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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Gene Page: HDAC3

Summary

GeneID

8841

Symbol

HDAC3

Synonyms

HD3|RPD3|RPD3-2

Description

histone deacetylase 3

Locus tag

Gene type

protein-coding

Map location

5q31

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.0032

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0004407

histone deacetylase activity

TAS

12711221

GO:0016787

hydrolase activity

IEA

GO:0008134

transcription factor binding

TAS

12711221

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006355

regulation of transcription, DNA-dependent

IEA

GO:0006350

transcription

IEA

GO:0006916

anti-apoptosis

TAS

10777477

GO:0016568

chromatin modification

TAS

12711221

GO:0016575

histone deacetylation

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000118

histone deacetylase complex

TAS

12711221

GO:0005634

nucleus

TAS

12711221

GO:0005737

cytoplasm

TAS

12711221

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ANKRD11	ANCO-1 \| LZ16 \| T13	ankyrin repeat domain 11	Affinity Capture-Western Reconstituted Complex	BioGRID	15184363
ANKRD11	ANCO-1 \| LZ16 \| T13	ankyrin repeat domain 11	ANCO-1 interacts with HDAC3. This interaction was modeled on a demonstrated interaction between human ANCO-1 and HDAC3 from an unspecified species.	BIND	15184363
AR	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \| TFM	androgen receptor	Reconstituted Complex	BioGRID	12943985
ARID4A	RBBP1 \| RBP-1 \| RBP1	AT rich interactive domain 4A (RBP1-like)	-	HPRD	10490602
BCL3	BCL4 \| D19S37	B-cell CLL/lymphoma 3	HDAC3 interacts with BCL-3.	BIND	15469820
BCOR	ANOP2 \| FLJ20285 \| FLJ38041 \| KIAA1575 \| MAA2 \| MCOPS2 \| MGC131961 \| MGC71031	BCL6 co-repressor	Affinity Capture-Western	BioGRID	10898795
BIRC3	AIP1 \| API2 \| CIAP2 \| HAIP1 \| HIAP1 \| MALT2 \| MIHC \| RNF49	baculoviral IAP repeat-containing 3	The cIAP-2 promoter interacts with HDAC3.	BIND	15494311
CBFA2T3	ETO2 \| MTG16 \| MTGR2 \| ZMYND4	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	-	HPRD,BioGRID	12242670
CCND1	BCL1 \| D11S287E \| PRAD1 \| U21B31	cyclin D1	Affinity Capture-Western	BioGRID	12048199 \|15558026
CCT5	CCT-epsilon \| CCTE \| KIAA0098 \| TCP-1-epsilon	chaperonin containing TCP1, subunit 5 (epsilon)	-	HPRD,BioGRID	12502735
CSNK2A1	CK2A1 \| CKII	casein kinase 2, alpha 1 polypeptide	CSNK2A1 (CK2) phosphorylates HDAC3.	BIND	15805470
CTBP1	BARS \| MGC104684	C-terminal binding protein 1	Reconstituted Complex	BioGRID	11022042
DAXX	BING2 \| DAP6 \| EAP1 \| MGC126245 \| MGC126246	death-domain associated protein	Far Western	BioGRID	10669754
GATA1	ERYF1 \| GF-1 \| GF1 \| NFE1	GATA binding protein 1 (globin transcription factor 1)	Affinity Capture-Western Reconstituted Complex	BioGRID	14668799
GATA2	MGC2306 \| NFE1B	GATA binding protein 2	-	HPRD,BioGRID	11567998
GPS2	AMF-1 \| MGC104294 \| MGC119287 \| MGC119288 \| MGC119289	G protein pathway suppressor 2	Affinity Capture-MS Affinity Capture-Western	BioGRID	11931768
GTF2I	BAP-135 \| BAP135 \| BTKAP1 \| DIWS \| FLJ38776 \| FLJ56355 \| IB291 \| SPIN \| TFII-I \| WBS \| WBSCR6	general transcription factor II, i	HDAC3 interacts with TFII-I. This interaction was modeled on a demonstrated interaction between HDAC3 and TFII-I isoforms both from unspecified species.	BIND	12239342
			-	HPRD,BioGRID	12239342 \|12393887
			-	HPRD	12393887
GTF2IRD1	BEN \| CREAM1 \| GTF3 \| MUSTRD1 \| RBAP2 \| WBS \| WBSCR11 \| WBSCR12 \| hMusTRD1alpha1	GTF2I repeat domain containing 1	-	HPRD,BioGRID	12239342
GTF2IRD1		GTF2I repeat domain containing 1	HDAC3 interacts with hMusTRD1. This interaction was modeled on a demonstrated interaction between HDAC3 from an unspecified species and human hMusTRD1.	BIND	12239342
