Gene Page: GSDMD
Summary ?
| GeneID | 79792 |
| Symbol | GSDMD |
| Synonyms | DF5L|DFNA5L|FKSG10|GSDMDC1 |
| Description | gasdermin D |
| Reference | HGNC:HGNC:25697|Ensembl:ENSG00000104518|HPRD:11014|Vega:OTTHUMG00000165132 |
| Gene type | protein-coding |
| Map location | 8q24.3 |
| Pascal p-value | 0.019 |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs17786145 | chr3 | 1505222 | GSDMD | 79792 | 0.03 | trans | ||
| rs17039822 | chr3 | 1513439 | GSDMD | 79792 | 0.15 | trans | ||
| rs4873797 | 8 | 144571187 | GSDMD | ENSG00000104518.6 | 2.773E-6 | 0 | -64190 | gtex_brain_ba24 |
| rs7013633 | 8 | 144571431 | GSDMD | ENSG00000104518.6 | 2.77E-6 | 0 | -63946 | gtex_brain_ba24 |
| rs10104402 | 8 | 144571600 | GSDMD | ENSG00000104518.6 | 1.97E-6 | 0 | -63777 | gtex_brain_ba24 |
| rs383439 | 8 | 144571710 | GSDMD | ENSG00000104518.6 | 3.373E-7 | 0 | -63667 | gtex_brain_ba24 |
| rs4874140 | 8 | 144571841 | GSDMD | ENSG00000104518.6 | 2.77E-6 | 0 | -63536 | gtex_brain_ba24 |
| rs392131 | 8 | 144572758 | GSDMD | ENSG00000104518.6 | 7.882E-9 | 0 | -62619 | gtex_brain_ba24 |
| rs11779488 | 8 | 144573123 | GSDMD | ENSG00000104518.6 | 6.831E-8 | 0 | -62254 | gtex_brain_ba24 |
| rs2382959 | 8 | 144614590 | GSDMD | ENSG00000104518.6 | 5.466E-8 | 0 | -20787 | gtex_brain_ba24 |
| rs1318196 | 8 | 144620342 | GSDMD | ENSG00000104518.6 | 6.2E-7 | 0 | -15035 | gtex_brain_ba24 |
| rs3750207 | 8 | 144621084 | GSDMD | ENSG00000104518.6 | 6.189E-7 | 0 | -14293 | gtex_brain_ba24 |
| rs964195 | 8 | 144621931 | GSDMD | ENSG00000104518.6 | 6.189E-7 | 0 | -13446 | gtex_brain_ba24 |
| rs536217714 | 8 | 144622387 | GSDMD | ENSG00000104518.6 | 6.199E-7 | 0 | -12990 | gtex_brain_ba24 |
| rs59151473 | 8 | 144623852 | GSDMD | ENSG00000104518.6 | 9.521E-7 | 0 | -11525 | gtex_brain_ba24 |
| rs6998917 | 8 | 144624128 | GSDMD | ENSG00000104518.6 | 4.688E-7 | 0 | -11249 | gtex_brain_ba24 |
| rs7814064 | 8 | 144625439 | GSDMD | ENSG00000104518.6 | 5.384E-7 | 0 | -9938 | gtex_brain_ba24 |
| rs56972823 | 8 | 144625793 | GSDMD | ENSG00000104518.6 | 2.332E-7 | 0 | -9584 | gtex_brain_ba24 |
| rs12716574 | 8 | 144628514 | GSDMD | ENSG00000104518.6 | 4.769E-7 | 0 | -6863 | gtex_brain_ba24 |
| rs58774177 | 8 | 144629194 | GSDMD | ENSG00000104518.6 | 4.808E-7 | 0 | -6183 | gtex_brain_ba24 |
| rs7018316 | 8 | 144630169 | GSDMD | ENSG00000104518.6 | 9.678E-7 | 0 | -5208 | gtex_brain_ba24 |
| rs58288565 | 8 | 144631031 | GSDMD | ENSG00000104518.6 | 7.346E-7 | 0 | -4346 | gtex_brain_ba24 |
| rs4874148 | 8 | 144631953 | GSDMD | ENSG00000104518.6 | 2.866E-7 | 0 | -3424 | gtex_brain_ba24 |
| rs73715669 | 8 | 144634735 | GSDMD | ENSG00000104518.6 | 1.497E-7 | 0 | -642 | gtex_brain_ba24 |
| rs34146789 | 8 | 144635394 | GSDMD | ENSG00000104518.6 | 1.272E-6 | 0 | 17 | gtex_brain_ba24 |
| rs116962724 | 8 | 144638888 | GSDMD | ENSG00000104518.6 | 7.86E-7 | 0 | 3511 | gtex_brain_ba24 |
