Gene Page: CDKN1A

Summary
GeneID  1026
Symbol  CDKN1A
Synonyms  CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1
Description  cyclin-dependent kinase inhibitor 1A (p21, Cip1)
See related  HGNC:1784|MIM:116899|Ensembl:ENSG00000124762|HPRD:00298|
Locus tag  -
Gene type  protein-coding
Map location  6p21.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.033 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.04433 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.1164 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ANKRD13D0.880.85
SYT30.860.83
MGAT4B0.850.86
ACOT70.850.83
PIP5KL10.830.78
RTN20.830.85
AC011479.20.830.81
FKBP1B0.820.81
CRIP20.820.86
AC024575.20.820.86
Top 10 negatively co-expressed genes
AF347015.8-0.62-0.62
AF347015.33-0.62-0.62
AF347015.27-0.60-0.62
AF347015.26-0.60-0.63
MT-CO2-0.60-0.58
AF347015.15-0.59-0.59
MT-CYB-0.58-0.58
MT-ATP8-0.58-0.64
AF347015.2-0.57-0.57
AF347015.21-0.57-0.58
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004861cyclin-dependent protein kinase inhibitor activityEXP10323868 
GO:0004861cyclin-dependent protein kinase inhibitor activityIEA-
GO:0004861cyclin-dependent protein kinase inhibitor activityTAS8242751 
GO:0004860protein kinase inhibitor activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0016301kinase activityIEA-
GO:0030332cyclin bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000082G1/S transition of mitotic cell cycleIDA10208428 
GO:0000086G2/M transition of mitotic cell cycleIMP17553787 
GO:0007050cell cycle arrestIEA-
GO:0008285negative regulation of cell proliferationIEA-
GO:0008629induction of apoptosis by intracellular signalsTAS9660939 
GO:0009411response to UVIEA-
GO:0006974response to DNA damage stimulusIEA-
GO:0043066negative regulation of apoptosisIEA-
GO:0042326negative regulation of phosphorylationIDA10208428 
GO:0043071positive regulation of non-apoptotic programmed cell deathIEA-
GO:0030890positive regulation of B cell proliferationIEA-
GO:0030308negative regulation of cell growthIDA10208428 
GO:0031668cellular response to extracellular stimulusIMP17553787 
GO:0045736negative regulation of cyclin-dependent protein kinase activityIEA-
GO:0048146positive regulation of fibroblast proliferationIMP17420273 
GO:0051726regulation of cell cycleIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000307cyclin-dependent protein kinase holoenzyme complexIEA-
GO:0005829cytosolEXP9106657 |9632134 
GO:0005829cytosolIEA-
GO:0005634nucleusIEA-
GO:0005654nucleoplasmEXP9190208 |9632134 |9840943 
|10323868 |11231585 
|11931757 |16782892 
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
APEX1APE | APE-1 | APE1 | APEN | APEX | APX | HAP1 | REF-1 | REF1APEX nuclease (multifunctional DNA repair enzyme) 1Ref1 interacts weakly with p21 promoter.BIND15674341 
BCCIPTOK-1 | TOK1BRCA2 and CDKN1A interacting protein-HPRD,BioGRID10878006 |14726710 
C7orf20CEE | CGI-20chromosome 7 open reading frame 20Two-hybridBioGRID16169070 
CCDC85BDIPAcoiled-coil domain containing 85BTwo-hybridBioGRID16189514 
CCNA1-cyclin A1cyclin A1 interacts with p21.BIND10022926 
CCNA2CCN1 | CCNAcyclin A2p21 interacts with cyclin A.BIND9632134 
cyclin A interacts with p21. This interaction was modeled on a demonstrated interaction between monkey cyclin A and monkey p21.BIND16009130 
CDKN1A (p21) interacts with CCNA2 (cyclin A).BIND8662825 
