Summary ?
GeneID8841
SymbolHDAC3
SynonymsHD3|RPD3|RPD3-2
Descriptionhistone deacetylase 3
ReferenceMIM:605166|HGNC:HGNC:4854|Ensembl:ENSG00000171720|HPRD:08950|Vega:OTTHUMG00000129629
Gene typeprotein-coding
Map location5q31
Pascal p-value0.45
Sherlock p-value0.956
Fetal beta0.498
SupportChromatin Remodeling Genes

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IGenome scan meta-analysisPsr: 0.0032 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004407histone deacetylase activityTAS12711221 
GO:0016787hydrolase activityIEA-
GO:0008134transcription factor bindingTAS12711221 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0006916anti-apoptosisTAS10777477 
GO:0016568chromatin modificationTAS12711221 
GO:0016575histone deacetylationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000118histone deacetylase complexTAS12711221 
GO:0005634nucleusTAS12711221 
GO:0005737cytoplasmTAS12711221 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ANKRD11ANCO-1 | LZ16 | T13ankyrin repeat domain 11Affinity Capture-Western
Reconstituted Complex
BioGRID15184363 
ANKRD11ANCO-1 | LZ16 | T13ankyrin repeat domain 11ANCO-1 interacts with HDAC3. This interaction was modeled on a demonstrated interaction between human ANCO-1 and HDAC3 from an unspecified species.BIND15184363 
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptorReconstituted ComplexBioGRID12943985 
ARID4ARBBP1 | RBP-1 | RBP1AT rich interactive domain 4A (RBP1-like)-HPRD10490602 
BCL3BCL4 | D19S37B-cell CLL/lymphoma 3HDAC3 interacts with BCL-3.BIND15469820 
BCORANOP2 | FLJ20285 | FLJ38041 | KIAA1575 | MAA2 | MCOPS2 | MGC131961 | MGC71031BCL6 co-repressorAffinity Capture-WesternBioGRID10898795 
BIRC3AIP1 | API2 | CIAP2 | HAIP1 | HIAP1 | MALT2 | MIHC | RNF49baculoviral IAP repeat-containing 3The cIAP-2 promoter interacts with HDAC3.BIND15494311 
CBFA2T3ETO2 | MTG16 | MTGR2 | ZMYND4core-binding factor, runt domain, alpha subunit 2; translocated to, 3-HPRD,BioGRID12242670 
CCND1BCL1 | D11S287E | PRAD1 | U21B31cyclin D1Affinity Capture-WesternBioGRID12048199 |15558026 
CCT5CCT-epsilon | CCTE | KIAA0098 | TCP-1-epsilonchaperonin containing TCP1, subunit 5 (epsilon)-HPRD,BioGRID12502735 
CSNK2A1CK2A1 | CKIIcasein kinase 2, alpha 1 polypeptideCSNK2A1 (CK2) phosphorylates HDAC3.BIND15805470 
CTBP1BARS | MGC104684C-terminal binding protein 1Reconstituted ComplexBioGRID11022042 
DAXXBING2 | DAP6 | EAP1 | MGC126245 | MGC126246death-domain associated proteinFar WesternBioGRID10669754 
GATA1ERYF1 | GF-1 | GF1 | NFE1GATA binding protein 1 (globin transcription factor 1)Affinity Capture-Western
Reconstituted Complex
BioGRID14668799 
GATA2MGC2306 | NFE1BGATA binding protein 2-HPRD,BioGRID11567998 
GPS2AMF-1 | MGC104294 | MGC119287 | MGC119288 | MGC119289G protein pathway suppressor 2Affinity Capture-MS
Affinity Capture-Western
BioGRID11931768 
GTF2IBAP-135 | BAP135 | BTKAP1 | DIWS | FLJ38776 | FLJ56355 | IB291 | SPIN | TFII-I | WBS | WBSCR6general transcription factor II, iHDAC3 interacts with TFII-I. This interaction was modeled on a demonstrated interaction between HDAC3 and TFII-I isoforms both from unspecified species.BIND12239342 
GTF2IBAP-135 | BAP135 | BTKAP1 | DIWS | FLJ38776 | FLJ56355 | IB291 | SPIN | TFII-I | WBS | WBSCR6general transcription factor II, i-HPRD,BioGRID12239342 |12393887 
GTF2IBAP-135 | BAP135 | BTKAP1 | DIWS | FLJ38776 | FLJ56355 | IB291 | SPIN | TFII-I | WBS | WBSCR6general transcription factor II, i-HPRD12393887 