HDAC1	DKFZp686H12203 \| GON-10 \| HD1 \| RPD3 \| RPD3L1	histone deacetylase 1	-	HPRD	10944117 \|11302704
HDAC10	DKFZp761B039 \| MGC149722	histone deacetylase 10	Affinity Capture-Western	BioGRID	11861901
HDAC3	HD3 \| RPD3 \| RPD3-2	histone deacetylase 3	Affinity Capture-Western Reconstituted Complex	BioGRID	11779848
HDAC4	HA6116 \| HD4 \| HDAC-A \| HDACA \| KIAA0288	histone deacetylase 4	-	HPRD	11804585
HDAC4	HA6116 \| HD4 \| HDAC-A \| HDACA \| KIAA0288	histone deacetylase 4	-	HPRD,BioGRID	11466315
HDAC5	FLJ90614 \| HD5 \| NY-CO-9	histone deacetylase 5	-	HPRD,BioGRID	11804585
HDAC5	FLJ90614 \| HD5 \| NY-CO-9	histone deacetylase 5	-	HPRD	11466315
HDAC7	DKFZp586J0917 \| FLJ99588 \| HD7A \| HDAC7A	histone deacetylase 7	Affinity Capture-Western Reconstituted Complex	BioGRID	11466315
HDAC9	DKFZp779K1053 \| HD7 \| HDAC \| HDAC7 \| HDAC7B \| HDAC9B \| HDAC9FL \| HDRP \| KIAA0744 \| MITR	histone deacetylase 9	An unspecified isoform of HDAC9 (MITR) interacts with HDAC3. This interaction was modelled on a demonstrated interaction between an unspecified isoform of human HDAC9 and HDAC3 from an unspecified species.	BIND	15711539
HDAC9		histone deacetylase 9	-	HPRD,BioGRID	10655483
HIF1A	HIF-1alpha \| HIF1 \| HIF1-ALPHA \| MOP1 \| PASD8	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	Reconstituted Complex	BioGRID	11641274
HIF1AN	DKFZp762F1811 \| FIH1 \| FLJ20615 \| FLJ22027	hypoxia-inducible factor 1, alpha subunit inhibitor	Reconstituted Complex	BioGRID	11641274
HR	ALUNC \| AU \| HSA277165	hairless homolog (mouse)	Affinity Capture-Western	BioGRID	11641275
HSPA4	APG-2 \| HS24/P52 \| MGC131852 \| RY \| hsp70 \| hsp70RY	heat shock 70kDa protein 4	-	HPRD,BioGRID	11777905
HSPA8	HSC54 \| HSC70 \| HSC71 \| HSP71 \| HSP73 \| HSPA10 \| LAP1 \| MGC131511 \| MGC29929 \| NIP71	heat shock 70kDa protein 8	-	HPRD,BioGRID	12502735
IKZF1	Hs.54452 \| IK1 \| IKAROS \| LYF1 \| PRO0758 \| ZNFN1A1 \| hIk-1	IKAROS family zinc finger 1 (Ikaros)	Affinity Capture-Western	BioGRID	12015313
IL8	CXCL8 \| GCP-1 \| GCP1 \| LECT \| LUCT \| LYNAP \| MDNCF \| MONAP \| NAF \| NAP-1 \| NAP1	interleukin 8	The IL-8 promoter interacts with HDAC3.	BIND	15494311
JUN	AP-1 \| AP1 \| c-Jun	jun oncogene	-	HPRD,BioGRID	12853483
MAP3K7IP2	FLJ21885 \| KIAA0733 \| TAB2	mitogen-activated protein kinase kinase kinase 7 interacting protein 2	-	HPRD,BioGRID	12150997
MAPK11	P38B \| P38BETA2 \| PRKM11 \| SAPK2 \| SAPK2B \| p38-2 \| p38Beta	mitogen-activated protein kinase 11	-	HPRD,BioGRID	15356147
NCOR1	KIAA1047 \| MGC104216 \| N-CoR \| TRAC1 \| hCIT529I10 \| hN-CoR	nuclear receptor co-repressor 1	Affinity Capture-MS Affinity Capture-Western Co-fractionation Co-purification Reconstituted Complex Two-hybrid	BioGRID	10944117 \|11013263 \|11466315 \|11804585 \|11931768 \|12628926 \|14527417
			N-CoR interacts with HDAC3.	BIND	12628926
			-	HPRD	10944117 \|11509652
NCOR2	CTG26 \| SMRT \| SMRTE \| SMRTE-tau \| TNRC14 \| TRAC-1 \| TRAC1	nuclear receptor co-repressor 2	Affinity Capture-MS Affinity Capture-Western Co-fractionation Co-purification Reconstituted Complex	BioGRID	10809664 \|10944117 \|11013263 \|11804585 \|12502735 \|12628926 \|14527417
NFKBIA	IKBA \| MAD-3 \| NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	HDAC3 interacts with I-kappa-B-alpha.	BIND	12972430
NR2C1	TR2	nuclear receptor subfamily 2, group C, member 1	-	HPRD,BioGRID	14521922
NR2C2	TAK1 \| TR2R1 \| TR4 \| hTAK1	nuclear receptor subfamily 2, group C, member 2	Reconstituted Complex	BioGRID	12943985
PML	MYL \| PP8675 \| RNF71 \| TRIM19	promyelocytic leukemia	Affinity Capture-Western Reconstituted Complex	BioGRID	11259576
PPARD	FAAR \| MGC3931 \| NR1C2 \| NUC1 \| NUCI \| NUCII \| PPAR-beta \| PPARB	peroxisome proliferator-activated receptor delta	Affinity Capture-Western Reconstituted Complex	BioGRID	11867749 \|12943985
PPARG	NR1C3 \| PPARG1 \| PPARG2 \| PPARgamma	peroxisome proliferator-activated receptor gamma	-	HPRD,BioGRID	12479814
PPP4C	PP4 \| PPH3 \| PPX	protein phosphatase 4 (formerly X), catalytic subunit	PPP4C (PP4C) interacts with HDAC3.	BIND	15805470
PPP4R1	PP4(Rmeg) \| PP4R1	protein phosphatase 4, regulatory subunit 1	PPP4R1 (PP4R1) interacts with HDAC3.	BIND	15805470
RARA	NR1B1 \| RAR	retinoic acid receptor, alpha	Reconstituted Complex	BioGRID	12943985
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	-	HPRD,BioGRID	12479814
RBBP4	NURF55 \| RBAP48	retinoblastoma binding protein 4	-	HPRD	11777905
RBBP4	NURF55 \| RBAP48	retinoblastoma binding protein 4	Reconstituted Complex	BioGRID	11470869
RBL1	CP107 \| MGC40006 \| PRB1 \| p107	retinoblastoma-like 1 (p107)	Affinity Capture-Western	BioGRID	10490602
RELA	MGC131774 \| NFKB3 \| p65	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Affinity Capture-Western	BioGRID	11533489
RUNX1T1	AML1T1 \| CBFA2T1 \| CDR \| ETO \| MGC2796 \| MTG8 \| MTG8b \| ZMYND2	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	Affinity Capture-Western	BioGRID	11533236
RUNX1T1			ETO interacts with HDAC3.	BIND	15333839
RUNX2	AML3 \| CBFA1 \| CCD \| CCD1 \| MGC120022 \| MGC120023 \| OSF2 \| PEA2aA \| PEBP2A1 \| PEBP2A2 \| PEBP2aA \| PEBP2aA1	runt-related transcription factor 2	Affinity Capture-Western Reconstituted Complex	BioGRID	15292260
RXRA	FLJ00280 \| FLJ00318 \| FLJ16020 \| FLJ16733 \| MGC102720 \| NR2B1	retinoid X receptor, alpha	Reconstituted Complex	BioGRID	12943985
SF3B1	PRP10 \| PRPF10 \| SAP155 \| SF3b155	splicing factor 3b, subunit 1, 155kDa	Affinity Capture-MS	BioGRID	17353931
SIN3A	DKFZp434K2235 \| FLJ90319 \| KIAA0700	SIN3 homolog A, transcription regulator (yeast)	-	HPRD	10944117
SMARCA4	BAF190 \| BRG1 \| FLJ39786 \| SNF2 \| SNF2-BETA \| SNF2L4 \| SNF2LB \| SWI2 \| hSNF2b	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	-	HPRD	10944117
STAT3	APRF \| FLJ20882 \| HIES \| MGC16063	signal transducer and activator of transcription 3 (acute-phase response factor)	Stat3 interacts with HDAC3.	BIND	15653507
SUV39H1	KMT1A \| MG44 \| SUV39H	suppressor of variegation 3-9 homolog 1 (Drosophila)	Affinity Capture-Western Reconstituted Complex	BioGRID	11788710
TBL1X	EBI \| SMAP55 \| TBL1	transducin (beta)-like 1X-linked	Affinity Capture-MS Affinity Capture-Western Reconstituted Complex	BioGRID	10809664 \|11931768
			HDAC3 interacts with TBL1.	BIND	12628926
			-	HPRD	10944117 \|11931768
TBL1XR1	C21 \| DC42 \| FLJ12894 \| IRA1 \| TBLR1	transducin (beta)-like 1 X-linked receptor 1	Affinity Capture-MS	BioGRID	11931768
TCP1	CCT-alpha \| CCT1 \| CCTa \| D6S230E \| TCP-1-alpha	t-complex 1	Affinity Capture-Western Reconstituted Complex	BioGRID	12502735
THRB	ERBA-BETA \| ERBA2 \| GRTH \| MGC126109 \| MGC126110 \| NR1A2 \| PRTH \| THR1 \| THRB1 \| THRB2	thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)	-	HPRD	10944117
TNFSF10	APO2L \| Apo-2L \| CD253 \| TL2 \| TRAIL	tumor necrosis factor (ligand) superfamily, member 10	HDAC3 interacts with the TNFSF10 promoter.	BIND	15619633
VHL	HRCA1 \| RCA1 \| VHL1	von Hippel-Lindau tumor suppressor	Reconstituted Complex	BioGRID	11641274
XPO1	CRM1 \| DKFZp686B1823	exportin 1 (CRM1 homolog, yeast)	-	HPRD,BioGRID	11779848
YY1	DELTA \| INO80S \| NF-E1 \| UCRBP \| YIN-YANG-1	YY1 transcription factor	-	HPRD,BioGRID	9346952
ZBTB16	PLZF \| ZNF145	zinc finger and BTB domain containing 16	Reconstituted Complex	BioGRID	15467736
ZBTB33	ZNF-kaiso \| ZNF348	zinc finger and BTB domain containing 33	Affinity Capture-MS Affinity Capture-Western	BioGRID	14527417

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
BIOCARTA_RELA_PATHWAY	16	12	All SZGR genes in this pathway
BIOCARTA_CARM_ER_PATHWAY	35	27	All SZGR genes in this pathway
BIOCARTA_RARRXR_PATHWAY	15	9	All SZGR genes in this pathway
PID_HDAC_CLASSII_PATHWAY	34	27	All SZGR genes in this pathway
PID_HDAC_CLASSI_PATHWAY	66	50	All SZGR genes in this pathway
PID_RETINOIC_ACID_PATHWAY	30	23	All SZGR genes in this pathway
PID_MYC_REPRESS_PATHWAY	63	52	All SZGR genes in this pathway
PID_RB_1PATHWAY	65	46	All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF	217	167	All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY	396	292	All SZGR genes in this pathway
REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION	36	27	All SZGR genes in this pathway
REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION	104	72	All SZGR genes in this pathway
REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION	24	17	All SZGR genes in this pathway
REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION	46	28	All SZGR genes in this pathway
REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA	23	16	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH1	70	46	All SZGR genes in this pathway
REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING	81	61	All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS	478	302	All SZGR genes in this pathway
REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM	168	115	All SZGR genes in this pathway
REACTOME_CIRCADIAN_CLOCK	53	40	All SZGR genes in this pathway
REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION	72	53	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH	103	64	All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP	1382	904	All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_DN	536	332	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN	1781	1082	All SZGR genes in this pathway
OZANNE_AP1_TARGETS_UP	18	11	All SZGR genes in this pathway
MANN_RESPONSE_TO_AMIFOSTINE_UP	20	12	All SZGR genes in this pathway
DAIRKEE_TERT_TARGETS_UP	380	213	All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK	1652	1023	All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK	423	265	All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN	514	330	All SZGR genes in this pathway
BENPORATH_MYC_TARGETS_WITH_EBOX	230	156	All SZGR genes in this pathway
BENPORATH_CYCLING_GENES	648	385	All SZGR genes in this pathway
CHEN_NEUROBLASTOMA_COPY_NUMBER_GAINS	50	35	All SZGR genes in this pathway
PEART_HDAC_PROLIFERATION_CLUSTER_UP	57	35	All SZGR genes in this pathway
LIN_APC_TARGETS	77	55	All SZGR genes in this pathway
MARTINEZ_RESPONSE_TO_TRABECTEDIN_UP	71	49	All SZGR genes in this pathway
HEDENFALK_BREAST_CANCER_BRCA1_VS_BRCA2	163	113	All SZGR genes in this pathway
HELLER_HDAC_TARGETS_UP	317	208	All SZGR genes in this pathway
DANG_BOUND_BY_MYC	1103	714	All SZGR genes in this pathway