SZGR2

Summary ?

GeneID	7529
Symbol	YWHAB
Synonyms	GW128\|HEL-S-1\|HS1\|KCIP-1\|YWHAA
Description	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
Reference	MIM:601289\|HGNC:HGNC:12849\|Ensembl:ENSG00000166913\|HPRD:03184\|Vega:OTTHUMG00000032549
Gene type	protein-coding
Map location	20q13.1
Pascal p-value	0.011
Sherlock p-value	0.807
Fetal beta	-0.55
DMG	1 (# studies)
eGene	Caudate basal ganglia Cerebellum Cortex Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia
Support	INTRACELLULAR SIGNAL TRANSDUCTION G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.human_clathrin G2Cdb.human_mGluR5 G2Cdb.human_Synaptosome G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0065

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg15324310	20	43514360	YWHAB	1.23E-5	-0.455	0.014	DMG:Wockner_2014

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs3838037	20	43525483	YWHAB	ENSG00000166913.8	1.14082E-8	0	11166	gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
FRS2	0.93	0.95
ZNF451	0.93	0.94
SOCS4	0.92	0.93
MIB1	0.92	0.93
KLHL24	0.92	0.93
GABPA	0.92	0.92
KLHL28	0.92	0.93
CEP97	0.91	0.94
ZNF148	0.91	0.90
CREB1	0.90	0.91

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
IFI27	-0.61	-0.70
MT-CO2	-0.61	-0.69
FXYD1	-0.61	-0.70
AF347015.21	-0.59	-0.69
CXCL14	-0.59	-0.69
AF347015.31	-0.59	-0.67
HIGD1B	-0.58	-0.67
AF347015.8	-0.57	-0.66
CSAG1	-0.57	-0.63
AC018755.7	-0.57	-0.61

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0004497	monooxygenase activity	IEA		-
GO:0019904	protein domain specific binding	IEA		-
GO:0019904	protein domain specific binding	IPI		11984006
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007265	Ras protein signal transduction	EXP		11520933
GO:0008633	activation of pro-apoptotic gene products	EXP		15231831
GO:0006605	protein targeting	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005813	centrosome	IDA		18029348
GO:0005829	cytosol	EXP		9069260 \|10195903 \|12657644
GO:0005634	nucleus	IDA		18029348
GO:0005737	cytoplasm	IDA		12963375
GO:0048471	perinuclear region of cytoplasm	IDA		12963375
GO:0042470	melanosome	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AKAP13	AKAP-Lbc \| BRX \| FLJ11952 \| FLJ43341 \| HA-3 \| Ht31 \| LBC \| PROTO-LB \| PROTO-LBC \| c-lbc	A kinase (PRKA) anchor protein 13	Affinity Capture-MS	BioGRID	17353931
BAD	BBC2 \| BCL2L8	BCL2-associated agonist of cell death	-	HPRD,BioGRID	9369453
BID	FP497 \| MGC15319 \| MGC42355	BH3 interacting domain death agonist	-	HPRD	12871587
BRAF	B-RAF1 \| BRAF1 \| FLJ95109 \| MGC126806 \| MGC138284 \| RAFB1	v-raf murine sarcoma viral oncogene homolog B1	BRAF (B-Raf) interacts with an unspecified isoform of YWHAB (14-3-3-beta).	BIND	12620389
BRAF	B-RAF1 \| BRAF1 \| FLJ95109 \| MGC126806 \| MGC138284 \| RAFB1	v-raf murine sarcoma viral oncogene homolog B1	B-RAF interacts with 14-3-3-beta.	BIND	12620389
BRAF	B-RAF1 \| BRAF1 \| FLJ95109 \| MGC126806 \| MGC138284 \| RAFB1	v-raf murine sarcoma viral oncogene homolog B1	-	HPRD,BioGRID	10931830
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	c-Cbl interacts with 14-3-3-beta.	BIND	9367879
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	9367879
CDC25A	CDC25A2	cell division cycle 25 homolog A (S. pombe)	-	HPRD,BioGRID	7644510
