Gene Page: ARMC7

Summary ?
GeneID79637
SymbolARMC7
Synonyms-
Descriptionarmadillo repeat containing 7
ReferenceHGNC:HGNC:26168|Ensembl:ENSG00000125449|HPRD:08649|Vega:OTTHUMG00000179345
Gene typeprotein-coding
Map location17q25.1
Pascal p-value0.057
Sherlock p-value0.804
Fetal beta-0.28
DMG1 (# studies)
eGeneCerebellum
Frontal Cortex BA9
Hippocampus
Nucleus accumbens basal ganglia
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
DMG:vanEijk_2014Genome-wide DNA methylation analysisThis dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg261299161773258208ARMC74.789E-43.166DMG:vanEijk_2014
cg237275831772869061ARMC71.343E-42.619DMG:vanEijk_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs16829545chr2151977407ARMC7796377.387E-4trans
rs3845734chr2171125572ARMC7796370trans
rs7584986chr2184111432ARMC7796370.1trans
rs2183142chr4159232695ARMC7796370.06trans
rs17762315chr576807576ARMC7796377.797E-4trans
rs7787830chr798797019ARMC7796370.06trans
rs16955618chr1529937543ARMC7796371.714E-4trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C1orf1490.900.89
CDK80.890.88
C9orf300.890.89
MRPL30.880.88
ARMCX10.880.90
DYNC1LI10.880.88
DYM0.880.88
RAB11A0.880.87
TADA1L0.870.88
BFAR0.870.87
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MT-CO2-0.76-0.81
AF347015.33-0.75-0.81
AF347015.8-0.75-0.82
AF347015.27-0.75-0.81
MT-CYB-0.74-0.81
AF347015.26-0.74-0.81
AF347015.15-0.73-0.82
AF347015.2-0.73-0.81
AF347015.31-0.72-0.79
HLA-F-0.72-0.77

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552347All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612367All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER UP 181108All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335181All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973570All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS NOT VIA AKT1 DN 8861All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839928All SZGR 2.0 genes in this pathway
ZWANG EGF INTERVAL DN 214124All SZGR 2.0 genes in this pathway