Gene Page: MASTL
Summary ?
| GeneID | 84930 |
| Symbol | MASTL |
| Synonyms | GREATWALL|GW|GWL|MAST-L|THC2 |
| Description | microtubule associated serine/threonine kinase like |
| Reference | MIM:608221|HGNC:HGNC:19042|Ensembl:ENSG00000120539|HPRD:10499|Vega:OTTHUMG00000017855 |
| Gene type | protein-coding |
| Map location | 10p12.1 |
| Pascal p-value | 0.002 |
| eGene | Caudate basal ganglia Cerebellar Hemisphere Cerebellum Hypothalamus Putamen basal ganglia Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs1411283 | chr10 | 27302771 | MASTL | 84930 | 0.04 | cis | ||
| rs11015570 | chr10 | 27434967 | MASTL | 84930 | 0.01 | cis | ||
| rs7068375 | chr10 | 27454110 | MASTL | 84930 | 7.6E-4 | cis | ||
| rs882475 | chr10 | 27477820 | MASTL | 84930 | 1.063E-4 | cis | ||
| rs1148167 | chr10 | 27532742 | MASTL | 84930 | 0.04 | cis | ||
| rs7068375 | chr10 | 27454110 | MASTL | 84930 | 0.06 | trans | ||
| rs882475 | chr10 | 27477820 | MASTL | 84930 | 0.01 | trans | ||
| rs10764668 | 10 | 27364894 | MASTL | ENSG00000120539.10 | 1.526E-6 | 0.01 | -82584 | gtex_brain_putamen_basal |
| rs3737055 | 10 | 27368126 | MASTL | ENSG00000120539.10 | 1.737E-6 | 0.01 | -79352 | gtex_brain_putamen_basal |
| rs10829173 | 10 | 27371623 | MASTL | ENSG00000120539.10 | 1.535E-6 | 0.01 | -75855 | gtex_brain_putamen_basal |
| rs10829174 | 10 | 27371647 | MASTL | ENSG00000120539.10 | 1.535E-6 | 0.01 | -75831 | gtex_brain_putamen_basal |
| rs10764669 | 10 | 27373198 | MASTL | ENSG00000120539.10 | 1.535E-6 | 0.01 | -74280 | gtex_brain_putamen_basal |
| rs10829176 | 10 | 27376619 | MASTL | ENSG00000120539.10 | 1.535E-6 | 0.01 | -70859 | gtex_brain_putamen_basal |
| rs2297147 | 10 | 27382240 | MASTL | ENSG00000120539.10 | 1.535E-6 | 0.01 | -65238 | gtex_brain_putamen_basal |
| rs11015522 | 10 | 27384160 | MASTL | ENSG00000120539.10 | 1.535E-6 | 0.01 | -63318 | gtex_brain_putamen_basal |
| rs10829180 | 10 | 27386726 | MASTL | ENSG00000120539.10 | 1.535E-6 | 0.01 | -60752 | gtex_brain_putamen_basal |
| rs10829181 | 10 | 27389548 | MASTL | ENSG00000120539.10 | 1.535E-6 | 0.01 | -57930 | gtex_brain_putamen_basal |
| rs4018760 | 10 | 27393142 | MASTL | ENSG00000120539.10 | 2.025E-6 | 0.01 | -54336 | gtex_brain_putamen_basal |
| rs6482596 | 10 | 27416747 | MASTL | ENSG00000120539.10 | 2.669E-6 | 0.01 | -30731 | gtex_brain_putamen_basal |
| rs7901653 | 10 | 27420185 | MASTL | ENSG00000120539.10 | 1.535E-6 | 0.01 | -27293 | gtex_brain_putamen_basal |
| rs3780920 | 10 | 27423510 | MASTL | ENSG00000120539.10 | 1.535E-6 | 0.01 | -23968 | gtex_brain_putamen_basal |
| rs11015563 | 10 | 27425021 | MASTL | ENSG00000120539.10 | 1.535E-6 | 0.01 | -22457 | gtex_brain_putamen_basal |
| rs1360007 | 10 | 27426775 | MASTL | ENSG00000120539.10 | 1.517E-6 | 0.01 | -20703 | gtex_brain_putamen_basal |
| rs11015570 | 10 | 27434968 | MASTL | ENSG00000120539.10 | 1.535E-6 | 0.01 | -12510 | gtex_brain_putamen_basal |
| rs3780926 | 10 | 27436295 | MASTL | ENSG00000120539.10 | 1.535E-6 | 0.01 | -11183 | gtex_brain_putamen_basal |
| rs7067696 | 10 | 27438284 | MASTL | ENSG00000120539.10 | 1.301E-6 | 0.01 | -9194 | gtex_brain_putamen_basal |