| rs80346174 | 8 | 144640506 | GSDMD | ENSG00000104518.6 | 2.415E-6 | 0 | 5129 | gtex_brain_ba24 |
| rs7840166 | 8 | 144641313 | GSDMD | ENSG00000104518.6 | 2.021E-6 | 0 | 5936 | gtex_brain_ba24 |
| rs4874151 | 8 | 144641753 | GSDMD | ENSG00000104518.6 | 2.015E-6 | 0 | 6376 | gtex_brain_ba24 |
| rs73375263 | 8 | 144642490 | GSDMD | ENSG00000104518.6 | 2.007E-6 | 0 | 7113 | gtex_brain_ba24 |
| rs59629369 | 8 | 144645959 | GSDMD | ENSG00000104518.6 | 2.068E-6 | 0 | 10582 | gtex_brain_ba24 |
| rs28600201 | 8 | 144646687 | GSDMD | ENSG00000104518.6 | 9.291E-7 | 0 | 11310 | gtex_brain_ba24 |
| rs967701 | 8 | 144647167 | GSDMD | ENSG00000104518.6 | 7.87E-7 | 0 | 11790 | gtex_brain_ba24 |
| rs28507938 | 8 | 144647991 | GSDMD | ENSG00000104518.6 | 4.199E-7 | 0 | 12614 | gtex_brain_ba24 |
| rs73375272 | 8 | 144648184 | GSDMD | ENSG00000104518.6 | 3.782E-7 | 0 | 12807 | gtex_brain_ba24 |
| rs73375273 | 8 | 144648193 | GSDMD | ENSG00000104518.6 | 3.776E-7 | 0 | 12816 | gtex_brain_ba24 |
| rs13279011 | 8 | 144650925 | GSDMD | ENSG00000104518.6 | 2.292E-7 | 0 | 15548 | gtex_brain_ba24 |
| rs80190095 | 8 | 144651062 | GSDMD | ENSG00000104518.6 | 2.285E-7 | 0 | 15685 | gtex_brain_ba24 |
| rs13265269 | 8 | 144502947 | GSDMD | ENSG00000104518.6 | 1.097E-6 | 0 | -132430 | gtex_brain_putamen_basal |
| rs398010150 | 8 | 144514016 | GSDMD | ENSG00000104518.6 | 6.327E-7 | 0 | -121361 | gtex_brain_putamen_basal |
| rs4874132 | 8 | 144535785 | GSDMD | ENSG00000104518.6 | 9.344E-7 | 0 | -99592 | gtex_brain_putamen_basal |
| rs13259078 | 8 | 144543976 | GSDMD | ENSG00000104518.6 | 7.258E-7 | 0 | -91401 | gtex_brain_putamen_basal |
| rs10111556 | 8 | 144545447 | GSDMD | ENSG00000104518.6 | 2.941E-6 | 0 | -89930 | gtex_brain_putamen_basal |
| rs28549005 | 8 | 144552610 | GSDMD | ENSG00000104518.6 | 1.274E-6 | 0 | -82767 | gtex_brain_putamen_basal |
| rs59809057 | 8 | 144554143 | GSDMD | ENSG00000104518.6 | 1.738E-7 | 0 | -81234 | gtex_brain_putamen_basal |
| rs151080260 | 8 | 144556338 | GSDMD | ENSG00000104518.6 | 5.861E-9 | 0 | -79039 | gtex_brain_putamen_basal |
| rs60861229 | 8 | 144561183 | GSDMD | ENSG00000104518.6 | 7.147E-7 | 0 | -74194 | gtex_brain_putamen_basal |
| rs60625971 | 8 | 144563528 | GSDMD | ENSG00000104518.6 | 2.264E-11 | 0 | -71849 | gtex_brain_putamen_basal |
| rs76551337 | 8 | 144563622 | GSDMD | ENSG00000104518.6 | 4.914E-11 | 0 | -71755 | gtex_brain_putamen_basal |
| rs6988822 | 8 | 144564745 | GSDMD | ENSG00000104518.6 | 2.266E-11 | 0 | -70632 | gtex_brain_putamen_basal |
| rs61206940 | 8 | 144565421 | GSDMD | ENSG00000104518.6 | 1.675E-14 | 0 | -69956 | gtex_brain_putamen_basal |
| rs79792035 | 8 | 144565798 | GSDMD | ENSG00000104518.6 | 1.59E-14 | 0 | -69579 | gtex_brain_putamen_basal |
| rs111679420 | 8 | 144568825 | GSDMD | ENSG00000104518.6 | 1.32E-14 | 0 | -66552 | gtex_brain_putamen_basal |
