Gene Page: CDC5L

Summary
GeneID  988
Symbol  CDC5L
Synonyms  CEF1|KIAA0432|PCDC5RP|dJ319D22.1|hCDC5
Description  CDC5 cell division cycle 5-like (S. pombe)
See related  HGNC:1743|MIM:602868|Ensembl:ENSG00000096401|HPRD:04184|
Locus tag  RP1-319D22.1
Gene type  protein-coding
Map location  6p21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.04433 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0114 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
CHEK10.930.79
TIMELESS0.920.81
GINS10.910.80
DEPDC1B0.910.78
MCM20.910.84
GINS20.910.73
FBXO50.910.81
DTL0.900.80
WEE10.900.80
RRM10.900.84
Top 10 negatively co-expressed genes
C5orf53-0.55-0.74
HLA-F-0.54-0.71
AF347015.27-0.51-0.78
PTH1R-0.51-0.66
ASPHD1-0.51-0.57
FBXO2-0.51-0.59
AF347015.31-0.51-0.77
CA4-0.51-0.69
SLC16A11-0.50-0.61
MT-CO2-0.50-0.79
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingNAS8917598 
GO:0003723RNA bindingIEA-
GO:0005515protein bindingIPI15232106 |17353931 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentNAS-
GO:0006397mRNA processingIEA-
GO:0008380RNA splicingIEA-
GO:0007049cell cycleIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusNAS-
GO:0005681spliceosomeIEA-
GO:0005730nucleolusIDA18029348 
GO:0005737cytoplasmIEA-
GO:0016607nuclear speckIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
PLRG1MGC110980 | PRL1pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)CDC5L interacts with PLRG1.BIND11544257 
-HPRD,BioGRID11101529 |11544257 
|14576297 
PPP1CAMGC15877 | MGC1674 | PP-1A | PPP1Aprotein phosphatase 1, catalytic subunit, alpha isoform-HPRD10827081 
PPP1R8ARD-1 | ARD1 | NIPP-1 | NIPP1 | PRO2047protein phosphatase 1, regulatory (inhibitor) subunit 8-HPRD,BioGRID10827081 
PPP2CAPP2Ac | PP2CA | RP-Cprotein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoformin vitro
in vivo
Two-hybrid		BioGRID10827081 
TTF2HuF2transcription termination factor, RNA polymerase II-HPRD,BioGRID12927788 
HuF2 interacts with CDC5L.BIND12927788 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_SPLICEOSOME 12872All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN 493298All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_UP 423283All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_UP 404246All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_6HR_UP 5534All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_DN 214133All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
XU_AKT1_TARGETS_6HR 2718All SZGR genes in this pathway
MOREAUX_MULTIPLE_MYELOMA_BY_TACI_UP 412249All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_UP 240152All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_16HR_UP 225139All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP 390242All SZGR genes in this pathway
JIANG_AGING_CEREBRAL_CORTEX_UP 3627All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
YAMAZAKI_TCEB3_TARGETS_DN 215132All SZGR genes in this pathway
MA_PITUITARY_FETAL_VS_ADULT_UP 2921All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_18HR_UP 178111All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_24HR_UP 14896All SZGR genes in this pathway
MARTINEZ_RESPONSE_TO_TRABECTEDIN_DN 271175All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP 973570All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP 863514All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_DN 315197All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
ALONSO_METASTASIS_UP 198128All SZGR genes in this pathway
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_DN 4022All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP 518299All SZGR genes in this pathway
OKAMOTO_LIVER_CANCER_MULTICENTRIC_OCCURRENCE_UP 2515All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_DN 336211All SZGR genes in this pathway
PASINI_SUZ12_TARGETS_UP 11265All SZGR genes in this pathway
YU_BAP1_TARGETS 2921All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_A 182108All SZGR genes in this pathway
PECE_MAMMARY_STEM_CELL_DN 14688All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-186213219m8hsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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