| rs2185808 | 10 | 27438713 | MASTL | ENSG00000120539.10 | 2.244E-6 | 0.01 | -8765 | gtex_brain_putamen_basal |
| rs10764676 | 10 | 27439160 | MASTL | ENSG00000120539.10 | 1.535E-6 | 0.01 | -8318 | gtex_brain_putamen_basal |
| rs3758403 | 10 | 27443623 | MASTL | ENSG00000120539.10 | 1.123E-6 | 0.01 | -3855 | gtex_brain_putamen_basal |
| rs3824593 | 10 | 27444303 | MASTL | ENSG00000120539.10 | 1.53E-6 | 0.01 | -3175 | gtex_brain_putamen_basal |
| rs7919803 | 10 | 27444328 | MASTL | ENSG00000120539.10 | 1.747E-6 | 0.01 | -3150 | gtex_brain_putamen_basal |
| rs7900024 | 10 | 27444763 | MASTL | ENSG00000120539.10 | 1.341E-6 | 0.01 | -2715 | gtex_brain_putamen_basal |
| rs11015575 | 10 | 27445574 | MASTL | ENSG00000120539.10 | 1.53E-6 | 0.01 | -1904 | gtex_brain_putamen_basal |
| rs7069942 | 10 | 27450684 | MASTL | ENSG00000120539.10 | 1.789E-6 | 0.01 | 3206 | gtex_brain_putamen_basal |
| rs7070117 | 10 | 27450822 | MASTL | ENSG00000120539.10 | 1.353E-6 | 0.01 | 3344 | gtex_brain_putamen_basal |
| rs10764680 | 10 | 27452553 | MASTL | ENSG00000120539.10 | 2.53E-6 | 0.01 | 5075 | gtex_brain_putamen_basal |
| rs397799120 | 10 | 27452867 | MASTL | ENSG00000120539.10 | 1.676E-6 | 0.01 | 5389 | gtex_brain_putamen_basal |
| rs10829197 | 10 | 27453031 | MASTL | ENSG00000120539.10 | 1.786E-6 | 0.01 | 5553 | gtex_brain_putamen_basal |
| rs7068375 | 10 | 27454111 | MASTL | ENSG00000120539.10 | 6.618E-7 | 0.01 | 6633 | gtex_brain_putamen_basal |
| rs10458708 | 10 | 27455605 | MASTL | ENSG00000120539.10 | 2.604E-6 | 0.01 | 8127 | gtex_brain_putamen_basal |
| rs12265358 | 10 | 27456924 | MASTL | ENSG00000120539.10 | 1.047E-6 | 0.01 | 9446 | gtex_brain_putamen_basal |
| rs10764683 | 10 | 27457971 | MASTL | ENSG00000120539.10 | 1.046E-6 | 0.01 | 10493 | gtex_brain_putamen_basal |
| rs11597298 | 10 | 27458568 | MASTL | ENSG00000120539.10 | 1.046E-6 | 0.01 | 11090 | gtex_brain_putamen_basal |
| rs1981296 | 10 | 27459670 | MASTL | ENSG00000120539.10 | 6.597E-7 | 0.01 | 12192 | gtex_brain_putamen_basal |
| rs7897241 | 10 | 27460302 | MASTL | ENSG00000120539.10 | 1.538E-6 | 0.01 | 12824 | gtex_brain_putamen_basal |
| rs34842077 | 10 | 27460501 | MASTL | ENSG00000120539.10 | 8.581E-7 | 0.01 | 13023 | gtex_brain_putamen_basal |
| rs6482600 | 10 | 27461953 | MASTL | ENSG00000120539.10 | 1.536E-6 | 0.01 | 14475 | gtex_brain_putamen_basal |
| rs10829200 | 10 | 27463012 | MASTL | ENSG00000120539.10 | 6.554E-7 | 0.01 | 15534 | gtex_brain_putamen_basal |
| rs7894187 | 10 | 27463114 | MASTL | ENSG00000120539.10 | 5.516E-7 | 0.01 | 15636 | gtex_brain_putamen_basal |
| rs7910367 | 10 | 27463236 | MASTL | ENSG00000120539.10 | 1.365E-6 | 0.01 | 15758 | gtex_brain_putamen_basal |
| rs9299837 | 10 | 27463655 | MASTL | ENSG00000120539.10 | 1.04E-6 | 0.01 | 16177 | gtex_brain_putamen_basal |
| rs7918395 | 10 | 27464370 | MASTL | ENSG00000120539.10 | 1.025E-6 | 0.01 | 16892 | gtex_brain_putamen_basal |
| rs2887190 | 10 | 27465828 | MASTL | ENSG00000120539.10 | 9.142E-7 | 0.01 | 18350 | gtex_brain_putamen_basal |