Affinity Capture-WesternBioGRID12947099 
CCNB1CCNBcyclin B1CDKN1A (p21) interacts with CCNB1 (cyclin B1).BIND8662825 
CCND1BCL1 | D11S287E | PRAD1 | U21B31cyclin D1-HPRD,BioGRID7478582 |8657154 
p21 interacts with cyclin D.BIND9632134 
Cyclin D1 interacts with p21.BIND8999999 
CDKN1A (p21) interacts with CCND1 (cyclin D1).BIND8662825 
CCND2KIAK0002 | MGC102758cyclin D2Two-hybridBioGRID16189514 
CCND3-cyclin D3Two-hybridBioGRID16189514 
CCNE1CCNEcyclin E1p21 interacts with cyclin E.BIND9632134 
Affinity Capture-WesternBioGRID12839982 
CDKN1A (p21) interacts with CCNE1 (cyclin E).BIND8662825 
CDC2CDC28A | CDK1 | DKFZp686L20222 | MGC111195cell division cycle 2, G1 to S and G2 to Mp21 interacts with CDC2. This interaction was modeled on a demonstrated interaction between human p21 and hamster CDC2.BIND9467962 
CDC7CDC7L1 | HsCDC7 | Hsk1 | MGC117361 | MGC126237 | MGC126238 | huCDC7cell division cycle 7 homolog (S. cerevisiae)-HPRD15232106 
CDK2p33(CDK2)cyclin-dependent kinase 2p21WAF1 interacts with an unspecified isoform of Cdk2. This interaction was modelled on a demonstrated interaction between human p21WAF1 and Cdk2 from an unspecified species.BIND7780738 
p21 interacts with an unspecified isoform of Cdk2.BIND11302688 
p21 interacts with CDK2. This interaction was modeled on a demonstrated interaction between human p21 and hamster CDK2.BIND9467962 
p21 interacts with Cdk2.BIND9546435 
-HPRD,BioGRID12839982 
CDK4CMM3 | MGC14458 | PSK-J3cyclin-dependent kinase 4Cdk4 interacts with p21.BIND8999999 
CDKN1BCDKN4 | KIP1 | MEN1B | MEN4 | P27KIP1cyclin-dependent kinase inhibitor 1B (p27, Kip1)-HPRD9858585 
CHEK1CHK1CHK1 checkpoint homolog (S. pombe)Affinity Capture-WesternBioGRID11896572 
CIZ1LSFR1 | NP94 | ZNF356CDKN1A interacting zinc finger protein 1-HPRD,BioGRID10529385 
CREBBPCBP | KAT3A | RSTSCREB binding proteinCREBBP (CBP) interacts with the p21 promoter.BIND15710329 
CBP interacts with p21.BIND10764767 
CSNK2A1CK2A1 | CKIIcasein kinase 2, alpha 1 polypeptide-HPRD11255227 
CSNK2BCK2B | CK2N | CSK2B | G5A | MGC138222 | MGC138224casein kinase 2, beta polypeptide-HPRD,BioGRID10679299 
DDX5DKFZp686J01190 | G17P1 | HLR1 | HUMP68 | p68DEAD (Asp-Glu-Ala-Asp) box polypeptide 5p68 interacts with the p21 promoter.BIND15660129 
FOXO1FKH1 | FKHR | FOXO1Aforkhead box O1FoxO1 binds the distal region of the p21Cip1 promoter. This interaction was modelled on a demonstrated interaction between FoxO1 from an unspecified species and p21Cip1 promoter from an unspecified species.BIND15084259 
FOXO3AF6q21 | DKFZp781A0677 | FKHRL1 | FKHRL1P2 | FOXO2 | FOXO3A | MGC12739 | MGC31925forkhead box O3FoxO3 binds the distal region of the p21Cip1 promoter.BIND15084259 
FOXO4AFX | AFX1 | MGC120490 | MLLT7forkhead box O4FoxO4 binds the distal region of the p21Cip1 promoter. This interaction was modelled on a demonstrated interaction between FoxO4 from an unspecified species and p21Cip1 promoter from an unspecified species.BIND15084259 
GADD45ADDIT1 | GADD45growth arrest and DNA-damage-inducible, alpha-HPRD7478594 |11498536 
Affinity Capture-Western
Reconstituted Complex		BioGRID10912791 |10973963 
GADD45BDKFZp566B133 | GADD45BETA | MYD118growth arrest and DNA-damage-inducible, beta-HPRD8700517 
GADD45GCR6 | DDIT2 | GADD45gamma | GRP17growth arrest and DNA-damage-inducible, gamma-HPRD,BioGRID10455148 
