Gene Page: DMD

Summary
GeneID  1756
Symbol  DMD
Synonyms  BMD|CMD3B|DXS142|DXS164|DXS206|DXS230|DXS239|DXS268|DXS269|DXS270|DXS272
Description  dystrophin
See related  HGNC:2928|MIM:300377|Ensembl:ENSG00000198947|HPRD:02303|
Locus tag  GS1-19O24.1
Gene type  protein-coding
Map location  Xp21.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.259 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
C10orf790.930.62
C12orf630.930.54
WDR520.930.57
DNAH30.920.38
CCDC400.920.60
SPAG170.920.59
C3orf150.910.71
DNAH120.910.58
DNAH20.910.75
LRP2BP0.890.42
Top 10 negatively co-expressed genes
MT-CO2-0.23-0.40
AF347015.31-0.23-0.43
COX4I2-0.22-0.40
MYL3-0.22-0.43
AF347015.8-0.22-0.38
AF347015.27-0.22-0.37
AF347015.2-0.22-0.37
AF347015.33-0.21-0.35
CXCL14-0.21-0.37
MUSTN1-0.21-0.34
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003779actin bindingIEA-
GO:0003779actin bindingISS2261642 
GO:0003779actin bindingTAS12376554 
GO:0005509calcium ion bindingIEA-
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI16000376 
GO:0005200structural constituent of cytoskeletonTAS3282674 
GO:0008270zinc ion bindingIEA-
GO:0008307structural constituent of muscleIDA16000376 
GO:0008307structural constituent of muscleTAS3287171 
GO:0050998nitric-oxide synthase bindingISS7545544 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007519skeletal muscle developmentIEAneuron (GO term level: 8)-
GO:0045213neurotransmitter receptor metabolic processIEASynap, Neurotransmitter (GO term level: 7)-
GO:0007517muscle developmentNAS1824797 
GO:0007016cytoskeletal anchoring at plasma membraneISS2261642 
GO:0007016cytoskeletal anchoring at plasma membraneNAS-
GO:0043043peptide biosynthetic processIDA16000376 
GO:0046716muscle maintenanceIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005792microsomeIEA-
GO:0005856cytoskeletonTAS3282674 
GO:0005626insoluble fractionIEA-
GO:0005634nucleusIDA18029348 
GO:0005737cytoplasmIEA-
GO:0030018Z discIEA-
GO:0009986cell surfaceIDA10867799 
GO:0016010dystrophin-associated glycoprotein complexIEA-
GO:0016010dystrophin-associated glycoprotein complexISS2261642 
GO:0016010dystrophin-associated glycoprotein complexNAS-
GO:0016010dystrophin-associated glycoprotein complexTAS8282811 
GO:0042383sarcolemmaIDA7545544 
GO:0042383sarcolemmaIEA-
GO:0030055cell-substrate junctionIEA-
GO:0043034costamereIDA16000376 
GO:0045121membrane raftIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTA1ACTA | ASMA | CFTD | CFTD1 | CFTDM | MPFD | NEM1 | NEM2 | NEM3actin, alpha 1, skeletal muscle-HPRD,BioGRID1544421|11259305 
-HPRD1544421 
ACTC1ACTC | CMD1R | CMH11actin, alpha, cardiac muscle 1-HPRD11997265 
CADPSCADPS1 | CAPS | CAPS1 | KIAA1121Ca++-dependent secretion activator-HPRD12659812 
CADPS2FLJ40851 | KIAA1591Ca++-dependent secretion activator 2-HPRD12659812 
DAG1156DAG | A3a | AGRNR | DAGdystroglycan 1 (dystrophin-associated glycoprotein 1)-HPRD,BioGRID10355629 |10932245 
DGKZDAGK5 | DAGK6 | DGK-ZETA | hDGKzetadiacylglycerol kinase, zeta 104kDa-HPRD11352924 
DTNAD18S892E | DRP3 | DTN | FLJ96209 | LVNC1dystrobrevin, alpha-HPRD,BioGRID9356463 
DTNBMGC17163 | MGC57126dystrobrevin, betaAffinity Capture-WesternBioGRID10545507 
FASLGAPT1LG1 | CD178 | CD95L | FASL | TNFSF6Fas ligand (TNF superfamily, member 6)-HPRD11741599 
KCNJ12FLJ14167 | IRK2 | KCNJN1 | Kir2.2 | Kir2.2v | hIRK | hIRK1 | hkir2.2x | kcnj12xpotassium inwardly-rectifying channel, subfamily J, member 12-HPRD,BioGRID15024025 
KCNJ4HIR | HIRK2 | HRK1 | IRK3 | Kir2.3 | MGC142066 | MGC142068potassium inwardly-rectifying channel, subfamily J, member 4Affinity Capture-WesternBioGRID15024025 
PGM5PGMRPphosphoglucomutase 5-HPRD7890770 |10867799 
SGCZMGC149397 | ZSG1sarcoglycan zeta-HPRD12189167 
SNTA1SNT1 | TACIP1 | dJ1187J4.5syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)-HPRD,BioGRID7890602 
SNTB159-DAP | A1B | BSYN2 | DAPA1B | FLJ22442 | MGC111389 | SNT2 | SNT2B1 | TIP-43syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)-HPRD,BioGRID7844150 
SNTB2D16S2531E | EST25263 | SNT2B2 | SNT3 | SNTLsyntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)Protein-peptideBioGRID8576247 
SNTG1G1SYN | SYN4syntrophin, gamma 1-HPRD10747910 |11352924 
SNTG2G2SYN | MGC133174 | SYN5syntrophin, gamma 2-HPRD10747910 
UTRNDMDL | DRP | DRP1 | FLJ23678utrophin-HPRD10767429 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 8565All SZGR genes in this pathway
KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 7659All SZGR genes in this pathway
KEGG_DILATED_CARDIOMYOPATHY 9268All SZGR genes in this pathway
KEGG_VIRAL_MYOCARDITIS 7358All SZGR genes in this pathway
BIOCARTA_AGR_PATHWAY 3631All SZGR genes in this pathway
REACTOME_STRIATED_MUSCLE_CONTRACTION 2712All SZGR genes in this pathway
REACTOME_MUSCLE_CONTRACTION 4824All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN 634384All SZGR genes in this pathway
LIU_PROSTATE_CANCER_DN 481290All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_UP 408247All SZGR genes in this pathway
TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_DUCTAL_NORMAL_DN 9153All SZGR genes in this pathway
TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP 9459All SZGR genes in this pathway
CORRE_MULTIPLE_MYELOMA_UP 7445All SZGR genes in this pathway
HUTTMANN_B_CLL_POOR_SURVIVAL_UP 276187All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN 455304All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
WANG_LMO4_TARGETS_DN 352225All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_DN 367220All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_20Q13_AMPLIFICATION_DN 180101All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP 194122All SZGR genes in this pathway
BILBAN_B_CLL_LPL_UP 6339All SZGR genes in this pathway
LEE_NEURAL_CREST_STEM_CELL_DN 11879All SZGR genes in this pathway
GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_DN 9557All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_DN 7752All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
BEGUM_TARGETS_OF_PAX3_FOXO1_FUSION_UP 6045All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_TTD_DN 8463All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_BASAL 330217All SZGR genes in this pathway
FARMER_BREAST_CANCER_BASAL_VS_LULMINAL 330215All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
WEINMANN_ADAPTATION_TO_HYPOXIA_UP 2924All SZGR genes in this pathway
WEINMANN_ADAPTATION_TO_HYPOXIA_DN 4133All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_DN 203134All SZGR genes in this pathway
RICKMAN_HEAD_AND_NECK_CANCER_A 10063All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN 464276All SZGR genes in this pathway
IIZUKA_LIVER_CANCER_PROGRESSION_L0_L1_UP 1712All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
HASLINGER_B_CLL_WITH_MUTATED_VH_GENES 1814All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
CHIBA_RESPONSE_TO_TSA_DN 2314All SZGR genes in this pathway
KRASNOSELSKAYA_ILF3_TARGETS_DN 4638All SZGR genes in this pathway
LEIN_CEREBELLUM_MARKERS 8547All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN 591366All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_UP 210124All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
MASRI_RESISTANCE_TO_TAMOXIFEN_AND_AROMATASE_INHIBITORS_UP 2010All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN 940425All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
HELLEBREKERS_SILENCED_DURING_TUMOR_ANGIOGENESIS 8056All SZGR genes in this pathway
SPIRA_SMOKERS_LUNG_CANCER_UP 3824All SZGR genes in this pathway
RUIZ_TNC_TARGETS_DN 14279All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G123_DN 5130All SZGR genes in this pathway
YAGI_AML_WITH_INV_16_TRANSLOCATION 422277All SZGR genes in this pathway
KORKOLA_EMBRYONIC_CARCINOMA_VS_SEMINOMA_DN 2514All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
HIRSCH_CELLULAR_TRANSFORMATION_SIGNATURE_DN 10367All SZGR genes in this pathway
GABRIELY_MIR21_TARGETS 289187All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_D 280158All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
IKEDA_MIR30_TARGETS_UP 11687All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/98184818551A,m8hsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-1011181241Ahsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-124.125412547m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/506254125471Ahsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-129-5p1962021Ahsa-miR-129brainCUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5pCUUUUUGCGGUCUGGGCUUGCU
miR-1391191261A,m8hsa-miR-139brainUCUACAGUGCACGUGUCU
miR-142-5p2542601Ahsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
hsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
hsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-1441171241A,m8hsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-1531831901A,m8hsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-186232623321Ahsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
hsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-190251725241A,m8hsa-miR-190UGAUAUGUUUGAUAUAUUAGGU
miR-19417111717m8hsa-miR-194UGUAACAGCAACUCCAUGUGGA
miR-200bc/429234223481Ahsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-30-5p72781Ahsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-312442501Ahsa-miR-31AGGCAAGAUGCUGGCAUAGCUG
miR-320227222781Ahsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
hsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-369-3p255325601A,m8hsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-37425542560m8hsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-4214134191Ahsa-miR-421GGCCUCAUUAAAUGUUUGUUG
miR-4481841901Ahsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-493-5p1921981Ahsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-494819825m8hsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
miR-4951551611Ahsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-4962182251A,m8hsa-miR-496AUUACAUGGCCAAUCUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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