Gene Page: NCOA4

Summary ?
GeneID8031
SymbolNCOA4
SynonymsARA70|ELE1|PTC3|RFG
Descriptionnuclear receptor coactivator 4
ReferenceMIM:601984|HGNC:HGNC:7671|Ensembl:ENSG00000266412|HPRD:03584|Vega:OTTHUMG00000188314
Gene typeprotein-coding
Map location10q11.2
Pascal p-value0.232
Sherlock p-value0.801
Fetal beta1.059
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg075889641051572303NCOA42.819E-4-0.5140.039DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs16879344chr832262520NCOA480310.18trans
rs17799628chr9106442995NCOA480310.15trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AQP40.880.87
PDLIM50.870.85
KAT2B0.860.88
TIMP30.850.85
SNTB10.840.84
SLC4A40.840.89
ADD30.840.86
PPAP2B0.830.82
BMPR1B0.830.75
PMP20.830.86
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
NR2C2AP-0.46-0.56
AC011491.1-0.45-0.55
BZW2-0.45-0.51
ISLR2-0.44-0.43
MYCN-0.44-0.40
ZNF821-0.44-0.47
SLA-0.43-0.44
KIAA1949-0.43-0.38
PLEKHO1-0.43-0.50
MPP3-0.43-0.44

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG PATHWAYS IN CANCER 328259All SZGR 2.0 genes in this pathway
KEGG THYROID CANCER 2926All SZGR 2.0 genes in this pathway
PID AR PATHWAY 6146All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS UP 13794All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP 255177All SZGR 2.0 genes in this pathway
LAIHO COLORECTAL CANCER SERRATED UP 11271All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER DN 406230All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
ROPERO HDAC2 TARGETS 11471All SZGR 2.0 genes in this pathway
CAFFAREL RESPONSE TO THC 24HR 5 UP 3423All SZGR 2.0 genes in this pathway
SAKAI TUMOR INFILTRATING MONOCYTES DN 8151All SZGR 2.0 genes in this pathway
GNATENKO PLATELET SIGNATURE 4828All SZGR 2.0 genes in this pathway
LENAOUR DENDRITIC CELL MATURATION DN 12890All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225163All SZGR 2.0 genes in this pathway
ZHAN V2 LATE DIFFERENTIATION GENES 4534All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN 354216All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540340All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940425All SZGR 2.0 genes in this pathway
ZHENG IL22 SIGNALING DN 4226All SZGR 2.0 genes in this pathway
ALONSO METASTASIS UP 198128All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374247All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323240All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 DN 315201All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418282All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP 408276All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536296All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S2 11574All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756494All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553343All SZGR 2.0 genes in this pathway