Gene Page: MCM3AP

Summary ?
GeneID8888
SymbolMCM3AP
SynonymsGANP|MAP80|SAC3
Descriptionminichromosome maintenance complex component 3 associated protein
ReferenceMIM:603294|HGNC:HGNC:6946|Ensembl:ENSG00000160294|HPRD:04483|Vega:OTTHUMG00000090630
Gene typeprotein-coding
Map location21q22.3
Pascal p-value0.025
Sherlock p-value0.125
eGenePutamen basal ganglia

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs171833182147661163MCM3APENSG00000160294.62.501E-6045048gtex_brain_putamen_basal
rs28391792147681041MCM3APENSG00000160294.68.207E-7025170gtex_brain_putamen_basal
rs28391832147687144MCM3APENSG00000160294.62.427E-6019067gtex_brain_putamen_basal
rs171827882147687982MCM3APENSG00000160294.68.245E-7018229gtex_brain_putamen_basal
rs28392172147766650MCM3APENSG00000160294.61.419E-60-60439gtex_brain_putamen_basal
rs28392182147771056MCM3APENSG00000160294.61.391E-60-64845gtex_brain_putamen_basal
rs679863012147786088MCM3APENSG00000160294.62.156E-60-79877gtex_brain_putamen_basal
rs28392292147789528MCM3APENSG00000160294.61.411E-60-83317gtex_brain_putamen_basal
rs2006039312147791131MCM3APENSG00000160294.62.014E-60-84920gtex_brain_putamen_basal
rs340955062147791132MCM3APENSG00000160294.62.874E-60-84921gtex_brain_putamen_basal
rs3978666552147795522MCM3APENSG00000160294.61.422E-60-89311gtex_brain_putamen_basal
rs81272512147797626MCM3APENSG00000160294.61.709E-60-91415gtex_brain_putamen_basal
rs28771432147799514MCM3APENSG00000160294.61.419E-60-93303gtex_brain_putamen_basal
rs110890632147800907MCM3APENSG00000160294.61.426E-60-94696gtex_brain_putamen_basal
rs110890642147800985MCM3APENSG00000160294.61.411E-60-94774gtex_brain_putamen_basal
rs37374382147811272MCM3APENSG00000160294.61.421E-60-105061gtex_brain_putamen_basal
rs117024332147813015MCM3APENSG00000160294.61.419E-60-106804gtex_brain_putamen_basal
rs99758542147813646MCM3APENSG00000160294.62.225E-60-107435gtex_brain_putamen_basal
rs20733822147818298MCM3APENSG00000160294.61.419E-60-112087gtex_brain_putamen_basal
rs20321092147820654MCM3APENSG00000160294.62.174E-60-114443gtex_brain_putamen_basal
rs28392412147821726MCM3APENSG00000160294.62.174E-60-115515gtex_brain_putamen_basal
rs28392422147825890MCM3APENSG00000160294.61.413E-60-119679gtex_brain_putamen_basal
rs72766372147829399MCM3APENSG00000160294.61.581E-60-123188gtex_brain_putamen_basal
rs117027182147839490MCM3APENSG00000160294.62.174E-60-133279gtex_brain_putamen_basal
rs28392502147841554MCM3APENSG00000160294.62.174E-60-135343gtex_brain_putamen_basal
rs2005774112147845990MCM3APENSG00000160294.62.665E-60-139779gtex_brain_putamen_basal
rs23005612147852581MCM3APENSG00000160294.62.178E-60-146370gtex_brain_putamen_basal
rs601350342147853029MCM3APENSG00000160294.62.004E-60-146818gtex_brain_putamen_basal
rs28392582147854229MCM3APENSG00000160294.62.199E-60-148018gtex_brain_putamen_basal
rs604074022147855509MCM3APENSG00000160294.61.427E-60-149298gtex_brain_putamen_basal
rs22366162147856106MCM3APENSG00000160294.68.294E-70-149895gtex_brain_putamen_basal
rs48188472148004563MCM3APENSG00000160294.69.346E-80-298352gtex_brain_putamen_basal
rs72784372148011220MCM3APENSG00000160294.61.751E-70-305009gtex_brain_putamen_basal
rs44643582148030617MCM3APENSG00000160294.61.502E-60-324406gtex_brain_putamen_basal
rs38105932148055357MCM3APENSG00000160294.68.972E-70-349146gtex_brain_putamen_basal
rs28393682148055377MCM3APENSG00000160294.68.927E-70-349166gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
CALY0.670.69
PHLDA30.670.70
GAL3ST10.660.62
SPATA200.650.63
C19orf460.650.70
ANKRD90.640.74
KLHDC90.640.73
LDHD0.640.73
KCNK40.630.70
LGI40.630.69
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SEMA3A-0.54-0.46
SSBP2-0.52-0.43
IGF2BP2-0.52-0.53
CBLB-0.52-0.42
ZNF238-0.52-0.43
DAB1-0.52-0.47
FOXG1B-0.51-0.44
NEUROD6-0.51-0.49
EML1-0.51-0.40
PBX1-0.51-0.43

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
ONKEN UVEAL MELANOMA UP 783507All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493298All SZGR 2.0 genes in this pathway
HOEBEKE LYMPHOID STEM CELL UP 9564All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS DN 536332All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485334All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584395All SZGR 2.0 genes in this pathway
FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE UP 16792All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPLICATION GENES 14787All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 21Q22 AMPLICON 1611All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL AND BRAIN QTL TRANS 185114All SZGR 2.0 genes in this pathway
LEE LIVER CANCER ACOX1 DN 6539All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
HESS TARGETS OF HOXA9 AND MEIS1 UP 6544All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI DN 172107All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
CERIBELLI PROMOTERS INACTIVE AND BOUND BY NFY 4420All SZGR 2.0 genes in this pathway