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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: MAGI1

Summary

GeneID

9223

Symbol

MAGI1

Synonyms

AIP3|BAIAP1|BAP1|MAGI-1|TNRC19|WWP3

Description

membrane associated guanylate kinase, WW and PDZ domain containing 1

Locus tag

Gene type

protein-coding

Map location

3p14.1

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Association

A combined odds ratio method (Sun et al. 2008), association studies

Link to SZGene

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]

Click to show detail

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

DSP

0.87

0.66

CFH

0.86

0.61

OGN

0.86

0.59

GJB2

0.85

0.46

SCARA5

0.85

0.61

BNC2

0.83

0.48

SIX1

0.81

0.46

SIX2

0.79

0.36

SLC47A1

0.79

0.60

FOXC2

0.79

0.49

Top 10 negatively co-expressed genes

HES4

-0.24

-0.39

AC217773.2

-0.21

-0.30

FAM128A

-0.21

-0.34

MRPL41

-0.20

-0.10

C1orf61

-0.20

-0.27

NUDT8

-0.19

-0.30

NBR2

-0.19

-0.14

C7orf55

-0.19

-0.26

C9orf142

-0.18

-0.29

C16orf14

-0.18

-0.11

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000166

nucleotide binding

IEA

GO:0005524

ATP binding

IEA

GO:0008022

protein C-terminus binding

TAS

9647739

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007155

cell adhesion

TAS

9647739

GO:0006461

protein complex assembly

NAS

9647739

GO:0007166

cell surface receptor linked signal transduction

TAS

9647739

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005923

tight junction

IEA

Brain (GO term level: 10)

GO:0005886

plasma membrane

TAS

9647739

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACCN3	ASIC3 \| DRASIC \| SLNAC1 \| TNaC1	amiloride-sensitive cation channel 3	-	HPRD,BioGRID	15317815
ACCN3	ASIC3 \| DRASIC \| SLNAC1 \| TNaC1	amiloride-sensitive cation channel 3	ASIC3 interacts with MAGI-1B.	BIND	15317815
ACTN4	ACTININ-4 \| DKFZp686K23158 \| FSGS \| FSGS1	actinin, alpha 4	-	HPRD,BioGRID	12042308
ATN1	B37 \| D12S755E \| DRPLA \| NOD	atrophin 1	Atrophin-1 interacts with AIP-3.	BIND	9647693
ATN1	B37 \| D12S755E \| DRPLA \| NOD	atrophin 1	-	HPRD,BioGRID	9647693
BAI1	FLJ41988	brain-specific angiogenesis inhibitor 1	-	HPRD,BioGRID	9647739
BZW1	BZAP45 \| KIAA0005 \| Nbla10236	basic leucine zipper and W2 domains 1	Affinity Capture-MS	BioGRID	17353931
CDH1	Arc-1 \| CD324 \| CDHE \| ECAD \| LCAM \| UVO	cadherin 1, type 1, E-cadherin (epithelial)	Affinity Capture-Western	BioGRID	10772923
CTNNB1	CTNNB \| DKFZp686D02253 \| FLJ25606 \| FLJ37923	catenin (cadherin-associated protein), beta 1, 88kDa	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	10772923
DLL1	DELTA1 \| DL1 \| Delta	delta-like 1 (Drosophila)	Delta1 interacts with MAGI-1.	BIND	15509766
FCHSD2	KIAA0769 \| NWK \| SH3MD3	FCH and double SH3 domains 2	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	14627983
IL6R	CD126 \| IL-6R-1 \| IL-6R-alpha \| IL6RA \| MGC104991	interleukin 6 receptor	-	HPRD	9169421
LRP2	DBS \| gp330	low density lipoprotein-related protein 2	-	HPRD,BioGRID	11274227
NET1	ARHGEF8 \| NET1A	neuroepithelial cell transforming 1	-	HPRD,BioGRID	11350080
RASA1	CM-AVM \| CMAVM \| DKFZp434N071 \| GAP \| PKWS \| RASA \| RASGAP \| p120GAP \| p120RASGAP	RAS p21 protein activator (GTPase activating protein) 1	-	HPRD	9169421
SFN	YWHAS	stratifin	Affinity Capture-MS	BioGRID	15778465
SYNPO	KIAA1029	synaptopodin	-	HPRD,BioGRID	12042308
TP53BP2	53BP2 \| ASPP2 \| BBP \| PPP1R13A \| p53BP2	tumor protein p53 binding protein, 2	-	HPRD	9169421
WBP1	MGC15305 \| WBP-1	WW domain binding protein 1	Protein-peptide	BioGRID	9169421
WBP2	MGC18269 \| WBP-2	WW domain binding protein 2	Protein-peptide	BioGRID	9169421

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_TIGHT_JUNCTION	134	86	All SZGR genes in this pathway
RODRIGUES_NTN1_TARGETS_DN	158	102	All SZGR genes in this pathway
WANG_CLIM2_TARGETS_UP	269	146	All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP	1821	933	All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN	805	505	All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN	537	339	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN	1781	1082	All SZGR genes in this pathway
KIM_MYC_AMPLIFICATION_TARGETS_UP	201	127	All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION	475	313	All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_MS_UP	48	32	All SZGR genes in this pathway
LEIN_ASTROCYTE_MARKERS	42	35	All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN	366	257	All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A	898	516	All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_UP	271	165	All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF	516	308	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	1455	1462	1A,m8	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-153	1929	1935	m8	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-182	237	244	1A,m8	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-185	328	334	m8	hsa-miR-185^brain	UGGAGAGAAAGGCAGUUC
miR-188	255	262	1A,m8	hsa-miR-188	CAUCCCUUGCAUGGUGGAGGGU
miR-205	576	583	1A,m8	hsa-miR-205	UCCUUCAUUCCACCGGAGUCUG
miR-23	1628	1634	m8	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	1628	1634	m8	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-24	1315	1322	1A,m8	hsa-miR-24^SZ	UGGCUCAGUUCAGCAGGAACAG
miR-320	1959	1965	1A	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-323	1628	1634	1A	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-34b	1306	1313	1A,m8	hsa-miR-34b	UAGGCAGUGUCAUUAGCUGAUUG
miR-381	1587	1594	1A,m8	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-411	26	32	m8	hsa-miR-411	AACACGGUCCACUAACCCUCAGU
miR-496	1707	1713	1A	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-96	238	244	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.