Gene Page: ESR1

Summary
GeneID  2099
Symbol  ESR1
Synonyms  DKFZp686N23123|ER|ESR|ESRA|Era|NR3A1
Description  estrogen receptor 1
See related  HGNC:3467|MIM:133430|Ensembl:ENSG00000091831|HPRD:00589|
Locus tag  RP1-130E4.1
Gene type  protein-coding
Map location  6q25.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 2.351 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenia, schizophrenias, schizophrenic]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.4727 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
CAMKK10.930.78
SYT120.930.86
EHD30.920.91
MAST30.920.87
SLC12A50.920.86
CNTNAP10.910.87
SIRPA0.910.90
IQSEC10.910.85
PHF150.910.82
MAP1A0.900.87
Top 10 negatively co-expressed genes
BCL7C-0.54-0.65
C9orf46-0.53-0.63
GTF3C6-0.52-0.57
EXOSC8-0.51-0.59
FAM36A-0.50-0.50
DYNLT1-0.49-0.67
AC006276.2-0.49-0.50
RBMX2-0.48-0.62
RPS8-0.48-0.65
RPL36-0.48-0.64
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0003677DNA bindingIEA-
GO:0003700transcription factor activityIEA-
GO:0003707steroid hormone receptor activityIEA-
GO:0003707steroid hormone receptor activityNAS11004670 
GO:0030235nitric-oxide synthase regulator activityNAS12389206 
GO:0005496steroid bindingIEA-
GO:0008270zinc ion bindingIEA-
GO:0030284estrogen receptor activityNAS3753802 
GO:0046872metal ion bindingIEA-
GO:0047485protein N-terminus bindingIPI12917342 
GO:0043565sequence-specific DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006355regulation of transcription, DNA-dependentNAS3753802 
GO:0030520estrogen receptor signaling pathwayNAS3753802 
GO:0006350transcriptionIEA-
GO:0007165signal transductionTAS10749889 |10970861 
GO:0048386positive regulation of retinoic acid receptor signaling pathwayIDA15831516 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005634nucleusNAS-
GO:0005730nucleolusIDA18029348 
GO:0005737cytoplasmIDA18029348 
GO:0005886plasma membraneIDA18029348 
GO:0016585chromatin remodeling complexNAS12351687 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ER interacts with LOC441967.BIND16009131 
AHR-aryl hydrocarbon receptor-HPRD,BioGRID10620335 |12612060 
AKAP13AKAP-Lbc | BRX | FLJ11952 | FLJ43341 | HA-3 | Ht31 | LBC | PROTO-LB | PROTO-LBC | c-lbcA kinase (PRKA) anchor protein 13-HPRD,BioGRID9627117 
ANP32AC15orf1 | I1PP2A | LANP | MAPM | MGC119787 | MGC150373 | PHAP1 | PHAPI | PP32acidic (leucine-rich) nuclear phosphoprotein 32 family, member AER-alpha interacts with pp32.BIND15308690 
AP1B1ADTB1 | AP105A | BAM22 | CLAPB2adaptor-related protein complex 1, beta 1 subunitER interacts with AP1B1.BIND16009131 
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptor-HPRD,BioGRID12389206 
ASCC2ASC1p100activating signal cointegrator 1 complex subunit 2ER interacts with ASC1p100.BIND16009131 
AXIN2AXIL | DKFZp781B0869 | MGC10366 | MGC126582axin 2ER-alpha interacts with the Axin2 promoter.BIND15304487 
BAG1RAP46BCL2-associated athanogene-HPRD,BioGRID8524784 
BAGE3-B melanoma antigen family, member 3ER interacts with BAGE3.BIND16009131 
BAZ1BWBSCR10 | WBSCR9 | WSTFbromodomain adjacent to zinc finger domain, 1BAffinity Capture-WesternBioGRID12837248 
BCAS2DAM1breast carcinoma amplified sequence 2BCAS2 interacts with ER-alpha. This interaction was modeled on a demonstrated interaction between human BCAS2 and ER-alpha from an unspecified species.BIND15694360 
BDNFMGC34632brain-derived neurotrophic factor-HPRD11923430 
BLOC1S1BLOS1 | FLJ39337 | FLJ97089 | GCN5L1 | MGC87455 | MICoA | RT14biogenesis of lysosomal organelles complex-1, subunit 1ER interacts with MICoABIND12639951 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onset-HPRD10334989 
Affinity Capture-Western