| rs7091723 | 10 | 27466165 | MASTL | ENSG00000120539.10 | 1.041E-6 | 0.01 | 18687 | gtex_brain_putamen_basal |
| rs7091128 | 10 | 27466473 | MASTL | ENSG00000120539.10 | 1.041E-6 | 0.01 | 18995 | gtex_brain_putamen_basal |
| rs7079792 | 10 | 27466970 | MASTL | ENSG00000120539.10 | 1.041E-6 | 0.01 | 19492 | gtex_brain_putamen_basal |
| rs7079885 | 10 | 27467010 | MASTL | ENSG00000120539.10 | 1.038E-6 | 0.01 | 19532 | gtex_brain_putamen_basal |
| rs7919316 | 10 | 27467486 | MASTL | ENSG00000120539.10 | 1.04E-6 | 0.01 | 20008 | gtex_brain_putamen_basal |
| rs11015588 | 10 | 27468762 | MASTL | ENSG00000120539.10 | 1.041E-6 | 0.01 | 21284 | gtex_brain_putamen_basal |
| rs10829201 | 10 | 27469101 | MASTL | ENSG00000120539.10 | 1.041E-6 | 0.01 | 21623 | gtex_brain_putamen_basal |
| rs10829202 | 10 | 27469165 | MASTL | ENSG00000120539.10 | 1.041E-6 | 0.01 | 21687 | gtex_brain_putamen_basal |
| rs11015589 | 10 | 27469503 | MASTL | ENSG00000120539.10 | 1.566E-6 | 0.01 | 22025 | gtex_brain_putamen_basal |
| rs11015590 | 10 | 27469678 | MASTL | ENSG00000120539.10 | 6.551E-7 | 0.01 | 22200 | gtex_brain_putamen_basal |
| rs10764684 | 10 | 27473624 | MASTL | ENSG00000120539.10 | 6.551E-7 | 0.01 | 26146 | gtex_brain_putamen_basal |
| rs1557168 | 10 | 27473901 | MASTL | ENSG00000120539.10 | 1.041E-6 | 0.01 | 26423 | gtex_brain_putamen_basal |
| rs1557169 | 10 | 27474078 | MASTL | ENSG00000120539.10 | 1.041E-6 | 0.01 | 26600 | gtex_brain_putamen_basal |
| rs1557170 | 10 | 27474288 | MASTL | ENSG00000120539.10 | 1.041E-6 | 0.01 | 26810 | gtex_brain_putamen_basal |
| rs10764685 | 10 | 27475010 | MASTL | ENSG00000120539.10 | 1.041E-6 | 0.01 | 27532 | gtex_brain_putamen_basal |
| rs10741130 | 10 | 27475444 | MASTL | ENSG00000120539.10 | 9.349E-7 | 0.01 | 27966 | gtex_brain_putamen_basal |
| rs10764686 | 10 | 27475494 | MASTL | ENSG00000120539.10 | 1.535E-6 | 0.01 | 28016 | gtex_brain_putamen_basal |
| rs1338 | 10 | 27475693 | MASTL | ENSG00000120539.10 | 1.041E-6 | 0.01 | 28215 | gtex_brain_putamen_basal |
| rs7924231 | 10 | 27476093 | MASTL | ENSG00000120539.10 | 2.743E-6 | 0.01 | 28615 | gtex_brain_putamen_basal |
| rs35459782 | 10 | 27477136 | MASTL | ENSG00000120539.10 | 1.535E-6 | 0.01 | 29658 | gtex_brain_putamen_basal |
| rs882474 | 10 | 27477865 | MASTL | ENSG00000120539.10 | 6.634E-7 | 0.01 | 30387 | gtex_brain_putamen_basal |
| rs79663979 | 10 | 27479255 | MASTL | ENSG00000120539.10 | 7.549E-7 | 0.01 | 31777 | gtex_brain_putamen_basal |
| rs10829208 | 10 | 27479322 | MASTL | ENSG00000120539.10 | 9.938E-7 | 0.01 | 31844 | gtex_brain_putamen_basal |
| rs7086553 | 10 | 27480049 | MASTL | ENSG00000120539.10 | 1.261E-6 | 0.01 | 32571 | gtex_brain_putamen_basal |
| rs4749235 | 10 | 27481667 | MASTL | ENSG00000120539.10 | 2.511E-6 | 0.01 | 34189 | gtex_brain_putamen_basal |
| rs10764688 | 10 | 27486669 | MASTL | ENSG00000120539.10 | 1.674E-6 | 0.01 | 39191 | gtex_brain_putamen_basal |
| rs11598615 | 10 | 27487072 | MASTL | ENSG00000120539.10 | 1.689E-6 | 0.01 | 39594 | gtex_brain_putamen_basal |
