Gene Page: KRT37
Summary ?
| GeneID | 8688 |
| Symbol | KRT37 |
| Synonyms | HA7|K37|KRTHA7 |
| Description | keratin 37 |
| Reference | MIM:604541|HGNC:HGNC:6455|Ensembl:ENSG00000108417|HPRD:05175|Vega:OTTHUMG00000133606 |
| Gene type | protein-coding |
| Map location | 17q21.2 |
| Pascal p-value | 0.326 |
| Fetal beta | 0.139 |
| DMG | 1 (# studies) |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg10226036 | 17 | 39581966 | KRT37 | 9.13E-5 | -0.696 | 0.027 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs10994209 | chr10 | 61877705 | KRT37 | 8688 | 0.19 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| PI4K2A | 0.91 | 0.91 |
| CYFIP2 | 0.90 | 0.90 |
| AP3M2 | 0.88 | 0.89 |
| KIAA1737 | 0.88 | 0.88 |
| ATP6V1A | 0.87 | 0.89 |
| TGOLN2 | 0.87 | 0.87 |
| MFN2 | 0.87 | 0.87 |
| STK24 | 0.86 | 0.83 |
| USP32 | 0.86 | 0.84 |
| PPTC7 | 0.86 | 0.87 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.59 | -0.48 |
| AF347015.18 | -0.53 | -0.44 |
| AC010300.1 | -0.51 | -0.49 |
| AF347015.8 | -0.50 | -0.43 |
| MT-CO2 | -0.50 | -0.44 |
| IL32 | -0.50 | -0.41 |
| AF347015.2 | -0.49 | -0.38 |
| AF347015.31 | -0.49 | -0.43 |
| AC098691.2 | -0.49 | -0.42 |
| CSAG1 | -0.48 | -0.42 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| TANAKA METHYLATED IN ESOPHAGEAL CARCINOMA | 103 | 58 | All SZGR 2.0 genes in this pathway |
| CAMPS COLON CANCER COPY NUMBER UP | 92 | 45 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 30MIN UP | 56 | 38 | All SZGR 2.0 genes in this pathway |
| MARTENS TRETINOIN RESPONSE UP | 857 | 456 | All SZGR 2.0 genes in this pathway |