Co-localization
Reconstituted Complex
BioGRID11244506 |11493692 
|11782371 |12400015 
C21orf129FLJ32835 | PRED76chromosome 21 open reading frame 129ER interacts with C21orf129.BIND16009131 
CALM1CALML2 | CAMI | DD132 | PHKDcalmodulin 1 (phosphorylase kinase, delta)-HPRD11981030 
CALM2CAMII | PHKD | PHKD2calmodulin 2 (phosphorylase kinase, delta)-HPRD11981030 
CALM3PHKD | PHKD3calmodulin 3 (phosphorylase kinase, delta)-HPRD11981030 
CAV1CAV | MSTP085 | VIP21caveolin 1, caveolae protein, 22kDa-HPRD,BioGRID11563984 
CCND1BCL1 | D11S287E | PRAD1 | U21B31cyclin D1-HPRD,BioGRID9039267 
ER-alpha interacts with cyclin D1 promoter.BIND15808510 
CCNHCAK | p34 | p37cyclin HAffinity Capture-WesternBioGRID12527756 
CDC25B-cell division cycle 25 homolog B (S. pombe)-HPRD,BioGRID11689696 
CDK7CAK1 | CDKN7 | MO15 | STK1 | p39MO15cyclin-dependent kinase 7Biochemical ActivityBioGRID10949034 
CEBPAC/EBP-alpha | CEBPCCAAT/enhancer binding protein (C/EBP), alphaReconstituted ComplexBioGRID9817600 
CEBPBC/EBP-beta | CRP2 | IL6DBP | LAP | MGC32080 | NF-IL6 | TCF5CCAAT/enhancer binding protein (C/EBP), beta-HPRD,BioGRID7651415 
CELSR1CDHF9 | DKFZp434P0729 | FMI2 | HFMI2 | ME2cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)ER interacts with CELSR1.BIND16009131 
CHUKIKBKA | IKK-alpha | IKK1 | IKKA | NFKBIKA | TCF16conserved helix-loop-helix ubiquitous kinaseIKK-alpha interacts with ER-alpha.BIND15808510 
COBRA1DKFZp586B0519 | KIAA1182 | NELF-B | NELFBcofactor of BRCA1-HPRD,BioGRID15342491 
CREBBPCBP | KAT3A | RSTSCREB binding proteinAffinity Capture-Western
Reconstituted Complex
BioGRID11113179 |11782371 
CSNK1EHCKIE | MGC10398casein kinase 1, epsilonER interacts with CSNK1E.BIND16009131 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDaAffinity Capture-WesternBioGRID15304487 
beta-catenin interacts with ER-alpha.BIND15304487 
CYB5R3B5R | DIA1cytochrome b5 reductase 3ER interacts with CYB5R3.BIND16009131 
DAP3DAP-3 | DKFZp686G12159 | MGC126058 | MGC126059 | MRP-S29 | MRPS29 | bMRP-10death associated protein 3Reconstituted ComplexBioGRID10903152 
DDX17DKFZp761H2016 | P72 | RH70DEAD (Asp-Glu-Ala-Asp) box polypeptide 17ESR1 (ER-alpha) interacts with an unspecified isoform of DDX17 (p72). This interaction was modeled on a demonstrated interaction between ESR1 from an unspecified species and DDX17 from an unspecified species.BIND12738788 
DDX5DKFZp686J01190 | G17P1 | HLR1 | HUMP68 | p68DEAD (Asp-Glu-Ala-Asp) box polypeptide 5Affinity Capture-Western
Two-hybrid
BioGRID10409727 
ESR1 (ER-alpha) interacts with DDX5 (p68). This interaction was modeled on a demonstrated interaction between ESR1 from an unspecified species and DDX5 from an unspecified species.BIND12738788 
DDX54DP97 | MGC2835DEAD (Asp-Glu-Ala-Asp) box polypeptide 54-HPRD,BioGRID12466272 
DNTTIP2ERBP | FCF2 | HSU15552 | LPTS-RP2 | MGC163494 | RP4-561L24.1 | TdIF2deoxynucleotidyltransferase, terminal, interacting protein 2-HPRD,BioGRID15047147 
DSCAMCHD2-42 | CHD2-52Down syndrome cell adhesion moleculeER interacts with DSCAM-1 enhancer.BIND16009131 
EBAG9EB9 | PDAF | RCAS1estrogen receptor binding site associated, antigen, 9ER-alpha interacts with EBAG9 promoter.BIND15808510 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)-HPRD,BioGRID11887937 
EIF3IEIF3S2 | PRO2242 | TRIP-1 | TRIP1 | eIF3-beta | eIF3-p36eukaryotic translation initiation factor 3, subunit IER alpha interacts with TRIP1. This interaction was modeled on a demonstrated interaction between TRIP1 from an unspecified source and human ER alpha.BIND10706629 
EP300KAT3B | p300E1A binding protein p300-HPRD,BioGRID11782371 