CDC25A	CDC25A2	cell division cycle 25 homolog A (S. pombe)	14-3-3-beta interacts with cdc25A.	BIND	7644510
CDC25B	-	cell division cycle 25 homolog B (S. pombe)	14-3-3-beta interacts with cdc25B.	BIND	7644510
CDC25B	-	cell division cycle 25 homolog B (S. pombe)	-	HPRD,BioGRID	7644510 \|10713667
CDC25C	CDC25	cell division cycle 25 homolog C (S. pombe)	-	HPRD	12937170
CDC2L1	CDC2L2 \| CDK11 \| CDK11-p110 \| CDK11-p46 \| CDK11-p58 \| CLK-1 \| FLJ59152 \| PK58 \| p58 \| p58CDC2L1 \| p58CLK-1	cell division cycle 2-like 1 (PITSLRE proteins)	CDK11-p110 interacts with 14-3-3-beta.	BIND	15883043
CGN	DKFZp779N1112 \| FLJ39281 \| KIAA1319	cingulin	Affinity Capture-MS	BioGRID	17353931
CRTC2	RP11-422P24.6 \| TORC2	CREB regulated transcription coactivator 2	TORC2 interacts with 14-3-3-beta.	BIND	15454081
CSNK2A1	CK2A1 \| CKII	casein kinase 2, alpha 1 polypeptide	Affinity Capture-MS	BioGRID	17353931
DAPK1	DAPK \| DKFZp781I035	death-associated protein kinase 1	-	HPRD	12911633
DENND4A	FLJ33949 \| IRLB \| KIAA0476 \| MYCPBP	DENN/MADD domain containing 4A	Affinity Capture-MS	BioGRID	17353931
EDC3	FLJ21128 \| FLJ31777 \| LSM16 \| YJDC \| YJEFN2	enhancer of mRNA decapping 3 homolog (S. cerevisiae)	Affinity Capture-MS	BioGRID	17353931
EPB41L3	4.1B \| DAL-1 \| DAL1 \| FLJ37633 \| KIAA0987	erythrocyte membrane protein band 4.1-like 3	-	HPRD,BioGRID	11996670
FAM82A2	FAM82C \| FLJ10579 \| RMD3 \| hRMD-3 \| ptpip51	family with sequence similarity 82, member A2	Affinity Capture-MS	BioGRID	17353931
FOXK1	FLJ14977 \| FOXK1L	forkhead box K1	Affinity Capture-MS	BioGRID	17353931
FRYL	DKFZp686E205 \| FLJ16177 \| KIAA0826	FRY-like	Affinity Capture-MS	BioGRID	17353931
HDAC4	HA6116 \| HD4 \| HDAC-A \| HDACA \| KIAA0288	histone deacetylase 4	Affinity Capture-Western	BioGRID	10869435
HDAC5	FLJ90614 \| HD5 \| NY-CO-9	histone deacetylase 5	-	HPRD,BioGRID	10869435
IGF1R	CD221 \| IGFIR \| JTK13 \| MGC142170 \| MGC142172 \| MGC18216	insulin-like growth factor 1 receptor	-	HPRD,BioGRID	9581554
IGF1R	CD221 \| IGFIR \| JTK13 \| MGC142170 \| MGC142172 \| MGC18216	insulin-like growth factor 1 receptor	IGFIR interacts with 14-3-3-beta isoform. This interaction was modelled on a demonstrated interaction between human IGFIR and mouse 14-3-3-beta.	BIND	9581554
IRS1	HIRS-1	insulin receptor substrate 1	-	HPRD,BioGRID	9422753
IRS2	-	insulin receptor substrate 2	Affinity Capture-MS	BioGRID	17353931
ITGB1	CD29 \| FNRB \| GPIIA \| MDF2 \| MSK12 \| VLA-BETA \| VLAB	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	-	HPRD,BioGRID	11313964
KCNK3	K2p3.1 \| OAT1 \| TASK \| TASK-1 \| TBAK1	potassium channel, subfamily K, member 3	Affinity Capture-Western Protein-peptide	BioGRID	12437930
KIF1C	KIAA0706 \| LTXS1	kinesin family member 1C	-	HPRD	10559254
KIF23	CHO1 \| KNSL5 \| MKLP-1 \| MKLP1	kinesin family member 23	Affinity Capture-MS	BioGRID	17353931
KIF5B	KINH \| KNS \| KNS1 \| UKHC	kinesin family member 5B	Affinity Capture-MS	BioGRID	17353931
KLC1	KLC \| KNS2 \| KNS2A \| MGC15245	kinesin light chain 1	Affinity Capture-MS	BioGRID	17353931
KRT18	CYK18 \| K18	keratin 18	-	HPRD	9524113
LARP1	KIAA0731 \| LARP \| MGC19556	La ribonucleoprotein domain family, member 1	Affinity Capture-MS	BioGRID	17353931
