Gene Page: YTHDC1
Summary ?
| GeneID | 91746 |
| Symbol | YTHDC1 |
| Synonyms | YT521|YT521-B |
| Description | YTH domain containing 1 |
| Reference | HGNC:HGNC:30626|Ensembl:ENSG00000083896|HPRD:11689|Vega:OTTHUMG00000129306 |
| Gene type | protein-coding |
| Map location | 4q13.2 |
| Pascal p-value | 0.655 |
| Sherlock p-value | 0.895 |
| TADA p-value | 0.002 |
| Fetal beta | 0.746 |
| eGene | Myers' cis & trans Meta |
| Support | CompositeSet Ascano FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DNM:Fromer_2014 | Whole Exome Sequencing analysis | This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA. |
Section I. Genetics and epigenetics annotation
DNM table
| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| YTHDC1 | chr4 | 69202841 | C | CAT | NM_001031732 NM_133370 | . . | frameshift frameshift | Schizophrenia | DNM:Fromer_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs10137389 | chr14 | 46361257 | YTHDC1 | 91746 | 0.05 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| ABL1 | ABL | JTK7 | bcr/abl | c-ABL | p150 | v-abl | c-abl oncogene 1, receptor tyrosine kinase | - | HPRD,BioGRID | 15175272 |
| CSK | MGC117393 | c-src tyrosine kinase | Affinity Capture-Western Biochemical Activity | BioGRID | 15175272 |
| EMD | EDMD | LEMD5 | STA | emerin | - | HPRD,BioGRID | 12755701 |
| FYN | MGC45350 | SLK | SYN | FYN oncogene related to SRC, FGR, YES | - | HPRD,BioGRID | 15175272 |
| KHDRBS1 | FLJ34027 | Sam68 | p62 | KH domain containing, RNA binding, signal transduction associated 1 | - | HPRD,BioGRID | 10564280 |
| KHDRBS2 | FLJ38664 | MGC26664 | SLM-1 | SLM1 | bA535F17.1 | KH domain containing, RNA binding, signal transduction associated 2 | - | HPRD | 15345239 |
| KHDRBS3 | Etle | SALP | SLM-2 | SLM2 | T-STAR | TSTAR | etoile | KH domain containing, RNA binding, signal transduction associated 3 | - | HPRD | 11118435 |
| SFRS1 | ASF | MGC5228 | SF2 | SF2p33 | SRp30a | splicing factor, arginine/serine-rich 1 | - | HPRD | 9473574 |
| SFRS10 | DKFZp686F18120 | Htra2-beta | SRFS10 | TRA2-BETA | TRA2B | TRAN2B | splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) | - | HPRD | 9473574 |
| SFRS2 | PR264 | SC-35 | SC35 | SFRS2A | SRp30b | splicing factor, arginine/serine-rich 2 | - | HPRD | 9473574 |
| SFRS9 | SRp30c | splicing factor, arginine/serine-rich 9 | - | HPRD | 11118435 |
| SRC | ASV | SRC1 | c-SRC | p60-Src | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | - | HPRD | 15175272 |
| TXK | BTKL | MGC22473 | PSCTK5 | PTK4 | RLK | TKL | TXK tyrosine kinase | - | HPRD,BioGRID | 15175272 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | 1382 | 904 | All SZGR 2.0 genes in this pathway |
| RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN | 805 | 505 | All SZGR 2.0 genes in this pathway |
| GOZGIT ESR1 TARGETS DN | 781 | 465 | All SZGR 2.0 genes in this pathway |
| ENK UV RESPONSE KERATINOCYTE UP | 530 | 342 | All SZGR 2.0 genes in this pathway |
| ENK UV RESPONSE KERATINOCYTE DN | 485 | 334 | All SZGR 2.0 genes in this pathway |
| SCHLOSSER SERUM RESPONSE DN | 712 | 443 | All SZGR 2.0 genes in this pathway |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN | 584 | 395 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| RICKMAN METASTASIS UP | 344 | 180 | All SZGR 2.0 genes in this pathway |
| SHEN SMARCA2 TARGETS UP | 424 | 268 | All SZGR 2.0 genes in this pathway |
| MORI MATURE B LYMPHOCYTE UP | 90 | 62 | All SZGR 2.0 genes in this pathway |
| NOUZOVA TRETINOIN AND H4 ACETYLATION | 143 | 85 | All SZGR 2.0 genes in this pathway |
| SU PANCREAS | 54 | 30 | All SZGR 2.0 genes in this pathway |
| DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP | 314 | 201 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 48HR DN | 504 | 323 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 6HR DN | 160 | 101 | All SZGR 2.0 genes in this pathway |
| BILD CTNNB1 ONCOGENIC SIGNATURE | 82 | 52 | All SZGR 2.0 genes in this pathway |
| STEARMAN LUNG CANCER EARLY VS LATE UP | 125 | 89 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER WITH H3K27ME3 UP | 295 | 149 | All SZGR 2.0 genes in this pathway |
| MILI PSEUDOPODIA HAPTOTAXIS UP | 518 | 299 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 1HR DN | 222 | 147 | All SZGR 2.0 genes in this pathway |
| JOHNSTONE PARVB TARGETS 3 DN | 918 | 550 | All SZGR 2.0 genes in this pathway |