GTF2IRD1BEN | CREAM1 | GTF3 | MUSTRD1 | RBAP2 | WBS | WBSCR11 | WBSCR12 | hMusTRD1alpha1GTF2I repeat domain containing 1-HPRD,BioGRID12239342 
GTF2IRD1BEN | CREAM1 | GTF3 | MUSTRD1 | RBAP2 | WBS | WBSCR11 | WBSCR12 | hMusTRD1alpha1GTF2I repeat domain containing 1HDAC3 interacts with hMusTRD1. This interaction was modeled on a demonstrated interaction between HDAC3 from an unspecified species and human hMusTRD1.BIND12239342 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1-HPRD10944117 |11302704 
HDAC10DKFZp761B039 | MGC149722histone deacetylase 10Affinity Capture-WesternBioGRID11861901 
HDAC3HD3 | RPD3 | RPD3-2histone deacetylase 3Affinity Capture-Western
Reconstituted Complex
BioGRID11779848 
HDAC4HA6116 | HD4 | HDAC-A | HDACA | KIAA0288histone deacetylase 4-HPRD11804585 
HDAC4HA6116 | HD4 | HDAC-A | HDACA | KIAA0288histone deacetylase 4-HPRD,BioGRID11466315 
HDAC5FLJ90614 | HD5 | NY-CO-9histone deacetylase 5-HPRD,BioGRID11804585 
HDAC5FLJ90614 | HD5 | NY-CO-9histone deacetylase 5-HPRD11466315 
HDAC7DKFZp586J0917 | FLJ99588 | HD7A | HDAC7Ahistone deacetylase 7Affinity Capture-Western
Reconstituted Complex
BioGRID11466315 
HDAC9DKFZp779K1053 | HD7 | HDAC | HDAC7 | HDAC7B | HDAC9B | HDAC9FL | HDRP | KIAA0744 | MITRhistone deacetylase 9An unspecified isoform of HDAC9 (MITR) interacts with HDAC3. This interaction was modelled on a demonstrated interaction between an unspecified isoform of human HDAC9 and HDAC3 from an unspecified species.BIND15711539 
HDAC9DKFZp779K1053 | HD7 | HDAC | HDAC7 | HDAC7B | HDAC9B | HDAC9FL | HDRP | KIAA0744 | MITRhistone deacetylase 9-HPRD,BioGRID10655483 
HIF1AHIF-1alpha | HIF1 | HIF1-ALPHA | MOP1 | PASD8hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Reconstituted ComplexBioGRID11641274 
HIF1ANDKFZp762F1811 | FIH1 | FLJ20615 | FLJ22027hypoxia-inducible factor 1, alpha subunit inhibitorReconstituted ComplexBioGRID11641274 
HRALUNC | AU | HSA277165hairless homolog (mouse)Affinity Capture-WesternBioGRID11641275 
HSPA4APG-2 | HS24/P52 | MGC131852 | RY | hsp70 | hsp70RYheat shock 70kDa protein 4-HPRD,BioGRID11777905 
HSPA8HSC54 | HSC70 | HSC71 | HSP71 | HSP73 | HSPA10 | LAP1 | MGC131511 | MGC29929 | NIP71heat shock 70kDa protein 8-HPRD,BioGRID12502735 
IKZF1Hs.54452 | IK1 | IKAROS | LYF1 | PRO0758 | ZNFN1A1 | hIk-1IKAROS family zinc finger 1 (Ikaros)Affinity Capture-WesternBioGRID12015313 
IL8CXCL8 | GCP-1 | GCP1 | LECT | LUCT | LYNAP | MDNCF | MONAP | NAF | NAP-1 | NAP1interleukin 8The IL-8 promoter interacts with HDAC3.BIND15494311 
JUNAP-1 | AP1 | c-Junjun oncogene-HPRD,BioGRID12853483 
MAP3K7IP2FLJ21885 | KIAA0733 | TAB2mitogen-activated protein kinase kinase kinase 7 interacting protein 2-HPRD,BioGRID12150997 
MAPK11P38B | P38BETA2 | PRKM11 | SAPK2 | SAPK2B | p38-2 | p38Betamitogen-activated protein kinase 11-HPRD,BioGRID15356147 
NCOR1KIAA1047 | MGC104216 | N-CoR | TRAC1 | hCIT529I10 | hN-CoRnuclear receptor co-repressor 1Affinity Capture-MS
Affinity Capture-Western
Co-fractionation
Co-purification
Reconstituted Complex
Two-hybrid
BioGRID10944117 |11013263 
|11466315 |11804585 
|11931768 |12628926 
|14527417 
NCOR1KIAA1047 | MGC104216 | N-CoR | TRAC1 | hCIT529I10 | hN-CoRnuclear receptor co-repressor 1N-CoR interacts with HDAC3.BIND12628926 
NCOR1KIAA1047 | MGC104216 | N-CoR | TRAC1 | hCIT529I10 | hN-CoRnuclear receptor co-repressor 1-HPRD10944117 |11509652 
NCOR2CTG26 | SMRT | SMRTE | SMRTE-tau | TNRC14 | TRAC-1 | TRAC1nuclear receptor co-repressor 2Affinity Capture-MS
Affinity Capture-Western
Co-fractionation
