Gene Page: DGCR6L
Summary ?
| GeneID | 85359 |
| Symbol | DGCR6L |
| Synonyms | DGCR6 |
| Description | DiGeorge syndrome critical region gene 6-like |
| Reference | MIM:609459|HGNC:HGNC:18551|Ensembl:ENSG00000128185|HPRD:16800|Vega:OTTHUMG00000150583 |
| Gene type | protein-coding |
| Map location | 22q11.21 |
| Pascal p-value | 0.437 |
| Sherlock p-value | 0.684 |
| Fetal beta | -0.722 |
| DMG | 1 (# studies) |
| eGene | Cerebellum Cortex Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CNV:YES | Copy number variation studies | Manual curation | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
| GSMA_I | Genome scan meta-analysis | Psr: 0.031 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg21900616 | 22 | 20286845 | DGCR6L | 3.77E-8 | -0.012 | 1.09E-5 | DMG:Jaffe_2016 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs752689 | chr22 | 20309392 | DGCR6L | 85359 | 0.17 | cis | ||
| rs719829 | chr5 | 124581781 | DGCR6L | 85359 | 0.14 | trans | ||
| rs1345091 | chr12 | 46542953 | DGCR6L | 85359 | 0.12 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005634 | nucleus | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| DAIRKEE TERT TARGETS UP | 380 | 213 | All SZGR 2.0 genes in this pathway |
| LOPEZ MBD TARGETS | 957 | 597 | All SZGR 2.0 genes in this pathway |
| ROPERO HDAC2 TARGETS | 114 | 71 | All SZGR 2.0 genes in this pathway |
| JIANG VHL TARGETS | 138 | 91 | All SZGR 2.0 genes in this pathway |
| JIANG HYPOXIA VIA VHL | 34 | 24 | All SZGR 2.0 genes in this pathway |