GNB2L1Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1Two-hybridBioGRID16169070 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1HDAC1 interacts with the p21 promoter.BIND15710329 
HDAC1 interacts with the CDKN1A (p21) promoter.BIND15674334 
HDAC11FLJ22237histone deacetylase 11Two-hybridBioGRID16169070 
HERC5CEB1 | CEBP1hect domain and RLD 5Reconstituted ComplexBioGRID10581175 
HIF1AHIF-1alpha | HIF1 | HIF1-ALPHA | MOP1 | PASD8hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)HIF-1alpha interacts with CDKN1A promoter.BIND15780936 
HIST4H4H4/p | MGC24116histone cluster 4, H4HIST4H4 (H4) interacts with the CDKN1A promoter.BIND15765097 
HIST4H4 (H4) interacts with the p21 promoter.BIND15710329 
MAP3K5ASK1 | MAPKKK5 | MEKK5mitogen-activated protein kinase kinase kinase 5Affinity Capture-WesternBioGRID12820963 
MDM2HDMX | MGC71221 | hdm2Mdm2 p53 binding protein homolog (mouse)Mdm2 interacts with the p21 promoter.BIND15546622 
MED1CRSP1 | CRSP200 | DRIP205 | DRIP230 | MGC71488 | PBP | PPARBP | PPARGBP | RB18A | TRAP220 | TRIP2mediator complex subunit 1MED1 interacts with p21 promoter.BIND15989967 
MED21SRB7 | SURB7mediator complex subunit 21MED21 interacts with p21 promoter.BIND15989967 
MITFMI | WS2A | bHLHe32microphthalmia-associated transcription factorAn unspecified isoform of Mitf interacts with the p21 promoter.BIND15716956 
MUC1CD227 | EMA | H23AG | MAM6 | PEM | PEMT | PUMmucin 1, cell surface associatedMUC1 C-ter interacts with the p21 promoter.BIND15710329 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)Myc interacts with CDKN1A promoter.BIND15780936 
c-Myc binds the proximal region of the p21Cip1 promoter.BIND15084259 
c-Myc interacts with p21WAF1 promoter.BIND15856024 
PARP1ADPRT | ADPRT1 | PARP | PARP-1 | PPOL | pADPRT-1poly (ADP-ribose) polymerase 1-HPRD,BioGRID12930846 
PCNAMGC8367proliferating cell nuclear antigenCDKN1A (p21) interacts with PCNA.BIND8662825 
p21WAF1 interacts with PCNA.BIND7780738 
PCNA interacts with p21.BIND9705499 
PCNA interacts with p21.BIND9178907 
p21 interacts with PCNA.BIND11302688 
PCNA interacts with p21.BIND8861969 
p21 interacts with PCNA.BIND9632134 
p21 interacts with PCNA. This interaction was modeled on a demonstrated interaction between human p21 and PCNA from an unspecified species.BIND9546435 
-HPRD,BioGRID8861913 
p21WAF1 interacts with PCNA. This interaction was modeled on a demonstrated interaction between human p21WAF1 and Pisum sativum v. Onward PCNA.BIND8647134 
p21 interacts with PCNA. This interaction was modeled on a demonstrated interaction between human p21 and hamster PCNA.BIND9467962 
PIAS2MGC102682 | MIZ1 | PIASX | PIASX-ALPHA | PIASX-BETA | SIZ2 | ZMIZ4 | mizprotein inhibitor of activated STAT, 2Miz1 interacts with p-P21CIP1.BIND15580267 
Miz-1 interacts with CDKN1A promoter.BIND15780936 
PIM1PIMpim-1 oncogene-HPRD,BioGRID12431783 
POLD2-polymerase (DNA directed), delta 2, regulatory subunit 50kDa-HPRD12522211 
Waf1 interacts with p50 subunit of DNA polymerase delta.BIND12522211 
PSMA3HC8 | MGC12306 | MGC32631 | PSC3proteasome (prosome, macropain) subunit, alpha type, 3-HPRD,BioGRID11350925 
RAB1ADKFZp564B163 | RAB1 | YPT1RAB1A, member RAS oncogene familyTwo-hybridBioGRID16169070 
RB1OSRC | RB | p105-Rb | pRb | pp110retinoblastoma 1Rb interacts with the p21 promoter.BIND15716956 
RNF144BIBRDC2 | KIAA0161 | MGC71786 | bA528A10.3 | p53RFPring finger 144B-HPRD12853982 