Co-purification
Reconstituted Complex
BioGRID10809664 |10944117 
|11013263 |11804585 
|12502735 |12628926 
|14527417 
NFKBIAIKBA | MAD-3 | NFKBInuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alphaHDAC3 interacts with I-kappa-B-alpha.BIND12972430 
NR2C1TR2nuclear receptor subfamily 2, group C, member 1-HPRD,BioGRID14521922 
NR2C2TAK1 | TR2R1 | TR4 | hTAK1nuclear receptor subfamily 2, group C, member 2Reconstituted ComplexBioGRID12943985 
PMLMYL | PP8675 | RNF71 | TRIM19promyelocytic leukemiaAffinity Capture-Western
Reconstituted Complex
BioGRID11259576 
PPARDFAAR | MGC3931 | NR1C2 | NUC1 | NUCI | NUCII | PPAR-beta | PPARBperoxisome proliferator-activated receptor deltaAffinity Capture-Western
Reconstituted Complex
BioGRID11867749 |12943985 
PPARGNR1C3 | PPARG1 | PPARG2 | PPARgammaperoxisome proliferator-activated receptor gamma-HPRD,BioGRID12479814 
PPP4CPP4 | PPH3 | PPXprotein phosphatase 4 (formerly X), catalytic subunitPPP4C (PP4C) interacts with HDAC3.BIND15805470 
PPP4R1PP4(Rmeg) | PP4R1protein phosphatase 4, regulatory subunit 1PPP4R1 (PP4R1) interacts with HDAC3.BIND15805470 
RARANR1B1 | RARretinoic acid receptor, alphaReconstituted ComplexBioGRID12943985 
RB1OSRC | RB | p105-Rb | pRb | pp110retinoblastoma 1-HPRD,BioGRID12479814 
RBBP4NURF55 | RBAP48retinoblastoma binding protein 4-HPRD11777905 
RBBP4NURF55 | RBAP48retinoblastoma binding protein 4Reconstituted ComplexBioGRID11470869 
RBL1CP107 | MGC40006 | PRB1 | p107retinoblastoma-like 1 (p107)Affinity Capture-WesternBioGRID10490602 
RELAMGC131774 | NFKB3 | p65v-rel reticuloendotheliosis viral oncogene homolog A (avian)Affinity Capture-WesternBioGRID11533489 
RUNX1T1AML1T1 | CBFA2T1 | CDR | ETO | MGC2796 | MTG8 | MTG8b | ZMYND2runt-related transcription factor 1; translocated to, 1 (cyclin D-related)Affinity Capture-WesternBioGRID11533236 
RUNX1T1AML1T1 | CBFA2T1 | CDR | ETO | MGC2796 | MTG8 | MTG8b | ZMYND2runt-related transcription factor 1; translocated to, 1 (cyclin D-related)ETO interacts with HDAC3.BIND15333839 
RUNX2AML3 | CBFA1 | CCD | CCD1 | MGC120022 | MGC120023 | OSF2 | PEA2aA | PEBP2A1 | PEBP2A2 | PEBP2aA | PEBP2aA1runt-related transcription factor 2Affinity Capture-Western
Reconstituted Complex
BioGRID15292260 
RXRAFLJ00280 | FLJ00318 | FLJ16020 | FLJ16733 | MGC102720 | NR2B1retinoid X receptor, alphaReconstituted ComplexBioGRID12943985 
SF3B1PRP10 | PRPF10 | SAP155 | SF3b155splicing factor 3b, subunit 1, 155kDaAffinity Capture-MSBioGRID17353931 
SIN3ADKFZp434K2235 | FLJ90319 | KIAA0700SIN3 homolog A, transcription regulator (yeast)-HPRD10944117 
SMARCA4BAF190 | BRG1 | FLJ39786 | SNF2 | SNF2-BETA | SNF2L4 | SNF2LB | SWI2 | hSNF2bSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4-HPRD10944117 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)Stat3 interacts with HDAC3.BIND15653507 
SUV39H1KMT1A | MG44 | SUV39Hsuppressor of variegation 3-9 homolog 1 (Drosophila)Affinity Capture-Western
Reconstituted Complex
BioGRID11788710 
TBL1XEBI | SMAP55 | TBL1transducin (beta)-like 1X-linkedAffinity Capture-MS
Affinity Capture-Western
Reconstituted Complex
BioGRID10809664 |11931768 
TBL1XEBI | SMAP55 | TBL1transducin (beta)-like 1X-linkedHDAC3 interacts with TBL1.BIND12628926 
TBL1XEBI | SMAP55 | TBL1transducin (beta)-like 1X-linked-HPRD10944117 |11931768 
TBL1XR1C21 | DC42 | FLJ12894 | IRA1 | TBLR1transducin (beta)-like 1 X-linked receptor 1Affinity Capture-MSBioGRID11931768 
TCP1CCT-alpha | CCT1 | CCTa | D6S230E | TCP-1-alphat-complex 1Affinity Capture-Western
Reconstituted Complex
BioGRID12502735 
THRBERBA-BETA | ERBA2 | GRTH | MGC126109 | MGC126110 | NR1A2 | PRTH | THR1 | THRB1 | THRB2thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)-HPRD10944117 
TNFSF10APO2L | Apo-2L | CD253 | TL2 | TRAILtumor necrosis factor (ligand) superfamily, member 10HDAC3 interacts with the TNFSF10 promoter.BIND15619633 
VHLHRCA1 | RCA1 | VHL1von Hippel-Lindau tumor suppressorReconstituted ComplexBioGRID11641274 
XPO1CRM1 | DKFZp686B1823exportin 1 (CRM1 homolog, yeast)-HPRD,BioGRID11779848 
YY1DELTA | INO80S | NF-E1 | UCRBP | YIN-YANG-1YY1 transcription factor-HPRD,BioGRID9346952 
ZBTB16PLZF | ZNF145zinc finger and BTB domain containing 16Reconstituted ComplexBioGRID15467736 
ZBTB33ZNF-kaiso | ZNF348zinc finger and BTB domain containing 33Affinity Capture-MS
Affinity Capture-Western
BioGRID14527417 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BIOCARTA RELA PATHWAY 1612All SZGR 2.0 genes in this pathway
BIOCARTA CARM ER PATHWAY 3527All SZGR 2.0 genes in this pathway
BIOCARTA RARRXR PATHWAY 159All SZGR 2.0 genes in this pathway
PID HDAC CLASSII PATHWAY 3427All SZGR 2.0 genes in this pathway
PID HDAC CLASSI PATHWAY 6650All SZGR 2.0 genes in this pathway
PID RETINOIC ACID PATHWAY 3023All SZGR 2.0 genes in this pathway
PID MYC REPRESS PATHWAY 6352All SZGR 2.0 genes in this pathway
PID RB 1PATHWAY 6546All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217167All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396292All SZGR 2.0 genes in this pathway
REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION 3627All SZGR 2.0 genes in this pathway
REACTOME PPARA ACTIVATES GENE EXPRESSION 10472All SZGR 2.0 genes in this pathway
REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION 2417All SZGR 2.0 genes in this pathway
REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 4628All SZGR 2.0 genes in this pathway
REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA 2316All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY NOTCH1 7046All SZGR 2.0 genes in this pathway
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING 8161All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478302All SZGR 2.0 genes in this pathway
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM 168115All SZGR 2.0 genes in this pathway
REACTOME CIRCADIAN CLOCK 5340All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 7253All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY NOTCH 10364All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS DN 536332All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
OZANNE AP1 TARGETS UP 1811All SZGR 2.0 genes in this pathway
MANN RESPONSE TO AMIFOSTINE UP 2012All SZGR 2.0 genes in this pathway
DAIRKEE TERT TARGETS UP 380213All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423265All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN 514330All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX 230156All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648385All SZGR 2.0 genes in this pathway
CHEN NEUROBLASTOMA COPY NUMBER GAINS 5035All SZGR 2.0 genes in this pathway
PEART HDAC PROLIFERATION CLUSTER UP 5735All SZGR 2.0 genes in this pathway
LIN APC TARGETS 7755All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN UP 7149All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRCA1 VS BRCA2 163113All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317208All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway