Gene Page: CARS

Summary
GeneID  833
Symbol  CARS
Synonyms  CARS1|CYSRS|MGC:11246
Description  cysteinyl-tRNA synthetase
See related  HGNC:1493|MIM:123859|Ensembl:ENSG00000110619|HPRD:00464|
Locus tag  -
Gene type  protein-coding
Map location  11p15.5
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 2.231 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
B2M0.710.74
XXbac-BPG116M5.10.680.74
VAMP50.680.72
TM4SF10.680.70
LST10.670.66
HIGD1B0.660.68
CFB0.660.73
NMI0.650.69
IGFBP70.650.68
IFI270.640.64
Top 10 negatively co-expressed genes
HNRNPUL2-0.58-0.57
CDC2L2-0.57-0.57
SUPT6H-0.57-0.58
PELP1-0.57-0.61
HERC1-0.57-0.60
NOC2L-0.56-0.59
SPTAN1-0.56-0.59
SMARCC2-0.56-0.59
MYO18A-0.56-0.55
NEURL4-0.56-0.59
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000049tRNA bindingIMP17303165 
GO:0000049tRNA bindingNAS7987009 
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIPI10908348 
GO:0005524ATP bindingIDA17303165 
GO:0005524ATP bindingIEA-
GO:0004817cysteine-tRNA ligase activityIDA10908348 |17303165 
GO:0004817cysteine-tRNA ligase activityIEA-
GO:0016874ligase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0042803protein homodimerization activityIMP17303165 
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006423cysteinyl-tRNA aminoacylationIDA10908348 |17303165 
GO:0006423cysteinyl-tRNA aminoacylationIEA-
GO:0006412translationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
EEF1GEF1G | GIG35eukaryotic translation elongation factor 1 gamma-HPRD,BioGRID10908348 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_AMINOACYL_TRNA_BIOSYNTHESIS 4133All SZGR genes in this pathway
REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION 2419All SZGR genes in this pathway
REACTOME_TRNA_AMINOACYLATION 4234All SZGR genes in this pathway
NAKAMURA_CANCER_MICROENVIRONMENT_DN 4629All SZGR genes in this pathway
LIU_SOX4_TARGETS_DN 309191All SZGR genes in this pathway
GARY_CD5_TARGETS_UP 473314All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP 633376All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
PROVENZANI_METASTASIS_UP 194112All SZGR genes in this pathway
XU_HGF_SIGNALING_NOT_VIA_AKT1_48HR_UP 3520All SZGR genes in this pathway
DIRMEIER_LMP1_RESPONSE_LATE_UP 5741All SZGR genes in this pathway
AMUNDSON_RESPONSE_TO_ARSENITE 217143All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_DN 156106All SZGR genes in this pathway
PENG_LEUCINE_DEPRIVATION_UP 14293All SZGR genes in this pathway
PENG_GLUCOSE_DEPRIVATION_UP 4826All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_UP 6446All SZGR genes in this pathway
ABE_VEGFA_TARGETS_2HR 3421All SZGR genes in this pathway
LEE_AGING_CEREBELLUM_DN 8666All SZGR genes in this pathway
GAJATE_RESPONSE_TO_TRABECTEDIN_UP 6745All SZGR genes in this pathway
TSENG_IRS1_TARGETS_UP 11371All SZGR genes in this pathway
TSENG_ADIPOGENIC_POTENTIAL_UP 3019All SZGR genes in this pathway
KRIGE_AMINO_ACID_DEPRIVATION 2920All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
PODAR_RESPONSE_TO_ADAPHOSTIN_UP 14798All SZGR genes in this pathway
CHEN_HOXA5_TARGETS_9HR_UP 223132All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_UP 245159All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
CHAUHAN_RESPONSE_TO_METHOXYESTRADIOL_UP 5132All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED 351238All SZGR genes in this pathway
GREGORY_SYNTHETIC_LETHAL_WITH_IMATINIB 14583All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38 337236All SZGR genes in this pathway


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