SET2PP2A | I2PP2A | IGAAD | IPP2A2 | PHAPII | TAF-I | TAF-IBETASET nuclear oncogene-HPRD,BioGRID12407107 
SMAD4DPC4 | JIP | MADH4SMAD family member 4Smad4 binds the distal region of the p21Cip1 promoter.BIND15084259 
SMARCA4BAF190 | BRG1 | FLJ39786 | SNF2 | SNF2-BETA | SNF2L4 | SNF2LB | SWI2 | hSNF2bSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4BRG1 interacts with p21 promoter.BIND15780937 
SP1-Sp1 transcription factorSP1 interacts with the CDKN1A (p21) promoter.BIND15674334 
Sp1 interacts with CDKN1A promoter.BIND15780936 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)-HPRD,BioGRID10764767 
TEX11TGC1 | TSGA3testis expressed 11Two-hybridBioGRID16189514 
TK1TK2thymidine kinase 1, soluble-HPRD,BioGRID11389691 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53p53 interacts with p21 promoter.BIND16009130 
TP53 (p53) interacts with the CDKN1A (p21) promoter.BIND15674334 
p53 interacts with the p21 promoter.BIND15660129 
Affinity Capture-WesternBioGRID11896572 
p53 interacts with p21 promoter.BIND15989967 
p53 interacts with the p21 promoter.BIND15710329 
TP73P73tumor protein p73p73-beta interacts with p21 promoter. This interaction was modeled on a demonstrated interaction between p73-beta from an unspecified species and human p21 promoter.BIND15893728 
p73-alpha interacts with p21 promoter.BIND15893728 
TSG101TSG10 | VPS23tumor susceptibility gene 101-HPRD,BioGRID11943869 
ZBTB17MIZ-1 | ZNF151 | ZNF60 | pHZ-67zinc finger and BTB domain containing 17Miz1 interacts with p21WAF1 promoter.BIND15856024 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ERBB_SIGNALING_PATHWAY 8771All SZGR genes in this pathway
KEGG_CELL_CYCLE 12884All SZGR genes in this pathway
KEGG_P53_SIGNALING_PATHWAY 6945All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_GLIOMA 6556All SZGR genes in this pathway
KEGG_PROSTATE_CANCER 8975All SZGR genes in this pathway
KEGG_MELANOMA 7157All SZGR genes in this pathway
KEGG_BLADDER_CANCER 4233All SZGR genes in this pathway
KEGG_CHRONIC_MYELOID_LEUKEMIA 7359All SZGR genes in this pathway
BIOCARTA_ATM_PATHWAY 2016All SZGR genes in this pathway
BIOCARTA_G1_PATHWAY 2821All SZGR genes in this pathway
BIOCARTA_G2_PATHWAY 2420All SZGR genes in this pathway
BIOCARTA_CELLCYCLE_PATHWAY 2315All SZGR genes in this pathway
BIOCARTA_CALCINEURIN_PATHWAY 2117All SZGR genes in this pathway
BIOCARTA_EPONFKB_PATHWAY 1111All SZGR genes in this pathway
BIOCARTA_P53HYPOXIA_PATHWAY 2321All SZGR genes in this pathway
BIOCARTA_RACCYCD_PATHWAY 2623All SZGR genes in this pathway
BIOCARTA_P53_PATHWAY 1613All SZGR genes in this pathway
SA_G1_AND_S_PHASES 1510All SZGR genes in this pathway
SA_G2_AND_M_PHASES 87All SZGR genes in this pathway
SA_TRKA_RECEPTOR 1715All SZGR genes in this pathway
PID_SMAD2_3NUCLEAR_PATHWAY 8263All SZGR genes in this pathway
PID_PRL_SIGNALING_EVENTS_PATHWAY 2317All SZGR genes in this pathway
PID_NOTCH_PATHWAY 5949All SZGR genes in this pathway
PID_P73PATHWAY 7959All SZGR genes in this pathway
PID_HDAC_CLASSIII_PATHWAY 2520All SZGR genes in this pathway
PID_E2F_PATHWAY 7448All SZGR genes in this pathway
PID_ANGIOPOIETIN_RECEPTOR_PATHWAY 5041All SZGR genes in this pathway
PID_REG_GR_PATHWAY 8260All SZGR genes in this pathway
PID_P53_DOWNSTREAM_PATHWAY 13794All SZGR genes in this pathway
PID_CMYB_PATHWAY 8461All SZGR genes in this pathway