| rs4873797 | 8 | 144571187 | GSDMD | ENSG00000104518.6 | 3.468E-14 | 0 | -64190 | gtex_brain_putamen_basal |
| rs7013633 | 8 | 144571431 | GSDMD | ENSG00000104518.6 | 3.411E-14 | 0 | -63946 | gtex_brain_putamen_basal |
| rs10104402 | 8 | 144571600 | GSDMD | ENSG00000104518.6 | 3.411E-14 | 0 | -63777 | gtex_brain_putamen_basal |
| rs383439 | 8 | 144571710 | GSDMD | ENSG00000104518.6 | 2.976E-6 | 0 | -63667 | gtex_brain_putamen_basal |
| rs4874140 | 8 | 144571841 | GSDMD | ENSG00000104518.6 | 3.411E-14 | 0 | -63536 | gtex_brain_putamen_basal |
| rs392131 | 8 | 144572758 | GSDMD | ENSG00000104518.6 | 1.147E-9 | 0 | -62619 | gtex_brain_putamen_basal |
| rs369942052 | 8 | 144573077 | GSDMD | ENSG00000104518.6 | 7.051E-8 | 0 | -62300 | gtex_brain_putamen_basal |
| rs11779488 | 8 | 144573123 | GSDMD | ENSG00000104518.6 | 1.605E-8 | 0 | -62254 | gtex_brain_putamen_basal |
| rs28569868 | 8 | 144596722 | GSDMD | ENSG00000104518.6 | 6.286E-8 | 0 | -38655 | gtex_brain_putamen_basal |
| rs7846152 | 8 | 144597472 | GSDMD | ENSG00000104518.6 | 6.286E-8 | 0 | -37905 | gtex_brain_putamen_basal |
| rs10099676 | 8 | 144597806 | GSDMD | ENSG00000104518.6 | 6.286E-8 | 0 | -37571 | gtex_brain_putamen_basal |
| rs7826922 | 8 | 144600768 | GSDMD | ENSG00000104518.6 | 6.281E-8 | 0 | -34609 | gtex_brain_putamen_basal |
| rs2060968 | 8 | 144603486 | GSDMD | ENSG00000104518.6 | 2.253E-14 | 0 | -31891 | gtex_brain_putamen_basal |
| rs4874144 | 8 | 144608418 | GSDMD | ENSG00000104518.6 | 1.178E-12 | 0 | -26959 | gtex_brain_putamen_basal |
| rs4242487 | 8 | 144608634 | GSDMD | ENSG00000104518.6 | 3.917E-8 | 0 | -26743 | gtex_brain_putamen_basal |
| rs2382955 | 8 | 144613172 | GSDMD | ENSG00000104518.6 | 6.232E-8 | 0 | -22205 | gtex_brain_putamen_basal |
| rs2382956 | 8 | 144613193 | GSDMD | ENSG00000104518.6 | 6.232E-8 | 0 | -22184 | gtex_brain_putamen_basal |
| rs3889129 | 8 | 144613680 | GSDMD | ENSG00000104518.6 | 6.232E-8 | 0 | -21697 | gtex_brain_putamen_basal |
| rs2382959 | 8 | 144614590 | GSDMD | ENSG00000104518.6 | 1.497E-6 | 0 | -20787 | gtex_brain_putamen_basal |
| rs10098046 | 8 | 144617923 | GSDMD | ENSG00000104518.6 | 8.972E-12 | 0 | -17454 | gtex_brain_putamen_basal |
| rs10719055 | 8 | 144619844 | GSDMD | ENSG00000104518.6 | 2.843E-11 | 0 | -15533 | gtex_brain_putamen_basal |
| rs4873802 | 8 | 144620855 | GSDMD | ENSG00000104518.6 | 6.053E-14 | 0 | -14522 | gtex_brain_putamen_basal |
| rs2242094 | 8 | 144623304 | GSDMD | ENSG00000104518.6 | 2.836E-11 | 0 | -12073 | gtex_brain_putamen_basal |
| rs59151473 | 8 | 144623852 | GSDMD | ENSG00000104518.6 | 1.074E-11 | 0 | -11525 | gtex_brain_putamen_basal |
| rs6991958 | 8 | 144624438 | GSDMD | ENSG00000104518.6 | 1.164E-12 | 0 | -10939 | gtex_brain_putamen_basal |
| rs60649827 | 8 | 144624917 | GSDMD | ENSG00000104518.6 | 1.164E-12 | 0 | -10460 | gtex_brain_putamen_basal |