LYST	CHS \| CHS1	lysosomal trafficking regulator	-	HPRD,BioGRID	11984006
MAPK7	BMK1 \| ERK4 \| ERK5 \| PRKM7	mitogen-activated protein kinase 7	-	HPRD,BioGRID	14679215
MAPT	DDPAC \| FLJ31424 \| FTDP-17 \| MAPTL \| MGC138549 \| MSTD \| MTBT1 \| MTBT2 \| PPND \| TAU	microtubule-associated protein tau	-	HPRD,BioGRID	10840038
MARK3	CTAK1 \| KP78 \| PAR1A	MAP/microtubule affinity-regulating kinase 3	Affinity Capture-MS	BioGRID	17353931
MLLT4	AF-6 \| AF6 \| AFADIN \| FLJ34371 \| RP3-431P23.3	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	Affinity Capture-MS	BioGRID	17353931
MLXIP	KIAA0867 \| MIR \| MONDOA \| bHLHe36	MLX interacting protein	-	HPRD,BioGRID	12446771
MPRIP	KIAA0864 \| M-RIP \| RHOIP3 \| p116Rip	myosin phosphatase Rho interacting protein	Affinity Capture-MS	BioGRID	17353931
NCKAP1	FLJ11291 \| HEM2 \| KIAA0587 \| MGC8981 \| NAP1 \| NAP125	NCK-associated protein 1	Affinity Capture-MS	BioGRID	17353931
OSBPL3	DKFZp667P1518 \| KIAA0704 \| MGC21526 \| ORP-3 \| ORP3 \| OSBP3	oxysterol binding protein-like 3	Affinity Capture-MS	BioGRID	17353931
PARD3	ASIP \| Baz \| Bazooka \| FLJ21015 \| PAR3 \| PAR3alpha \| PARD3A \| SE2-5L16 \| SE2-5LT1 \| SE2-5T2	par-3 partitioning defective 3 homolog (C. elegans)	Affinity Capture-MS	BioGRID	17353931
PDCL2	GCPHLP	phosducin-like 2	-	HPRD	12424248
PDE3B	HcGIP1 \| cGIPDE1	phosphodiesterase 3B, cGMP-inhibited	-	HPRD	12453887
PI4KB	PI4K-BETA \| PI4KIIIbeta \| PI4Kbeta \| PIK4CB \| pi4K92	phosphatidylinositol 4-kinase, catalytic, beta	-	HPRD	15324660
PI4KB	PI4K-BETA \| PI4KIIIbeta \| PI4Kbeta \| PIK4CB \| pi4K92	phosphatidylinositol 4-kinase, catalytic, beta	Affinity Capture-MS	BioGRID	17353931
PRKCZ	PKC-ZETA \| PKC2	protein kinase C, zeta	-	HPRD,BioGRID	10620507
PRPF6	ANT-1 \| C20orf14 \| TOM \| U5-102K \| hPrp6	PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)	Two-hybrid	BioGRID	10848612
PTPN3	DKFZp686N0569 \| PTPH1	protein tyrosine phosphatase, non-receptor type 3	-	HPRD,BioGRID	9341175
RABGEF1	FLJ32302 \| RABEX5 \| rabex-5	RAB guanine nucleotide exchange factor (GEF) 1	Affinity Capture-MS	BioGRID	17353931
RACGAP1	HsCYK-4 \| ID-GAP \| MgcRacGAP	Rac GTPase activating protein 1	Affinity Capture-MS	BioGRID	17353931
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	C-RAF interacts with 14-3-3-beta.	BIND	12620389
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	-	HPRD	8702721 \|12360521
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	RAF1 (C-Raf) interacts with YWHAB (14-3-3-beta).	BIND	12620389
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	8702721 \|10620507 \|10848612 \|12360521 \|12620389
RAI14	DKFZp564G013 \| KIAA1334 \| NORPEG \| RAI13	retinoic acid induced 14	Affinity Capture-MS	BioGRID	17353931
RASGRF1	CDC25 \| CDC25L \| GNRP \| GRF1 \| GRF55 \| H-GRF55 \| PP13187	Ras protein-specific guanine nucleotide-releasing factor 1	Reconstituted Complex	BioGRID	9543386
RGS3	C2PA \| FLJ20370 \| FLJ31516 \| FLJ90496 \| PDZ-RGS3 \| RGP3	regulator of G-protein signaling 3	Affinity Capture-Western	BioGRID	10862767
RIN1	-	Ras and Rab interactor 1	-	HPRD	9144171 \|11784866
RPS6KA1	HU-1 \| MAPKAPK1A \| RSK \| RSK1	ribosomal protein S6 kinase, 90kDa, polypeptide 1	-	HPRD,BioGRID	12618428
