATHOGEN_LOAD_BY_MACROPHAGES 275155All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1011791851Ahsa-miR-101UACAGUACUGUGAUAACUGAAG
hsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-130/301133613431A,m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-144137713831Ahsa-miR-144UACAGUAUAGAUGAUGUACUAG
hsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-19158815941Ahsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-2242822881Ahsa-miR-224CAAGUCACUAGUGGUUCCGUUUA
miR-30-5p121127m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-3422572641A,m8hsa-miR-342brainUCUCACACAGAAAUCGCACCCGUC
miR-3768692m8hsa-miR-376aAUCAUAGAGGAAAAUCCACGU
hsa-miR-376bAUCAUAGAGGAAAAUCCAUGUU
miR-377223229m8hsa-miR-377AUCACACAAAGGCAACUUUUGU
hsa-miR-377AUCACACAAAGGCAACUUUUGU
miR-433-3p99910061A,m8hsa-miR-433brainAUCAUGAUGGGCUCCUCGGUGU
miR-5396936991Ahsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
miR-713981404m8hsa-miR-7SZUGGAAGACUAGUGAUUUUGUUG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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