| rs7814064 | 8 | 144625439 | GSDMD | ENSG00000104518.6 | 4.794E-12 | 0 | -9938 | gtex_brain_putamen_basal |
| rs56972823 | 8 | 144625793 | GSDMD | ENSG00000104518.6 | 4.81E-12 | 0 | -9584 | gtex_brain_putamen_basal |
| rs59378841 | 8 | 144626708 | GSDMD | ENSG00000104518.6 | 1.265E-11 | 0 | -8669 | gtex_brain_putamen_basal |
| rs28665893 | 8 | 144628078 | GSDMD | ENSG00000104518.6 | 1.265E-11 | 0 | -7299 | gtex_brain_putamen_basal |
| rs28708516 | 8 | 144628208 | GSDMD | ENSG00000104518.6 | 1.265E-11 | 0 | -7169 | gtex_brain_putamen_basal |
| rs57652216 | 8 | 144629346 | GSDMD | ENSG00000104518.6 | 1.253E-11 | 0 | -6031 | gtex_brain_putamen_basal |
| rs7014108 | 8 | 144629889 | GSDMD | ENSG00000104518.6 | 3.777E-9 | 0 | -5488 | gtex_brain_putamen_basal |
| rs7002899 | 8 | 144630174 | GSDMD | ENSG00000104518.6 | 1.245E-11 | 0 | -5203 | gtex_brain_putamen_basal |
| rs10100461 | 8 | 144630847 | GSDMD | ENSG00000104518.6 | 1.265E-11 | 0 | -4530 | gtex_brain_putamen_basal |
| rs4874148 | 8 | 144631953 | GSDMD | ENSG00000104518.6 | 2.736E-13 | 0 | -3424 | gtex_brain_putamen_basal |
| rs4874149 | 8 | 144631988 | GSDMD | ENSG00000104518.6 | 1.164E-12 | 0 | -3389 | gtex_brain_putamen_basal |
| rs28665475 | 8 | 144632006 | GSDMD | ENSG00000104518.6 | 1.265E-11 | 0 | -3371 | gtex_brain_putamen_basal |
| rs73715669 | 8 | 144634735 | GSDMD | ENSG00000104518.6 | 5.258E-13 | 0 | -642 | gtex_brain_putamen_basal |
| rs13439498 | 8 | 144638273 | GSDMD | ENSG00000104518.6 | 6.692E-14 | 0 | 2896 | gtex_brain_putamen_basal |
| rs116962724 | 8 | 144638888 | GSDMD | ENSG00000104518.6 | 3.883E-13 | 0 | 3511 | gtex_brain_putamen_basal |
| rs80346174 | 8 | 144640506 | GSDMD | ENSG00000104518.6 | 3.405E-11 | 0 | 5129 | gtex_brain_putamen_basal |
| rs7840166 | 8 | 144641313 | GSDMD | ENSG00000104518.6 | 5.339E-12 | 0 | 5936 | gtex_brain_putamen_basal |
| rs4874151 | 8 | 144641753 | GSDMD | ENSG00000104518.6 | 2.454E-9 | 0 | 6376 | gtex_brain_putamen_basal |
| rs73375262 | 8 | 144642244 | GSDMD | ENSG00000104518.6 | 5.702E-12 | 0 | 6867 | gtex_brain_putamen_basal |
| rs73375263 | 8 | 144642490 | GSDMD | ENSG00000104518.6 | 5.767E-12 | 0 | 7113 | gtex_brain_putamen_basal |
| rs11551202 | 8 | 144642854 | GSDMD | ENSG00000104518.6 | 3.013E-12 | 0 | 7477 | gtex_brain_putamen_basal |
| rs13255282 | 8 | 144643815 | GSDMD | ENSG00000104518.6 | 4.695E-9 | 0 | 8438 | gtex_brain_putamen_basal |
| rs59629369 | 8 | 144645959 | GSDMD | ENSG00000104518.6 | 8.717E-12 | 0 | 10582 | gtex_brain_putamen_basal |
| rs28600201 | 8 | 144646687 | GSDMD | ENSG00000104518.6 | 1.407E-9 | 0 | 11310 | gtex_brain_putamen_basal |
| rs967701 | 8 | 144647167 | GSDMD | ENSG00000104518.6 | 9.385E-10 | 0 | 11790 | gtex_brain_putamen_basal |
| rs28507938 | 8 | 144647991 | GSDMD | ENSG00000104518.6 | 1.225E-10 | 0 | 12614 | gtex_brain_putamen_basal |