EP300 (p300) acetylates ESR1 (ER-alpha). This interaction was modeled on a demonstrated interaction between EP300 from an unspecified species and ESR1 from an unspecified species.BIND14761960 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1Two-hybridBioGRID12198596 
ESR2ER-BETA | ESR-BETA | ESRB | ESTRB | Erb | NR3A2estrogen receptor 2 (ER beta)ER alpha interacts with ER beta to form heterodimer. This interaction was modeled on a demonstrated interaction between human ER alpha and mouse ER beta.BIND10706629 
-HPRD,BioGRID9473491 
FHL2AAG11 | DRAL | SLIM3four and a half LIM domains 2ER-alpha interacts with FHL2.BIND15666801 
FKBP4FKBP52 | FKBP59 | HBI | Hsp56 | PPIase | p52FK506 binding protein 4, 59kDaReconstituted ComplexBioGRID9222609 
FKBP5FKBP51 | FKBP54 | MGC111006 | P54 | PPIase | Ptg-10FK506 binding protein 5Reconstituted ComplexBioGRID9222609 
FOXO1FKH1 | FKHR | FOXO1Aforkhead box O1-HPRD,BioGRID11435445 
FOXO4AFX | AFX1 | MGC120490 | MLLT7forkhead box O4-HPRD,BioGRID11435445 
GADD45ADDIT1 | GADD45growth arrest and DNA-damage-inducible, alphaAffinity Capture-WesternBioGRID10872826 
GADD45BDKFZp566B133 | GADD45BETA | MYD118growth arrest and DNA-damage-inducible, beta-HPRD10872826 
GADD45GCR6 | DDIT2 | GADD45gamma | GRP17growth arrest and DNA-damage-inducible, gamma-HPRD,BioGRID10872826 
GTF2H1BTF2 | TFB1 | TFIIHgeneral transcription factor IIH, polypeptide 1, 62kDa-HPRD,BioGRID10949034 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1ER-alpha interacts with HDAC1.BIND14506733 
HSP90AA1FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2heat shock protein 90kDa alpha (cytosolic), class A member 1-HPRD,BioGRID11911945 
HSPA4APG-2 | HS24/P52 | MGC131852 | RY | hsp70 | hsp70RYheat shock 70kDa protein 4Reconstituted ComplexBioGRID9222609 
IGF1RCD221 | IGFIR | JTK13 | MGC142170 | MGC142172 | MGC18216insulin-like growth factor 1 receptorAffinity Capture-WesternBioGRID16113100 
ISL1Isl-1ISL LIM homeobox 1-HPRD,BioGRID11043578 
JARID1AKDM5A | RBBP2 | RBP2jumonji, AT rich interactive domain 1AAffinity Capture-Western
Reconstituted Complex
BioGRID11358960 
Rbp2 interacts with ER.BIND11358960 
JUNAP-1 | AP1 | c-Junjun oncogeneER-alpha interacts with c-Jun. This interaction was modeled on a demonstrated interaction between human ER-alpha, and mouse c-Jun.BIND11477071 
-HPRD,BioGRID11477071 
JUNBAP-1jun B proto-oncogeneER-alpha interacts with JunB. This interaction was modeled on a demonstrated interaction between human ER-alpha and mouse JunB.BIND11477071 
LOH3CR2AERR-10 | ERR10 | NAG-7 | NAG7loss of heterozygosity, 3, chromosomal region 2, gene A-HPRD15474036 
MAPK1ERK | ERK2 | ERT1 | MAPK2 | P42MAPK | PRKM1 | PRKM2 | p38 | p40 | p41 | p41mapkmitogen-activated protein kinase 1-HPRD,BioGRID12093745 
MDM2HDMX | MGC71221 | hdm2Mdm2 p53 binding protein homolog (mouse)Reconstituted ComplexBioGRID10766163 
MED1CRSP1 | CRSP200 | DRIP205 | DRIP230 | MGC71488 | PBP | PPARBP | PPARGBP | RB18A | TRAP220 | TRIP2mediator complex subunit 1ESR1 (ER-alpha) interacts with PPARBP (TRAP220). This interaction was modeled on a demonstrated interaction between ESR1 from an unspecified species and PPARBP from an unspecified species.BIND12738788 
Affinity Capture-WesternBioGRID12837248 
-HPRD9653119 
MED24ARC100 | CRSP100 | CRSP4 | DRIP100 | KIAA0130 | MGC8748 | THRAP4 | TRAP100mediator complex subunit 24-HPRD9653119 
Affinity Capture-MSBioGRID12837248 
MGMT-O-6-methylguanine-DNA methyltransferaseAffinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID11564893 
MKNK2GPRK7 | MNK2MAP kinase interacting serine/threonine kinase 2-HPRD,BioGRID11013076 
MMS19FLJ34167 | FLJ95146 | MET18 | MGC99604 | MMS19L | hMMS19MMS19 nucleotide excision repair homolog (S. cerevisiae)-HPRD11279242 
MNAT1MAT1 | RNF66 | TFB3menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)-HPRD,BioGRID12527756 
MPGAAG | APNG | CRA36.1 | MDG | Mid1 | PIG11 | PIG16 | anpgN-methylpurine-DNA glycosylaseESR1 (ER-alpha) interacts with MPG.BIND14761960 
MTA1-metastasis associated 1-HPRD,BioGRID12167865 
MVPLRP | VAULT1major vault protein-HPRD,BioGRID9628887 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)ER-alpha interacts with c-myc promoter.BIND15808510 
NCAM2MGC51008 | NCAM21neural cell adhesion molecule 2ER interacts with NCAM2.BIND16009131 
NCOA1F-SRC-1 | KAT13A | MGC129719 | MGC129720 | NCoA-1 | RIP160 | SRC-1 | SRC1 | bHLHe42nuclear receptor coactivator 1ER-alpha interacts with SRC-1BIND10938099 
-HPRD9427757 |11165056 
Reconstituted ComplexBioGRID9427757 |11003650 
|11113179 
NCOA2GRIP1 | KAT13C | MGC138808 | NCoA-2 | TIF2nuclear receptor coactivator 2ER alpha interacts with TIF2. This interaction was modeled on a demonstrated interaction between TIF2 from an unspecified source and human ER alpha.BIND10706629 
-HPRD,BioGRID11937504 
NCOA3ACTR | AIB-1 | AIB1 | CAGH16 | CTG26 | KAT13B | MGC141848 | RAC3 | SRC3 | TNRC14 | TNRC16 | TRAM-1 | pCIPnuclear receptor coactivator 3-HPRD,BioGRID11050174 
SRC-3 interacts with ER. This interaction was modelled on a demonstrated interaction between human SRC-3 and ER from an unspecified species.BIND15383283 
TRAM-1 interacts with ER.BIND9346901 
NCOA4ARA70 | DKFZp762E1112 | ELE1 | PTC3 | RFGnuclear receptor coactivator 4Reconstituted ComplexBioGRID9892017 
NCOA6AIB3 | ANTP | ASC2 | HOX1.1 | HOXA7 | KIAA0181 | NRC | PRIP | RAP250 | TRBPnuclear receptor coactivator 6Reconstituted Complex
Two-hybrid
BioGRID10567404 |11158331 
|11773444 
NCOA7ERAP140 | ESNA1 | FLJ45605 | MGC88425 | Nbla00052 | Nbla10993 | dJ187J11.3nuclear receptor coactivator 7-HPRD,BioGRID11971969 
NCOR1KIAA1047 | MGC104216 | N-CoR | TRAC1 | hCIT529I10 | hN-CoRnuclear receptor co-repressor 1-HPRD,BioGRID12145334 
ESR1 (ER-alpha) interacts with NCOR1 (N-CoR). This interaction was modeled on a demonstrated interaction between ESR1 from an unspecified species and human NCOR1.BIND12738788 
NCOR2CTG26 | SMRT | SMRTE | SMRTE-tau | TNRC14 | TRAC-1 | TRAC1nuclear receptor co-repressor 2ESR1 (ER-alpha) interacts with NCOR2 (SMRT). This interaction was modeled on a demonstrated interaction between ESR1 from an unspecified species and NCOR2 from an unspecified species.BIND12738788 
-HPRD9702189 
NR0B2FLJ17090 | SHP | SHP1nuclear receptor subfamily 0, group B, member 2-HPRD,BioGRID9773978 |11861507 
NR2C1TR2nuclear receptor subfamily 2, group C, member 1-HPRD,BioGRID12093804 
NR2C2TAK1 | TR2R1 | TR4 | hTAK1nuclear receptor subfamily 2, group C, member 2-HPRD,BioGRID11844790 
NR2F1COUP-TFI | EAR-3 | EAR3 | ERBAL3 | NR2F2 | SVP44 | TCFCOUP1 | TFCOUP1nuclear receptor subfamily 2, group F, member 1-HPRD,BioGRID12093745 
NR2F6EAR-2 | EAR2 | ERBAL2nuclear receptor subfamily 2, group F, member 6-HPRD,BioGRID10713182 
NRIP1FLJ77253 | RIP140nuclear receptor interacting protein 1ESR1 (ER-alpha) interacts with NRIP1 (RIP140). This interaction was modelled on a demonstrated interaction between human ESR1 and mouse NRIP1.BIND9774463 
ER interacts with NRIP-1 enhancer.BIND16009131 
-HPRD,BioGRID7641693 
NSD1ARA267 | DKFZp666C163 | FLJ10684 | FLJ22263 | FLJ44628 | KMT3B | SOTOS | STOnuclear receptor binding SET domain protein 1-HPRD9628876 
PAK6PAK5p21 protein (Cdc42/Rac)-activated kinase 6-HPRD,BioGRID11773441 
PELP1HMX3 | MNAR | P160proline, glutamate and leucine rich protein 1-HPRD,BioGRID11481323 
PGRNR3C3 | PRprogesterone receptorER-alpha interacts with the PgRA promoter.BIND15019994 
ER-alpha interacts with the PgRB promoter.BIND15019994 
PHB2BAP | BCAP37 | Bap37 | MGC117268 | PNAS-141 | REA | p22prohibitin 2ER-alpha interacts with REABIND10938099 
Two-hybridBioGRID12943695 
PIAS1DDXBP1 | GBP | GU/RH-II | MGC141878 | MGC141879 | ZMIZ3protein inhibitor of activated STAT, 1ER-alpha interacts with PIAS1.BIND15666801 
-HPRD15666801 
PIAS2MGC102682 | MIZ1 | PIASX | PIASX-ALPHA | PIASX-BETA | SIZ2 | ZMIZ4 | mizprotein inhibitor of activated STAT, 2Reconstituted ComplexBioGRID11117529 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)-HPRD,BioGRID11689445 
PNRC2FLJ20312 | MGC99541proline-rich nuclear receptor coactivator 2-HPRD11574675 
POU2F1OCT1 | OTF1POU class 2 homeobox 1Reconstituted ComplexBioGRID10480874 
POU2F2OCT2 | OTF2 | Oct-2POU class 2 homeobox 2Reconstituted ComplexBioGRID10480874 
POU4F1BRN3A | FLJ13449 | Oct-T1 | RDC-1POU class 4 homeobox 1Reconstituted Complex
Two-hybrid
BioGRID9448000 
POU4F2BRN3.2 | BRN3B | Brn-3bPOU class 4 homeobox 2-HPRD,BioGRID9448000 
PPARGC1ALEM6 | PGC-1(alpha) | PGC-1v | PGC1 | PGC1A | PPARGC1peroxisome proliferator-activated receptor gamma, coactivator 1 alpha-HPRD,BioGRID10748020 
PPARGC1BERRL1 | PERC | PGC-1(beta) | PGC1Bperoxisome proliferator-activated receptor gamma, coactivator 1 beta-HPRD,BioGRID11854298 
PPIDCYP-40 | CYPD | MGC33096peptidylprolyl isomerase DReconstituted ComplexBioGRID9222609 
PRDM2HUMHOXY1 | KMT8 | MTB-ZF | RIZ | RIZ1 | RIZ2PR domain containing 2, with ZNF domain-HPRD,BioGRID10706618 
PRMT1ANM1 | HCP1 | HRMT1L2 | IR1B4protein arginine methyltransferase 1Reconstituted ComplexBioGRID11050077 
PRMT2HRMT1L1 | MGC111373protein arginine methyltransferase 2Affinity Capture-Western
Reconstituted Complex
BioGRID12039952 
PRMT2 interacts with ER-alpha.BIND12039952 
PRPF6ANT-1 | C20orf14 | TOM | U5-102K | hPrp6PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)-HPRD12039962 
PTEN10q23del | BZS | MGC11227 | MHAM | MMAC1 | PTEN1 | TEP1phosphatase and tensin homologReconstituted ComplexBioGRID15205473 
PTGES3P23 | TEBP | cPGESprostaglandin E synthase 3 (cytosolic)Reconstituted ComplexBioGRID9222609 
-HPRD10207098 
PTMAMGC104802 | TMSAprothymosin, alphaReconstituted ComplexBioGRID12943695 
RBM23CAPERbeta | FLJ10482 | MGC4458 | PP239 | RNPC4RNA binding motif protein 23RBM23 (CAPER-beta) interacts with ESR1(ER-alpha)BIND15694343 
RBM39CAPER | CAPERalpha | CC1.3 | DKFZp781C0423 | FLJ44170 | HCC1 | RNPC2 | fSAP59RNA binding motif protein 39-HPRD,BioGRID11704680 
RBM9FOX2 | Fox-2 | HNRBP2 | HRNBP2 | RTA | dJ106I20.3 | fxhRNA binding motif protein 9-HPRD,BioGRID11875103 
REXO4REX4 | XPMC2 | XPMC2HREX4, RNA exonuclease 4 homolog (S. cerevisiae)-HPRD,BioGRID10908561 
RFX4NYD-SP10regulatory factor X, 4 (influences HLA class II expression)-HPRD1603086 |10706293 
RNF14ARA54 | FLJ26004 | HFB30 | HRIHFB2038 | TRIAD2ring finger protein 14-HPRD10085091 
RNF4RES4-26 | SNURFring finger protein 4Two-hybridBioGRID9710597 
SAFBDKFZp779C1727 | HAP | HET | SAFB1scaffold attachment factor B-HPRD,BioGRID10707955 
SAFB2KIAA0138scaffold attachment factor B2Affinity Capture-Western
Reconstituted Complex
BioGRID12660241 
SFI1MGC131712 | MGC150663 | MGC156283 | MGC57874 | PISD | RP5-858B16.1 | hSfi1pSfi1 homolog, spindle assembly associated (yeast)ER interacts with SFI1.BIND16009131 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1-HPRD,BioGRID11773443 
SLC37A1FLJ22340 | G3PPsolute carrier family 37 (glycerol-3-phosphate transporter), member 1ER interacts with SLC37A1.BIND16009131 