PID_PI3KCI_AKT_PATHWAY 3530All SZGR genes in this pathway
PID_MYC_REPRESS_PATHWAY 6352All SZGR genes in this pathway
PID_TAP63_PATHWAY 5440All SZGR genes in this pathway
PID_RB_1PATHWAY 6546All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_SIGNALING_BY_SCF_KIT 7859All SZGR genes in this pathway
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB4 9067All SZGR genes in this pathway
REACTOME_ORC1_REMOVAL_FROM_CHROMATIN 6737All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB2 10178All SZGR genes in this pathway
REACTOME_SIGNALING_BY_EGFR_IN_CANCER 10980All SZGR genes in this pathway
REACTOME_PI3K_EVENTS_IN_ERBB4_SIGNALING 3828All SZGR genes in this pathway
REACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING 4434All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR 9766All SZGR genes in this pathway
REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 12690All SZGR genes in this pathway
REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 137105All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 12788All SZGR genes in this pathway
REACTOME_PI3K_AKT_ACTIVATION 3829All SZGR genes in this pathway
REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL 1210All SZGR genes in this pathway
REACTOME_GAB1_SIGNALOSOME 3829All SZGR genes in this pathway
REACTOME_CELL_CYCLE_MITOTIC 325185All SZGR genes in this pathway
REACTOME_CELL_CYCLE_CHECKPOINTS 12470All SZGR genes in this pathway
REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ 6540All SZGR genes in this pathway
REACTOME_G1_PHASE 3823All SZGR genes in this pathway
REACTOME_P53_DEPENDENT_G1_DNA_DAMAGE_RESPONSE 5735All SZGR genes in this pathway
REACTOME_SIGNALING_BY_PDGF 12293All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 9576All SZGR genes in this pathway
REACTOME_G1_S_TRANSITION 11263All SZGR genes in this pathway
REACTOME_SYNTHESIS_OF_DNA 9253All SZGR genes in this pathway
REACTOME_MITOTIC_G1_G1_S_PHASES 13779All SZGR genes in this pathway
REACTOME_PI_3K_CASCADE 5639All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR 10074All SZGR genes in this pathway
REACTOME_DNA_REPLICATION 192110All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_PIP3_ACTIVATES_AKT_SIGNALING 2920All SZGR genes in this pathway
REACTOME_S_PHASE 10966All SZGR genes in this pathway
REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21 5634All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR 11280All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
KIM_RESPONSE_TO_TSA_AND_DECITABINE_UP 12973All SZGR genes in this pathway
CHEMNITZ_RESPONSE_TO_PROSTAGLANDIN_E2_DN 391222All SZGR genes in this pathway
ZERBINI_RESPONSE_TO_SULINDAC_DN 65All SZGR genes in this pathway
ZHONG_RESPONSE_TO_AZACITIDINE_AND_TSA_UP 183119All SZGR genes in this pathway
GARY_CD5_TARGETS_UP 473314All SZGR genes in this pathway
HUTTMANN_B_CLL_POOR_SURVIVAL_UP 276187All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_DN 241146All SZGR genes in this pathway
NEWMAN_ERCC6_TARGETS_DN 3924All SZGR genes in this pathway
SMIRNOV_CIRCULATING_ENDOTHELIOCYTES_IN_CANCER_UP 158103All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP 233161All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLACK_UP 3522All SZGR genes in this pathway
UDAYAKUMAR_MED1_TARGETS_DN 240171All SZGR genes in this pathway