| rs73375272 | 8 | 144648184 | GSDMD | ENSG00000104518.6 | 6.766E-11 | 0 | 12807 | gtex_brain_putamen_basal |
| rs73375273 | 8 | 144648193 | GSDMD | ENSG00000104518.6 | 6.773E-11 | 0 | 12816 | gtex_brain_putamen_basal |
| rs13279011 | 8 | 144650925 | GSDMD | ENSG00000104518.6 | 2.362E-8 | 0 | 15548 | gtex_brain_putamen_basal |
| rs80190095 | 8 | 144651062 | GSDMD | ENSG00000104518.6 | 1.471E-9 | 0 | 15685 | gtex_brain_putamen_basal |
| rs4874153 | 8 | 144654255 | GSDMD | ENSG00000104518.6 | 1.168E-6 | 0 | 18878 | gtex_brain_putamen_basal |
| rs9771743 | 8 | 144657801 | GSDMD | ENSG00000104518.6 | 1.717E-6 | 0 | 22424 | gtex_brain_putamen_basal |
| rs896954 | 8 | 144660046 | GSDMD | ENSG00000104518.6 | 1.702E-6 | 0 | 24669 | gtex_brain_putamen_basal |
| rs2242095 | 8 | 144678874 | GSDMD | ENSG00000104518.6 | 2.73E-6 | 0 | 43497 | gtex_brain_putamen_basal |
| rs73718114 | 8 | 144684702 | GSDMD | ENSG00000104518.6 | 1.4E-6 | 0 | 49325 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AK5 | 0.89 | 0.87 |
| OXR1 | 0.87 | 0.87 |
| ATP6V1C1 | 0.85 | 0.84 |
| NAPB | 0.85 | 0.83 |
| SLC4A10 | 0.85 | 0.80 |
| UHMK1 | 0.85 | 0.79 |
| HTR2A | 0.84 | 0.83 |
| RASGRF2 | 0.84 | 0.80 |
| NSF | 0.84 | 0.82 |
| EFR3A | 0.83 | 0.81 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| BCL7C | -0.48 | -0.62 |
| FADS2 | -0.44 | -0.39 |
| HYAL2 | -0.43 | -0.52 |
| SH3BP2 | -0.43 | -0.54 |
| SLC38A5 | -0.43 | -0.46 |
| TBC1D10A | -0.43 | -0.37 |
| TRAF4 | -0.43 | -0.53 |
| SEMA4B | -0.42 | -0.40 |
| SH2D2A | -0.42 | -0.52 |
| AC006276.2 | -0.42 | -0.39 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| HOLLMANN APOPTOSIS VIA CD40 DN | 267 | 178 | All SZGR 2.0 genes in this pathway |
| ONKEN UVEAL MELANOMA UP | 783 | 507 | All SZGR 2.0 genes in this pathway |
| OSMAN BLADDER CANCER DN | 406 | 230 | All SZGR 2.0 genes in this pathway |
| BIDUS METASTASIS DN | 161 | 93 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 8Q23 Q24 AMPLICON | 157 | 87 | All SZGR 2.0 genes in this pathway |
| MASSARWEH TAMOXIFEN RESISTANCE UP | 578 | 341 | All SZGR 2.0 genes in this pathway |
| WEST ADRENOCORTICAL TUMOR DN | 546 | 362 | All SZGR 2.0 genes in this pathway |
| AGUIRRE PANCREATIC CANCER COPY NUMBER UP | 298 | 174 | All SZGR 2.0 genes in this pathway |
| CHEN METABOLIC SYNDROM NETWORK | 1210 | 725 | All SZGR 2.0 genes in this pathway |
| MEISSNER NPC HCP WITH H3 UNMETHYLATED | 536 | 296 | All SZGR 2.0 genes in this pathway |
| COULOUARN TEMPORAL TGFB1 SIGNATURE DN | 138 | 99 | All SZGR 2.0 genes in this pathway |
| BOYLAN MULTIPLE MYELOMA PCA3 DN | 69 | 38 | All SZGR 2.0 genes in this pathway |
| HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP | 242 | 159 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP D | 280 | 158 | All SZGR 2.0 genes in this pathway |
| LEE BMP2 TARGETS UP | 745 | 475 | All SZGR 2.0 genes in this pathway |