SAMD4B	FLJ10211 \| MGC99832 \| SMGB	sterile alpha motif domain containing 4B	Affinity Capture-MS	BioGRID	17353931
SLC4A7	DKFZp686H168 \| NBC2 \| NBC3 \| SBC2 \| SLC4A6	solute carrier family 4, sodium bicarbonate cotransporter, member 7	Affinity Capture-MS	BioGRID	17353931
SNCA	MGC110988 \| NACP \| PARK1 \| PARK4 \| PD1	synuclein, alpha (non A4 component of amyloid precursor)	-	HPRD	10407019
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	-	HPRD	8702721
SRRM2	300-KD \| CWF21 \| DKFZp686O15166 \| FLJ21926 \| FLJ22250 \| KIAA0324 \| MGC40295 \| SRL300 \| SRm300	serine/arginine repetitive matrix 2	Affinity Capture-MS	BioGRID	17353931
TESK1	-	testis-specific kinase 1	-	HPRD,BioGRID	11555644
TESK2	-	testis-specific kinase 2	-	HPRD,BioGRID	11555644
TJP2	MGC26306 \| X104 \| ZO-2 \| ZO2	tight junction protein 2 (zona occludens 2)	Affinity Capture-MS	BioGRID	17353931
TNFAIP3	A20 \| MGC104522 \| MGC138687 \| MGC138688 \| OTUD7C \| TNFA1P2	tumor necrosis factor, alpha-induced protein 3	-	HPRD,BioGRID	8702721
TSC1	KIAA0243 \| LAM \| MGC86987 \| TSC	tuberous sclerosis 1	Hamartin interacts with 14-3-3-beta. This interaction is modeled on demonstrated interaction between human hamartin and mouse 14-3-3-beta isoform.	BIND	12176984
TSC2	FLJ43106 \| LAM \| TSC4	tuberous sclerosis 2	-	HPRD	12438239 \|12468542
TSC2	FLJ43106 \| LAM \| TSC4	tuberous sclerosis 2	The tumor suppressor protein tuberin interacts with 14-3-3-beta isoform. This interaction is modeled on demonstrated interaction between human tuberin and mouse 14-3-3-beta isoform.	BIND	12176984
UCP2	BMIQ4 \| SLC25A8 \| UCPH	uncoupling protein 2 (mitochondrial, proton carrier)	-	HPRD,BioGRID	10785390
UCP2	BMIQ4 \| SLC25A8 \| UCPH	uncoupling protein 2 (mitochondrial, proton carrier)	UCP2 interacts with 14.3.3-beta.	BIND	10785390
UCP3	SLC25A9	uncoupling protein 3 (mitochondrial, proton carrier)	UCP3 interacts with 14.3.3-beta.	BIND	10785390
UCP3	SLC25A9	uncoupling protein 3 (mitochondrial, proton carrier)	-	HPRD,BioGRID	10785390
USP8	FLJ34456 \| HumORF8 \| KIAA0055 \| MGC129718 \| UBPY	ubiquitin specific peptidase 8	Affinity Capture-MS	BioGRID	17353931
WEE1	DKFZp686I18166 \| FLJ16446 \| WEE1A \| WEE1hu	WEE1 homolog (S. pombe)	-	HPRD,BioGRID	10775038
YWHAB	GW128 \| HS1 \| KCIP-1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	-	HPRD	12453887
ZFP36	G0S24 \| GOS24 \| NUP475 \| RNF162A \| TIS11 \| TTP	zinc finger protein 36, C3H type, homolog (mouse)	-	HPRD,BioGRID	11886850

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CELL CYCLE	128	84	All SZGR 2.0 genes in this pathway
KEGG OOCYTE MEIOSIS	114	79	All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY	126	103	All SZGR 2.0 genes in this pathway
BIOCARTA CHREBP2 PATHWAY	42	35	All SZGR 2.0 genes in this pathway
SIG PIP3 SIGNALING IN CARDIAC MYOCTES	67	54	All SZGR 2.0 genes in this pathway
SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	51	41	All SZGR 2.0 genes in this pathway
ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	37	29	All SZGR 2.0 genes in this pathway
PID HDAC CLASSII PATHWAY	34	27	All SZGR 2.0 genes in this pathway
PID ATR PATHWAY	39	25	All SZGR 2.0 genes in this pathway
PID ATM PATHWAY	34	25	All SZGR 2.0 genes in this pathway
