Gene Page: ASH2L

Summary ?
GeneID9070
SymbolASH2L
SynonymsASH2|ASH2L1|ASH2L2|Bre2
Descriptionash2 (absent, small, or homeotic)-like (Drosophila)
ReferenceMIM:604782|HGNC:HGNC:744|Ensembl:ENSG00000129691|HPRD:05309|Vega:OTTHUMG00000164016
Gene typeprotein-coding
Map location8p11.2
Pascal p-value1.842E-5
Sherlock p-value0.241
Fetal beta-0.083
DMG1 (# studies)
eGeneMyers' cis & trans
SupportChromatin Remodeling Genes

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg03024183837963317ASH2L2.26E-7-0.3110.005DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs7132043chr1280968399ASH2L90700.14trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ATRNL10.900.87
CACNB40.890.82
FAM126B0.890.87
GABRB20.880.75
SORL10.870.80
UBR30.870.88
TTC39B0.870.78
ARFGEF20.860.83
CHM0.860.84
CPEB30.860.83
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
EFEMP2-0.50-0.60
RAB34-0.48-0.64
GATSL3-0.44-0.55
RHOC-0.43-0.61
DBI-0.43-0.60
NKAIN4-0.41-0.55
C19orf36-0.41-0.53
NUDT8-0.40-0.49
C1orf61-0.40-0.67
VEGFB-0.39-0.49

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ASH2LASH2 | ASH2L1 | ASH2L2 | Bre2ash2 (absent, small, or homeotic)-like (Drosophila)Reconstituted ComplexBioGRID15199122 
DPY30HDPY-30 | Saf19dpy-30 homolog (C. elegans)Two-hybridBioGRID16189514 
HCFC1CFF | HCF-1 | HCF1 | HFC1 | MGC70925 | VCAFhost cell factor C1 (VP16-accessory protein)Reconstituted ComplexBioGRID15199122 
HCFC2FLJ94012 | HCF-2 | HCF2host cell factor C2Reconstituted ComplexBioGRID15199122 
HIST3H3H3.4 | H3/g | H3FT | H3t | MGC126886 | MGC126888histone cluster 3, H3Reconstituted ComplexBioGRID12482968 
MEN1MEAI | SCG2multiple endocrine neoplasia IReconstituted ComplexBioGRID15199122 
MLLALL-1 | CXXC7 | FLJ11783 | HRX | HTRX1 | KMT2A | MLL/GAS7 | MLL1A | TET1-MLL | TRX1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)Affinity Capture-Western
Co-purification		BioGRID15199122 
MLL3DKFZp686C08112 | FLJ12625 | FLJ38309 | HALR | KIAA1506 | KMT2C | MGC119851 | MGC119852 | MGC119853myeloid/lymphoid or mixed-lineage leukemia 3Reconstituted ComplexBioGRID12482968 
RBBP5RBQ3 | SWD1retinoblastoma binding protein 5Reconstituted ComplexBioGRID15199122 
UNC119HRG4unc-119 homolog (C. elegans)Two-hybridBioGRID16169070 
WDR5BIG-3 | SWD3WD repeat domain 5Reconstituted ComplexBioGRID15199122 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
HOLLMANN APOPTOSIS VIA CD40 UP 201125All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663425All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485334All SZGR 2.0 genes in this pathway
JAERVINEN AMPLIFIED IN LARYNGEAL CANCER 4024All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584395All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775494All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 8P12 P11 AMPLICON 5732All SZGR 2.0 genes in this pathway
DING LUNG CANCER EXPRESSION BY COPY NUMBER 10062All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237837All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS DN 215132All SZGR 2.0 genes in this pathway
MCCLUNG CREB1 TARGETS UP 10072All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE UP 393244All SZGR 2.0 genes in this pathway
ALONSO METASTASIS UP 198128All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374247All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER UP 298174All SZGR 2.0 genes in this pathway
MIKKELSEN PLURIPOTENT STATE UP 118All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422277All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway