Gene Page: MED26
Summary ?
GeneID | 9441 |
Symbol | MED26 |
Synonyms | CRSP7|CRSP70 |
Description | mediator complex subunit 26 |
Reference | MIM:605043|HGNC:HGNC:2376|Ensembl:ENSG00000105085|HPRD:05437|Vega:OTTHUMG00000182433 |
Gene type | protein-coding |
Map location | 19p13.11 |
Pascal p-value | 0.968 |
Fetal beta | 0.544 |
DMG | 1 (# studies) |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
CV:PGCnp | Genome-wide Association Study | GWAS | |
DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
---|---|---|---|---|---|---|---|
cg13393793 | 19 | 16686742 | MED26 | 1.098E-4 | 0.393 | 0.028 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
GRAMD1B | 0.93 | 0.92 |
DNAJC16 | 0.91 | 0.92 |
PHLPP2 | 0.91 | 0.93 |
MYCBP2 | 0.91 | 0.92 |
CAMTA1 | 0.91 | 0.93 |
ZCCHC2 | 0.91 | 0.92 |
MYO5A | 0.91 | 0.93 |
LMTK2 | 0.90 | 0.93 |
BTBD9 | 0.90 | 0.92 |
TGOLN2 | 0.90 | 0.91 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
AF347015.21 | -0.61 | -0.63 |
AF347015.31 | -0.57 | -0.59 |
C1orf54 | -0.57 | -0.67 |
FXYD1 | -0.56 | -0.56 |
C1orf61 | -0.56 | -0.69 |
HIGD1B | -0.56 | -0.60 |
PLA2G5 | -0.55 | -0.57 |
AP002478.3 | -0.55 | -0.59 |
MT-CO2 | -0.55 | -0.59 |
ACSF2 | -0.55 | -0.57 |
Section IV. Protein-protein interaction annotation
Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
---|---|---|---|---|---|
CDC2L6 | CDK11 | KIAA1028 | bA346C16.3 | cell division cycle 2-like 6 (CDK8-like) | Affinity Capture-MS | BioGRID | 15175163 |
CDK8 | K35 | MGC126074 | MGC126075 | cyclin-dependent kinase 8 | Affinity Capture-MS Affinity Capture-Western | BioGRID | 15175163 |
CEBPB | C/EBP-beta | CRP2 | IL6DBP | LAP | MGC32080 | NF-IL6 | TCF5 | CCAAT/enhancer binding protein (C/EBP), beta | Affinity Capture-Western | BioGRID | 14759369 |
MED1 | CRSP1 | CRSP200 | DRIP205 | DRIP230 | MGC71488 | PBP | PPARBP | PPARGBP | RB18A | TRAP220 | TRIP2 | mediator complex subunit 1 | Affinity Capture-MS | BioGRID | 15175163 |
MED10 | L6 | MGC5309 | NUT2 | TRG20 | mediator complex subunit 10 | Affinity Capture-MS | BioGRID | 15175163 |
MED11 | HSPC296 | MGC88387 | mediator complex subunit 11 | Affinity Capture-MS | BioGRID | 15175163 |
MED12 | CAGH45 | HOPA | KIAA0192 | OPA1 | TNRC11 | TRAP230 | mediator complex subunit 12 | Affinity Capture-MS Affinity Capture-Western | BioGRID | 15175163 |
MED13 | ARC250 | DRIP250 | HSPC221 | KIAA0593 | THRAP1 | TRAP240 | mediator complex subunit 13 | Affinity Capture-MS | BioGRID | 15175163 |
MED13L | DKFZp781D0112 | FLJ21627 | KIAA1025 | PROSIT240 | THRAP2 | TRAP240L | mediator complex subunit 13-like | Affinity Capture-MS | BioGRID | 15175163 |
MED14 | CRSP150 | CRSP2 | CSRP | CXorf4 | DRIP150 | EXLM1 | MGC104513 | RGR1 | TRAP170 | mediator complex subunit 14 | Affinity Capture-MS | BioGRID | 15175163 |
MED15 | ARC105 | CAG7A | CTG7A | DKFZp686A2214 | DKFZp762B1216 | FLJ42282 | FLJ42935 | PCQAP | TIG-1 | TIG1 | TNRC7 | mediator complex subunit 15 | Affinity Capture-MS | BioGRID | 15175163 |
MED16 | DRIP92 | THRAP5 | TRAP95 | mediator complex subunit 16 | Affinity Capture-MS | BioGRID | 15175163 |
MED17 | CRSP6 | CRSP77 | DRIP80 | FLJ10812 | TRAP80 | mediator complex subunit 17 | Affinity Capture-MS | BioGRID | 15175163 |
MED18 | FLJ20045 | p28b | mediator complex subunit 18 | Affinity Capture-MS | BioGRID | 15175163 |
MED19 | DT2P1G7 | LCMR1 | mediator complex subunit 19 | Affinity Capture-MS | BioGRID | 15175163 |
MED20 | DKFZp586D2223 | MGC29869 | PRO0213 | TRFP | mediator complex subunit 20 | Affinity Capture-MS | BioGRID | 15175163 |
MED21 | SRB7 | SURB7 | mediator complex subunit 21 | Affinity Capture-MS | BioGRID | 15175163 |
MED22 | MED24 | MGC48682 | SURF5 | mediator complex subunit 22 | Affinity Capture-MS | BioGRID | 15175163 |
MED23 | CRSP130 | CRSP133 | CRSP3 | DKFZp434H0117 | DRIP130 | SUR2 | mediator complex subunit 23 | Affinity Capture-MS | BioGRID | 15175163 |
MED24 | ARC100 | CRSP100 | CRSP4 | DRIP100 | KIAA0130 | MGC8748 | THRAP4 | TRAP100 | mediator complex subunit 24 | Affinity Capture-MS | BioGRID | 15175163 |
MED25 | ACID1 | ARC92 | DKFZp434K0512 | MGC70671 | P78 | PTOV2 | TCBAP0758 | mediator complex subunit 25 | Affinity Capture-MS | BioGRID | 15175163 |
MED26 | CRSP7 | CRSP70 | mediator complex subunit 26 | Affinity Capture-MS | BioGRID | 15175163 |
MED27 | CRAP34 | CRSP34 | CRSP8 | MGC11274 | TRAP37 | mediator complex subunit 27 | Affinity Capture-MS | BioGRID | 15175163 |
MED28 | 1500003D12Rik | DKFZp434N185 | EG1 | magicin | mediator complex subunit 28 | - | HPRD,BioGRID | 15175163 |
MED29 | DKFZp434H247 | IXL | mediator complex subunit 29 | - | HPRD | 14576168 |
MED29 | DKFZp434H247 | IXL | mediator complex subunit 29 | Affinity Capture-MS | BioGRID | 15175163 |
MED30 | MGC9890 | THRAP6 | TRAP25 | mediator complex subunit 30 | Affinity Capture-MS | BioGRID | 15175163 |
MED31 | 3110004H13Rik | CGI-125 | FLJ27436 | FLJ36714 | Soh1 | mediator complex subunit 31 | Affinity Capture-MS | BioGRID | 15175163 |
MED4 | DRIP36 | FLJ10956 | HSPC126 | RP11-90M2.2 | TRAP36 | VDRIP | mediator complex subunit 4 | Affinity Capture-MS | BioGRID | 15175163 |
MED6 | NY-REN-28 | mediator complex subunit 6 | Affinity Capture-MS | BioGRID | 15175163 |
MED7 | CRSP33 | CRSP9 | MGC12284 | mediator complex subunit 7 | Affinity Capture-MS | BioGRID | 15175163 |
MED8 | ARC32 | MGC17544 | MGC19641 | mediator complex subunit 8 | Affinity Capture-MS Affinity Capture-Western | BioGRID | 15175163 |
MED9 | FLJ10193 | MED25 | MGC138234 | mediator complex subunit 9 | - | HPRD | 14638676 |
MED9 | FLJ10193 | MED25 | MGC138234 | mediator complex subunit 9 | Affinity Capture-MS | BioGRID | 15175163 |
POLR2A | MGC75453 | POLR2 | POLRA | RPB1 | RPBh1 | RPO2 | RPOL2 | RpIILS | hRPB220 | hsRPB1 | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | Affinity Capture-MS Affinity Capture-Western | BioGRID | 15175163 |
POLR2B | POL2RB | RPB2 | hRPB140 | hsRPB2 | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | Affinity Capture-MS | BioGRID | 15175163 |
POLR2C | RPB3 | RPB31 | hRPB33 | hsRPB3 | polymerase (RNA) II (DNA directed) polypeptide C, 33kDa | Affinity Capture-MS | BioGRID | 15175163 |
POLR2D | HSRBP4 | HSRPB4 | RBP4 | polymerase (RNA) II (DNA directed) polypeptide D | Affinity Capture-MS | BioGRID | 15175163 |
POLR2E | RPABC1 | RPB5 | XAP4 | hRPB25 | hsRPB5 | polymerase (RNA) II (DNA directed) polypeptide E, 25kDa | Affinity Capture-MS | BioGRID | 15175163 |
POLR2F | HRBP14.4 | POLRF | RPABC2 | RPB14.4 | RPB6 | polymerase (RNA) II (DNA directed) polypeptide F | Affinity Capture-MS | BioGRID | 15175163 |
POLR2G | MGC138367 | MGC138369 | RPB7 | hRPB19 | hsRPB7 | polymerase (RNA) II (DNA directed) polypeptide G | Affinity Capture-MS | BioGRID | 15175163 |
POLR2H | RPABC3 | RPB17 | RPB8 | hsRPB8 | polymerase (RNA) II (DNA directed) polypeptide H | Affinity Capture-MS | BioGRID | 15175163 |
POLR2I | RPB9 | hRPB14.5 | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | Affinity Capture-MS | BioGRID | 15175163 |
POLR2J | MGC71910 | POLR2J1 | RPB11 | RPB11A | RPB11m | hRPB14 | polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa | Affinity Capture-MS | BioGRID | 15175163 |
POLR2L | RBP10 | RPABC5 | RPB10 | RPB10beta | RPB7.6 | hRPB7.6 | hsRPB10b | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa | Affinity Capture-MS | BioGRID | 15175163 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
REACTOME DEVELOPMENTAL BIOLOGY | 396 | 292 | All SZGR 2.0 genes in this pathway |
REACTOME PPARA ACTIVATES GENE EXPRESSION | 104 | 72 | All SZGR 2.0 genes in this pathway |
REACTOME GENERIC TRANSCRIPTION PATHWAY | 352 | 181 | All SZGR 2.0 genes in this pathway |
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS | 478 | 302 | All SZGR 2.0 genes in this pathway |
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM | 168 | 115 | All SZGR 2.0 genes in this pathway |
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | 72 | 53 | All SZGR 2.0 genes in this pathway |
ZHOU INFLAMMATORY RESPONSE LIVE UP | 485 | 293 | All SZGR 2.0 genes in this pathway |
POS RESPONSE TO HISTAMINE DN | 11 | 9 | All SZGR 2.0 genes in this pathway |
POS HISTAMINE RESPONSE NETWORK | 32 | 22 | All SZGR 2.0 genes in this pathway |
BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |
PEDRIOLI MIR31 TARGETS DN | 418 | 245 | All SZGR 2.0 genes in this pathway |