ODONNELL_TFRC_TARGETS_UP 456228All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP 6446All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_UP 12895All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP 11784All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
LAU_APOPTOSIS_CDKN2A_UP 5540All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_CDC25_UP 5839All SZGR genes in this pathway
MARKEY_RB1_CHRONIC_LOF_UP 11578All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_UP 239157All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP 612367All SZGR genes in this pathway
CAIRO_PML_TARGETS_BOUND_BY_MYC_DN 1412All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP 536340All SZGR genes in this pathway
KERLEY_RESPONSE_TO_CISPLATIN_UP 4430All SZGR genes in this pathway
MISSIAGLIA_REGULATED_BY_METHYLATION_UP 12678All SZGR genes in this pathway
TANG_SENESCENCE_TP53_TARGETS_UP 3320All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_3_4WK_DN 3927All SZGR genes in this pathway
MCBRYAN_PUBERTAL_TGFB1_TARGETS_UP 169127All SZGR genes in this pathway
NUNODA_RESPONSE_TO_DASATINIB_IMATINIB_DN 1310All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
SANCHEZ_MDM2_TARGETS 1510All SZGR genes in this pathway
HUMMERICH_SKIN_CANCER_PROGRESSION_UP 8858All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_2 12792All SZGR genes in this pathway
SCHAVOLT_TARGETS_OF_TP53_AND_TP63 1612All SZGR genes in this pathway
KOMMAGANI_TP63_GAMMA_TARGETS 97All SZGR genes in this pathway
HERNANDEZ_ABERRANT_MITOSIS_BY_DOCETACEL_4NM_UP 2315All SZGR genes in this pathway
AMUNDSON_DNA_DAMAGE_RESPONSE_TP53 169All SZGR genes in this pathway
SEITZ_NEOPLASTIC_TRANSFORMATION_BY_8P_DELETION_DN 3025All SZGR genes in this pathway
MEINHOLD_OVARIAN_CANCER_LOW_GRADE_UP 1915All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_NEUROEPITHELIUM_UP 176111All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_UP 227137All SZGR genes in this pathway
MANN_RESPONSE_TO_AMIFOSTINE_UP 2012All SZGR genes in this pathway
MURATA_VIRULENCE_OF_H_PILORI 2416All SZGR genes in this pathway
TSAI_RESPONSE_TO_IONIZING_RADIATION 149101All SZGR genes in this pathway
KHETCHOUMIAN_TRIM24_TARGETS_UP 4738All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
SCIAN_CELL_CYCLE_TARGETS_OF_TP53_AND_TP73_UP 97All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_DN 382224All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_MODERATELY_DN 11064All SZGR genes in this pathway
RICKMAN_METASTASIS_DN 261155All SZGR genes in this pathway
FRIDMAN_SENESCENCE_UP 7760All SZGR genes in this pathway
FRIDMAN_IMMORTALIZATION_DN 3424All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN 206136All SZGR genes in this pathway
HE_PTEN_TARGETS_UP 1615All SZGR genes in this pathway
AMIT_EGF_RESPONSE_120_HELA 6947All SZGR genes in this pathway
ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP 223140All SZGR genes in this pathway
MORI_PRE_BI_LYMPHOCYTE_UP 8054All SZGR genes in this pathway
MORI_LARGE_PRE_BII_LYMPHOCYTE_UP 8649All SZGR genes in this pathway
MORI_SMALL_PRE_BII_LYMPHOCYTE_DN 7652All SZGR genes in this pathway
MORI_IMMATURE_B_LYMPHOCYTE_DN 9055All SZGR genes in this pathway
KAUFFMANN_DNA_REPAIR_GENES 230137All SZGR genes in this pathway
LE_EGR2_TARGETS_DN 10884All SZGR genes in this pathway
PENG_LEUCINE_DEPRIVATION_UP 14293All SZGR genes in this pathway
KANNAN_TP53_TARGETS_UP 5840All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
LEE_LIVER_CANCER_CIPROFIBRATE_UP 6042All SZGR genes in this pathway
NING_CHRONIC_OBSTRUCTIVE_PULMONARY_DISEASE_UP 157105All SZGR genes in this pathway
COLLER_MYC_TARGETS_DN 95All SZGR genes in this pathway
LEI_MYB_TARGETS 318215All SZGR genes in this pathway
NEMETH_INFLAMMATORY_RESPONSE_LPS_UP 8864All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_UP 6446All SZGR genes in this pathway
PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN 162102All SZGR genes in this pathway
AFFAR_YY1_TARGETS_UP 214133All SZGR genes in this pathway
VERNELL_RETINOBLASTOMA_PATHWAY_UP 7047All SZGR genes in this pathway
MA_MYELOID_DIFFERENTIATION_UP 3929All SZGR genes in this pathway
ABE_VEGFA_TARGETS_2HR 3421All SZGR genes in this pathway
BRACHAT_RESPONSE_TO_CISPLATIN 2211All SZGR genes in this pathway
WHITESIDE_CISPLATIN_RESISTANCE_UP 117All SZGR genes in this pathway
GENTILE_UV_LOW_DOSE_UP 2719All SZGR genes in this pathway
ONGUSAHA_TP53_TARGETS 3823All SZGR genes in this pathway
HARRIS_HYPOXIA 8164All SZGR genes in this pathway
HENDRICKS_SMARCA4_TARGETS_UP 5635All SZGR genes in this pathway
RAMALHO_STEMNESS_UP 206118All SZGR genes in this pathway
MCDOWELL_ACUTE_LUNG_INJURY_UP 4529All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_2 5034All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_24HR_DN 148102All SZGR genes in this pathway
KAYO_AGING_MUSCLE_UP 244165All SZGR genes in this pathway
WANG_CISPLATIN_RESPONSE_AND_XPC_DN 228146All SZGR genes in this pathway
MURAKAMI_UV_RESPONSE_6HR_UP 3731All SZGR genes in this pathway
SIMBULAN_PARP1_TARGETS_UP 3123All SZGR genes in this pathway
KANG_FLUOROURACIL_RESISTANCE_UP 2215All SZGR genes in this pathway
DELASERNA_MYOD_TARGETS_UP 8951All SZGR genes in this pathway
INGA_TP53_TARGETS 1713All SZGR genes in this pathway
CHIBA_RESPONSE_TO_TSA 5031All SZGR genes in this pathway
CHEN_LVAD_SUPPORT_OF_FAILING_HEART_UP 10369All SZGR genes in this pathway
BRACHAT_RESPONSE_TO_METHOTREXATE_UP 2616All SZGR genes in this pathway
MACLACHLAN_BRCA1_TARGETS_UP 2116All SZGR genes in this pathway
GAJATE_RESPONSE_TO_TRABECTEDIN_UP 6745All SZGR genes in this pathway
DELLA_RESPONSE_TO_TSA_AND_BUTYRATE 2117All SZGR genes in this pathway
BRACHAT_RESPONSE_TO_CAMPTOTHECIN_UP 2818All SZGR genes in this pathway
WELCSH_BRCA1_TARGETS_UP 198132All SZGR genes in this pathway
JACKSON_DNMT1_TARGETS_UP 7757All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C1 7245All SZGR genes in this pathway
SEMENZA_HIF1_TARGETS 3632All SZGR genes in this pathway
VARELA_ZMPSTE24_TARGETS_UP 4030All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
KRIGE_AMINO_ACID_DEPRIVATION 2920All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_DN 409268All SZGR genes in this pathway
KANG_CISPLATIN_RESISTANCE_UP 1911All SZGR genes in this pathway
HELLER_SILENCED_BY_METHYLATION_UP 282183All SZGR genes in this pathway
HELLER_HDAC_TARGETS_UP 317208All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP 461298All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_DN 543317All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN 591366All SZGR genes in this pathway
FUJII_YBX1_TARGETS_UP 4328All SZGR genes in this pathway
OUYANG_PROSTATE_CANCER_MARKERS 1916All SZGR genes in this pathway
HUANG_FOXA2_TARGETS_DN 3621All SZGR genes in this pathway
SAGIV_CD24_TARGETS_DN 4626All SZGR genes in this pathway
CHUNG_BLISTER_CYTOTOXICITY_UP 13484All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_UP 245159All SZGR genes in this pathway
WINTER_HYPOXIA_METAGENE 242168All SZGR genes in this pathway
ALONSO_METASTASIS_UP 198128All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_D_UP 13995All SZGR genes in this pathway
HELLEBREKERS_SILENCED_DURING_TUMOR_ANGIOGENESIS 8056All SZGR genes in this pathway
REICHERT_G1S_REGULATORS_AS_PI3K_TARGETS 86All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP 338225All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_DN 235144All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_DN 245150All SZGR genes in this pathway
CHANG_CORE_SERUM_RESPONSE_DN 209137All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
SWEET_KRAS_ONCOGENIC_SIGNATURE 8956All SZGR genes in this pathway
HINATA_NFKB_TARGETS_KERATINOCYTE_UP 9163All SZGR genes in this pathway
HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_UP 163102All SZGR genes in this pathway
HOFMANN_MYELODYSPLASTIC_SYNDROM_LOW_RISK_UP 2215All SZGR genes in this pathway
ZHANG_TLX_TARGETS_36HR_UP 221150All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_UP 293203All SZGR genes in this pathway
ZHANG_TLX_TARGETS_UP 10878All SZGR genes in this pathway
MIKKELSEN_PARTIALLY_REPROGRAMMED_TO_PLURIPOTENCY 106All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3 142103All SZGR genes in this pathway
JISON_SICKLE_CELL_DISEASE_UP 181106All SZGR genes in this pathway
ONO_FOXP3_TARGETS_DN 4223All SZGR genes in this pathway
TSAI_DNAJB4_TARGETS_UP 138All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3 210148All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_LITERATURE 4425All SZGR genes in this pathway
WU_APOPTOSIS_BY_CDKN1A_VIA_TP53 5531All SZGR genes in this pathway
LI_INDUCED_T_TO_NATURAL_KILLER_UP 307182All SZGR genes in this pathway
QI_HYPOXIA 14096All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
WAGSCHAL_EHMT2_TARGETS_UP 137All SZGR genes in this pathway
IVANOVSKA_MIR106B_TARGETS 9056All SZGR genes in this pathway
ZHU_SKIL_TARGETS_UP 2014All SZGR genes in this pathway
KIM_PTEN_TARGETS_UP 189All SZGR genes in this pathway
PASINI_SUZ12_TARGETS_DN 315215All SZGR genes in this pathway
KASLER_HDAC7_TARGETS_2_DN 3223All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_7 403240All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_8D 882506All SZGR genes in this pathway
HUANG_GATA2_TARGETS_UP 14996All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_PARTIAL 160106All SZGR genes in this pathway
FOSTER_KDM1A_TARGETS_UP 266142All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
SMIRNOV_RESPONSE_TO_IR_2HR_UP 5333All SZGR genes in this pathway
SMIRNOV_RESPONSE_TO_IR_6HR_UP 16697All SZGR genes in this pathway
GHANDHI_DIRECT_IRRADIATION_UP 11068All SZGR genes in this pathway
WARTERS_RESPONSE_TO_IR_SKIN 8344All SZGR genes in this pathway
WARTERS_IR_RESPONSE_5GY 4723All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-17-5p/20/93.mr/106/519.d468474m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-20886921Ahsa-miR-208AUAAGACGAGCAAAAAGCUUGU
miR-22951957m8hsa-miR-22brainAAGCUGCCAGUUGAAGAACUGU
miR-49986921Ahsa-miR-499UUAAGACUUGCAGUGAUGUUUAA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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