Summary ?
Descriptionhistone cluster 3, H3
Gene typeprotein-coding
Map location1q42
Fetal beta-0.761
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AOF2BHC110 | KDM1 | KIAA0601 | LSD1amine oxidase (flavin containing) domain 2LSD1 interacts with and demethylates H3.BIND15620353 
ASF1ACGI-98 | CIA | DKFZp547E2110 | HSPC146ASF1 anti-silencing function 1 homolog A (S. cerevisiae)H3 interacts with Asf1a.BIND15664198 
ASH2LASH2 | ASH2L1 | ASH2L2 | Bre2ash2 (absent, small, or homeotic)-like (Drosophila)Reconstituted ComplexBioGRID12482968 
BIRC3AIP1 | API2 | CIAP2 | HAIP1 | HIAP1 | MALT2 | MIHC | RNF49baculoviral IAP repeat-containing 3The cIAP-2 promoter interacts with phosphorylated and/or acetylated H3.BIND15494311 
BRD7BP75 | CELTIX1 | NAG4bromodomain containing 7-HPRD12489984 
DNTTIP2ERBP | FCF2 | HSU15552 | LPTS-RP2 | MGC163494 | RP4-561L24.1 | TdIF2deoxynucleotidyltransferase, terminal, interacting protein 2-HPRD12786946 
DYRK2FLJ21217 | FLJ21365dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2-HPRD9748265 
FOXA1HNF3A | MGC33105 | TCF3Aforkhead box A1-HPRD11864602 
GTF3C4FLJ21002 | KAT12 | MGC138450 | TFIII90 | TFIIIC90 | TFIIICdelta | TFiiiC2-90general transcription factor IIIC, polypeptide 4, 90kDa-HPRD10523658 
HIRIP3-HIRA interacting protein 3-HPRD9710638 
IL8CXCL8 | GCP-1 | GCP1 | LECT | LUCT | LYNAP | MDNCF | MONAP | NAF | NAP-1 | NAP1interleukin 8The IL-8 promoter interacts with phosphorylated and/or acetylated H3.BIND15494311 
KPNA1IPOA5 | NPI-1 | RCH2 | SRP1karyopherin alpha 1 (importin alpha 5)-HPRD11824786 
MCM2BM28 | CCNL1 | CDCL1 | D3S3194 | KIAA0030 | MGC10606 | MITOTIN | cdc19minichromosome maintenance complex component 2-HPRD,BioGRID8798650 
MCM7CDABP0042 | CDC47 | MCM2 | P1.1-MCM3 | P1CDC47 | P85MCM | PNAS-146minichromosome maintenance complex component 7-HPRD,BioGRID8798650 
MDM2HDMX | MGC71221 | hdm2Mdm2 p53 binding protein homolog (mouse)Mdm2 interacts with H3.BIND15546622 
NAP1L4MGC4565 | NAP2 | NAP2L | hNAP2nucleosome assembly protein 1-like 4-HPRD9325046 
NPM1B23 | MGC104254 | NPMnucleophosmin (nucleolar phosphoprotein B23, numatrin)-HPRD,BioGRID11602260 
PADI4PAD | PAD4 | PADI5 | PDI4 | PDI5peptidyl arginine deiminase, type IVPAD4 interacts with and demethyliminates Histone H3.BIND15345777 
PGRNR3C3 | PRprogesterone receptorH3 interacts with the PgRA promoter.BIND15019994 
PGRNR3C3 | PRprogesterone receptorH3 interacts with the PgRB promoter.BIND15019994 
PTMAMGC104802 | TMSAprothymosin, alpha-HPRD11310559 
RAD51L1MGC34245 | R51H2 | RAD51B | REC2 | hREC2RAD51-like 1 (S. cerevisiae)RAD51B interacts with H3.BIND14595808 
SET2PP2A | I2PP2A | IGAAD | IPP2A2 | PHAPII | TAF-I | TAF-IBETASET nuclear oncogene-HPRD,BioGRID11163245 
SIRT1SIR2L1sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)SirT1 interacts with and deacetylates H3.BIND15469825 
SMYD3FLJ21080 | MGC104324 | ZMYND1 | ZNFN3A1 | bA74P14.1SET and MYND domain containing 3Biochemical ActivityBioGRID15235609 
TAF1BA2R | CCG1 | CCGS | DYT3 | KAT4 | N-TAF1 | NSCL2 | OF | P250 | TAF2A | TAFII250TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa-HPRD8980232 
TFF1BCEI | D21S21 | HP1.A | HPS2 | pNR-2 | pS2trefoil factor 1H3 interacts with the pS2 promoter.BIND15019994 
TNFSF10APO2L | Apo-2L | CD253 | TL2 | TRAILtumor necrosis factor (ligand) superfamily, member 10Acetylated H3 interacts with the TNFSF10 promoter.BIND15619633 
TNPO1IPO2 | KPNB2 | MIP | MIP1 | TRNtransportin 1-HPRD11824786 
TRPM7CHAK | CHAK1 | FLJ20117 | FLJ25718 | LTRPC7 | TRP-PLIKtransient receptor potential cation channel, subfamily M, member 7-HPRD,BioGRID14594813 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG SYSTEMIC LUPUS ERYTHEMATOSUS 140100All SZGR 2.0 genes in this pathway
REACTOME MEIOSIS 11681All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421253All SZGR 2.0 genes in this pathway
REACTOME CHROMOSOME MAINTENANCE 12280All SZGR 2.0 genes in this pathway
REACTOME MEIOTIC RECOMBINATION 8662All SZGR 2.0 genes in this pathway
REACTOME MEIOTIC SYNAPSIS 7357All SZGR 2.0 genes in this pathway
REACTOME PACKAGING OF TELOMERE ENDS 4840All SZGR 2.0 genes in this pathway
REACTOME TELOMERE MAINTENANCE 7557All SZGR 2.0 genes in this pathway
ABRAMSON INTERACT WITH AIRE 4533All SZGR 2.0 genes in this pathway