SMAD2JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2SMAD family member 2-HPRD,BioGRID11555647 
SMARCA2BAF190 | BRM | FLJ36757 | MGC74511 | SNF2 | SNF2L2 | SNF2LA | SWI2 | Sth1p | hBRM | hSNF2aSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2-HPRD,BioGRID9099865 
SMARCA4BAF190 | BRG1 | FLJ39786 | SNF2 | SNF2-BETA | SNF2L4 | SNF2LB | SWI2 | hSNF2bSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4-HPRD,BioGRID9099865 
SMARCD1BAF60A | CRACD1 | Rsc6pSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1Reconstituted ComplexBioGRID12917342 
SMARCE1BAF57SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1-HPRD,BioGRID12145209 
SNAP29CEDNIK | FLJ21051 | SNAP-29synaptosomal-associated protein, 29kDaER interacts with SNAP29.BIND16009131 
SNURF-SNRPN upstream reading frameTwo-hybridBioGRID11696545 
SOD1ALS | ALS1 | IPOA | SOD | homodimersuperoxide dismutase 1, solubleER interacts with SOD-1 enhancer.BIND16009131 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)Affinity Capture-Western
Reconstituted Complex
BioGRID10454579 |11032808 
|11564893 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)Affinity Capture-WesternBioGRID11429412 
STAT5AMGF | STAT5signal transducer and activator of transcription 5AER-alpha interacts with STAT5a.BIND15304355 
Reconstituted ComplexBioGRID11682624 
STRNMGC125642 | SG2NAstriatin, calmodulin binding protein-HPRD15569929 
SVILDKFZp686A17191supervillinTwo-hybridBioGRID11792840 
TADA3LADA3 | FLJ20221 | FLJ21329 | hADA3transcriptional adaptor 3 (NGG1 homolog, yeast)-like-HPRD,BioGRID12034840 
TAF10TAF2A | TAF2H | TAFII30TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa-HPRD7923369 
TBPGTF2D | GTF2D1 | MGC117320 | MGC126054 | MGC126055 | SCA17 | TFIIDTATA box binding protein-HPRD,BioGRID11595744 
TDG-thymine-DNA glycosylase-HPRD,BioGRID12874288 
TFF1BCEI | D21S21 | HP1.A | HPS2 | pNR-2 | pS2trefoil factor 1ER-alpha interacts with pS2.BIND10490106 
ER interacts with TFF-1 promoter.BIND16009131 
ER interacts with TFF-1 enhancer.BIND16009131 
ER-alpha interacts with the pS2 promoter.BIND15304487 
THOC5C22orf19 | Fmip | PK1.3 | fSAP79THO complex 5ER interacts with C22orf19.BIND16009131 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53-HPRD,BioGRID10766163 
P53 interacts with ER-alpha.BIND10766163 
TRIM24PTC6 | RNF82 | TF1A | TIF1 | TIF1A | TIF1ALPHA | hTIF1tripartite motif-containing 24Reconstituted ComplexBioGRID9115274 |10598587 
-HPRD9115274 |9632676 
|10598587 
ESR1 (ER-alpha) interacts with TIF1. This interaction was modeled on a demonstrated interaction between human ESR1 and mouse TIF1.BIND9774463 
TRIP4HsT17391thyroid hormone receptor interactor 4-HPRD,BioGRID10454579 
TRRAPFLJ10671 | PAF350/400 | PAF400 | STAF40 | TR-AP | Tra1transformation/transcription domain-associated proteinESR1 (ER-alpha) interacts with TRRAP. This interaction was modeled on a demonstrated interaction between ESR1 from an unspecified species and TRRAP from an unspecified species.BIND12738788 
Affinity Capture-MSBioGRID12837248 
UBE2IC358B7.1 | P18 | UBC9ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)ER-alpha interacts with an unspecified isoform of Ubc9.BIND15666801 
XBP1TREB5 | XBP2X-box binding protein 1-HPRD,BioGRID12954762 
ER interacts with XBP-1 enhancer.BIND16009131 
YWHAHYWHA1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide-HPRD11266503 
YWHAQ14-3-3 | 1C5 | HS1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptideReconstituted ComplexBioGRID11266503 
ZBTB16PLZF | ZNF145zinc finger and BTB domain containing 16-HPRD,BioGRID14521715 
ZNF398KIAA1339 | P51 | P71 | ZER6zinc finger protein 398-HPRD,BioGRID11779858 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BIOCARTA_CARM_ER_PATHWAY 3527All SZGR genes in this pathway
