Gene Page: CARS

Summary ?
GeneID833
SymbolCARS
SynonymsCARS1|CYSRS|MGC:11246
Descriptioncysteinyl-tRNA synthetase
ReferenceMIM:123859|HGNC:HGNC:1493|Ensembl:ENSG00000110619|HPRD:00464|Vega:OTTHUMG00000010927
Gene typeprotein-coding
Map location11p15.5
Pascal p-value0.646
Sherlock p-value0.592
Fetal beta-0.684
DMG1 (# studies)
eGeneMyers' cis & trans
SupportAscano FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:vanEijk_2014Genome-wide DNA methylation analysisThis dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
ExpressionMeta-analysis of gene expressionP value: 2.231 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg03336167112930995CARS0.003-2.163DMG:vanEijk_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs6048101chr2022429986CARS8330.11trans
rs4632416chr2022437090CARS8330.05trans
rs4459793chr2022439811CARS8330.07trans
rs6048112chr2022442814CARS8330.1trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
B2M0.710.74
XXbac-BPG116M5.10.680.74
VAMP50.680.72
TM4SF10.680.70
LST10.670.66
HIGD1B0.660.68
CFB0.660.73
NMI0.650.69
IGFBP70.650.68
IFI270.640.64
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
HNRNPUL2-0.58-0.57
CDC2L2-0.57-0.57
SUPT6H-0.57-0.58
PELP1-0.57-0.61
HERC1-0.57-0.60
NOC2L-0.56-0.59
SPTAN1-0.56-0.59
SMARCC2-0.56-0.59
MYO18A-0.56-0.55
NEURL4-0.56-0.59

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000049tRNA bindingIMP17303165 
GO:0000049tRNA bindingNAS7987009 
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIPI10908348 
GO:0005524ATP bindingIDA17303165 
GO:0005524ATP bindingIEA-
GO:0004817cysteine-tRNA ligase activityIDA10908348 |17303165 
GO:0004817cysteine-tRNA ligase activityIEA-
GO:0016874ligase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0042803protein homodimerization activityIMP17303165 
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006423cysteinyl-tRNA aminoacylationIDA10908348 |17303165 
GO:0006423cysteinyl-tRNA aminoacylationIEA-
GO:0006412translationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG AMINOACYL TRNA BIOSYNTHESIS 4133All SZGR 2.0 genes in this pathway
REACTOME CYTOSOLIC TRNA AMINOACYLATION 2419All SZGR 2.0 genes in this pathway
REACTOME TRNA AMINOACYLATION 4234All SZGR 2.0 genes in this pathway
NAKAMURA CANCER MICROENVIRONMENT DN 4629All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS DN 309191All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP 473314All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633376All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722443All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS UP 194112All SZGR 2.0 genes in this pathway
XU HGF SIGNALING NOT VIA AKT1 48HR UP 3520All SZGR 2.0 genes in this pathway
DIRMEIER LMP1 RESPONSE LATE UP 5741All SZGR 2.0 genes in this pathway
AMUNDSON RESPONSE TO ARSENITE 217143All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 DN 156106All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION UP 14293All SZGR 2.0 genes in this pathway
PENG GLUCOSE DEPRIVATION UP 4826All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA UP 6446All SZGR 2.0 genes in this pathway
ABE VEGFA TARGETS 2HR 3421All SZGR 2.0 genes in this pathway
LEE AGING CEREBELLUM DN 8666All SZGR 2.0 genes in this pathway
GAJATE RESPONSE TO TRABECTEDIN UP 6745All SZGR 2.0 genes in this pathway
TSENG IRS1 TARGETS UP 11371All SZGR 2.0 genes in this pathway
TSENG ADIPOGENIC POTENTIAL UP 3019All SZGR 2.0 genes in this pathway
KRIGE AMINO ACID DEPRIVATION 2920All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953554All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783442All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673430All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602364All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601369All SZGR 2.0 genes in this pathway
PODAR RESPONSE TO ADAPHOSTIN UP 14798All SZGR 2.0 genes in this pathway
CHEN HOXA5 TARGETS 9HR UP 223132All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB UP 245159All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323240All SZGR 2.0 genes in this pathway
CHAUHAN RESPONSE TO METHOXYESTRADIOL UP 5132All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351238All SZGR 2.0 genes in this pathway
GREGORY SYNTHETIC LETHAL WITH IMATINIB 14583All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38 337236All SZGR 2.0 genes in this pathway