Gene Page: PAN2
Summary ?
| GeneID | 9924 |
| Symbol | PAN2 |
| Synonyms | USP52 |
| Description | PAN2 poly(A) specific ribonuclease subunit |
| Reference | HGNC:HGNC:20074|Ensembl:ENSG00000135473|HPRD:15640|Vega:OTTHUMG00000170412 |
| Gene type | protein-coding |
| Map location | 12q13.3 |
| Pascal p-value | 0.042 |
| Sherlock p-value | 0.592 |
| eGene | Myers' cis & trans |
| Support | Ascano FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs16829545 | chr2 | 151977407 | PAN2 | 9924 | 0.09 | trans | ||
| rs16955618 | chr15 | 29937543 | PAN2 | 9924 | 0 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MOCS2 | 0.86 | 0.86 |
| TMEM111 | 0.85 | 0.87 |
| CISD1 | 0.83 | 0.87 |
| UBE2F | 0.82 | 0.83 |
| MDH1 | 0.81 | 0.85 |
| NDUFAF4 | 0.80 | 0.81 |
| CACYBP | 0.80 | 0.83 |
| POP4 | 0.79 | 0.78 |
| TTC1 | 0.79 | 0.81 |
| NDUFA9 | 0.79 | 0.82 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SMTN | -0.45 | -0.51 |
| ANP32C | -0.41 | -0.42 |
| AC010300.1 | -0.40 | -0.36 |
| AF347015.18 | -0.39 | -0.16 |
| RP4-697K14.1 | -0.39 | -0.46 |
| CASKIN2 | -0.38 | -0.37 |
| SH2D2A | -0.37 | -0.43 |
| AC100783.1 | -0.37 | -0.32 |
| CDC42EP4 | -0.37 | -0.39 |
| SH3BP2 | -0.37 | -0.41 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| GARY CD5 TARGETS UP | 473 | 314 | All SZGR 2.0 genes in this pathway |
| EBAUER TARGETS OF PAX3 FOXO1 FUSION UP | 207 | 128 | All SZGR 2.0 genes in this pathway |
| LUI THYROID CANCER CLUSTER 2 | 42 | 31 | All SZGR 2.0 genes in this pathway |
| NUYTTEN EZH2 TARGETS DN | 1024 | 594 | All SZGR 2.0 genes in this pathway |
| ONDER CDH1 TARGETS 1 UP | 140 | 85 | All SZGR 2.0 genes in this pathway |
| BROCKE APOPTOSIS REVERSED BY IL6 | 144 | 98 | All SZGR 2.0 genes in this pathway |
| ZHAN MULTIPLE MYELOMA CD1 AND CD2 UP | 89 | 51 | All SZGR 2.0 genes in this pathway |
| KUMAR TARGETS OF MLL AF9 FUSION | 405 | 264 | All SZGR 2.0 genes in this pathway |
| DOUGLAS BMI1 TARGETS DN | 314 | 188 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY E2F4 UNSTIMULATED | 728 | 415 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER BASAL DN | 701 | 446 | All SZGR 2.0 genes in this pathway |
| TOYOTA TARGETS OF MIR34B AND MIR34C | 463 | 262 | All SZGR 2.0 genes in this pathway |
| SWEET LUNG CANCER KRAS UP | 491 | 316 | All SZGR 2.0 genes in this pathway |
| WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP | 397 | 206 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 36HR | 152 | 88 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D | 882 | 506 | All SZGR 2.0 genes in this pathway |