| rs11015604 | 10 | 27488069 | MASTL | ENSG00000120539.10 | 1.009E-6 | 0.01 | 40591 | gtex_brain_putamen_basal |
| rs4747589 | 10 | 27490226 | MASTL | ENSG00000120539.10 | 2.373E-6 | 0.01 | 42748 | gtex_brain_putamen_basal |
| rs7074295 | 10 | 27495406 | MASTL | ENSG00000120539.10 | 2.373E-6 | 0.01 | 47928 | gtex_brain_putamen_basal |
| rs4749236 | 10 | 27495743 | MASTL | ENSG00000120539.10 | 2.373E-6 | 0.01 | 48265 | gtex_brain_putamen_basal |
| rs6482603 | 10 | 27496877 | MASTL | ENSG00000120539.10 | 2.373E-6 | 0.01 | 49399 | gtex_brain_putamen_basal |
| rs7902126 | 10 | 27500490 | MASTL | ENSG00000120539.10 | 2.374E-6 | 0.01 | 53012 | gtex_brain_putamen_basal |
| rs4749238 | 10 | 27504681 | MASTL | ENSG00000120539.10 | 2.748E-6 | 0.01 | 57203 | gtex_brain_putamen_basal |
| rs11015613 | 10 | 27507958 | MASTL | ENSG00000120539.10 | 2.742E-6 | 0.01 | 60480 | gtex_brain_putamen_basal |
| rs2780675 | 10 | 27515771 | MASTL | ENSG00000120539.10 | 1.553E-6 | 0.01 | 68293 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| SENGUPTA NASOPHARYNGEAL CARCINOMA UP | 294 | 178 | All SZGR 2.0 genes in this pathway |
| KINSEY TARGETS OF EWSR1 FLII FUSION UP | 1278 | 748 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA DN | 1375 | 806 | All SZGR 2.0 genes in this pathway |
| RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP | 633 | 376 | All SZGR 2.0 genes in this pathway |
| WEI MYCN TARGETS WITH E BOX | 795 | 478 | All SZGR 2.0 genes in this pathway |
| BENPORATH CYCLING GENES | 648 | 385 | All SZGR 2.0 genes in this pathway |
| SHEPARD BMYB MORPHOLINO DN | 200 | 112 | All SZGR 2.0 genes in this pathway |
| SHEPARD BMYB TARGETS | 74 | 41 | All SZGR 2.0 genes in this pathway |
| SHEPARD CRUSH AND BURN MUTANT DN | 185 | 111 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS LATE PROGENITOR | 544 | 307 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY E2F4 UNSTIMULATED | 728 | 415 | All SZGR 2.0 genes in this pathway |
| FINETTI BREAST CANCER KINOME RED | 16 | 11 | All SZGR 2.0 genes in this pathway |
| FUJII YBX1 TARGETS DN | 202 | 132 | All SZGR 2.0 genes in this pathway |
| FIRESTEIN PROLIFERATION | 175 | 125 | All SZGR 2.0 genes in this pathway |
| ZHANG TLX TARGETS 36HR DN | 185 | 116 | All SZGR 2.0 genes in this pathway |
| ZHANG TLX TARGETS 60HR DN | 277 | 166 | All SZGR 2.0 genes in this pathway |
| ZHANG TLX TARGETS DN | 89 | 50 | All SZGR 2.0 genes in this pathway |
| WHITFIELD CELL CYCLE S | 162 | 86 | All SZGR 2.0 genes in this pathway |
| WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN | 374 | 217 | All SZGR 2.0 genes in this pathway |
| DUTERTRE ESTRADIOL RESPONSE 24HR UP | 324 | 193 | All SZGR 2.0 genes in this pathway |
| JOHNSTONE PARVB TARGETS 3 DN | 918 | 550 | All SZGR 2.0 genes in this pathway |
| KOINUMA TARGETS OF SMAD2 OR SMAD3 | 824 | 528 | All SZGR 2.0 genes in this pathway |
| GOBERT OLIGODENDROCYTE DIFFERENTIATION DN | 1080 | 713 | All SZGR 2.0 genes in this pathway |
| PLASARI TGFB1 TARGETS 10HR DN | 244 | 157 | All SZGR 2.0 genes in this pathway |
| KRIEG HYPOXIA NOT VIA KDM3A | 770 | 480 | All SZGR 2.0 genes in this pathway |