Gene Page: CIR1
Summary ?
| GeneID | 9541 |
| Symbol | CIR1 |
| Synonyms | CIR |
| Description | corepressor interacting with RBPJ, 1 |
| Reference | MIM:605228|HGNC:HGNC:24217|Ensembl:ENSG00000138433|HPRD:05568|Vega:OTTHUMG00000132338 |
| Gene type | protein-coding |
| Map location | 2q31.1 |
| Pascal p-value | 0.027 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs1570589 | chr9 | 116874354 | CIR1 | 9541 | 0.06 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ATF2 | 0.94 | 0.94 |
| ZFR | 0.94 | 0.93 |
| KPNA4 | 0.93 | 0.94 |
| RAD23B | 0.93 | 0.93 |
| FBXO38 | 0.93 | 0.92 |
| ZBTB11 | 0.93 | 0.94 |
| IARS | 0.92 | 0.93 |
| COPB2 | 0.92 | 0.92 |
| TBC1D23 | 0.92 | 0.92 |
| GOLPH3 | 0.92 | 0.93 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| FXYD1 | -0.77 | -0.80 |
| MT-CO2 | -0.75 | -0.77 |
| HIGD1B | -0.74 | -0.76 |
| AF347015.21 | -0.74 | -0.75 |
| IFI27 | -0.74 | -0.77 |
| AF347015.31 | -0.73 | -0.76 |
| AF347015.33 | -0.72 | -0.73 |
| AF347015.8 | -0.72 | -0.75 |
| AC021016.1 | -0.71 | -0.71 |
| MT-CYB | -0.70 | -0.72 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG NOTCH SIGNALING PATHWAY | 47 | 35 | All SZGR 2.0 genes in this pathway |
| PARENT MTOR SIGNALING UP | 567 | 375 | All SZGR 2.0 genes in this pathway |
| GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN | 493 | 298 | All SZGR 2.0 genes in this pathway |
| DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN | 320 | 184 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN MLL SIGNATURE 1 DN | 242 | 165 | All SZGR 2.0 genes in this pathway |
| HAMAI APOPTOSIS VIA TRAIL UP | 584 | 356 | All SZGR 2.0 genes in this pathway |
| SHIRAISHI PLZF TARGETS UP | 10 | 5 | All SZGR 2.0 genes in this pathway |
| SCHLOSSER SERUM RESPONSE DN | 712 | 443 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| BUYTAERT PHOTODYNAMIC THERAPY STRESS UP | 811 | 508 | All SZGR 2.0 genes in this pathway |
| BENPORATH MYC MAX TARGETS | 775 | 494 | All SZGR 2.0 genes in this pathway |
| CHEOK RESPONSE TO MERCAPTOPURINE DN | 22 | 15 | All SZGR 2.0 genes in this pathway |
| URS ADIPOCYTE DIFFERENTIATION UP | 74 | 51 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS MATURE CELL | 293 | 160 | All SZGR 2.0 genes in this pathway |
| KYNG DNA DAMAGE BY UV | 62 | 43 | All SZGR 2.0 genes in this pathway |
| KYNG DNA DAMAGE DN | 195 | 135 | All SZGR 2.0 genes in this pathway |
| IWANAGA CARCINOGENESIS BY KRAS PTEN DN | 353 | 226 | All SZGR 2.0 genes in this pathway |
| RIZKI TUMOR INVASIVENESS 3D DN | 270 | 181 | All SZGR 2.0 genes in this pathway |
| DANG BOUND BY MYC | 1103 | 714 | All SZGR 2.0 genes in this pathway |