PID LKB1 PATHWAY	47	37	All SZGR 2.0 genes in this pathway
PID NFAT 3PATHWAY	54	47	All SZGR 2.0 genes in this pathway
PID MTOR 4PATHWAY	69	55	All SZGR 2.0 genes in this pathway
PID FOXO PATHWAY	49	43	All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY	105	78	All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY	129	103	All SZGR 2.0 genes in this pathway
PID P38 MK2 PATHWAY	21	19	All SZGR 2.0 genes in this pathway
PID BETA CATENIN NUC PATHWAY	80	60	All SZGR 2.0 genes in this pathway
PID A6B1 A6B4 INTEGRIN PATHWAY	46	35	All SZGR 2.0 genes in this pathway
PID INSULIN GLUCOSE PATHWAY	26	24	All SZGR 2.0 genes in this pathway
PID PI3KCI AKT PATHWAY	35	30	All SZGR 2.0 genes in this pathway
PID PI3K PLC TRK PATHWAY	36	31	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY SCF KIT	78	59	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB4	90	67	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2	101	78	All SZGR 2.0 genes in this pathway
REACTOME GRB2 EVENTS IN ERBB2 SIGNALING	22	20	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY EGFR IN CANCER	109	80	All SZGR 2.0 genes in this pathway
REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	20	17	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY HIPPO	22	15	All SZGR 2.0 genes in this pathway
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE	87	64	All SZGR 2.0 genes in this pathway
REACTOME ARMS MEDIATED ACTIVATION	17	17	All SZGR 2.0 genes in this pathway
REACTOME PROLONGED ERK ACTIVATION EVENTS	19	18	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO RAS	27	23	All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	137	105	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO ERKS	36	30	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE	127	88	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO P38 VIA RIT AND RIN	15	14	All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	205	136	All SZGR 2.0 genes in this pathway
REACTOME SHC1 EVENTS IN EGFR SIGNALING	15	13	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR	920	449	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF	122	93	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	95	76	All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE	251	188	All SZGR 2.0 genes in this pathway
REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH	64	49	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA	284	128	All SZGR 2.0 genes in this pathway
REACTOME FRS2 MEDIATED CASCADE	36	27	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA	330	155	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR	100	74	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS	107	86	All SZGR 2.0 genes in this pathway
REACTOME RAP1 SIGNALLING	17	12	All SZGR 2.0 genes in this pathway
REACTOME DESTABILIZATION OF MRNA BY BRF1	17	9	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	84	50	All SZGR 2.0 genes in this pathway
REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP	17	7	All SZGR 2.0 genes in this pathway
REACTOME IL 2 SIGNALING	41	34	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY INSULIN RECEPTOR	108	72	All SZGR 2.0 genes in this pathway
REACTOME SOS MEDIATED SIGNALLING	14	13	All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS	148	94	All SZGR 2.0 genes in this pathway
REACTOME RAF MAP KINASE CASCADE	10	10	All SZGR 2.0 genes in this pathway
REACTOME SHC MEDIATED SIGNALLING	15	12	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF BH3 ONLY PROTEINS	17	12	All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	270	204	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR	112	80	All SZGR 2.0 genes in this pathway
REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	30	21	All SZGR 2.0 genes in this pathway
REACTOME SHC RELATED EVENTS	17	13	All SZGR 2.0 genes in this pathway
WIKMAN ASBESTOS LUNG CANCER UP	17	11	All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER 20Q13 AMPLIFICATION UP	119	66	All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 UP	341	197	All SZGR 2.0 genes in this pathway
CREIGHTON AKT1 SIGNALING VIA MTOR DN	23	16	All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER UP	142	96	All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW UP	162	104	All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH DN	180	110	All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA UP	146	104	All SZGR 2.0 genes in this pathway
SCHEIDEREIT IKK TARGETS	18	15	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
BERTUCCI INVASIVE CARCINOMA DUCTAL VS LOBULAR UP	25	17	All SZGR 2.0 genes in this pathway
DEN INTERACT WITH LCA5	26	21	All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 20Q12 Q13 AMPLICON	149	76	All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH3 21 DN	49	29	All SZGR 2.0 genes in this pathway
LEE AGING NEOCORTEX DN	80	49	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS UP	206	118	All SZGR 2.0 genes in this pathway
PAL PRMT5 TARGETS UP	203	135	All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND FIBROBLAST	132	93	All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP	425	253	All SZGR 2.0 genes in this pathway
BEIER GLIOMA STEM CELL DN	66	42	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL DN	175	103	All SZGR 2.0 genes in this pathway
CHAUHAN RESPONSE TO METHOXYESTRADIOL DN	102	65	All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES	389	245	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP	518	299	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP	548	370	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE	1137	655	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D	882	506	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-128	273	280	1A,m8	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	273	280	1A,m8	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-148/152	1667	1674	1A,m8	hsa-miR-148a	UCAGUGCACUACAGAACUUUGU
				hsa-miR-152^brain	UCAGUGCAUGACAGAACUUGGG
				hsa-miR-148b	UCAGUGCAUCACAGAACUUUGU
miR-200bc/429	1841	1847	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-214	1640	1646	1A	hsa-miR-214^brain	ACAGCAGGCACAGACAGGCAG
miR-218	1888	1894	m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-27	274	280	m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	274	280	m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-361	363	369	m8	hsa-miR-361^brain	UUAUCAGAAUCUCCAGGGGUAC
miR-488	1804	1810	m8	hsa-miR-488	CCCAGAUAAUGGCACUCUCAA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: YWHAB