Gene Page: FBLN2

Summary
GeneID  2199
Symbol  FBLN2
Synonyms  -
Description  fibulin 2
See related  HGNC:3601|MIM:135821|Ensembl:ENSG00000163520|HPRD:00630|
Locus tag  -
Gene type  protein-coding
Map location  3p25.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.006 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SIGLEC100.870.79
FCGR2A0.840.78
LAPTM50.830.78
ITGB20.830.77
NCKAP1L0.820.75
SIGLEC80.820.72
LCP10.820.76
HCK0.820.72
TLR70.800.71
CD530.800.77
Top 10 negatively co-expressed genes
AC098691.2-0.27-0.36
AF347015.18-0.24-0.27
AC016705.1-0.23-0.21
AC010300.1-0.22-0.30
ANP32C-0.21-0.20
MT-CO2-0.21-0.27
AF347015.21-0.21-0.24
AC100783.1-0.21-0.22
AF347015.26-0.21-0.22
AC073957.1-0.21-0.21
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005509calcium ion bindingIEA-
GO:0005509calcium ion bindingTAS7806230 
GO:0005201extracellular matrix structural constituentTAS7806230 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005578proteinaceous extracellular matrixTAS7806230 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACANAGC1 | AGCAN | CSPG1 | CSPGCP | MSK16 | SEDKaggrecan-HPRD,BioGRID11038354 
BCANBEHAB | CSPG7 | MGC13038brevican-HPRD,BioGRID11038354 
COL18A1FLJ27325 | FLJ34914 | KNO | KNO1 | MGC74745collagen, type XVIII, alpha 1-HPRD10544250 
COL4A1arrestencollagen, type IV, alpha 1-HPRD,BioGRID7500359 
COL4A2DKFZp686I14213 | FLJ22259collagen, type IV, alpha 2-HPRD,BioGRID7500359 
COL4A3-collagen, type IV, alpha 3 (Goodpasture antigen)-HPRD,BioGRID7500359 
COL4A4CA44collagen, type IV, alpha 4-HPRD,BioGRID7500359 
COL4A5ASLN | ATS | CA54 | MGC167109 | MGC42377collagen, type IV, alpha 5-HPRD,BioGRID7500359 
COL4A6MGC88184collagen, type IV, alpha 6-HPRD,BioGRID7500359 
ELNFLJ38671 | FLJ43523 | SVAS | WBS | WSelastin-HPRD,BioGRID10544250 
FBLN2-fibulin 2-HPRD,BioGRID9214621 
FBN1FBN | MASS | MFS1 | OCTD | SGS | WMSfibrillin 1Fibrillin-1 interacts with Fibulin-2.BIND8702639 
-HPRD,BioGRID8702639 |9886271 
FN1CIG | DKFZp686F10164 | DKFZp686H0342 | DKFZp686I1370 | DKFZp686O13149 | ED-B | FINC | FN | FNZ | GFND | GFND2 | LETS | MSFfibronectin 1-HPRD10848816 
HSPG2PLC | PRCAN | SJA | SJS | SJS1heparan sulfate proteoglycan 2-HPRD9431988 
Reconstituted ComplexBioGRID11493006 
LAMA1LAMAlaminin, alpha 1-HPRD,BioGRID9006922 |10934193 
LAMA5KIAA1907laminin, alpha 5-HPRD,BioGRID9006922 
LAMC2B2T | BM600 | CSF | EBR2 | EBR2A | LAMB2T | LAMNB2 | MGC138491 | MGC141938laminin, gamma 2-HPRD11733994 
NID1NIDnidogen 1-HPRD,BioGRID7500359 |11493006 
PRELPMGC45323 | MST161 | MSTP161 | SLRR2Aproline/arginine-rich end leucine-rich repeat protein-HPRD,BioGRID11847210 
VCANCSPG2 | DKFZp686K06110 | ERVR | PG-M | WGN | WGN1versican-HPRD,BioGRID11038354 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP 351230All SZGR genes in this pathway
CASTELLANO_NRAS_TARGETS_DN 1414All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_1_DN 378231All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2B 392251All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
SASAI_RESISTANCE_TO_NEOPLASTIC_TRANSFROMATION 5031All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_DN 411249All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_UP 6955All SZGR genes in this pathway
SUNG_METASTASIS_STROMA_UP 11070All SZGR genes in this pathway
LEE_LIVER_CANCER_DENA_UP 6040All SZGR genes in this pathway
NADLER_OBESITY_UP 6134All SZGR genes in this pathway
GUO_HEX_TARGETS_UP 8154All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_SPIKED 2213All SZGR genes in this pathway
IGLESIAS_E2F_TARGETS_UP 151103All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_UP 249170All SZGR genes in this pathway
YAMAZAKI_TCEB3_TARGETS_UP 175116All SZGR genes in this pathway
BURTON_ADIPOGENESIS_7 5134All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
RAMASWAMY_METASTASIS_UP 6643All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_MUSCLE_DN 5128All SZGR genes in this pathway
SANSOM_APC_TARGETS 212121All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_4NQO 3824All SZGR genes in this pathway
KYNG_DNA_DAMAGE_DN 195135All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN 591366All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
MCGARVEY_SILENCED_BY_METHYLATION_IN_COLON_CANCER 4229All SZGR genes in this pathway
ZHENG_GLIOBLASTOMA_PLASTICITY_UP 250168All SZGR genes in this pathway
LABBE_WNT3A_TARGETS_UP 11271All SZGR genes in this pathway
LABBE_TGFB1_TARGETS_UP 10264All SZGR genes in this pathway
LABBE_TARGETS_OF_TGFB1_AND_WNT3A_UP 11170All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_DN 277166All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2 491319All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
KARLSSON_TGFB1_TARGETS_UP 12778All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_1HR_UP 3426All SZGR genes in this pathway
DELACROIX_RARG_BOUND_MEF 367231All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
NABA_ECM_GLYCOPROTEINS 19699All SZGR genes in this pathway
NABA_CORE_MATRISOME 275148All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1283553621A,m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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