Gene Page: NPEPL1
Summary ?
| GeneID | 79716 |
| Symbol | NPEPL1 |
| Synonyms | bA261P9.2 |
| Description | aminopeptidase-like 1 |
| Reference | HGNC:HGNC:16244|Ensembl:ENSG00000215440|HPRD:07496|Vega:OTTHUMG00000033060 |
| Gene type | protein-coding |
| Map location | 20q13.32 |
| Pascal p-value | 6.072E-4 |
| Sherlock p-value | 0.408 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs16829545 | chr2 | 151977407 | NPEPL1 | 79716 | 0.07 | trans | ||
| rs16955618 | chr15 | 29937543 | NPEPL1 | 79716 | 5.996E-4 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| U47924.1 | 0.61 | 0.63 |
| MED14 | 0.61 | 0.66 |
| SETD5 | 0.61 | 0.67 |
| NDST2 | 0.61 | 0.65 |
| UBAP2 | 0.60 | 0.63 |
| HGSNAT | 0.60 | 0.64 |
| TMEM131 | 0.60 | 0.64 |
| GBF1 | 0.59 | 0.64 |
| INTS3 | 0.59 | 0.66 |
| MOGS | 0.59 | 0.62 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.49 | -0.54 |
| AF347015.27 | -0.48 | -0.53 |
| MT-CO2 | -0.47 | -0.54 |
| FXYD1 | -0.47 | -0.54 |
| AF347015.33 | -0.47 | -0.52 |
| AF347015.21 | -0.47 | -0.59 |
| S100B | -0.46 | -0.52 |
| AC021016.1 | -0.45 | -0.52 |
| TSC22D4 | -0.45 | -0.47 |
| MT-CYB | -0.44 | -0.50 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| LOPEZ MBD TARGETS | 957 | 597 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 20Q12 Q13 AMPLICON | 149 | 76 | All SZGR 2.0 genes in this pathway |
| MOREAUX MULTIPLE MYELOMA BY TACI UP | 412 | 249 | All SZGR 2.0 genes in this pathway |
| MOREAUX B LYMPHOCYTE MATURATION BY TACI UP | 92 | 58 | All SZGR 2.0 genes in this pathway |
| KUMAR TARGETS OF MLL AF9 FUSION | 405 | 264 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS EARLY PROGENITOR | 532 | 309 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RB1 TARGETS DN | 543 | 317 | All SZGR 2.0 genes in this pathway |
| MARTINEZ TP53 TARGETS DN | 593 | 372 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RB1 AND TP53 TARGETS DN | 591 | 366 | All SZGR 2.0 genes in this pathway |
| SHEDDEN LUNG CANCER GOOD SURVIVAL A12 | 317 | 177 | All SZGR 2.0 genes in this pathway |
| MEISSNER NPC HCP WITH H3 UNMETHYLATED | 536 | 296 | All SZGR 2.0 genes in this pathway |
| VERHAAK GLIOBLASTOMA CLASSICAL | 162 | 122 | All SZGR 2.0 genes in this pathway |
| CERIBELLI GENES INACTIVE AND BOUND BY NFY | 45 | 27 | All SZGR 2.0 genes in this pathway |
| FOSTER KDM1A TARGETS DN | 211 | 119 | All SZGR 2.0 genes in this pathway |