SZGR2

Summary ?

GeneID	8290
Symbol	HIST3H3
Synonyms	H3.4\|H3/g\|H3FT\|H3t
Description	histone cluster 3, H3
Reference	MIM:602820\|HGNC:HGNC:4778\|Ensembl:ENSG00000168148\|HPRD:04156\|Vega:OTTHUMG00000040044
Gene type	protein-coding
Map location	1q42
Fetal beta	-0.761
DMG	1 (# studies)

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	2

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg11412256	1	228612818	HIST3H3	1.086E-4	0.27	0.028	DMG:Wockner_2014
cg25955816	1	228612876	HIST3H3	5.068E-4	0.316	0.047	DMG:Wockner_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AOF2	BHC110 \| KDM1 \| KIAA0601 \| LSD1	amine oxidase (flavin containing) domain 2	LSD1 interacts with and demethylates H3.	BIND	15620353
ASF1A	CGI-98 \| CIA \| DKFZp547E2110 \| HSPC146	ASF1 anti-silencing function 1 homolog A (S. cerevisiae)	H3 interacts with Asf1a.	BIND	15664198
ASH2L	ASH2 \| ASH2L1 \| ASH2L2 \| Bre2	ash2 (absent, small, or homeotic)-like (Drosophila)	Reconstituted Complex	BioGRID	12482968
BIRC3	AIP1 \| API2 \| CIAP2 \| HAIP1 \| HIAP1 \| MALT2 \| MIHC \| RNF49	baculoviral IAP repeat-containing 3	The cIAP-2 promoter interacts with phosphorylated and/or acetylated H3.	BIND	15494311
BRD7	BP75 \| CELTIX1 \| NAG4	bromodomain containing 7	-	HPRD	12489984
DNTTIP2	ERBP \| FCF2 \| HSU15552 \| LPTS-RP2 \| MGC163494 \| RP4-561L24.1 \| TdIF2	deoxynucleotidyltransferase, terminal, interacting protein 2	-	HPRD	12786946
DYRK2	FLJ21217 \| FLJ21365	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	-	HPRD	9748265
FOXA1	HNF3A \| MGC33105 \| TCF3A	forkhead box A1	-	HPRD	11864602
GTF3C4	FLJ21002 \| KAT12 \| MGC138450 \| TFIII90 \| TFIIIC90 \| TFIIICdelta \| TFiiiC2-90	general transcription factor IIIC, polypeptide 4, 90kDa	-	HPRD	10523658
HIRIP3	-	HIRA interacting protein 3	-	HPRD	9710638
IL8	CXCL8 \| GCP-1 \| GCP1 \| LECT \| LUCT \| LYNAP \| MDNCF \| MONAP \| NAF \| NAP-1 \| NAP1	interleukin 8	The IL-8 promoter interacts with phosphorylated and/or acetylated H3.	BIND	15494311
KPNA1	IPOA5 \| NPI-1 \| RCH2 \| SRP1	karyopherin alpha 1 (importin alpha 5)	-	HPRD	11824786
MCM2	BM28 \| CCNL1 \| CDCL1 \| D3S3194 \| KIAA0030 \| MGC10606 \| MITOTIN \| cdc19	minichromosome maintenance complex component 2	-	HPRD,BioGRID	8798650
MCM7	CDABP0042 \| CDC47 \| MCM2 \| P1.1-MCM3 \| P1CDC47 \| P85MCM \| PNAS-146	minichromosome maintenance complex component 7	-	HPRD,BioGRID	8798650
MDM2	HDMX \| MGC71221 \| hdm2	Mdm2 p53 binding protein homolog (mouse)	Mdm2 interacts with H3.	BIND	15546622
NAP1L4	MGC4565 \| NAP2 \| NAP2L \| hNAP2	nucleosome assembly protein 1-like 4	-	HPRD	9325046
NPM1	B23 \| MGC104254 \| NPM	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	-	HPRD,BioGRID	11602260
PADI4	PAD \| PAD4 \| PADI5 \| PDI4 \| PDI5	peptidyl arginine deiminase, type IV	PAD4 interacts with and demethyliminates Histone H3.	BIND	15345777
PGR	NR3C3 \| PR	progesterone receptor	H3 interacts with the PgRA promoter.	BIND	15019994
PGR	NR3C3 \| PR	progesterone receptor	H3 interacts with the PgRB promoter.	BIND	15019994
PTMA	MGC104802 \| TMSA	prothymosin, alpha	-	HPRD	11310559
RAD51L1	MGC34245 \| R51H2 \| RAD51B \| REC2 \| hREC2	RAD51-like 1 (S. cerevisiae)	RAD51B interacts with H3.	BIND	14595808
SET	2PP2A \| I2PP2A \| IGAAD \| IPP2A2 \| PHAPII \| TAF-I \| TAF-IBETA	SET nuclear oncogene	-	HPRD,BioGRID	11163245
SIRT1	SIR2L1	sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)	SirT1 interacts with and deacetylates H3.	BIND	15469825
SMYD3	FLJ21080 \| MGC104324 \| ZMYND1 \| ZNFN3A1 \| bA74P14.1	SET and MYND domain containing 3	Biochemical Activity	BioGRID	15235609
TAF1	BA2R \| CCG1 \| CCGS \| DYT3 \| KAT4 \| N-TAF1 \| NSCL2 \| OF \| P250 \| TAF2A \| TAFII250	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	-	HPRD	8980232
TFF1	BCEI \| D21S21 \| HP1.A \| HPS2 \| pNR-2 \| pS2	trefoil factor 1	H3 interacts with the pS2 promoter.	BIND	15019994
TNFSF10	APO2L \| Apo-2L \| CD253 \| TL2 \| TRAIL	tumor necrosis factor (ligand) superfamily, member 10	Acetylated H3 interacts with the TNFSF10 promoter.	BIND	15619633
TNPO1	IPO2 \| KPNB2 \| MIP \| MIP1 \| TRN	transportin 1	-	HPRD	11824786
TRPM7	CHAK \| CHAK1 \| FLJ20117 \| FLJ25718 \| LTRPC7 \| TRP-PLIK	transient receptor potential cation channel, subfamily M, member 7	-	HPRD,BioGRID	14594813

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG SYSTEMIC LUPUS ERYTHEMATOSUS	140	100	All SZGR 2.0 genes in this pathway
REACTOME MEIOSIS	116	81	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE	421	253	All SZGR 2.0 genes in this pathway
REACTOME CHROMOSOME MAINTENANCE	122	80	All SZGR 2.0 genes in this pathway
REACTOME MEIOTIC RECOMBINATION	86	62	All SZGR 2.0 genes in this pathway
REACTOME MEIOTIC SYNAPSIS	73	57	All SZGR 2.0 genes in this pathway
REACTOME PACKAGING OF TELOMERE ENDS	48	40	All SZGR 2.0 genes in this pathway
REACTOME TELOMERE MAINTENANCE	75	57	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP	461	298	All SZGR 2.0 genes in this pathway
ABRAMSON INTERACT WITH AIRE	45	33	All SZGR 2.0 genes in this pathway

Gene Page: HIST3H3