Gene Page: C2CD4B

Summary ?
GeneID388125
SymbolC2CD4B
SynonymsFAM148B|NLF2
DescriptionC2 calcium-dependent domain containing 4B
ReferenceMIM:610344|HGNC:HGNC:33628|Ensembl:ENSG00000205502|HPRD:17636|Vega:OTTHUMG00000171959
Gene typeprotein-coding
Map location15q22.2
Pascal p-value0.046
Fetal beta-0.28
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
CV:PheWASPhenome-wide association studies (PheWAS)157 SNPs associated with schizophrenia 0
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@CV:PheWAS

SNP IDChromosomePositionAllelePFunctionGeneUp/Down Distance

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg204315651562684395C2CD4B6.06E-8-0.0081.52E-5DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs3738369chr141486407C2CD4B3881250.13trans
rs6692027chr193787740C2CD4B3881250.01trans
rs1342707chr1147264296C2CD4B3881250.02trans
rs2284755chr1168403681C2CD4B3881250.16trans
rs6658896chr1206926845C2CD4B3881250.02trans
rs17022385chr1207357521C2CD4B3881250.07trans
rs10209546chr253408320C2CD4B3881250.02trans
rs1597005chr2116736707C2CD4B3881251.144E-6trans
rs7585275chr2201344041C2CD4B3881250.08trans
rs16839485chr2208117480C2CD4B3881250.03trans
rs17303478chr347897366C2CD4B3881250.02trans
rs6784955chr396346542C2CD4B3881250.06trans
rs3772753chr3124145424C2CD4B3881250.01trans
rs4680298chr3156387114C2CD4B3881250.08trans
rs133510190C2CD4B3881250.1trans
rs16898010chr419036545C2CD4B3881250.19trans
rs7664889chr477087703C2CD4B3881250.07trans
rs2053487chr477097335C2CD4B3881250.08trans
rs13117802chr477103928C2CD4B3881250.04trans
rs4859625chr477104528C2CD4B3881250.04trans
rs336304chr4143019414C2CD4B3881250.02trans
rs336306chr4143019811C2CD4B3881250.02trans
rs336330chr4143022762C2CD4B3881250.11trans
rs3846532chr555701103C2CD4B3881250.15trans
rs17334370chr5101914561C2CD4B3881251.954E-4trans
rs17168672chr5134913655C2CD4B3881250.06trans
rs10063177chr5145081194C2CD4B3881250.18trans
rs11749499chr5172288696C2CD4B3881250.14trans
rs11743007chr5172288906C2CD4B3881250.14trans
rs793014chr5172288950C2CD4B3881250.03trans
rs2962835chr5176331831C2CD4B3881250.02trans
rs10516136chr5176381368C2CD4B3881250.02trans
rs10069302chr5176461594C2CD4B3881250.08trans
rs6881260chr5176464003C2CD4B3881250.08trans
rs6860827chr5176479648C2CD4B3881250.08trans
rs6887893chr5176493262C2CD4B3881250.08trans
rs6886832chr5177874002C2CD4B3881250.02trans
rs7774296chr66391151C2CD4B3881250.17trans
rs2281127chr611735767C2CD4B3881250.07trans
rs2313754chr676652442C2CD4B3881250.01trans
snp_a-19872010C2CD4B3881255.562E-5trans
rs1159646chr6147914445C2CD4B3881250.18trans
rs16899916chr6167579101C2CD4B3881250.06trans
rs10952038chr77176854C2CD4B3881250.01trans
rs6960358chr719307526C2CD4B3881250.03trans
rs2191892chr719327087C2CD4B3881250.14trans
rs12536066chr7101263880C2CD4B3881250.08trans
rs2469395chr83511971C2CD4B3881250.13trans
rs2469394chr83512186C2CD4B3881250.1trans
rs7822021chr88145522C2CD4B3881254.698E-6trans
rs10108493chr816448604C2CD4B3881250.01trans
rs2623858chr868677367C2CD4B3881250.12trans
rs2623857chr868677408C2CD4B3881250.12trans
rs6989092chr894989037C2CD4B3881250.1trans
rs17722245chr91070774C2CD4B3881250trans
rs10756499chr913769689C2CD4B3881250.11trans
rs1930367chr981584844C2CD4B3881250.08trans
rs16911887chr997734604C2CD4B3881250.19trans
rs10993422chr997735638C2CD4B3881250.19trans
rs10993429chr997739464C2CD4B3881250.19trans
rs10512250chr997763154C2CD4B3881250.19trans
rs10993509chr998071989C2CD4B3881250.12trans
rs7019048chr9102278601C2CD4B3881250.13trans
rs2151040chr9111364777C2CD4B3881250trans
rs10994649chr1062900245C2CD4B3881259.199E-4trans
rs11188623chr1097896966C2CD4B3881250.19trans
rs3814226chr1097920061C2CD4B3881250.19trans
rs3009929chr10121307427C2CD4B3881250.09trans
rs2912754chr10123261693C2CD4B3881250.08trans
rs16937405chr1143252926C2CD4B3881250.2trans
rs2512874chr11131461291C2CD4B3881250.02trans
rs4143624chr1280947210C2CD4B3881250.19trans
rs4761632chr1294944971C2CD4B3881250.08trans
rs1019348chr12127402726C2CD4B3881250.03trans
rs17103839chr1467491122C2CD4B3881250.2trans
rs10147304chr1479079175C2CD4B3881250.2trans
rs8021089chr1479101790C2CD4B3881250.08trans
rs1515411chr1490614916C2CD4B3881250.19trans
rs7172208chr1532994905C2CD4B3881250.04trans
rs2711647chr1554235527C2CD4B3881250.13trans
rs8060783chr1674544560C2CD4B3881250.19trans
rs231523chr1741953997C2CD4B3881250.01trans
rs16977108chr1770142677C2CD4B3881250.18trans
rs16976379chr1840198836C2CD4B3881250.05trans
rs16962554chr1929590544C2CD4B3881250.01trans
rs6516466chr209511571C2CD4B3881250.06trans
rs16979378chr2054701229C2CD4B3881250.11trans
rs458491chr2143366286C2CD4B3881250trans
rs738494chr2244370438C2CD4B3881250.18trans
rs16985093chrX8629830C2CD4B3881250.05trans
rs7054479chrX27852083C2CD4B3881250.01trans
rs16988033chrX27911766C2CD4B3881250.05trans
rs16997889chrX27923926C2CD4B3881250.05trans
rs5971151chrX28024320C2CD4B3881250.03trans
rs93065580C2CD4B3881250.15trans
rs7883016chrX53924269C2CD4B3881250.16trans
rs2516036chrX54198701C2CD4B3881250.18trans
rs1886581chrX68600054C2CD4B3881250.01trans
rs6624414chrX68645139C2CD4B3881250.04trans
rs5977398chrX130127548C2CD4B3881250.12trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
ABBUD LIF SIGNALING 2 UP 1413All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K4ME3 AND H3K27ME3 210148All SZGR 2.0 genes in this pathway
GHANDHI DIRECT IRRADIATION UP 11068All SZGR 2.0 genes in this pathway
GHANDHI BYSTANDER IRRADIATION UP 8654All SZGR 2.0 genes in this pathway