Gene Page: LINGO1

Summary ?
GeneID84894
SymbolLINGO1
SynonymsLERN1|LRRN6A|UNQ201
Descriptionleucine rich repeat and Ig domain containing 1
ReferenceMIM:609791|HGNC:HGNC:21205|Ensembl:ENSG00000169783|HPRD:14322|Vega:OTTHUMG00000172629
Gene typeprotein-coding
Map location15q24.3
Pascal p-value0.067
Sherlock p-value0.49
Fetal beta0.702
DMG1 (# studies)
eGeneCaudate basal ganglia
Cerebellar Hemisphere
Putamen basal ganglia
SupportINTRACELLULAR SIGNAL TRANSDUCTION
CompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg101073301577922677LINGO11.26E-50.6470.014DMG:Wockner_2014
cg268847751577906127LINGO14.059E-40.3510.044DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs26677811577858619LINGO1ENSG00000169783.82.411E-60.04254623gtex_brain_putamen_basal
rs26677821577862296LINGO1ENSG00000169783.82.46E-60.04250946gtex_brain_putamen_basal
rs26677831577862529LINGO1ENSG00000169783.82.468E-60.04250713gtex_brain_putamen_basal
rs26677751577864802LINGO1ENSG00000169783.82.468E-60.04248440gtex_brain_putamen_basal
rs26829211577865459LINGO1ENSG00000169783.82.468E-60.04247783gtex_brain_putamen_basal
rs9394881577867780LINGO1ENSG00000169783.82.721E-60.04245462gtex_brain_putamen_basal
rs8682971577873769LINGO1ENSG00000169783.82.571E-60.04239473gtex_brain_putamen_basal
rs26677691577874877LINGO1ENSG00000169783.82.552E-60.04238365gtex_brain_putamen_basal
rs26677681577875117LINGO1ENSG00000169783.82.56E-60.04238125gtex_brain_putamen_basal
rs26829111577875591LINGO1ENSG00000169783.82.571E-60.04237651gtex_brain_putamen_basal
rs26677671577876031LINGO1ENSG00000169783.82.113E-60.04237211gtex_brain_putamen_basal
rs8679181577882726LINGO1ENSG00000169783.82.593E-60.04230516gtex_brain_putamen_basal
rs586008271577884322LINGO1ENSG00000169783.82.583E-60.04228920gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID P75 NTR PATHWAY 6951All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217167All SZGR 2.0 genes in this pathway
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING 8161All SZGR 2.0 genes in this pathway
PEREZ TP63 TARGETS 355243All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
BENPORATH OCT4 TARGETS 290172All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734436All SZGR 2.0 genes in this pathway
BENPORATH NOS TARGETS 179105All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION UP 195138All SZGR 2.0 genes in this pathway
STAEGE EWING FAMILY TUMOR 3322All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 2 473224All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430288All SZGR 2.0 genes in this pathway
YAMASHITA LIVER CANCER STEM CELL UP 4738All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway