Gene Page: ZNF616
Summary ?
| GeneID | 90317 |
| Symbol | ZNF616 |
| Synonyms | - |
| Description | zinc finger protein 616 |
| Reference | HGNC:HGNC:28062|HPRD:15876| |
| Gene type | protein-coding |
| Map location | 19q13.41 |
| Pascal p-value | 0.1 |
| Fetal beta | 1.369 |
| DMG | 2 (# studies) |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 2 |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 2 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg26240532 | 19 | 52643172 | ZNF616 | 2.703E-4 | -0.233 | 0.038 | DMG:Wockner_2014 |
| cg00231521 | 19 | 52643038 | ZNF616 | 1.64E-8 | -0.009 | 6.06E-6 | DMG:Jaffe_2016 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MTF2 | 0.96 | 0.95 |
| ZNF558 | 0.96 | 0.95 |
| PCF11 | 0.95 | 0.94 |
| SUV420H1 | 0.94 | 0.95 |
| ADNP | 0.94 | 0.97 |
| ZNF564 | 0.94 | 0.95 |
| PDE7A | 0.94 | 0.95 |
| ZNF180 | 0.94 | 0.94 |
| ZNF623 | 0.94 | 0.96 |
| ZNF709 | 0.94 | 0.93 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.73 | -0.88 |
| FXYD1 | -0.73 | -0.88 |
| AIFM3 | -0.72 | -0.78 |
| TSC22D4 | -0.72 | -0.81 |
| MT-CO2 | -0.72 | -0.88 |
| HLA-F | -0.72 | -0.76 |
| AF347015.27 | -0.72 | -0.85 |
| IFI27 | -0.71 | -0.87 |
| S100B | -0.71 | -0.82 |
| AF347015.33 | -0.71 | -0.84 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME GENERIC TRANSCRIPTION PATHWAY | 352 | 181 | All SZGR 2.0 genes in this pathway |
| HOOI ST7 TARGETS UP | 94 | 57 | All SZGR 2.0 genes in this pathway |
| RODRIGUES THYROID CARCINOMA ANAPLASTIC UP | 722 | 443 | All SZGR 2.0 genes in this pathway |
| XU GH1 EXOGENOUS TARGETS DN | 120 | 69 | All SZGR 2.0 genes in this pathway |
| LU EZH2 TARGETS UP | 295 | 155 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |