Gene Page: CIAO1
Summary ?
| GeneID | 9391 |
| Symbol | CIAO1 |
| Synonyms | CIA1|WDR39 |
| Description | cytosolic iron-sulfur assembly component 1 |
| Reference | MIM:604333|HGNC:HGNC:14280|HPRD:16057| |
| Gene type | protein-coding |
| Map location | 2q11.2 |
| Pascal p-value | 2.108E-5 |
| eGene | Caudate basal ganglia Cerebellum Cortex Frontal Cortex BA9 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.0004 | |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0033 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| PTPRR | 0.77 | 0.78 |
| ARL1 | 0.74 | 0.82 |
| OXCT1 | 0.74 | 0.72 |
| ASPH | 0.72 | 0.76 |
| ATP6AP2 | 0.72 | 0.75 |
| HPCAL4 | 0.72 | 0.72 |
| MYRIP | 0.72 | 0.69 |
| NKIRAS1 | 0.72 | 0.77 |
| BNIP3 | 0.72 | 0.77 |
| GABRA5 | 0.72 | 0.71 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SH2D2A | -0.43 | -0.48 |
| HYAL2 | -0.39 | -0.42 |
| SH3BP2 | -0.38 | -0.42 |
| SMTN | -0.38 | -0.44 |
| SLC16A13 | -0.37 | -0.40 |
| AC132872.1 | -0.36 | -0.42 |
| ZNF814 | -0.36 | -0.44 |
| AF347015.18 | -0.35 | -0.12 |
| SH2B2 | -0.34 | -0.36 |
| SEMA4B | -0.34 | -0.35 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005515 | protein binding | IPI | 17353931 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | TAS | 9556563 | |
| GO:0008284 | positive regulation of cell proliferation | TAS | 9556563 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005634 | nucleus | IEA | - |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| CCDC7 | BioT2-A | BioT2-B | BioT2-C | DKFZp686N0559 | FLJ32762 | RP11-479G22.1 | coiled-coil domain containing 7 | Two-hybrid | BioGRID | 16189514 |
| FAM96A | FLJ22875 | family with sequence similarity 96, member A | Two-hybrid | BioGRID | 16189514 |
| FAM96B | CGI-128 | family with sequence similarity 96, member B | Two-hybrid | BioGRID | 16189514 |
| GAS8 | GAS11 | MGC138326 | growth arrest-specific 8 | Affinity Capture-MS | BioGRID | 17353931 |
| HEATR2 | FLJ20397 | FLJ25564 | FLJ31671 | FLJ39381 | HEAT repeat containing 2 | Affinity Capture-MS | BioGRID | 17353931 |
| KIAA1967 | DBC-1 | DBC1 | KIAA1967 | Affinity Capture-MS | BioGRID | 17353931 |
| MCM5 | CDC46 | MGC5315 | P1-CDC46 | minichromosome maintenance complex component 5 | Affinity Capture-MS | BioGRID | 17353931 |
| MLF2 | NTN4 | myeloid leukemia factor 2 | Affinity Capture-MS | BioGRID | 17353931 |
| MYO1C | FLJ23903 | MMI-beta | MMIb | NMI | myr2 | myosin IC | Affinity Capture-MS | BioGRID | 17353931 |
| USP11 | UHX1 | ubiquitin specific peptidase 11 | Affinity Capture-MS | BioGRID | 17353931 |
| WT1 | GUD | WAGR | WIT-2 | WT33 | Wilms tumor 1 | - | HPRD | 9556563 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| ONKEN UVEAL MELANOMA UP | 783 | 507 | All SZGR 2.0 genes in this pathway |
| GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN | 493 | 298 | All SZGR 2.0 genes in this pathway |
| ZHOU INFLAMMATORY RESPONSE LIVE DN | 384 | 220 | All SZGR 2.0 genes in this pathway |
| BARRIER COLON CANCER RECURRENCE UP | 42 | 28 | All SZGR 2.0 genes in this pathway |
| SMIRNOV CIRCULATING ENDOTHELIOCYTES IN CANCER UP | 158 | 103 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN MLL SIGNATURE 2 UP | 418 | 263 | All SZGR 2.0 genes in this pathway |
| TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC DN | 187 | 115 | All SZGR 2.0 genes in this pathway |
| BENPORATH MYC MAX TARGETS | 775 | 494 | All SZGR 2.0 genes in this pathway |
| MANALO HYPOXIA DN | 289 | 166 | All SZGR 2.0 genes in this pathway |
| JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION DN | 66 | 47 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR | 681 | 420 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 2 | 473 | 224 | All SZGR 2.0 genes in this pathway |
| MOOTHA PGC | 420 | 269 | All SZGR 2.0 genes in this pathway |
| SHEDDEN LUNG CANCER POOR SURVIVAL A6 | 456 | 285 | All SZGR 2.0 genes in this pathway |
| YAGI AML WITH INV 16 TRANSLOCATION | 422 | 277 | All SZGR 2.0 genes in this pathway |
| CAIRO HEPATOBLASTOMA CLASSES UP | 605 | 377 | All SZGR 2.0 genes in this pathway |
| DANG BOUND BY MYC | 1103 | 714 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |