Gene Page: FCGBP

Summary ?
GeneID8857
SymbolFCGBP
SynonymsFC(GAMMA)BP
DescriptionFc fragment of IgG binding protein
ReferenceHGNC:HGNC:13572|Ensembl:ENSG00000275395|HPRD:10956|Vega:OTTHUMG00000182580
Gene typeprotein-coding
Map location19q13.1
Pascal p-value0.166
Sherlock p-value0.094
Fetal beta0.669
DMG1 (# studies)
eGeneCaudate basal ganglia
Cortex
Hippocampus
Nucleus accumbens basal ganglia
Myers' cis & trans
SupportCompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
DNM:Xu_2012Whole Exome Sequencing analysisDe novo mutations of 4 genes were identified by exome sequencing of 795 samples in this study

Section I. Genetics and epigenetics annotation

@DNM table

GeneChromosomePositionRefAltTranscriptAA changeMutation typeSiftCG46TraitStudy
FCGBPchr1940430427CANM_003890p.506D>YmissenseSchizophreniaDNM:Xu_2012

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg180517621940388677FCGBP1.517E-4-0.3660.032DMG:Wockner_2014
cg248642751940421453FCGBP1.606E-40.2330.032DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs473411chr1110846615FCGBP88570.19trans
rs17004962chr481563338FCGBP88570.08trans
rs16873760chr645729388FCGBP88570.08trans
rs16873861chr645752854FCGBP88570.03trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ACVR1B0.890.92
OSBPL100.890.89
GPD1L0.890.88
USP6NL0.890.89
SPTAN10.880.88
LMO70.880.86
CTNND20.870.83
HERC30.870.89
C5orf250.860.89
SEC31A0.860.90
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SERPINB6-0.73-0.78
HSD17B14-0.72-0.83
MT-CO2-0.72-0.83
AF347015.31-0.72-0.82
FXYD1-0.70-0.83
HIGD1B-0.70-0.84
AF347015.33-0.69-0.78
MT-CYB-0.69-0.79
IFI27-0.68-0.81
AF347015.8-0.68-0.81

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
LIU PROSTATE CANCER DN 481290All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP 368234All SZGR 2.0 genes in this pathway
JAEGER METASTASIS DN 258141All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D DN 14383All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508354All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER DN 232154All SZGR 2.0 genes in this pathway
WANG BARRETTS ESOPHAGUS UP 5127All SZGR 2.0 genes in this pathway
WATTEL AUTONOMOUS THYROID ADENOMA UP 7347All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS UP 292168All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366238All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720440All SZGR 2.0 genes in this pathway
KUUSELO PANCREATIC CANCER 19Q13 AMPLIFICATION 3522All SZGR 2.0 genes in this pathway
FONTAINE FOLLICULAR THYROID ADENOMA UP 7543All SZGR 2.0 genes in this pathway
FONTAINE PAPILLARY THYROID CARCINOMA DN 8053All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S1 237159All SZGR 2.0 genes in this pathway