Gene Page: PPIP5K1
Summary ?
| GeneID | 9677 |
| Symbol | PPIP5K1 |
| Synonyms | HISPPD2A|IP6K|IPS1|VIP1|hsVIP1 |
| Description | diphosphoinositol pentakisphosphate kinase 1 |
| Reference | MIM:610979|HGNC:HGNC:29023|Ensembl:ENSG00000168781|HPRD:13798|Vega:OTTHUMG00000059758 |
| Gene type | protein-coding |
| Map location | 15q15.3 |
| Pascal p-value | 2.383E-4 |
| Sherlock p-value | 0.296 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs16829545 | chr2 | 151977407 | PPIP5K1 | 9677 | 2.732E-4 | trans | ||
| rs16955618 | chr15 | 29937543 | PPIP5K1 | 9677 | 7.896E-4 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| CUL5 | 0.92 | 0.94 |
| BAG5 | 0.91 | 0.93 |
| API5L1 | 0.91 | 0.92 |
| SLC30A9 | 0.91 | 0.93 |
| TBL1XR1 | 0.91 | 0.92 |
| RNMT | 0.91 | 0.93 |
| MIER1 | 0.91 | 0.94 |
| KIAA1012 | 0.91 | 0.92 |
| CAB39 | 0.91 | 0.92 |
| USP33 | 0.90 | 0.93 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| HSD17B14 | -0.67 | -0.69 |
| FXYD1 | -0.67 | -0.71 |
| HIGD1B | -0.67 | -0.71 |
| MT-CO2 | -0.67 | -0.70 |
| IFI27 | -0.66 | -0.71 |
| METRN | -0.66 | -0.73 |
| AF347015.31 | -0.65 | -0.69 |
| CST3 | -0.65 | -0.71 |
| AF347015.21 | -0.65 | -0.67 |
| MT-CYB | -0.65 | -0.67 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN | 493 | 298 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| TAKAYAMA BOUND BY AR | 10 | 6 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR UP | 953 | 554 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR UP | 783 | 442 | All SZGR 2.0 genes in this pathway |
| MCCABE BOUND BY HOXC6 | 469 | 239 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER BASAL DN | 701 | 446 | All SZGR 2.0 genes in this pathway |
| TOYOTA TARGETS OF MIR34B AND MIR34C | 463 | 262 | All SZGR 2.0 genes in this pathway |
| CADWELL ATG16L1 TARGETS DN | 70 | 43 | All SZGR 2.0 genes in this pathway |
| POOLA INVASIVE BREAST CANCER DN | 134 | 83 | All SZGR 2.0 genes in this pathway |
| KOINUMA TARGETS OF SMAD2 OR SMAD3 | 824 | 528 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D | 882 | 506 | All SZGR 2.0 genes in this pathway |