BIOCARTA_MTA3_PATHWAY 1910All SZGR genes in this pathway
BIOCARTA_HER2_PATHWAY 2217All SZGR genes in this pathway
PID_SMAD2_3NUCLEAR_PATHWAY 8263All SZGR genes in this pathway
PID_HDAC_CLASSII_PATHWAY 3427All SZGR genes in this pathway
PID_ER_NONGENOMIC_PATHWAY 4135All SZGR genes in this pathway
PID_LKB1_PATHWAY 4737All SZGR genes in this pathway
PID_TELOMERASE_PATHWAY 6848All SZGR genes in this pathway
PID_ATF2_PATHWAY 5943All SZGR genes in this pathway
PID_AP1_PATHWAY 7060All SZGR genes in this pathway
PID_FOXM1_PATHWAY 4030All SZGR genes in this pathway
PID_ERA_GENOMIC_PATHWAY 6537All SZGR genes in this pathway
PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY 3829All SZGR genes in this pathway
PID_HNF3A_PATHWAY 4429All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB4 9067All SZGR genes in this pathway
REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 3830All SZGR genes in this pathway
REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 352181All SZGR genes in this pathway
REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY 4936All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_DN 384220All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_UP 380215All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP 450256All SZGR genes in this pathway
DOANE_BREAST_CANCER_ESR1_UP 11272All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_DN 384230All SZGR genes in this pathway
WANG_CLIM2_TARGETS_UP 269146All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_UP 7848All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_20Q13_AMPLIFICATION_UP 11966All SZGR genes in this pathway
ELVIDGE_HYPOXIA_DN 14694All SZGR genes in this pathway
ELVIDGE_HYPOXIA_BY_DMOG_DN 5940All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_A_DN 9061All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION_12HR 4335All SZGR genes in this pathway
SCHEIDEREIT_IKK_TARGETS 1815All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL 326213All SZGR genes in this pathway
FARMER_BREAST_CANCER_BASAL_VS_LULMINAL 330215All SZGR genes in this pathway
JAERVINEN_AMPLIFIED_IN_LARYNGEAL_CANCER 4024All SZGR genes in this pathway
LIEN_BREAST_CARCINOMA_METAPLASTIC_VS_DUCTAL_DN 11458All SZGR genes in this pathway
DAWSON_METHYLATED_IN_LYMPHOMA_TCL1 5945All SZGR genes in this pathway
YANG_BREAST_CANCER_ESR1_UP 3622All SZGR genes in this pathway
HATADA_METHYLATED_IN_LUNG_CANCER_UP 390236All SZGR genes in this pathway
PUJANA_BREAST_CANCER_LIT_INT_NETWORK 10173All SZGR genes in this pathway
OHM_METHYLATED_IN_ADULT_CANCERS 2723All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN 428306All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
SAKAI_CHRONIC_HEPATITIS_VS_LIVER_CANCER_DN 3624All SZGR genes in this pathway
PENG_GLUCOSE_DEPRIVATION_UP 4826All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
WESTON_VEGFA_TARGETS_6HR 5938All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL 254164All SZGR genes in this pathway
WESTON_VEGFA_TARGETS 10871All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_UP 428266All SZGR genes in this pathway
WESTON_VEGFA_TARGETS_3HR 7447All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
LOPES_METHYLATED_IN_COLON_CANCER_UP 2720All SZGR genes in this pathway
RIGGINS_TAMOXIFEN_RESISTANCE_DN 220147All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_DN 258160All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN 540340All SZGR genes in this pathway
HOQUE_METHYLATED_IN_CANCER 5645All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BRAIN_DN 8558All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_UP 9761All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_UP 172109All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_A_UP 8452All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C 463262All SZGR genes in this pathway
BUCKANOVICH_T_LYMPHOCYTE_HOMING_ON_TUMOR_UP 2411All SZGR genes in this pathway
MATZUK_PREOVULATORY_FOLLICLE 108All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP 425298All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_ESR1_UP 16799All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A4 196124All SZGR genes in this pathway
JISON_SICKLE_CELL_DISEASE_DN 18197All SZGR genes in this pathway
POOLA_INVASIVE_BREAST_CANCER_DN 13483All SZGR genes in this pathway
YAMASHITA_LIVER_CANCER_STEM_CELL_UP 4738All SZGR genes in this pathway
YAMASHITA_LIVER_CANCER_STEM_CELL_DN 7651All SZGR genes in this pathway
LI_PROSTATE_CANCER_EPIGENETIC 3022All SZGR genes in this pathway
PYEON_CANCER_HEAD_AND_NECK_VS_CERVICAL_UP 19395All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_2 8650All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_3 157All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_DN 8859All SZGR genes in this pathway
ACOSTA_PROLIFERATION_INDEPENDENT_MYC_TARGETS_DN 11674All SZGR genes in this pathway
BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN 8861All SZGR genes in this pathway
BHAT_ESR1_TARGETS_VIA_AKT1_DN 8251All SZGR genes in this pathway
SERVITJA_LIVER_HNF1A_TARGETS_DN 157105All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_7 403240All SZGR genes in this pathway
WANG_MLL_TARGETS 289188All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_DN 428246All SZGR genes in this pathway
LIM_MAMMARY_LUMINAL_MATURE_UP 11665All SZGR genes in this pathway
FARMER_BREAST_CANCER_CLUSTER_6 1613All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-130/30137663772m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-148/15237673773m8hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-18193819451A,m8hsa-miR-18aUAAGGUGCAUCUAGUGCAGAUA
hsa-miR-18bUAAGGUGCAUCUAGUGCAGUUA
miR-181199820051A,m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-188196202m8hsa-miR-188CAUCCCUUGCAUGGUGGAGGGU
miR-1942164222m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-203.1216521721A,m8hsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-204/211195201m8hsa-miR-204brainUUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211UUCCCUUUGUCAUCCUUCGCCU
miR-21922442250m8hsa-miR-219brainUGAUUGUCCAAACGCAAUUCU
miR-22229222991A,m8hsa-miR-22brainAAGCUGCCAGUUGAAGAACUGU
miR-221/222225322601A,m8hsa-miR-221brainAGCUACAUUGUCUGCUGGGUUUC
hsa-miR-222brainAGCUACAUCUGGCUACUGGGUCUC
miR-26398239881Ahsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-33041824188m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-361323332391Ahsa-miR-361brainUUAUCAGAAUCUCCAGGGGUAC
miR-496384138471Ahsa-miR-496AUUACAUGGCCAAUCUC
miR-9308630921Ahsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
miR-93.hd/291-3p/294/295/302/372/373/520379385m8hsa-miR-93brainAAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302aUAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302bUAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302cUAAGUGCUUCCAUGUUUCAGUGG
hsa-miR-302dUAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520eAAAGUGCUUCCUUUUUGAGGG
hsa-miR-520aAAAGUGCUUCCCUUUGGACUGU
hsa-miR-520bAAAGUGCUUCCUUUUAGAGGG
hsa-miR-520cAAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520dAAAGUGCUUCUCUUUGGUGGGUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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